{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:43:57Z","timestamp":1792482237271,"version":"4.5.0"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat. Plants"],"DOI":"10.1038\/s41477-021-00913-1","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T11:02:38Z","timestamp":1621335758000},"page":"696-705","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["A general non-self response as part of plant immunity"],"prefix":"10.1038","volume":"7","author":[{"given":"Benjamin A.","family":"Maier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kiefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Hemmerle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Bortfeld-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Emmenegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-6163","authenticated-orcid":false,"given":"Sebastian","family":"Pfeilmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3065-0314","authenticated-orcid":false,"given":"Shinichi","family":"Sunagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6011-4910","authenticated-orcid":false,"given":"Julia A.","family":"Vorholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"913_CR1","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nrmicro2910","volume":"10","author":"JA Vorholt","year":"2012","unstructured":"Vorholt, J. A. Microbial life in the phyllosphere. Nat. Rev. Microbiol. 10, 828\u2013840 (2012).","journal-title":"Nat. Rev. Microbiol."},{"key":"913_CR2","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1128\/AEM.69.4.1875-1883.2003","volume":"69","author":"SE Lindow","year":"2003","unstructured":"Lindow, S. E. & Brandl, M. T. Microbiology of the phyllosphere. Appl. Environ. Microbiol. 69, 1875\u20131883 (2003).","journal-title":"Appl. Environ. Microbiol."},{"key":"913_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev-genet-120215-034952","volume":"50","author":"DB M\u00fcller","year":"2016","unstructured":"M\u00fcller, D. B., Vogel, C., Bai, Y. & Vorholt, J. A. The plant microbiota: systems-level insights and perspectives. Annu. Rev. Genet 50, 211\u2013234 (2016).","journal-title":"Annu. Rev. Genet"},{"key":"913_CR4","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1146\/annurev-phyto-080516-035623","volume":"55","author":"S Hacquard","year":"2017","unstructured":"Hacquard, S., Spaepen, S., Garrido-Oter, R. & Schulze-Lefert, P. Interplay between innate immunity and the plant microbiota. Annu. Rev. Phytopathol. 55, 565\u2013589 (2017).","journal-title":"Annu. Rev. Phytopathol."},{"key":"913_CR5","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1094\/MPMI-19-0665","volume":"19","author":"RF Ditt","year":"2006","unstructured":"Ditt, R. F. et al. The Arabidopsis thaliana transcriptome in response to Agrobacterium tumefaciens. Mol. Plant Microbe Interact. 19, 665\u2013681 (2006).","journal-title":"Mol. Plant Microbe Interact."},{"key":"913_CR6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1365-313X.2006.02725.x","volume":"46","author":"R Thilmony","year":"2006","unstructured":"Thilmony, R., Underwood, W. & He, S. Y. Genome-wide transcriptional analysis of the Arabidopsis thaliana interaction with the plant pathogen Pseudomonas syringae pv. tomato DC3000 and the human pathogen Escherichia coli O157:H7. Plant J. 46, 34\u201353 (2006).","journal-title":"Plant J."},{"key":"913_CR7","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1094\/MPMI.2004.17.8.895","volume":"17","author":"BW Verhagen","year":"2004","unstructured":"Verhagen, B. W. et al. The transcriptome of rhizobacteria-induced systemic resistance in Arabidopsis. Mol. Plant Microbe Interact. 17, 895\u2013908 (2004).","journal-title":"Mol. Plant Microbe Interact."},{"key":"913_CR8","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1104\/pp.112.207324","volume":"160","author":"JE van de Mortel","year":"2012","unstructured":"van de Mortel, J. E. et al. Metabolic and transcriptomic changes induced in Arabidopsis by the rhizobacterium Pseudomonas fluorescens SS101. Plant Physiol. 160, 2173\u20132188 (2012).","journal-title":"Plant Physiol."