{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T15:47:42Z","timestamp":1794584862109,"version":"4.9.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272296"],"award-info":[{"award-number":["82272296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-026-69540-8","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T06:45:22Z","timestamp":1772001922000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spatiotemporally controlled restoration of GAS6 signaling via mRNA therapy promotes scarless healing in preclinical models"],"prefix":"10.1038","volume":"17","author":[{"given":"Yan","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengtai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8234-368X","authenticated-orcid":false,"given":"Parnia","family":"Ghanad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-2856","authenticated-orcid":false,"given":"Zhengwei","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0798-3444","authenticated-orcid":false,"given":"Zhigang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggang","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"69540_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nature07039","volume":"453","author":"GC Gurtner","year":"2008","unstructured":"Gurtner, G. C., Werner, S., Barrandon, Y. & Longaker, M. T. Wound repair and regeneration. Nature 453, 314\u2013321 (2008).","journal-title":"Nature"},{"key":"69540_CR2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41572-022-00377-3","volume":"8","author":"V Falanga","year":"2022","unstructured":"Falanga, V. et al. Chronic wounds. Nat. Rev. Dis. Primers 8, 50 (2022).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"69540_CR3","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1001\/jama.2018.12426","volume":"320","author":"RE Jones","year":"2018","unstructured":"Jones, R. E., Foster, D. S. & Longaker, M. T. Management of chronic wounds-2018. JAMA 320, 1481\u20131482 (2018).","journal-title":"JAMA"},{"key":"69540_CR4","doi-asserted-by":"publisher","first-page":"eadp2974","DOI":"10.1126\/science.adp2974","volume":"386","author":"P Martin","year":"2024","unstructured":"Martin, P., Pardo-Pastor, C., Jenkins, R. G. & Rosenblatt, J. Imperfect wound healing sets the stage for chronic diseases. Science 386, eadp2974 (2024).","journal-title":"Science"},{"key":"69540_CR5","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","volume":"25","author":"OA Pena","year":"2024","unstructured":"Pena, O. A. & Martin, P. Cellular and molecular mechanisms of skin wound healing. Nat. Rev. Mol. Cell Biol. 25, 599\u2013616 (2024).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"69540_CR6","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1152\/physrev.00067.2017","volume":"99","author":"M Rodrigues","year":"2019","unstructured":"Rodrigues, M., Kosaric, N., Bonham, C. A. & Gurtner, G. C. Wound healing: a cellular perspective. Physiol. Rev. 99, 665\u2013706 (2019).","journal-title":"Physiol. Rev."},{"key":"69540_CR7","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41579-024-01035-z","volume":"22","author":"A Uberoi","year":"2024","unstructured":"Uberoi, A., McCready-Vangi, A. & Grice, E. A. The wound microbiota: microbial mechanisms of impaired wound healing and infection. Nat. Rev. Microbiol. 22, 507\u2013521 (2024).","journal-title":"Nat. Rev. Microbiol."},{"key":"69540_CR8","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","volume":"9","author":"MG Jeschke","year":"2023","unstructured":"Jeschke, M. G. et al. Scars. Nat. Rev. Dis. Primers 9, 64 (2023).