{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:58:29Z","timestamp":1790456309600,"version":"4.1.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000925","name":"Department of Health | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["CNIG20nov-0018"],"award-info":[{"award-number":["CNIG20nov-0018"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Aging"],"DOI":"10.1038\/s41514-024-00187-9","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T09:52:01Z","timestamp":1732960321000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina"],"prefix":"10.1038","volume":"10","author":[{"given":"Samyuktha","family":"Suresh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1876-0975","authenticated-orcid":false,"given":"Gayathri","family":"Karthik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki","family":"Chrysostomou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See Aik","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Petretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Crowston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4127-1635","authenticated-orcid":false,"given":"Katharina C.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"187_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","volume":"25","author":"L Hayflick","year":"1961","unstructured":"Hayflick, L. & Moorhead, P. S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585\u2013621 (1961).","journal-title":"Exp. Cell Res."},{"key":"187_CR2","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","volume":"9","author":"R Kumari","year":"2021","unstructured":"Kumari, R. & Jat, P. Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype. Front. Cell Dev. Biol. 9, 645593 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"187_CR3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","volume":"75","author":"J Campisi","year":"2013","unstructured":"Campisi, J. Aging, cellular senescence, and cancer. Annu. Rev. Physiol. 75, 685\u2013705 (2013).","journal-title":"Annu. Rev. Physiol."},{"key":"187_CR4","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1172\/JCI95148","volume":"128","author":"N Herranz","year":"2018","unstructured":"Herranz, N. & Gil, J. Mechanisms and functions of cellular senescence. J. Clin. Invest. 128, 1238\u20131246 (2018).","journal-title":"J. Clin. Invest."},{"key":"187_CR5","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1038\/nrm2233","volume":"8","author":"J Campisi","year":"2007","unstructured":"Campisi, J. & D\u2019Adda Di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 8, 729\u2013740 (2007).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"187_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32552-1","volume":"13","author":"D Saul","year":"2022","unstructured":"Saul, D. et al. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat. Commun. 13, 4827 (2022).","journal-title":"Nat. Commun."},{"key":"187_CR7","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn, C., Blasco, M. A., Partridge, L., Serrano, M. & Kroemer, G. The hallmarks of aging. Cell 153, 1194 (2013).","journal-title":"Cell"},{"key":"187_CR8","doi-asserted-by":"publisher","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","volume":"92","author":"GP Dimri","year":"1995","unstructured":"Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363\u20139367 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"187_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature10600","volume":"479","author":"DJ Baker","year":"2011","unstructured":"Baker, D. J. et al. Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479, 232\u2013236 (2011).","journal-title":"Nature"},{"key":"187_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12861","volume":"18","author":"V Atella","year":"2019","unstructured":"Atella, V. et al. Trends in age-related disease burden and healthcare utilization. Aging Cell 18, e12861 (2019).","journal-title":"Aging Cell"},{"key":"187_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13073-015-0232-5","volume":"7","author":"R Guerreiro","year":"2015","unstructured":"Guerreiro, R. & Bras, J. The age factor in Alzheimer\u2019s disease. Genome Med. 7, 1\u20133 (2015).","journal-title":"Genome Med."