},{"key":"913_CR9","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/nph.14036","volume":"212","author":"C Vogel","year":"2016","unstructured":"Vogel, C., Bodenhausen, N., Gruissem, W. & Vorholt, J. A. The Arabidopsis leaf transcriptome reveals distinct but also overlapping responses to colonization by phyllosphere commensals and pathogen infection with impact on plant health. New Phytol. 212, 192\u2013207 (2016).","journal-title":"New Phytol."},{"key":"913_CR10","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.pbi.2005.03.012","volume":"8","author":"JC D\u2019Auria","year":"2005","unstructured":"D\u2019Auria, J. C. & Gershenzon, J. The secondary metabolism of Arabidopsis thaliana: growing like a weed. Curr. Opin. Plant Biol. 8, 308\u2013316 (2005).","journal-title":"Curr. Opin. Plant Biol."},{"key":"913_CR11","doi-asserted-by":"publisher","unstructured":"Sato, F. in Encyclopedia of Life Sciences (ELS, 2014); https:\/\/doi.org\/10.1002\/9780470015902.a0001812.pub2","DOI":"10.1002\/9780470015902.a0001812.pub2"},{"key":"913_CR12","doi-asserted-by":"publisher","first-page":"eaau6389","DOI":"10.1126\/science.aau6389","volume":"364","author":"AC Huang","year":"2019","unstructured":"Huang, A. C. et al. A specialized metabolic network selectively modulates Arabidopsis root microbiota. Science 364, eaau6389 (2019).","journal-title":"Science"},{"key":"913_CR13","doi-asserted-by":"publisher","first-page":"12558","DOI":"10.1073\/pnas.1820691116","volume":"116","author":"M Voges","year":"2019","unstructured":"Voges, M., Bai, Y., Schulze-Lefert, P. & Sattely, E. S. Plant-derived coumarins shape the composition of an Arabidopsis synthetic root microbiome. Proc. Natl Acad. Sci. USA 116, 12558\u201312565 (2019).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"913_CR14","doi-asserted-by":"publisher","first-page":"4502","DOI":"10.1074\/jbc.M112.433300","volume":"288","author":"DV Badri","year":"2013","unstructured":"Badri, D. V., Chaparro, J. M., Zhang, R., Shen, Q. & Vivanco, J. M. Application of natural blends of phytochemicals derived from the root exudates of Arabidopsis to the soil reveal that phenolic-related compounds predominantly modulate the soil microbiome. J. Biol. Chem. 288, 4502\u20134512 (2013).","journal-title":"J. Biol. Chem."},{"key":"913_CR15","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/nph.16118","volume":"225","author":"M Pastorczyk","year":"2020","unstructured":"Pastorczyk, M. et al. The role of CYP71A12 monooxygenase in pathogen-triggered tryptophan metabolism and Arabidopsis immunity. New Phytol. 225, 400\u2013412 (2020).","journal-title":"New Phytol."},{"key":"913_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1126\/science.1164627","volume":"323","author":"NK Clay","year":"2009","unstructured":"Clay, N. K., Adio, A. M., Denoux, C., Jander, G. & Ausubel, F. M. Glucosinolate metabolites required for an Arabidopsis innate immune response. Science 323, 95\u2013101 (2009).","journal-title":"Science"},{"key":"913_CR17","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1111\/j.1365-313X.2010.04197.x","volume":"62","author":"K Schlaeppi","year":"2010","unstructured":"Schlaeppi, K., Abou-Mansour, E., Buchala, A. & Mauch, F. Disease resistance of Arabidopsis to Phytophthora brassicae is established by the sequential action of indole glucosinolates and camalexin. Plant J. 62, 840\u2013851 (2010).","journal-title":"Plant J."},{"key":"913_CR18","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature14907","volume":"525","author":"J Rajniak","year":"2015","unstructured":"Rajniak, J., Barco, B., Clay, N. K. & Sattely, E. S. A new cyanogenic metabolite in Arabidopsis required for inducible pathogen defence. Nature 525, 376\u2013379 (2015).","journal-title":"Nature"},{"key":"913_CR19","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1094\/MPMI-03-12-0071-R","volume":"25","author":"PL Nongbri","year":"2012","unstructured":"Nongbri, P. L. et al. Indole-3-acetaldoxime-derived compounds restrict root colonization in the beneficial interaction between Arabidopsis roots and the endophyte Piriformospora indica. Mol. Plant Microbe Interact. 