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Instructed by environmental signals, type 1 conventional dendritic cells (cDC1) contribute to both processes but how the balance may be achieved is unclear. Here, we uncover an interferon (IFN)\u03b3-driven regulatory circuit in early life that relays dietary cues to spleen cDC1. IFN\u03b3-mediated STAT1-signaling induces an immunogenic maturation program in spleen cDC1 that enables them to shape the effector differentiation of antigen-experienced effector memory CD8\u207a T cells. This cDC1 program emerges during the transition from breastfeeding to solid food at weaning, occurs in germ-free mice, and remains operative to dietary intervention in adult mice. At weaning, this IFN\u03b3 signal enables spleen cDC1 to shape the effector phenotype of food-antigen-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in a feedforward manner, thereby recalibrating the developing T cell pool. Our findings identify diet as a modifiable cue that can tune systemic cDC1-mediated immunity, opening new opportunities to steer immune responses during early life and beyond.\n                  <\/jats:p>","DOI":"10.1038\/s41467-026-75853-5","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T09:02:06Z","timestamp":1785834126000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peri-weaning, diet-induced activation of an IFN\u03b3-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell 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