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"69540_CR9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","volume":"326","author":"A Bayat","year":"2003","unstructured":"Bayat, A., McGrouther, D. A. & Ferguson, M. W. Skin scarring. BMJ 326, 88\u201392 (2003).","journal-title":"BMJ"},{"key":"69540_CR10","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1016\/S0140-6736(16)31406-4","volume":"388","author":"CC Finnerty","year":"2016","unstructured":"Finnerty, C. C. et al. Hypertrophic scarring: the greatest unmet challenge after burn injury. Lancet 388, 1427\u20131436 (2016).","journal-title":"Lancet"},{"key":"69540_CR11","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1016\/j.stem.2022.07.006","volume":"29","author":"HE Talbott","year":"2022","unstructured":"Talbott, H. E., Mascharak, S., Griffin, M., Wan, D. C. & Longaker, M. T. Wound healing, fibroblast heterogeneity, and fibrosis. Cell Stem Cell 29, 1161\u20131180 (2022).","journal-title":"Cell Stem Cell"},{"key":"69540_CR12","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41586-023-06725-x","volume":"623","author":"D Correa-Gallegos","year":"2023","unstructured":"Correa-Gallegos, D. et al. CD201(+) fascia progenitors choreograph injury repair. Nature 623, 792\u2013802 (2023).","journal-title":"Nature"},{"key":"69540_CR13","doi-asserted-by":"publisher","first-page":"4717","DOI":"10.1016\/j.cell.2022.11.004","volume":"185","author":"S Sinha","year":"2022","unstructured":"Sinha, S. et al. Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell 185, 4717\u20134736.e4725 (2022).","journal-title":"Cell"},{"key":"69540_CR14","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/s41577-021-00540-z","volume":"21","author":"S Davidson","year":"2021","unstructured":"Davidson, S. et al. Fibroblasts as immune regulators in infection, inflammation and cancer. Nat. Rev. Immunol. 21, 704\u2013717 (2021).","journal-title":"Nat. Rev. Immunol."},{"key":"69540_CR15","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1016\/j.jid.2016.05.107","volume":"136","author":"B Shook","year":"2016","unstructured":"Shook, B., Xiao, E., Kumamoto, Y., Iwasaki, A. & Horsley, V. CD301b+ macrophages are essential for effective skin wound healing. J. Investig. Dermatol. 136, 1885\u20131891 (2016).","journal-title":"J. Investig. Dermatol."},{"key":"69540_CR16","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1016\/j.cmet.2021.07.017","volume":"33","author":"SA Eming","year":"2021","unstructured":"Eming, S. A., Murray, P. J. & Pearce, E. J. Metabolic orchestration of the wound healing response. Cell Metab. 33, 1726\u20131743 (2021).","journal-title":"Cell Metab."},{"key":"69540_CR17","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","volume":"635","author":"JM Amrute","year":"2024","unstructured":"Amrute, J. M. et al. Targeting immune-fibroblast cell communication in heart failure. Nature 635, 423\u2013433 (2024).","journal-title":"Nature"},{"key":"69540_CR18","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1016\/j.cmet.2024.05.013","volume":"36","author":"Y Jiang","year":"2024","unstructured":"Jiang, Y. et al. Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer. Cell Metab. 36, 1806\u20131822.e1811 (2024).","journal-title":"Cell Metab."},{"key":"69540_CR19","doi-asserted-by":"publisher","first-page":"eadj9559","DOI":"10.1126\/sciadv.adj9559","volume":"10","author":"Y Xu","year":"2024","unstructured":"Xu, Y., Ying, L., Lang, J. K., Hinz, B. & Zhao, R. Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy. Sci. Adv. 10, eadj9559 (2024).","journal-title":"Sci. Adv."},{"key":"69540_CR20","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41573-023-00846-8","volume":"23","author":"YR Miao","year":"2024","unstructured":"Miao, Y. R., Rankin, E. B. & Giaccia, A. J. Therapeutic targeting of the functionally elusive TAM receptor family. Nat. Rev. Drug Discov. 23, 201\u2013217 (2024).","journal-title":"Nat. Rev. Drug Discov."},{"key":"69540_CR21","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1146\/annurev-immunol-032414-112103","volume":"33","author":"CV Rothlin","year":"2015","unstructured":"Rothlin, C. V., Carrera-Silva, E. A., Bosurgi, L. & Ghosh, S. TAM receptor signaling in immune homeostasis. Annu. Rev. Immunol. 33, 355\u2013391 (2015).","journal-title":"Annu. Rev. Immunol."},{"key":"69540_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33938-x","volume":"13","author":"J Engelmann","year":"2022","unstructured":"Engelmann, J. et al. Regulation of bone homeostasis by MERTK and TYRO3. Nat. Commun. 