25, 1186\u20131197 (2012).","journal-title":"Mol. Plant Microbe Interact."},{"key":"913_CR20","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nature16192","volume":"528","author":"Y Bai","year":"2015","unstructured":"Bai, Y. et al. Functional overlap of the Arabidopsis leaf and root microbiota. Nature 528, 364\u2013369 (2015).","journal-title":"Nature"},{"key":"913_CR21","doi-asserted-by":"publisher","first-page":"5529","DOI":"10.1128\/AEM.00639-12","volume":"78","author":"C Vogel","year":"2012","unstructured":"Vogel, C., Innerebner, G., Zingg, J., Guder, J. & Vorholt, J. A. Forward genetic in planta screen for identification of plant-protective traits of Sphingomonas sp. strain Fr1 against Pseudomonas syringae DC3000. Appl. Environ. Microbiol. 78, 5529\u20135535 (2012).","journal-title":"Appl. Environ. Microbiol."},{"key":"913_CR22","doi-asserted-by":"publisher","first-page":"420747","DOI":"10.1155\/2008\/420747","volume":"2008","author":"T Hruz","year":"2008","unstructured":"Hruz, T. et al. Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes. Adv. Bioinforma. 2008, 420747 (2008).","journal-title":"Adv. Bioinforma."},{"key":"913_CR23","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1104\/pp.113.227637","volume":"164","author":"G Bethke","year":"2014","unstructured":"Bethke, G. et al. Arabidopsis PECTIN METHYLESTERASEs contribute to immunity against Pseudomonas syringae. Plant Physiol. 164, 1093\u20131107 (2014).","journal-title":"Plant Physiol."},{"key":"913_CR24","doi-asserted-by":"publisher","first-page":"20119","DOI":"10.1073\/pnas.1218059109","volume":"109","author":"T Maekawa","year":"2012","unstructured":"Maekawa, T., Kracher, B., Vernaldi, S., Ver Loren van Themaat, E. & Schulze-Lefert, P. Conservation of NLR-triggered immunity across plant lineages. Proc. Natl Acad. Sci. USA 109, 20119\u201320123 (2012).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"913_CR25","doi-asserted-by":"publisher","first-page":"e07295","DOI":"10.7554\/eLife.07295","volume":"4","author":"S Liu","year":"2015","unstructured":"Liu, S., Kracher, B., Ziegler, J., Birkenbihl, R. P. & Somssich, I. E. Negative regulation of ABA signaling by WRKY33 is critical for Arabidopsis immunity towards Botrytis cinerea 2100. eLife 4, e07295 (2015).","journal-title":"eLife"},{"key":"913_CR26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11362","volume":"7","author":"S Hacquard","year":"2016","unstructured":"Hacquard, S. et al. Survival trade-offs in plant roots during colonization by closely related beneficial and pathogenic fungi. Nat. Commun. 7, 11362 (2016).","journal-title":"Nat. Commun."},{"key":"913_CR27","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.cell.2016.02.028","volume":"165","author":"K Hiruma","year":"2016","unstructured":"Hiruma, K. et al. Root endophyte Colletotrichum tofieldiae confers plant fitness benefits that are phosphate status dependent. Cell 165, 464\u2013474 (2016).","journal-title":"Cell"},{"key":"913_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1365-313X.2011.04578.x","volume":"67","author":"HU Stotz","year":"2011","unstructured":"Stotz, H. U. et al. Role of camalexin, indole glucosinolates, and side chain modification of glucosinolate-derived isothiocyanates in defense of Arabidopsis against Sclerotinia sclerotiorum. Plant J. 67, 81\u201393 (2011).","journal-title":"Plant J."},{"key":"913_CR29","doi-asserted-by":"publisher","first-page":"e74183","DOI":"10.1371\/journal.pone.0074183","volume":"8","author":"BE Howard","year":"2013","unstructured":"Howard, B. E. et al. High-throughput RNA sequencing of Pseudomonas-infected Arabidopsis reveals hidden transcriptome complexity and novel splice variants. PLoS ONE 8, e74183 (2013).","journal-title":"PLoS ONE"},{"key":"913_CR30","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1105\/tpc.114.134809","volume":"27","author":"B Li","year":"2015","unstructured":"Li, B. et al. Phosphorylation of trihelix transcriptional repressor ASR3 by MAP KINASE4 negatively regulates Arabidopsis immunity. Plant Cell 27, 839\u2013856 (2015).","journal-title":"Plant Cell"},{"key":"913_CR31","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9139","volume":"6","author":"X Zhan","year":"2015","unstructured":"Zhan, X. et al. