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However, detrimental effects on plants arising from bacterial colonization that exploits plant-derived metabolites are rarely documented. Here, we demonstrate that the rhizosphere-derived\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    sp. strain NyZ480 exhibits a versatile capacity to effectively degrade and utilize simple coumarins\n                    <jats:bold>\u2014<\/jats:bold>\n                    a class of root exudates essential for plant iron acquisition and pathogen defense. This robust catabolic capability is mediated by conserved genetic determinants in NyZ480. In particular, redundant degradation-initiating\n                    <jats:italic>xenA<\/jats:italic>\n                    genes confer NyZ480 not only growth using simple coumarins but also resistance to these antimicrobial metabolites. Consequently, NyZ480 significantly colonizes iron-stressed, coumarin-secreting Arabidopsis roots, trapping plants in perpetual iron scarcity and progressively compromising iron acquisition and overall fitness. Bioinformatic analyses indicate that\n                    <jats:italic>xenA<\/jats:italic>\n                    homologs are prevalent and redundant in environmental bacteria. Thus, we reveal a rhizospheric phenomenon where microorganisms opportunistically utilize and detoxify host-secreted specialized metabolites under stress conditions, enhancing colonization and impairing plant fitness.\n                  <\/jats:p>","DOI":"10.1038\/s41467-026-71037-3","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T13:34:57Z","timestamp":1774445697000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Rhizobacteria opportunistically boost colonization and impair plant fitness by degrading plant-derived coumarins under iron deficiency"],"prefix":"10.1038","volume":"17","author":[{"given":"Yichao","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3247-7511","authenticated-orcid":false,"given":"Piaopiao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6720-7490","authenticated-orcid":false,"given":"Gang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-5750","authenticated-orcid":false,"given":"Ning-Yi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"71037_CR1","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.molp.2019.06.001","volume":"12","author":"S Wang","year":"2019","unstructured":"Wang, S., Alseekh, S., Fernie, A. 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