{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:13:44Z","timestamp":1793229224077,"version":"4.5.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL168198"],"award-info":[{"award-number":["HL168198"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL147844"],"award-info":[{"award-number":["HL147844"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL165813"],"award-info":[{"award-number":["HL165813"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL165826"],"award-info":[{"award-number":["HL165826"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23TPA1141824"],"award-info":[{"award-number":["23TPA1141824"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"U.S. Department of Health & Human Services | NIH | NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD025178"],"award-info":[{"award-number":["S10OD025178"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM127607"],"award-info":[{"award-number":["GM127607"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Commun"],"DOI":"10.1038\/s41467-026-73646-4","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:55:16Z","timestamp":1779796516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["TAK1 drives inflammatory fibroblast acquisition and shapes myocardial infarction responses in male mice"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-0300","authenticated-orcid":false,"given":"Daniel C.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8957-1277","authenticated-orcid":false,"given":"Jonah K.","family":"Stephan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2724-0492","authenticated-orcid":false,"given":"Lianay Gutierrez","family":"Luque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Brainard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth R.","family":"Brittian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8497-2848","authenticated-orcid":false,"given":"Collin K.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6810-1105","authenticated-orcid":false,"given":"Madison S.","family":"Teer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0201-2840","authenticated-orcid":false,"given":"Yania","family":"Martinez-Ondaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-7586","authenticated-orcid":false,"given":"Kara R.","family":"Gouwens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle T.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7934-7821","authenticated-orcid":false,"given":"Yibing","family":"Nong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-6040","authenticated-orcid":false,"given":"Nolan L.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-2848","authenticated-orcid":false,"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5376-8089","authenticated-orcid":false,"given":"Steven P.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hellmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Wysoczynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5332-8286","authenticated-orcid":false,"given":"Bradford G.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"73646_CR1","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","volume":"119","author":"SD Prabhu","year":"2016","unstructured":"Prabhu, S. D. & Frangogiannis, N. G. The biological basis for cardiac repair after myocardial infarction: from inflammation to fibrosis. Circ. Res 119, 91\u2013112 (2016).","journal-title":"Circ. Res"},{"key":"73646_CR2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","volume":"45","author":"MA Matter","year":"2024","unstructured":"Matter, M. A. et al. Inflammation in acute myocardial infarction: the good, the bad and the ugly. Eur. Heart J. 45, 89\u2013103 (2024).","journal-title":"Eur. Heart J."