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses. Nat. Commun. 6, 8139 (2015).","journal-title":"Nat. Commun."},{"key":"913_CR32","doi-asserted-by":"publisher","first-page":"D1064","DOI":"10.1093\/nar\/gkw1041","volume":"45","author":"CM Hooper","year":"2017","unstructured":"Hooper, C. M., Castleden, I. R., Tanz, S. K., Aryamanesh, N. & Millar, A. H. SUBA4: the interactive data analysis centre for Arabidopsis subcellular protein locations. Nucleic Acids Res. 45, D1064\u2013D1074 (2017).","journal-title":"Nucleic Acids Res."},{"key":"913_CR33","doi-asserted-by":"publisher","first-page":"D1185","DOI":"10.1093\/nar\/gks1151","volume":"41","author":"SK Tanz","year":"2013","unstructured":"Tanz, S. K. et al. SUBA3: a database for integrating experimentation and prediction to define the SUBcellular location of proteins in Arabidopsis. Nucleic Acids Res. 41, D1185\u2013D1191 (2013).","journal-title":"Nucleic Acids Res."},{"key":"913_CR34","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1073\/pnas.040569997","volume":"97","author":"AK Hull","year":"2000","unstructured":"Hull, A. K., Vij, R. & Celenza, J. L. Arabidopsis cytochrome P450s that catalyze the first step of tryptophan-dependent indole-3-acetic acid biosynthesis. Proc. Natl Acad. Sci. USA 97, 2379\u20132384 (2000).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"913_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.phytochem.2019.01.009","volume":"161","author":"TM Muller","year":"2019","unstructured":"Muller, T. M., Bottcher, C. & Glawischnig, E. Dissection of the network of indolic defence compounds in Arabidopsis thaliana by multiple mutant analysis. Phytochemistry 161, 11\u201320 (2019).","journal-title":"Phytochemistry"},{"key":"913_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.phytochem.2006.12.005","volume":"68","author":"E Glawischnig","year":"2007","unstructured":"Glawischnig, E. Camalexin. Phytochemistry 68, 401\u2013406 (2007).","journal-title":"Phytochemistry"},{"key":"913_CR37","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1111\/j.1364-3703.2006.00363.x","volume":"7","author":"G Wei","year":"2006","unstructured":"Wei, G. & Shirsat, A. H. Extensin over-expression in Arabidopsis limits pathogen invasiveness. Mol. Plant Pathol. 7, 579\u2013592 (2006).","journal-title":"Mol. Plant Pathol."},{"key":"913_CR38","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/j.1365-313X.2006.03017.x","volume":"49","author":"C Chassot","year":"2007","unstructured":"Chassot, C., Nawrath, C. & Metraux, J. P. Cuticular defects lead to full immunity to a major plant pathogen. Plant J. 49, 972\u2013980 (2007).","journal-title":"Plant J."},{"key":"913_CR39","doi-asserted-by":"crossref","unstructured":"Yu, Z. et al. The Brassicaceae-specific secreted peptides, STMPs, function in plant growth and pathogen defense. J. Integr. Plant Biol. 62, 403\u2013420 (2020).","DOI":"10.1111\/jipb.12817"},{"key":"913_CR40","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1105\/tpc.111.084301","volume":"23","author":"M Roux","year":"2011","unstructured":"Roux, M. et al. The Arabidopsis leucine-rich repeat receptor-like kinases BAK1\/SERK3 and BKK1\/SERK4 are required for innate immunity to hemibiotrophic and biotrophic pathogens. Plant Cell 23, 2440\u20132455 (2011).","journal-title":"Plant Cell"},{"key":"913_CR41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.mib.2019.08.003","volume":"49","author":"PJP Teixeira","year":"2019","unstructured":"Teixeira, P. J. P., Colaianni, N. R., Fitzpatrick, C. R. & Dangl, J. L. Beyond pathogens: microbiota interactions with the plant immune system. Curr. Opin. Microbiol. 49, 7\u201317 (2019).","journal-title":"Curr. Opin. Microbiol."},{"key":"913_CR42","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3389\/fpls.2014.00287","volume":"5","author":"SL Lebeis","year":"2014","unstructured":"Lebeis, S. L. The potential for give and take in plant\u2013microbiome relationships. Front. Plant Sci. 5, 287 (2014).","journal-title":"Front. Plant Sci."