},{"key":"187_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.arr.2014.01.004","volume":"14","author":"A Reeve","year":"2014","unstructured":"Reeve, A., Simcox, E. & Turnbull, D. Ageing and Parkinson\u2019s disease: why is advancing age the biggest risk factor? Ageing Res. Rev. 14, 19\u201330 (2014).","journal-title":"Ageing Res. Rev."},{"key":"187_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1136\/bjophthalmol-2015-307223","volume":"100","author":"VV Kapetanakis","year":"2016","unstructured":"Kapetanakis, V. V. et al. Global variations and time trends in the prevalence of primary open angle glaucoma (POAG): a systematic review and meta-analysis. Br. J. Ophthalmol. 100, 86\u201393 (2016).","journal-title":"Br. J. Ophthalmol."},{"key":"187_CR14","doi-asserted-by":"publisher","first-page":"473","DOI":"10.2147\/CIA.S2777","volume":"3","author":"R Ehrlich","year":"2008","unstructured":"Ehrlich, R. et al. Age-related macular degeneration and the aging eye. Clin. Interv. Aging 3, 473\u2013482 (2008).","journal-title":"Clin. Interv. Aging"},{"key":"187_CR15","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1111\/j.1474-9726.2012.00870.x","volume":"11","author":"D Jurk","year":"2012","unstructured":"Jurk, D. et al. Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell 11, 996\u20131004 (2012).","journal-title":"Aging Cell"},{"key":"187_CR16","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.tcb.2018.03.003","volume":"28","author":"P Sapieha","year":"2018","unstructured":"Sapieha, P. & Mallette, F. A. Cellular senescence in postmitotic cells: beyond growth arrest. Trends Cell Biol. 28, 595\u2013607 (2018).","journal-title":"Trends Cell Biol."},{"key":"187_CR17","doi-asserted-by":"publisher","first-page":"646924","DOI":"10.3389\/fnagi.2021.646924","volume":"13","author":"E Sikora","year":"2021","unstructured":"Sikora, E. et al. Cellular senescence in brain aging. Front. Aging Neurosci. 13, 646924 (2021).","journal-title":"Front. Aging Neurosci."},{"key":"187_CR18","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.molcel.2015.07.027","volume":"59","author":"D Skowronska-Krawczyk","year":"2015","unstructured":"Skowronska-Krawczyk, D. et al. P16INK4a upregulation mediated by SIX6 defines retinal ganglion cell pathogenesis in glaucoma. Mol. Cell 59, 931\u2013940 (2015).","journal-title":"Mol. Cell"},{"key":"187_CR19","doi-asserted-by":"crossref","unstructured":"Binet, F. et al. Neutrophil extracellular traps target senescent vasculature for tissue remodeling in retinopathy. Science 369, eaay5356 (2020).","DOI":"10.1126\/science.aay5356"},{"key":"187_CR20","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","volume":"33","author":"S Crespo-Garcia","year":"2021","unstructured":"Crespo-Garcia, S. et al. Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition. Cell Metab. 33, 818\u2013832.e7 (2021).","journal-title":"Cell Metab."},{"key":"187_CR21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1167\/iovs.65.10.29","volume":"65","author":"R Terao","year":"2024","unstructured":"Terao, R. et al. Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration. Invest. Ophthalmol. Vis. Sci. 65, 29 (2024).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"187_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-01990-9","volume":"21","author":"RA Avelar","year":"2020","unstructured":"Avelar, R. A. et al. A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol. 21, 91 (2020).","journal-title":"Genome Biol."},{"key":"187_CR23","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/bioinformatics\/btp073","volume":"25","author":"JP de Magalh\u00e3es","year":"2009","unstructured":"de Magalh\u00e3es, J. P., Curado, J. & Church, G. M. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 25, 875\u2013881 (2009).","journal-title":"Bioinformatics"},{"key":"187_CR24","doi-asserted-by":"crossref","unstructured":"Tominaga, K. & Suzuki, H. I. TGF-\u03b2 signaling in cellular senescence and aging-related pathology. Int. J. Mol. Sci. 20, 5002 (2019).","DOI":"10.3390\/ijms20205002"},{"key":"187_CR25","doi-asserted-by":"publisher","first-page":"5718","DOI":"10.1167\/iovs.10-5679","volume":"51","author":"AL Yu","year":"2010","unstructured":"Yu, A. L., Birke, K., Moriniere, J. & Welge-L\u00fcssen, U. TGF-{beta}2 induces senescence-associated changes in human trabecular meshwork cells. Invest. Ophthalmol. Vis. Sci. 51, 5718\u20135723 (2010).