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Plants"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hybrid seed failure arising from wide crosses between plant species is a recurring obstacle in plant breeding, impeding the transfer of desirable traits. This postzygotic reproductive barrier primarily occurs in the endosperm, a tissue that nourishes the embryo and functions similarly to the placenta in mammals. We found that incompatible seeds show a loss of DNA methylation and chromatin condensation in the endosperm, similar to seeds lacking maternal RNA polymerase IV activity. This similarity is linked to a decrease in small interfering RNAs in the endosperm (sirenRNAs), maternal RNA polymerase IV-dependent short interfering RNAs that regulate DNA methylation. Several AGAMOUS-like MADS-box transcription factor genes (\n                    <jats:italic>AGL<\/jats:italic>\n                    s), key regulators of endosperm development, are targeted by sirenRNAs in\n                    <jats:italic>cis<\/jats:italic>\n                    and in\n                    <jats:italic>trans<\/jats:italic>\n                    . This finding aligns with the enrichment of AGL target genes among deregulated genes. We propose that hybrid seed failure results from reduced maternal sirenRNAs combined with increased\n                    <jats:italic>AGL<\/jats:italic>\n                    expression, leading to abnormal gene regulation in the endosperm.\n                  <\/jats:p>","DOI":"10.1038\/s41477-024-01844-3","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T05:02:40Z","timestamp":1731301360000},"page":"1969-1983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dosage-sensitive maternal siRNAs determine hybridization success in Capsella"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-1417","authenticated-orcid":false,"given":"Katarzyna","family":"Dziasek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8712-9776","authenticated-orcid":false,"given":"Juan","family":"Santos-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5370-4170","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Rigola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Nijbroek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-4857","authenticated-orcid":false,"given":"Claudia","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"1844_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajb2.16135","volume":"110","author":"JM Coughlan","year":"2023","unstructured":"Coughlan, J. 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