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In principle, such approaches would allow the impact of a single-atom change within a molecular framework to be distinguished from the effects of also altering the peripheral substituents. Yet despite this conceptual power, single-step methodologies for single-atom exchange in aromatic systems remain rare. Herein, we present a boron-to-carbon swapping reaction via a substituent-rebound process, converting 1,2-benzazaborines into the corresponding quinolines. The employment of glyoxylic acid as the carbon-atom source allows the original substituent on the boron atom to be recaptured and incorporated into the quinoline product, representing a rare example of true single-atom skeletal editing. The transformation exhibits high levels of functional group tolerance and is applicable to the late-stage modifications of natural product and pharmaceutical derivatives. Furthermore, comprehensive mechanistic investigations elucidate the intricacies of this process, establishing a foundation for future single-atom editing manifolds that can facilitate the interrogation of structure\u2013function relationships with atom-level precision.<\/jats:p>","DOI":"10.1038\/s41467-026-75992-9","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T02:46:04Z","timestamp":1784947564000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Substituent-rebound skeletal editing for precise boron-to-carbon single-atom swapping"],"prefix":"10.1038","volume":"17","author":[{"given":"Yan-Bo","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Peng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-1847","authenticated-orcid":false,"given":"Jasper L.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6709-3673","authenticated-orcid":false,"given":"Constantin G.","family":"Daniliuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0648-956X","authenticated-orcid":false,"given":"Frank","family":"Glorius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"75992_CR1","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1021\/cr950066q","volume":"96","author":"GA Patani","year":"1996","unstructured":"Patani, G. 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