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"187_CR26","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1007\/s11357-023-00785-7","volume":"45","author":"C Cherry","year":"2023","unstructured":"Cherry, C. et al. Transfer learning in a biomaterial fibrosis model identifies in vivo senescence heterogeneity and contributions to vascularization and matrix production across species and diverse pathologies. GeroScience 45, 2559\u20132587 (2023).","journal-title":"GeroScience"},{"key":"187_CR27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000365","volume":"17","author":"Y Hu","year":"2019","unstructured":"Hu, Y. et al. Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis. PLoS Biol. 17, e3000365 (2019).","journal-title":"PLoS Biol."},{"key":"187_CR28","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/s41416-018-0066-1","volume":"118","author":"JM Gonzalez-Meljem","year":"2018","unstructured":"Gonzalez-Meljem, J. M., Apps, J. R., Fraser, H. C. & Martinez-Barbera, J. P. Paracrine roles of cellular senescence in promoting tumourigenesis. Br. J. Cancer 118, 1283\u20131288 (2018).","journal-title":"Br. J. Cancer"},{"key":"187_CR29","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s12272-009-1513-6","volume":"32","author":"NY Kim","year":"2009","unstructured":"Kim, N. Y., Woo, A. M., Kim, J. R. & Lee, C. Exploration of senescence-associated genes by differential display reverse transcription polymerase chain reaction: Prosaposin as a novel senescence-associated gene. Arch. Pharm. Res. 32, 737\u2013745 (2009).","journal-title":"Arch. Pharm. Res."},{"key":"187_CR30","doi-asserted-by":"publisher","first-page":"568814","DOI":"10.3389\/fneur.2020.568814","volume":"11","author":"E Ross-Munro","year":"2020","unstructured":"Ross-Munro, E. et al. Midkine: the who, what, where, and when of a promising neurotrophic therapy for perinatal brain injury. Front. Neurol. 11, 568814 (2020).","journal-title":"Front. Neurol."},{"key":"187_CR31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4103\/aja202258","volume":"25","author":"DC Feng","year":"2023","unstructured":"Feng, D. C. et al. Identification of senescence-related molecular subtypes and key genes for prostate cancer. Asian J. Androl. 25, 223\u2013229 (2023).","journal-title":"Asian J. Androl."},{"key":"187_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbcan.2019.04.003","volume":"1872","author":"F Bejjani","year":"2019","unstructured":"Bejjani, F., Evanno, E., Zibara, K., Piechaczyk, M. & Jariel-Encontre, I. The AP-1 transcriptional complex: local switch or remote command? Biochim. Biophys. Acta Rev. Cancer 1872, 11\u201323 (2019).","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"187_CR33","doi-asserted-by":"crossref","unstructured":"Kolesnichenko, M. et al. Transcriptional repression of NFKBIA triggers constitutive IKK\u2010 and proteasome\u2010independent p65\/RelA activation in senescence. EMBO J. 40, e104296 (2021).","DOI":"10.15252\/embj.2019104296"},{"key":"187_CR34","doi-asserted-by":"crossref","unstructured":"Chen, D. et al. LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11\u2010dependent repression of CDKN2A. Clin. Transl. Med. 13, e1418 (2023).","DOI":"10.1002\/ctm2.1418"},{"key":"187_CR35","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01280-4","volume":"21","author":"Y Oguma","year":"2023","unstructured":"Oguma, Y. et al. Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics. Cell Commun. Signal. 21, 262 (2023).","journal-title":"Cell Commun. Signal."},{"key":"187_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11357-016-9886-1","volume":"38","author":"LA Maciel-Bar\u00f3n","year":"2016","unstructured":"Maciel-Bar\u00f3n, L. A. et al. Senescence associated secretory phenotype profile from primary lung mice fibroblasts depends on the senescence induction stimuli. Age 38, 1\u201314 (2016).","journal-title":"Age"},{"key":"187_CR37","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1038\/s41556-020-0529-5","volume":"22","author":"RI Mart\u00ednez-Zamudio","year":"2020","unstructured":"Mart\u00ednez-Zamudio, R. I. et al. AP-1 imprints a reversible transcriptional programme of senescent cells. Nat. Cell Biol. 22, 842\u2013855 (2020).","journal-title":"Nat. Cell Biol."