},{"key":"913_CR43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1046\/j.1365-2672.1998.00340.x","volume":"84","author":"FP Hu","year":"1998","unstructured":"Hu, F. P. & Young, J. M. Biocidal activity in plant pathogenic Acidovorax, Burkholderia, Herbaspirillum, Ralstonia and Xanthomonas spp. J. Appl. Microbiol. 84, 263\u2013271 (1998).","journal-title":"J. Appl. Microbiol."},{"key":"913_CR44","doi-asserted-by":"crossref","unstructured":"van der Wolf, J. & De Boer, S. H. in Principles of Plant\u2013Microbe Interactions: Microbes for Sustainable Agriculture (ed. Lugtenberg, B.) 65\u201377 (Springer, 2015).","DOI":"10.1007\/978-3-319-08575-3_9"},{"key":"913_CR45","first-page":"551","volume":"92","author":"CT Bull","year":"2010","unstructured":"Bull, C. T. et al. Comprehensive list of names of plant pathogenic bacteria, 1980\u20132007. J. Plant Pathol. 92, 551\u2013592 (2010).","journal-title":"J. Plant Pathol."},{"key":"913_CR46","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/jipb.12334","volume":"57","author":"J Shigeto","year":"2015","unstructured":"Shigeto, J. et al. Simultaneously disrupting AtPrx2, AtPrx25 and AtPrx71 alters lignin content and structure in Arabidopsis stem. J. Integr. Plant Biol. 57, 349\u2013356 (2015).","journal-title":"J. Integr. Plant Biol."},{"key":"913_CR47","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/j.1365-313X.2006.02716.x","volume":"46","author":"C Barth","year":"2006","unstructured":"Barth, C. & Jander, G. Arabidopsis myrosinases TGG1 and TGG2 have redundant function in glucosinolate breakdown and insect defense. Plant J. 46, 549\u2013562 (2006).","journal-title":"Plant J."},{"key":"913_CR48","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1104\/pp.15.00481","volume":"168","author":"TM Muller","year":"2015","unstructured":"Muller, T. M. et al. TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASE-mediated generation and metabolic analysis of camalexin-deficient cyp71a12 cyp71a13 double knockout lines. Plant Physiol. 168, 849\u2013858 (2015).","journal-title":"Plant Physiol."},{"key":"913_CR49","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.jplph.2009.11.006","volume":"167","author":"M Hara","year":"2010","unstructured":"Hara, M., Yatsuzuka, Y., Tabata, K. & Kuboi, T. Exogenously applied isothiocyanates enhance glutathione S-transferase expression in Arabidopsis but act as herbicides at higher concentrations. J. Plant Physiol. 167, 643\u2013649 (2010).","journal-title":"J. Plant Physiol."},{"key":"913_CR50","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/j.celrep.2013.03.030","volume":"3","author":"K Yu","year":"2013","unstructured":"Yu, K. et al. A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity. Cell Rep. 3, 1266\u20131278 (2013).","journal-title":"Cell Rep."},{"key":"913_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8658","volume":"6","author":"NM Cecchini","year":"2015","unstructured":"Cecchini, N. M., Steffes, K., Schlappi, M. R., Gifford, A. N. & Greenberg, J. T. Arabidopsis AZI1 family proteins mediate signal mobilization for systemic defence priming. Nat. Commun. 6, 7658 (2015).","journal-title":"Nat. Commun."},{"key":"913_CR52","first-page":"1573","volume":"9","author":"SA Bowling","year":"1997","unstructured":"Bowling, S. A., Clarke, J. D., Liu, Y., Klessig, D. F. & Dong, X. The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance. Plant Cell 9, 1573\u20131584 (1997).","journal-title":"Plant Cell"},{"key":"913_CR53","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1094\/MPMI.2001.14.10.1131","volume":"14","author":"X Li","year":"2001","unstructured":"Li, X., Clarke, J. D., Zhang, Y. & Dong, X. Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance. Mol. Plant Microbe Interact. 14, 1131\u20131139 (2001).","journal-title":"Mol. Plant Microbe Interact."},{"key":"913_CR54","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1094\/MPMI-10-14-0334-FI","volume":"28","author":"K Schlaeppi","year":"2015","unstructured":"Schlaeppi, K. & Bulgarelli, D. The plant microbiome at work. Mol. Plant Microbe Interact. 28, 212\u2013217 (2015).","journal-title":"Mol. Plant Microbe Interact."