},{"key":"73646_CR3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41586-024-08008-5","volume":"635","author":"JM Amrute","year":"2024","unstructured":"Amrute, J. M. et al. Targeting immune-fibroblast cell communication in heart failure. Nature 635, 423\u2013433 (2024).","journal-title":"Nature"},{"key":"73646_CR4","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/s41586-024-08085-6","volume":"635","author":"M Alexanian","year":"2024","unstructured":"Alexanian, M. et al. Chromatin remodelling drives immune cell-fibroblast communication in heart failure. Nature 635, 434\u2013443 (2024).","journal-title":"Nature"},{"key":"73646_CR5","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14110","volume":"54","author":"MG Del Buono","year":"2024","unstructured":"Del Buono, M. G. et al. Pathogenic pathways and therapeutic targets of inflammation in heart diseases: a focus on Interleukin-1. Eur. J. Clin. Invest 54, e14110 (2024).","journal-title":"Eur. J. Clin. Invest"},{"key":"73646_CR6","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jacbts.2019.02.006","volume":"4","author":"C Humeres","year":"2019","unstructured":"Humeres, C. & Frangogiannis, N. G. Fibroblasts in the infarcted, remodeling, and failing heart. JACC Basic Transl. Sci. 4, 449\u2013467 (2019).","journal-title":"JACC Basic Transl. Sci."},{"key":"73646_CR7","doi-asserted-by":"publisher","unstructured":"Bageghni, S. A. et al. Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction. JCI Insight https:\/\/doi.org\/10.1172\/jci.insight.125074 (2019).","DOI":"10.1172\/jci.insight.125074"},{"key":"73646_CR8","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.4049\/jimmunol.1300725","volume":"191","author":"A Saxena","year":"2013","unstructured":"Saxena, A. et al. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J. Immunol. 191, 4838\u20134848 (2013).","journal-title":"J. Immunol."},{"key":"73646_CR9","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1126\/science.270.5244.2008","volume":"270","author":"K Yamaguchi","year":"1995","unstructured":"Yamaguchi, K. et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270, 2008\u20132011 (1995).","journal-title":"Science"},{"key":"73646_CR10","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.it.2013.03.007","volume":"34","author":"AA Ajibade","year":"2013","unstructured":"Ajibade, A. A., Wang, H. Y. & Wang, R. F. Cell type-specific function of TAK1 in innate immune signaling. Trends Immunol. 34, 307\u2013316 (2013).","journal-title":"Trends Immunol."},{"key":"73646_CR11","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/iub.1078","volume":"64","author":"L Dai","year":"2012","unstructured":"Dai, L., Aye Thu, C., Liu, X. Y., Xi, J. & Cheung, P. C. TAK1, more than just innate immunity. IUBMB Life 64, 825\u2013834 (2012).","journal-title":"IUBMB Life"},{"key":"73646_CR12","doi-asserted-by":"publisher","unstructured":"Singhal, R. et al. Temporal dynamics in murine cardiac transcriptome following myocardial infarction. Circ. Res. https:\/\/doi.org\/10.1161\/CIRCRESAHA.125.327367 (2025).","DOI":"10.1161\/CIRCRESAHA.125.327367"},{"key":"73646_CR13","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1172\/JCI98215","volume":"128","author":"X Fu","year":"2018","unstructured":"Fu, X. et al. Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart. J. Clin. Invest 128, 2127\u20132143 (2018).","journal-title":"J. Clin. Invest"},{"key":"73646_CR14","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1093\/eurheartj\/ehy128","volume":"39","author":"LF Buckley","year":"2018","unstructured":"Buckley, L. F. & Abbate, A. Interleukin-1 blockade in cardiovascular diseases: a clinical update. Eur. Heart J. 39, 2063\u20132069 (2018).","journal-title":"Eur. Heart J."},{"key":"73646_CR15","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nmeth.1314","volume":"6","author":"EK Schmidt","year":"2009","unstructured":"Schmidt, E. K., Clavarino, G., Ceppi, M. & Pierre, P. SUnSET, a nonradioactive method to monitor protein synthesis. Nat. Methods 6, 275\u2013277 (2009).","journal-title":"Nat. Methods"},{"key":"73646_CR16","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/ni1255","volume":"6","author":"S Sato","year":"2005","unstructured":"Sato, S. et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6, 1087\u20131095 (2005).","journal-title":"Nat. Immunol."},{"key":"73646_CR17","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature13839","volume":"514","author":"E Ubil","year":"2014","unstructured":"Ubil, E. et al. Mesenchymal-endothelial transition contributes to cardiac neovascularization. Nature 514, 585\u2013590 (2014).","journal-title":"Nature"},{"key":"73646_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-019-0722-5","volume":"114","author":"L Bacmeister","year":"2019","unstructured":"Bacmeister, L. et al. Inflammation and fibrosis in murine models of heart failure. Basic Res. Cardiol. 114, 19 (2019).","journal-title":"Basic Res. Cardiol."