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For inherited\n                    <jats:italic>POT1<\/jats:italic>\n                    mutations, it remains unclear whether elongated telomeres are transmitted to the next generation and whether the inherited long telomeres elevate cancer risk. Using a nanopore sequencing approach that provides haplotype-specific telomere length resolution, we examined telomere inheritance in families carrying\n                    <jats:italic>POT1<\/jats:italic>\n                    mutations. We found that offspring preferentially inherit their longest telomeres from the carrier parent, consistent with extensive germline telomere elongation, whereas comparatively short telomeres predominantly derive from the non-carrier parent. Analysis of carrier and non-carrier siblings demonstrated that telomeres from both parents are elongated in\n                    <jats:italic>POT1<\/jats:italic>\n                    carriers, with preferential elongation of the shortest telomeres. These findings support a potential mechanism of genetic anticipation in which\n                    <jats:italic>POT1<\/jats:italic>\n                    mutations progressively deplete short telomeres capable of enforcing telomere-based tumor suppression from the carrier germline. Therefore, telomeres inherited from both parents jointly shape telomere-based tumor suppressive barriers.\n                  <\/jats:p>","DOI":"10.1038\/s41467-026-77414-2","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T11:03:06Z","timestamp":1789383786000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Telomere length of both parents contributes to heritable POT1 cancer-predisposition syndrome"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3369-1495","authenticated-orcid":false,"given":"Annika","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alise","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-6555","authenticated-orcid":false,"given":"Kim E.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago E.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5580-7512","authenticated-orcid":false,"given":"Steven E.","family":"Artandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-0740","authenticated-orcid":false,"given":"Sharon A.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5598-5092","authenticated-orcid":false,"given":"Dirk","family":"Hockemeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"77414_CR1","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/ng.2941","volume":"46","author":"J Shi","year":"2014","unstructured":"Shi, J. et al. 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