},{"key":"187_CR38","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1007\/s13238-021-00894-z","volume":"13","author":"Y Wang","year":"2022","unstructured":"Wang, Y., Liu, L., Song, Y., Yu, X. & Deng, H. Unveiling E2F4, TEAD1 and AP-1 as regulatory transcription factors of the replicative senescence program by multi-omics analysis. Protein Cell 13, 742\u2013759 (2022).","journal-title":"Protein Cell"},{"key":"187_CR39","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1007\/s00011-024-01892-7","volume":"73","author":"I Muela-Zarzuela","year":"2024","unstructured":"Muela-Zarzuela, I. et al. NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. Inflamm. Res. 73, 1253\u20131266 (2024).","journal-title":"Inflamm. Res."},{"key":"187_CR40","doi-asserted-by":"publisher","first-page":"204","DOI":"10.7150\/ijbs.38841","volume":"16","author":"P Zhou","year":"2020","unstructured":"Zhou, P., Wan, X., Zou, Y., Chen, Z. & Zhong, A. Transforming growth factor beta (TGF-\u03b2) is activated by the CtBP2-p300-AP1 transcriptional complex in chronic renal failure. Int. J. Biol. Sci. 16, 204\u2013215 (2020).","journal-title":"Int. J. Biol. Sci."},{"key":"187_CR41","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1158\/1541-7786.MCR-10-0105","volume":"9","author":"R Vartanian","year":"2011","unstructured":"Vartanian, R. et al. AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: Role of AIP4\/Itch-mediated JUNB degradation. Mol. Cancer Res. 9, 115\u2013130 (2011).","journal-title":"Mol. Cancer Res."},{"key":"187_CR42","doi-asserted-by":"crossref","unstructured":"Saraiva, M., Vieira, P. & O\u2019Garra, A. Biology and therapeutic potential of interleukin-10. J. Exp. Med. 217, e20190418 (2020).","DOI":"10.1084\/jem.20190418"},{"key":"187_CR43","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.molimm.2004.04.027","volume":"41","author":"IM Wang","year":"2004","unstructured":"Wang, I. M., Lin, H., Goldman, S. J. & Kobayashi, M. STAT-1 is activated by IL-4 and IL-13 in multiple cell types. Mol. Immunol. 41, 873\u2013884 (2004).","journal-title":"Mol. Immunol."},{"key":"187_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89860-7","volume":"11","author":"LP Deimel","year":"2021","unstructured":"Deimel, L. P., Li, Z., Roy, S. & Ranasinghe, C. STAT3 determines IL-4 signalling outcomes in na\u00efve T cells. Sci. Rep. 11, 10495 (2021).","journal-title":"Sci. Rep."},{"key":"187_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2017.00300","volume":"11","author":"WT Farmer","year":"2017","unstructured":"Farmer, W. T. & Murai, K. Resolving astrocyte heterogeneity in the CNS. Front. Cell. Neurosci. 11, 1\u20137 (2017).","journal-title":"Front. Cell. Neurosci."},{"key":"187_CR46","doi-asserted-by":"crossref","unstructured":"Tworig, J. M. & Feller, M. B. M\u00fcller glia in retinal development: from specification to circuit integration. Front. Neural Circuits 15, 815923 (2022).","DOI":"10.3389\/fncir.2021.815923"},{"key":"187_CR47","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/ncb2070","volume":"12","author":"JI Jun","year":"2010","unstructured":"Jun, J. I. & Lau, L. F. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat. Cell Biol. 12, 676\u2013685 (2010).","journal-title":"Nat. Cell Biol."},{"key":"187_CR48","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s11658-021-00287-4","volume":"26","author":"P Uruski","year":"2021","unstructured":"Uruski, P. et al. Primary high-grade serous ovarian cancer cells are sensitive to senescence induced by carboplatin and paclitaxel in vitro. Cell. Mol. Biol. Lett. 26, 44 (2021).","journal-title":"Cell. Mol. Biol. Lett."},{"key":"187_CR49","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nature08996","volume":"465","author":"X Wu","year":"2010","unstructured":"Wu, X. et al. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465, 368\u2013372 (2010).","journal-title":"Nature"},{"key":"187_CR50","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1038\/s41368-022-00180-6","volume":"14","author":"M Zhu","year":"2022","unstructured":"Zhu, M. et al. Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis. Int. J. Oral Sci. 14, 29 (2022).","journal-title":"Int. J. Oral Sci."},{"key":"187_CR51","doi-asserted-by":"publisher","first-page":"28743","DOI":"10.1074\/jbc.M113.499053","volume":"288","author":"HD Kim","year":"2013","unstructured":"Kim, H. D. et al. Interleukin-4 induces senescence in human renal carcinoma cell lines through STAT6 and p38 MAPK. J. Biol. Chem. 288, 28743\u201328754 (2013).","journal-title":"J. Biol. Chem."