},{"key":"73646_CR19","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.ajpath.2019.04.009","volume":"189","author":"FJ Carrillo-Salinas","year":"2019","unstructured":"Carrillo-Salinas, F. J., Ngwenyama, N., Anastasiou, M., Kaur, K. & Alcaide, P. Heart inflammation: immune cell roles and roads to the heart.  Am. J. Pathol. 189, 1482\u20131494 (2019).","journal-title":"Am. J. Pathol."},{"key":"73646_CR20","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","volume":"11","author":"NG Frangogiannis","year":"2014","unstructured":"Frangogiannis, N. G. The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev. Cardiol. 11, 255\u2013265 (2014).","journal-title":"Nat. Rev. Cardiol."},{"key":"73646_CR21","doi-asserted-by":"publisher","first-page":"H1056","DOI":"10.1152\/ajpheart.00459.2021","volume":"321","author":"ML Lindsey","year":"2021","unstructured":"Lindsey, M. L. et al. Guidelines for in vivo mouse models of myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 321, H1056\u2013H1073 (2021).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"73646_CR22","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1161\/CIRCRESAHA.118.314028","volume":"124","author":"G Bajpai","year":"2019","unstructured":"Bajpai, G. et al. Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury. Circ. Res 124, 263\u2013278 (2019).","journal-title":"Circ. Res"},{"key":"73646_CR23","doi-asserted-by":"publisher","unstructured":"Little, D. T. et al. Activated cardiac fibroblasts are a primary source high molecular weight hyaluronan production. 328, C939\u2013C953 Am. J. Physiol. Cell Physiol. https:\/\/doi.org\/10.1152\/ajpcell.00786.2024 (2025).","DOI":"10.1152\/ajpcell.00786.2024"},{"key":"73646_CR24","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.immuni.2014.02.009","volume":"40","author":"CD Buckley","year":"2014","unstructured":"Buckley, C. D., Gilroy, D. W. & Serhan, C. N. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity 40, 315\u2013327 (2014).","journal-title":"Immunity"},{"key":"73646_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103992","volume":"79","author":"GV Halade","year":"2022","unstructured":"Halade, G. V. & Lee, D. H. Inflammation and resolution signaling in cardiac repair and heart failure. EBioMedicine 79, 103992 (2022).","journal-title":"EBioMedicine"},{"key":"73646_CR26","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abe4932","volume":"14","author":"H Abe","year":"2021","unstructured":"Abe, H. et al. NF-kappaB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C(hi) monocytes in pressure-overloaded hearts. Sci. Signal 14, eabe4932 (2021).","journal-title":"Sci. Signal"},{"key":"73646_CR27","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1042\/CS20243091","volume":"139","author":"EB Taylor","year":"2025","unstructured":"Taylor, E. B. et al. Sex differences in the chronic autoimmune response to myocardial infarction. Clin. Sci. (Lond.) 139, 627\u2013648 (2025).","journal-title":"Clin. Sci. (Lond.)"},{"key":"73646_CR28","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1007\/s00395-014-0444-7","volume":"109","author":"V Kain","year":"2014","unstructured":"Kain, V., Prabhu, S. D. & Halade, G. V. Inflammation revisited: inflammation versus resolution of inflammation following myocardial infarction. Basic Res Cardiol. 109, 444 (2014).","journal-title":"Basic Res Cardiol."},{"key":"73646_CR29","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/jcb.22488","volume":"109","author":"CW Lee","year":"2010","unstructured":"Lee, C. W. et al. Activation and induction of cytosolic phospholipase A2 by IL-1beta in human tracheal smooth muscle cells: role of MAPKs\/p300 and NF-kappaB. J. Cell Biochem 109, 1045\u20131056 (2010).","journal-title":"J. Cell Biochem"},{"key":"73646_CR30","doi-asserted-by":"publisher","first-page":"43842","DOI":"10.1074\/jbc.M101516200","volume":"276","author":"N Degousee","year":"2001","unstructured":"Degousee, N. et al. p38 MAPK regulates group IIa phospholipase A2 expression in interleukin-1beta -stimulated rat neonatal cardiomyocytes. J. Biol. Chem. 276, 43842\u201343849 (2001).","journal-title":"J. Biol. Chem."},{"key":"73646_CR31","doi-asserted-by":"publisher","first-page":"552","DOI":"10.5483\/BMBRep.2009.42.9.552","volume":"42","author":"UR Mbonye","year":"2009","unstructured":"Mbonye, U. R. & Song, I. Posttranscriptional and posttranslational determinants of cyclooxygenase expression. BMB Rep. 42, 552\u2013560 (2009).","journal-title":"BMB Rep."