13, 7689 (2022).","journal-title":"Nat. Commun."},{"key":"69540_CR23","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1136\/gutjnl-2016-313615","volume":"67","author":"E Triantafyllou","year":"2018","unstructured":"Triantafyllou, E. et al. MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure. Gut 67, 333\u2013347 (2018).","journal-title":"Gut"},{"key":"69540_CR24","doi-asserted-by":"publisher","first-page":"eadj0133","DOI":"10.1126\/scitranslmed.adj0133","volume":"16","author":"Z Pan","year":"2024","unstructured":"Pan, Z. et al. Inhibition of MERTK reduces organ fibrosis in mouse models of fibrotic disease. Sci. Transl. Med. 16, eadj0133 (2024).","journal-title":"Sci. Transl. Med."},{"key":"69540_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46564-6","volume":"15","author":"A Nerviani","year":"2024","unstructured":"Nerviani, A. et al. Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis. Nat. Commun. 15, 2398 (2024).","journal-title":"Nat. Commun."},{"key":"69540_CR26","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","volume":"26","author":"S Alivernini","year":"2020","unstructured":"Alivernini, S. et al. Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis. Nat. Med. 26, 1295\u20131306 (2020).","journal-title":"Nat. Med."},{"key":"69540_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-45341-9","volume":"15","author":"MTH Ng","year":"2024","unstructured":"Ng, M. T. H. et al. A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution. Nat. Commun. 15, 1394 (2024).","journal-title":"Nat. Commun."},{"key":"69540_CR28","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.immuni.2024.11.018","volume":"58","author":"C Lantz","year":"2025","unstructured":"Lantz, C. et al. Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration. Immunity 58, 344\u2013361.e347 (2025).","journal-title":"Immunity"},{"key":"69540_CR29","doi-asserted-by":"publisher","unstructured":"DeBerge, M. et al. Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. J. Clin. Investig. 131, https:\/\/doi.org\/10.1172\/JCI139576 (2021).","DOI":"10.1172\/JCI139576"},{"key":"69540_CR30","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41571-023-00813-7","volume":"20","author":"D DeRyckere","year":"2023","unstructured":"DeRyckere, D., Huelse, J. M., Earp, H. S. & Graham, D. K. TAM family kinases as therapeutic targets at the interface of cancer and immunity. Nat. Rev. Clin. Oncol. 20, 755\u2013779 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"69540_CR31","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-02041-7","volume":"18","author":"H Wu","year":"2021","unstructured":"Wu, H. et al. Mer regulates microglial\/macrophage M1\/M2 polarization and alleviates neuroinflammation following traumatic brain injury. J. Neuroinflammation 18, 2 (2021).","journal-title":"J. Neuroinflammation"},{"key":"69540_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1022-2","volume":"18","author":"KV Myers","year":"2019","unstructured":"Myers, K. V., Amend, S. R. & Pienta, K. J. Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment. Mol. Cancer 18, 94 (2019).","journal-title":"Mol. Cancer"},{"key":"69540_CR33","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/S0140-6736(23)02444-3","volume":"403","author":"H Parhiz","year":"2024","unstructured":"Parhiz, H., Atochina-Vasserman, E. N. & Weissman, D. mRNA-based therapeutics: looking beyond COVID-19 vaccines. Lancet 403, 1192\u20131204 (2024).","journal-title":"Lancet"},{"key":"69540_CR34","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/s41573-024-01042-y","volume":"23","author":"N Pardi","year":"2024","unstructured":"Pardi, N. & Krammer, F. mRNA vaccines for infectious diseases\u2014advances, challenges and opportunities. Nat. Rev. Drug Discov. 23, 838\u2013861 (2024).","journal-title":"Nat. Rev. Drug Discov."},{"key":"69540_CR35","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/s41392-024-02002-z","volume":"9","author":"Y Shi","year":"2024","unstructured":"Shi, Y., Shi, M., Wang, Y. & You, J. Progress and prospects of mRNA-based drugs in pre-clinical and clinical applications. Signal Transduct. Target. Ther. 9, 322 (2024).","journal-title":"Signal Transduct. Target. Ther."