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P.A. has received funding from Boston Scientific, Johnson & Johnson, Casen Recordati, and Viatris as a lecturer and to attend medical conferences. J.B. has, in the past 3 years, served as a consultant, advisory-board member, and\/or speaker for Takeda, Roche, Medice, Angelini, Neuraxpharm, and Servier; he is not an employee or shareholder of any of these companies and reports no other financial or material support, including expert testimony, patents, or royalties. J.D.F. receives consultation fees from NOCD, Inc. P.M. has, in the past 3 years, received grants, CME-related honoraria, or consulting fees from Angelini, AstraZeneca, Bial, Biogen, DGS-Portugal, CES, FCT, FLAD, Janssen-Cilag, Gulbenkian Foundation, Lundbeck, Springer Healthcare, Tecnimede, Viatris, and 2CA-Braga. D.M.-C. receives royalties for articles contributed to UpToDate, Inc., and is part-owner of Scandinavian E-Health AB (all outside the submitted work). Y.S. is an employee of XNef, Inc. R.G.S. holds a scientific productivity grant from the National Council for Scientific and Technological Development (#307386\/2021-0). D.J.S. has, in the past 3 years, received consultancy honoraria from Discovery Vitality, Johnson & Johnson, Kanna, L\u2019Or\u00e9al, Lundbeck, Orion, Sanofi, Servier, Takeda, and Vistagen. C.P. has, in the past 3 years, consulted for Biohaven Pharmaceuticals, Ceruvia Lifesciences, Freedom Biosciences, UCB BioPharma, Nobilis Therapeutics, Transcend Therapeutics, F-Prime Capital Partners, Madison Avenue Partners, and Lundbeck Therapeutics; received research support from Transcend, Freedom, and Biohaven; and holds equity in Alco Therapeutics, Biohaven Pharmaceuticals, and Mind Therapeutics, none of which relate to the current work, and is an inventor on several unrelated patents. 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