},{"key":"73646_CR32","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/9550","volume":"5","author":"DW Gilroy","year":"1999","unstructured":"Gilroy, D. W. et al. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med 5, 698\u2013701 (1999).","journal-title":"Nat. Med"},{"key":"73646_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60586-8","volume":"16","author":"P Fabre","year":"2025","unstructured":"Fabre, P. et al. Bioactive lipid mediator class switching regulates myogenic cell progression and muscle regeneration. Nat. Commun. 16, 5578 (2025).","journal-title":"Nat. Commun."},{"key":"73646_CR34","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev-pathmechdis-012418-012718","volume":"15","author":"M Locati","year":"2020","unstructured":"Locati, M., Curtale, G. & Mantovani, A. Diversity, mechanisms, and significance of macrophage plasticity. Annu Rev. Pathol. 15, 123\u2013147 (2020).","journal-title":"Annu Rev. Pathol."},{"key":"73646_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2020.109888","volume":"79","author":"IM Reichardt","year":"2021","unstructured":"Reichardt, I. M., Robeson, K. Z., Regnier, M. & Davis, J. Controlling cardiac fibrosis through fibroblast state space modulation. Cell Signal 79, 109888 (2021).","journal-title":"Cell Signal"},{"key":"73646_CR36","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.matbio.2024.08.001","volume":"133","author":"AG Fischer","year":"2024","unstructured":"Fischer, A. G. et al. Matricellular protein CCN1 promotes collagen alignment and scar integrity after myocardial infarction. Matrix Biol. 133, 14\u201332 (2024).","journal-title":"Matrix Biol."},{"key":"73646_CR37","doi-asserted-by":"publisher","unstructured":"Hindi, S. M. et al. TAK1 regulates skeletal muscle mass and mitochondrial function. JCI Insight https:\/\/doi.org\/10.1172\/jci.insight.98441 (2018).","DOI":"10.1172\/jci.insight.98441"},{"key":"73646_CR38","doi-asserted-by":"publisher","first-page":"H784","DOI":"10.1152\/ajpheart.00411.2021","volume":"321","author":"TN Audam","year":"2021","unstructured":"Audam, T. N. et al. Cardiac PANK1 deletion exacerbates ventricular dysfunction during pressure overload. Am. J. Physiol. Heart Circ. Physiol. 321, H784\u2013H797 (2021).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"73646_CR39","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1093\/toxsci\/kfab125","volume":"185","author":"IN Zelko","year":"2021","unstructured":"Zelko, I. N. et al. Chronic benzene exposure aggravates pressure overload-induced cardiac dysfunction. Toxicol. Sci. 185, 64\u201376 (2021).","journal-title":"Toxicol. Sci."},{"key":"73646_CR40","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.yjmcc.2024.11.009","volume":"198","author":"TN Audam","year":"2025","unstructured":"Audam, T. N. et al. Hyaluronan provokes inflammation but suppresses phagocytotic function in macrophages. J. Mol. Cell Cardiol. 198, 24\u201335 (2025).","journal-title":"J. Mol. Cell Cardiol."},{"key":"73646_CR41","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.yjmcc.2025.07.005","volume":"206","author":"CK Wells","year":"2025","unstructured":"Wells, C. K. et al. Pyruvate kinase splice variants in fibroblasts influence cardiac remodeling after myocardial infarction in male mice. J. Mol. Cell Cardiol. 206, 11\u201326 (2025).","journal-title":"J. Mol. Cell Cardiol."},{"key":"73646_CR42","doi-asserted-by":"publisher","first-page":"H733","DOI":"10.1152\/ajpheart.00339.2017","volume":"314","author":"ML Lindsey","year":"2018","unstructured":"Lindsey, M. L., Kassiri, Z., Virag, J. A. I., de Castro Bras, L. E. & Scherrer-Crosbie, M. Guidelines for measuring cardiac physiology in mice. Am. J. Physiol. Heart Circ. Physiol. 314, H733\u2013H752 (2018).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"73646_CR43","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1161\/hc3601.094298","volume":"104","author":"M Scherrer-Crosbie","year":"2001","unstructured":"Scherrer-Crosbie, M. et al. Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation 104, 1286\u20131291 (2001).","journal-title":"Circulation"},{"key":"73646_CR44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3727\/096368916X692221","volume":"26","author":"M Wysoczynski","year":"2017","unstructured":"Wysoczynski, M. et al. Poor mobilization in T-cell-deficient nude mice is explained by defective activation of granulocytes and monocytes. Cell Transpl. 26, 83\u201393 (2017).","journal-title":"Cell Transpl."},{"key":"73646_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71580-z","volume":"10","author":"Y Kang","year":"2020","unstructured":"Kang, Y. et al. Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice. Sci. Rep. 10, 14754 (2020).","journal-title":"Sci. Rep."},{"key":"73646_CR46","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401654R","volume":"39","author":"JK Stephan","year":"2025","unstructured":"Stephan, J. K. et al. Neutrophil-secreted CHI3L1 exacerbates cardiac dysfunction and inflammation after myocardial infarction. FASEB J. 39, e70422 (2025).","journal-title":"FASEB J."},{"key":"73646_CR47","doi-asserted-by":"publisher","unstructured":"Stephan, J. K. et al. G-CSF-induced emergency granulopoiesis modulates neutrophil effector function in mice. Stem Cell Rev. Rep. https:\/\/doi.org\/10.1007\/s12015-025-10885-w (2025).","DOI":"10.1007\/s12015-025-10885-w"},{"key":"73646_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.108091","volume":"301","author":"T Jobe","year":"2025","unstructured":"Jobe, T. et al. Phase partitioning of the neutrophil oxidative burst is coordinated by accessory pathways of glucose metabolism and mitochondrial activity. J. Biol. Chem. 301, 108091 (2025).","journal-title":"J. Biol. Chem."},{"key":"73646_CR49","doi-asserted-by":"publisher","first-page":"H109","DOI":"10.1152\/ajpheart.00114.2020","volume":"319","author":"TN Audam","year":"2020","unstructured":"Audam, T. N. et al. Cardiac mesenchymal cells from failing and nonfailing hearts limit ventricular dilation when administered late after infarction. Am. J. Physiol. Heart Circ. Physiol. 319, H109\u2013h122 (2020).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"73646_CR50","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/bs.mcb.2017.08.017","volume":"143","author":"RJ Midura","year":"2018","unstructured":"Midura, R. J., Cali, V., Lauer, M. E., Calabro, A. & Hascall, V. C. Quantification of hyaluronan (HA) using a simplified fluorophore-assisted carbohydrate electrophoresis (FACE) procedure. Methods Cell Biol. 143, 297\u2013316 (2018).","journal-title":"Methods Cell Biol."},{"key":"73646_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101637","volume":"66","author":"EP Calderin","year":"2022","unstructured":"Calderin, E. P. et al. Exercise-induced specialized proresolving mediators stimulate AMPK phosphorylation to promote mitochondrial respiration in macrophages. Mol. Metab. 66, 101637 (2022).","journal-title":"Mol. Metab."},{"key":"73646_CR52","unstructured":"Andrews, S. FastQC: A Quality Control Tool for High Throughput Sequence Data, http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/ (2015)."},{"key":"73646_CR53","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013).","journal-title":"Bioinformatics"},{"key":"73646_CR54","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"73646_CR55","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq-a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"key":"73646_CR56","doi-asserted-by":"publisher","first-page":"D463","DOI":"10.1093\/nar\/gkv1042","volume":"44","author":"M Sud","year":"2016","unstructured":"Sud, M. et al. Metabolomics Workbench: an international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools. Nucleic acids Res. 44, D463\u2013D470 (2016).","journal-title":"Nucleic acids Res."}],"container-title":["Nature Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-73646-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-73646-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-73646-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:39:33Z","timestamp":1784950773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41467-026-73646-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["73646"],"URL":"https:\/\/doi.org\/10.1038\/s41467-026-73646-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6122755\/v1","asserted-by":"object"}]},"ISSN":["2041-1723"],"issn-type":[{"value":"2041-1723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"6861"}}