},{"key":"913_CR55","doi-asserted-by":"crossref","unstructured":"El-Esawi, M. A., Al-Ghamdi, A. A., Ali, H. M. & Ahmad, M. Overexpression of AtWRKY30 transcription factor enhances heat and drought stress tolerance in wheat (Triticum aestivum L.). Genes 10, 163 (2019).","DOI":"10.3390\/genes10020163"},{"key":"913_CR56","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s11103-013-0090-8","volume":"83","author":"TE Scarpeci","year":"2013","unstructured":"Scarpeci, T. E., Zanor, M. I., Mueller-Roeber, B. & Valle, E. M. Overexpression of AtWRKY30 enhances abiotic stress tolerance during early growth stages in Arabidopsis thaliana. Plant Mol. Biol. 83, 265\u2013277 (2013).","journal-title":"Plant Mol. Biol."},{"key":"913_CR57","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/BF02772594","volume":"21","author":"B Schlesier","year":"2003","unstructured":"Schlesier, B., Breton, F. & Mock, H. P. A hydroponic culture system for growing Arabidopsis thaliana plantlets under sterile conditions. Plant Mol. Biol. Rep. 21, 449\u2013456 (2003).","journal-title":"Plant Mol. Biol. Rep."},{"key":"913_CR58","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1365-313X.2007.03303.x","volume":"53","author":"J Fan","year":"2008","unstructured":"Fan, J., Crooks, C. & Lamb, C. High-throughput quantitative luminescence assay of the growth in planta of Pseudomonas syringae chromosomally tagged with Photorhabdus luminescens luxCDABE. Plant J. 53, 393\u2013399 (2008).","journal-title":"Plant J."},{"key":"913_CR59","first-page":"301","volume":"44","author":"EO King","year":"1954","unstructured":"King, E. O., Ward, M. K. & Raney, D. E. Two simple media for the demonstration of pyocyanin and fluorescin. J. Lab. Clin. Med. 44, 301\u2013307 (1954).","journal-title":"J. Lab. Clin. Med."},{"key":"913_CR60","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/1471-2105-12-323","volume":"12","author":"B Li","year":"2011","unstructured":"Li, B. & Dewey, C. N. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinf. 12, 323 (2011).","journal-title":"BMC Bioinf."},{"key":"913_CR61","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).","journal-title":"Bioinformatics"},{"key":"913_CR62","doi-asserted-by":"crossref","first-page":"4288","DOI":"10.1093\/nar\/gks042","volume":"40","author":"DJ McCarthy","year":"2012","unstructured":"McCarthy, D. J., Chen, Y. & Smyth, G. K. Differential expression analysis of multifactor RNA-seq experiments with respect to biological variation. Nucleic Acids Res. 40, 4288\u20134297 (2012).","journal-title":"Nucleic Acids Res."},{"key":"913_CR63","doi-asserted-by":"publisher","first-page":"W122","DOI":"10.1093\/nar\/gkx382","volume":"45","author":"T Tian","year":"2017","unstructured":"Tian, T. et al. agriGO v2.0: a GO analysis toolkit for the agricultural community, 2017 update. Nucleic Acids Res. 45, W122\u2013W129 (2017).","journal-title":"Nucleic Acids Res."},{"key":"913_CR64","doi-asserted-by":"publisher","first-page":"pdb.prot089094","DOI":"10.1101\/pdb.prot089094","volume":"2017","author":"M Mulleder","year":"2017","unstructured":"Mulleder, M., Bluemlein, K. & Ralser, M. A high-throughput method for the quantitative determination of free amino acids in Saccharomyces cerevisiae by hydrophilic interaction chromatography\u2013tandem mass spectrometry. Cold Spring Harb. Protoc. 2017, pdb.prot089094 (2017).","journal-title":"Cold Spring Harb. Protoc."},{"key":"913_CR65","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nmeth.3959","volume":"13","author":"HL Rost","year":"2016","unstructured":"Rost, H. L. et al. OpenMS: a flexible open-source software platform for mass spectrometry data analysis. Nat. Methods 13, 741\u2013748 (2016).","journal-title":"Nat. Methods"},{"key":"913_CR66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"913_CR67","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gky962","volume":"47","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M., Sato, Y., Furumichi, M., Morishima, K. & Tanabe, M. New approach for understanding genome variations in KEGG. Nucleic Acids Res. 47, D590\u2013D595 (2019).","journal-title":"Nucleic Acids Res."