},{"key":"69540_CR36","doi-asserted-by":"publisher","first-page":"e2322935121","DOI":"10.1073\/pnas.2322935121","volume":"121","author":"S Wang","year":"2024","unstructured":"Wang, S. et al. Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle-mRNA formulation. Proc. Natl. Acad. Sci. USA 121, e2322935121 (2024).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"69540_CR37","doi-asserted-by":"publisher","first-page":"eadr2631","DOI":"10.1126\/sciadv.adr2631","volume":"11","author":"EL Meany","year":"2025","unstructured":"Meany, E. L. et al. Generation of an inflammatory niche in a hydrogel depot through recruitment of key immune cells improves efficacy of mRNA vaccines. Sci. Adv. 11, eadr2631 (2025).","journal-title":"Sci. Adv."},{"key":"69540_CR38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61299-8","volume":"16","author":"Y Zhu","year":"2025","unstructured":"Zhu, Y. et al. An mRNA lipid nanoparticle-incorporated nanofiber-hydrogel composite for cancer immunotherapy. Nat. Commun. 16, 5707 (2025).","journal-title":"Nat. Commun."},{"key":"69540_CR39","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.cmet.2019.11.013","volume":"31","author":"B Cai","year":"2020","unstructured":"Cai, B. et al. Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis. Cell Metab. 31, 406\u20134421.e407 (2020).","journal-title":"Cell Metab."},{"key":"69540_CR40","first-page":"18","volume":"8","author":"S Wei","year":"2021","unstructured":"Wei, S. et al. Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs. Mil. Med. Res. 8, 18 (2021).","journal-title":"Mil. Med. Res."},{"key":"69540_CR41","doi-asserted-by":"publisher","first-page":"210","DOI":"10.2337\/dc12-1323","volume":"36","author":"CM Valenzuela-Silva","year":"2013","unstructured":"Valenzuela-Silva, C. M. et al. Granulation response and partial wound closure predict healing in clinical trials on advanced diabetes foot ulcers treated with recombinant human epidermal growth factor. Diabetes Care 36, 210\u2013215 (2013).","journal-title":"Diabetes Care"},{"key":"69540_CR42","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1038\/s41586-022-04754-6","volume":"606","author":"S Maschalidi","year":"2022","unstructured":"Maschalidi, S. et al. Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes. Nature 606, 776\u2013784 (2022).","journal-title":"Nature"},{"key":"69540_CR43","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.abm0594","volume":"375","author":"JG Rurik","year":"2022","unstructured":"Rurik, J. G. et al. CAR T cells produced in vivo to treat cardiac injury. Science 375, 91\u201396 (2022).","journal-title":"Science"},{"key":"69540_CR44","doi-asserted-by":"publisher","first-page":"eadt9694","DOI":"10.1126\/sciadv.adt9694","volume":"11","author":"T Yang","year":"2025","unstructured":"Yang, T. et al. Preclinical evaluation of AGT mRNA replacement therapy for primary hyperoxaluria type I disease. Sci. Adv. 11, eadt9694 (2025).","journal-title":"Sci. Adv."},{"key":"69540_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47460-9","volume":"15","author":"R Baek","year":"2024","unstructured":"Baek, R. et al. Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria. Nat. Commun. 15, 3804 (2024).","journal-title":"Nat. Commun."},{"key":"69540_CR46","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1038\/s41587-022-01491-z","volume":"40","author":"E Rohner","year":"2022","unstructured":"Rohner, E., Yang, R., Foo, K. S., Goedel, A. & Chien, K. R. Unlocking the promise of mRNA therapeutics. Nat. Biotechnol. 40, 1586\u20131600 (2022).","journal-title":"Nat. Biotechnol."},{"key":"69540_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51056-8","volume":"15","author":"X Bai","year":"2024","unstructured":"Bai, X. et al. Optimized inhaled LNP formulation for enhanced treatment of idiopathic pulmonary fibrosis via mRNA-mediated antibody therapy. Nat. Commun. 15, 6844 (2024).","journal-title":"Nat. Commun."