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Micro-lensed fibers offer a promising solution, yet scalable fabrication with predictable geometry and deterministic optical performance has remained elusive. Here, we introduce laser-controlled wet-chemical etching (LCWCE), a single-parameter strategy that directly sculpts micro-lenses, from hyperbolic to parabolic and prolate elliptical profiles, on standard optical fibers. Local laser illumination establishes an axially confined etching-rate gradient, enabling sub-micrometer control of curvature and working distance independent of fiber type or internal structure. A physics-separated multiphysics framework combining wave optics, heat-transfer, and temperature-dependent etching kinetics captures the observed geometry evolution and validates the underlying mechanism. LCWCE enables milliwatt-scale, minimal-power fiber-based optical trapping, as well as minimally invasive in vivo dendritic detection and single-cell neural interrogation beyond 1.5\u2009mm depth\u00a0in live brains, transforming ubiquitous optical fibers into scalable, high-performance photonic probes.<\/jats:p>","DOI":"10.1038\/s41467-026-75331-y","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:45:18Z","timestamp":1786124718000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deterministic wet etching of aspheric fiber microlenses with tunable conic geometry for tailored optical functionality"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6988-245X","authenticated-orcid":false,"given":"Sanggon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9640-3511","authenticated-orcid":false,"given":"Iason","family":"Keramidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Plasencia-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louison","family":"Brochoire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Bories","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie","family":"Barbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-2726","authenticated-orcid":false,"given":"Younes","family":"Messaddeq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5779-9330","authenticated-orcid":false,"given":"Yves","family":"De Koninck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,7]]},"reference":[{"key":"75331_CR1","doi-asserted-by":"publisher","first-page":"24190","DOI":"10.1364\/OE.26.024190","volume":"26","author":"PJ Winzer","year":"2018","unstructured":"Winzer, P. 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