},{"key":"187_CR52","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nrc2772","volume":"10","author":"M Collado","year":"2010","unstructured":"Collado, M. & Serrano, M. Senescence in tumours: evidence from mice and humans. Nat. Rev. Cancer 10, 51\u201357 (2010).","journal-title":"Nat. Rev. Cancer"},{"key":"187_CR53","doi-asserted-by":"publisher","first-page":"4554","DOI":"10.1074\/jbc.M109.029280","volume":"285","author":"E Khattar","year":"2010","unstructured":"Khattar, E. & Kumar, V. Mitogenic regulation of p27Kip1 gene is mediated by AP-1 transcription factors. J. Biol. Chem. 285, 4554\u20134561 (2010).","journal-title":"J. Biol. Chem."},{"key":"187_CR54","doi-asserted-by":"crossref","unstructured":"M\u00fchl, H. Pro-inflammatory signaling by IL-10 and IL-22: Bad habit stirred up by interferons? Front. Immunol. 4, 18 (2013).","DOI":"10.3389\/fimmu.2013.00018"},{"key":"187_CR55","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0014-5793(96)00990-8","volume":"394","author":"J Wehinger","year":"1996","unstructured":"Wehinger, J. et al. IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. FEBS Lett. 394, 365\u2013370 (1996).","journal-title":"FEBS Lett."},{"key":"187_CR56","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s12079-019-00544-4","volume":"14","author":"DAB Rex","year":"2020","unstructured":"Rex, D. A. B. et al. A comprehensive pathway map of IL-18-mediated signalling. J. Cell Commun. Signal. 14, 257\u2013266 (2020).","journal-title":"J. Cell Commun. Signal."},{"key":"187_CR57","doi-asserted-by":"publisher","first-page":"108756","DOI":"10.1016\/j.biopha.2019.108756","volume":"113","author":"LM Zhang","year":"2019","unstructured":"Zhang, L. M. et al. Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression. Biomed. Pharmacother. 113, 108756 (2019).","journal-title":"Biomed. Pharmacother."},{"key":"187_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2023.156159","volume":"164","author":"L Kummola","year":"2023","unstructured":"Kummola, L. et al. IL-4, IL-13 and IFN-\u03b3 -induced genes in highly purified human neutrophils. Cytokine 164, 156159 (2023).","journal-title":"Cytokine"},{"key":"187_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-66092-9","volume":"10","author":"W Yan","year":"2020","unstructured":"Yan, W. et al. Cell atlas of the human fovea and peripheral retina. Sci. Rep. 10, 1\u201317 (2020).","journal-title":"Sci. Rep."},{"key":"187_CR60","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1161\/CIRCRESAHA.124.324722","volume":"135","author":"Q Chu","year":"2024","unstructured":"Chu, Q. et al. Oxysterol sensing through GPR183 triggers endothelial senescence in hypertension. Circ. Res. 135, 708\u2013721 (2024).","journal-title":"Circ. Res."},{"key":"187_CR61","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1038\/cdd.2012.91","volume":"19","author":"Y-T Chou","year":"2012","unstructured":"Chou, Y.-T. et al. CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence. Cell Death Differ. 19, 2015\u20132028 (2012).","journal-title":"Cell Death Differ."},{"key":"187_CR62","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29824-1","volume":"13","author":"M Troiani","year":"2022","unstructured":"Troiani, M. et al. Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer. Nat. Commun. 13, 2177 (2022).","journal-title":"Nat. Commun."},{"key":"187_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40370-2","volume":"14","author":"P Sinner","year":"2023","unstructured":"Sinner, P. et al. Microglial expression of CD83 governs cellular activation and restrains neuroinflammation in experimental autoimmune encephalomyelitis. Nat. Commun. 14, 4601 (2023).","journal-title":"Nat. Commun."},{"key":"187_CR64","doi-asserted-by":"crossref","unstructured":"Prieto-L\u00f3pez, L., Pereiro, X. & Vecino, E. The mechanics of the retina: M\u00fcller glia role on retinal extracellular matrix and modelling. Front. Med. 11, 1393057 (2024).","DOI":"10.3389\/fmed.2024.1393057"},{"key":"187_CR65","doi-asserted-by":"publisher","first-page":"C633","DOI":"10.1152\/ajpcell.00178.2023","volume":"325","author":"E Mavrogonatou","year":"2023","unstructured":"Mavrogonatou, E., Papadopoulou, A., Pratsinis, H. & Kletsas, D. Senescence-associated alterations in the extracellular matrix: deciphering their role in the regulation of cellular function. Am. J. Physiol. Cell Physiol. 