},{"key":"913_CR68","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-1-4939-3167-5_3","volume":"1374","author":"M Kanehisa","year":"2016","unstructured":"Kanehisa, M. KEGG bioinformatics resource for plant genomics and metabolomics. Methods Mol. Biol. 1374, 55\u201370 (2016).","journal-title":"Methods Mol. Biol."},{"key":"913_CR69","doi-asserted-by":"publisher","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","volume":"47","author":"S Kim","year":"2019","unstructured":"Kim, S. et al. PubChem 2019 update: improved access to chemical data. Nucleic Acids Res. 47, D1102\u2013D1109 (2019).","journal-title":"Nucleic Acids Res."},{"key":"913_CR70","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1104\/pp.16.01942","volume":"173","author":"P Schlapfer","year":"2017","unstructured":"Schlapfer, P. et al. Genome-wide prediction of metabolic enzymes, pathways, and gene clusters in plants. Plant Physiol. 173, 2041\u20132059 (2017).","journal-title":"Plant Physiol."},{"key":"913_CR71","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).","journal-title":"Nucleic Acids Res."},{"key":"913_CR72","first-page":"1","volume":"1695","author":"G Csardi","year":"2006","unstructured":"Csardi, G. & Nepusz, T. The igraph software package for complex network research. InterJournal 1695, 1\u20139 (2006).","journal-title":"InterJournal"},{"key":"913_CR73","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"913_CR74","unstructured":"Oksanen, J. et al. vegan: Community ecology. R package version 2.5-6 (2013)."},{"key":"913_CR75","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1093\/bioinformatics\/btn603","volume":"25","author":"S Bocker","year":"2009","unstructured":"Bocker, S., Letzel, M. C., Liptak, Z. & Pervukhin, A. SIRIUS: decomposing isotope patterns for metabolite identification. Bioinformatics 25, 218\u2013224 (2009).","journal-title":"Bioinformatics"},{"key":"913_CR76","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13321-016-0116-8","volume":"8","author":"S Bocker","year":"2016","unstructured":"Bocker, S. & Duhrkop, K. Fragmentation trees reloaded. J. Cheminform. 8, 5 (2016).","journal-title":"J. Cheminform."},{"key":"913_CR77","doi-asserted-by":"publisher","first-page":"12580","DOI":"10.1073\/pnas.1509788112","volume":"112","author":"K Duhrkop","year":"2015","unstructured":"Duhrkop, K., Shen, H., Meusel, M., Rousu, J. & Bocker, S. Searching molecular structure databases with tandem mass spectra using CSI:FingerID. Proc. Natl Acad. Sci. USA 112, 12580\u201312585 (2015).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"913_CR78","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1038\/nbt.3597","volume":"34","author":"M Wang","year":"2016","unstructured":"Wang, M. et al. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat. Biotechnol. 34, 828\u2013837 (2016).","journal-title":"Nat. Biotechnol."},{"key":"913_CR79","first-page":"D440","volume":"48","author":"K Haug","year":"2020","unstructured":"Haug, K. et al. MetaboLights: a resource evolving in response to the needs of its scientific community. Nucleic Acids Res. 48, D440\u2013D444 (2020).","journal-title":"Nucleic Acids Res."}],"container-title":["Nature Plants"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41477-021-00913-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41477-021-00913-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41477-021-00913-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T14:57:37Z","timestamp":1669993057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41477-021-00913-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,17]]},"references-count":79,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5]]}},"alternative-id":["913"],"URL":"https:\/\/doi.org\/10.1038\/s41477-021-00913-1","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740126690.793587712","asserted-by":"object"}]},"ISSN":["2055-0278"],"issn-type":[{"value":"2055-0278","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,17]]},"assertion":[{"value":"31 December 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}