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Our results show a large overlap of the genetic makeup associated with functional connectivity across brain networks but also identify network specific signals, suggesting a potential genetic stratification between cognitive and sensory-motor networks. We also identify a large genetic overlap between functional connectivity and risk for neuropsychiatric disorders, suggesting that regions of the genome important for neuronal communication are enriched for neuropsychiatric risk SNPs. The work presented here expands our understanding of the common allele architecture of brain connectivity, as well as provides novel targets to functional genomics research.<\/jats:p>","DOI":"10.1038\/s41467-026-77476-2","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:33:15Z","timestamp":1788319995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Common alleles associated with connectivity within and across the brain\u2019s main functional networks"],"prefix":"10.1038","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8490-6891","authenticated-orcid":false,"given":"Xavier","family":"Caseras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynsey","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6845-7590","authenticated-orcid":false,"given":"Antonio F.","family":"Pardi\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-407X","authenticated-orcid":false,"given":"Richard JL","family":"Anney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"77476_CR1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1002\/hbm.20580","volume":"29","author":"A Shmuel","year":"2008","unstructured":"Shmuel, A. & Leopold, D. 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