},{"key":"69540_CR48","doi-asserted-by":"publisher","unstructured":"Mascharak, S. et al. Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring. Science 372, https:\/\/doi.org\/10.1126\/science.aba2374 (2021).","DOI":"10.1126\/science.aba2374"},{"key":"69540_CR49","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.stem.2021.12.011","volume":"29","author":"S Mascharak","year":"2022","unstructured":"Mascharak, S. et al. Multi-omic analysis reveals divergent molecular events in scarring and regenerative wound healing. Cell Stem Cell 29, 315\u2013327.e316 (2022).","journal-title":"Cell Stem Cell"},{"key":"69540_CR50","doi-asserted-by":"publisher","first-page":"eabb3312","DOI":"10.1126\/scitranslmed.abb3312","volume":"13","author":"MF Griffin","year":"2021","unstructured":"Griffin, M. F. et al. JUN promotes hypertrophic skin scarring via CD36 in preclinical in vitro and in vivo models. Sci. Transl. Med. 13, eabb3312 (2021).","journal-title":"Sci. Transl. Med."},{"key":"69540_CR51","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.immuni.2023.01.011","volume":"56","author":"SK Wculek","year":"2023","unstructured":"Wculek, S. K. et al. Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis. Immunity 56, 516\u2013530 e519 (2023).","journal-title":"Immunity"},{"key":"69540_CR52","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.cmet.2019.01.006","volume":"29","author":"L Du","year":"2019","unstructured":"Du, L. et al. IGF-2 preprograms maturing macrophages to acquire oxidative phosphorylation-dependent anti-inflammatory properties. Cell Metab. 29, 1363\u20131375.e1368 (2019).","journal-title":"Cell Metab."},{"key":"69540_CR53","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/s41573-022-00470-y","volume":"21","author":"P Mehrotra","year":"2022","unstructured":"Mehrotra, P. & Ravichandran, K. S. Drugging the efferocytosis process: concepts and opportunities. Nat. Rev. Drug Discov. 21, 601\u2013620 (2022).","journal-title":"Nat. Rev. Drug Discov."},{"key":"69540_CR54","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo, Q. et al. NF-kappaB in biology and targeted therapy: new insights and translational implications. Signal Transduct. Target. Ther. 9, 53 (2024).","journal-title":"Signal Transduct. Target. Ther."},{"key":"69540_CR55","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s41392-023-01705-z","volume":"8","author":"ME Bahar","year":"2023","unstructured":"Bahar, M. E., Kim, H. J. & Kim, D. R. Targeting the RAS\/RAF\/MAPK pathway for cancer therapy: from mechanism to clinical studies. Signal Transduct. Target. Ther. 8, 455 (2023).","journal-title":"Signal Transduct. Target. Ther."},{"key":"69540_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-06122-0","volume":"23","author":"Y Li","year":"2025","unstructured":"Li, Y. et al. Exploring TNFR1: from discovery to targeted therapy development. J. Transl. Med. 23, 71 (2025).","journal-title":"J. Transl. Med."},{"key":"69540_CR57","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1016\/j.bbadis.2017.06.002","volume":"1863","author":"MC Erlandsson","year":"2017","unstructured":"Erlandsson, M. C. et al. IGF-1R signalling contributes to IL-6 production and T cell dependent inflammation in rheumatoid arthritis. Biochim. Biophys. Acta Mol. Basis Dis. 1863, 2158\u20132170 (2017).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"69540_CR58","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.cytogfr.2019.03.001","volume":"50","author":"SW Jere","year":"2019","unstructured":"Jere, S. W., Houreld, N. N. & Abrahamse, H. Role of the PI3K\/AKT (mTOR and GSK3beta) signalling pathway and photobiomodulation in diabetic wound healing. Cytokine Growth Factor Rev. 50, 52\u201359 (2019).","journal-title":"Cytokine Growth Factor Rev."},{"key":"69540_CR59","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1681\/ASN.2019030321","volume":"30","author":"E Kefaloyianni","year":"2019","unstructured":"Kefaloyianni, E. et al. Proximal tubule-derived amphiregulin amplifies and integrates profibrotic EGF receptor signals in kidney fibrosis. J. Am. Soc. Nephrol. 