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Here we present a flexible microelectrode platform for repeated recordings in awake rhesus macaques. We fabricated a 32-channel, 7-\u03bcm-thick Parylene-C array and developed a telescopic insertion method using concentric guide tubes and a retractable microwire shuttle to repeatedly deliver free-floating arrays through intact dura using standard recording chambers. Across two animals, we optimized the electrode geometry and insertion to achieve an 80% single-unit recording success rate. During an oculomotor delayed response task, we recorded stable task-responsive neurons from prefrontal and posterior parietal cortex. Compared with rigid probes in the same animals and recording chambers, flexible arrays achieved a comparable single-unit yield while reducing drift from hundreds to tens of micrometers. Our work establishes flexible microelectrodes as a practical and high-performing technology for primate neuroscience.<\/jats:p>","DOI":"10.1038\/s41467-026-77421-3","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T09:34:48Z","timestamp":1788946488000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Repeatable, low-drift recordings in behaving nonhuman primates using flexible microelectrodes"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2453-4010","authenticated-orcid":false,"given":"Daniel P.","family":"Woods","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2910-8272","authenticated-orcid":false,"given":"Grace M.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3147-840X","authenticated-orcid":false,"given":"Rana","family":"Mozumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxime","family":"Chev\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7441-022X","authenticated-orcid":false,"given":"Christos","family":"Constantinidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4120-9383","authenticated-orcid":false,"given":"Daniel L.","family":"Gonzales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"77421_CR1","doi-asserted-by":"crossref","unstructured":"Bastos, A. 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