30, 2370\u20132383 (2019).","journal-title":"J. Am. Soc. Nephrol."},{"key":"69540_CR60","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.kint.2019.04.012","volume":"96","author":"H Li","year":"2019","unstructured":"Li, H. et al. Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int. 96, 674\u2013688 (2019).","journal-title":"Kidney Int."},{"key":"69540_CR61","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-58987-w","volume":"16","author":"F Zhang","year":"2025","unstructured":"Zhang, F. et al. A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing. Nat. Commun. 16, 3738 (2025).","journal-title":"Nat. Commun."},{"key":"69540_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39129-6","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. Scarless wound healing programmed by core-shell microneedles. Nat. Commun. 14, 3431 (2023).","journal-title":"Nat. Commun."},{"key":"69540_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21964-0","volume":"12","author":"J Zhang","year":"2021","unstructured":"Zhang, J. et al. A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing. Nat. Commun. 12, 1670 (2021).","journal-title":"Nat. Commun."},{"key":"69540_CR64","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.jhep.2023.08.016","volume":"79","author":"R Chen","year":"2023","unstructured":"Chen, R. et al. A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis. J. Hepatol. 79, 1478\u20131490 (2023).","journal-title":"J. Hepatol."},{"key":"69540_CR65","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1126\/science.aaf1358","volume":"352","author":"PY Chan","year":"2016","unstructured":"Chan, P. Y. et al. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352, 99\u2013103 (2016).","journal-title":"Science"},{"key":"69540_CR66","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.actbio.2025.02.046","volume":"196","author":"X Li","year":"2025","unstructured":"Li, X. et al. A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis. Acta Biomater. 196, 109\u2013122 (2025).","journal-title":"Acta Biomater."},{"key":"69540_CR67","doi-asserted-by":"publisher","unstructured":"Kim, D. H. et al. Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarization. Eur Respir J. https:\/\/doi.org\/10.1183\/13993003.00615-2024 (2025).","DOI":"10.1183\/13993003.00615-2024"},{"key":"69540_CR68","doi-asserted-by":"publisher","first-page":"G1043","DOI":"10.1152\/ajpgi.00311.2010","volume":"300","author":"A Fourcot","year":"2011","unstructured":"Fourcot, A. et al. Gas6 deficiency prevents liver inflammation, steatohepatitis, and fibrosis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G1043\u2013G1053 (2011).","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"69540_CR69","doi-asserted-by":"publisher","first-page":"e2412253","DOI":"10.1002\/adma.202412253","volume":"36","author":"Z Chen","year":"2024","unstructured":"Chen, Z. et al. Engineered enucleated mesenchymal stem cells regulating immune microenvironment and promoting wound healing. Adv. Mater. 36, e2412253 (2024).","journal-title":"Adv. Mater."},{"key":"69540_CR70","doi-asserted-by":"publisher","unstructured":"Lin, Y. et al. Tissue-specific mRNA delivery and prime editing with peptide-ionizable lipid nanoparticles. Nat. Mater. https:\/\/doi.org\/10.1038\/s41563-025-02320-9 (2025).","DOI":"10.1038\/s41563-025-02320-9"}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-69540-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-69540-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-69540-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T12:03:03Z","timestamp":1775131383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-69540-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,25]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["69540"],"URL":"https:\/\/doi.org\/10.1038\/s41467-026-69540-8","relation":{},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,25]]},"assertion":[{"value":"9 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"3171"}}