325, C633\u2013C647 (2023).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"187_CR66","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.3390\/ijms25105332","volume":"25","author":"D Matveeva","year":"2024","unstructured":"Matveeva, D. et al. Senescence-associated alterations in matrisome of mesenchymal stem cells. Int. J. Mol. Sci. 25, 5332 (2024).","journal-title":"Int. J. Mol. Sci."},{"key":"187_CR67","doi-asserted-by":"publisher","first-page":"E1027","DOI":"10.1152\/ajpendo.00040.2016","volume":"310","author":"H Toba","year":"2016","unstructured":"Toba, H. et al. Increased ADAMTS1 mediates SPARC-dependent collagen deposition in the aging myocardium. Am. J. Physiol. Endocrinol. Metab. 310, E1027\u2013E1035 (2016).","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"187_CR68","doi-asserted-by":"crossref","unstructured":"Kucukdereli, H. et al. Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins hevin and SPARC. Proc. Natl Acad. Sci. USA 108, E440\u20139 (2011).","DOI":"10.1073\/pnas.1104977108"},{"key":"187_CR69","doi-asserted-by":"publisher","first-page":"720111","DOI":"10.3389\/fcell.2021.720111","volume":"9","author":"S Wang","year":"2021","unstructured":"Wang, S. et al. Inhibition of calcineurin\/NFAT signaling blocks oncogenic H-Ras induced autophagy in primary human keratinocytes. Front. Cell Dev. Biol. 9, 720111 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"187_CR70","doi-asserted-by":"publisher","first-page":"579629","DOI":"10.3389\/fcell.2020.579629","volume":"8","author":"M Zhang","year":"2020","unstructured":"Zhang, M. et al. Fra-1 inhibits cell growth and the Warburg effect in cervical cancer cells via STAT1 regulation of the p53 signaling pathway. Front. Cell Dev. Biol. 8, 579629 (2020).","journal-title":"Front. Cell Dev. Biol."},{"key":"187_CR71","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1038\/s41593-022-01022-8","volume":"25","author":"SE Marsh","year":"2022","unstructured":"Marsh, S. E. et al. Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain. Nat. Neurosci. 25, 306\u2013316 (2022).","journal-title":"Nat. Neurosci."},{"key":"187_CR72","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13083","volume":"19","author":"CSL Tuttle","year":"2020","unstructured":"Tuttle, C. S. L. et al. Cellular senescence and chronological age in various human tissues: a systematic review and meta-analysis. Aging Cell 19, e13083 (2020).","journal-title":"Aging Cell"},{"key":"187_CR73","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1523\/JNEUROSCI.20-06-02238.2000","volume":"20","author":"K Kolkova","year":"2000","unstructured":"Kolkova, K., Novitskaya, V., Pedersen, N., Berezin, V. & Bock, E. Neural cell adhesion molecule-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-mitogen-activated protein kinase pathway. J. Neurosci. 20, 2238\u20132246 (2000).","journal-title":"J. Neurosci."},{"key":"187_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.100817","volume":"23","author":"P Sharma","year":"2020","unstructured":"Sharma, P. et al. Biphasic role of Tgf-\u03b2 signaling during M\u00fcller glia reprogramming and retinal regeneration in zebrafish. iScience 23, 100817 (2020).","journal-title":"iScience"},{"key":"187_CR75","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew, M. V. Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol. 41, 758\u2013770 (2020).","journal-title":"Trends Immunol."},{"key":"187_CR76","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.it.2015.02.009","volume":"36","author":"A Lasry","year":"2015","unstructured":"Lasry, A. & Ben-Neriah, Y. Senescence-associated inflammatory responses: aging and cancer perspectives. Trends Immunol. 36, 217\u2013228 (2015).","journal-title":"Trends Immunol."},{"key":"187_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","volume":"51","author":"E Vecino","year":"2016","unstructured":"Vecino, E., Rodriguez, F. D., Ruzafa, N., Pereiro, X. & Sharma, S. C. Glia-neuron interactions in the mammalian retina. Prog. Retin. Eye Res. 51, 1\u201340 (2016).","journal-title":"Prog. Retin. Eye Res."},{"key":"187_CR78","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","volume":"562","author":"TJ Bussian","year":"2018","unstructured":"Bussian, T. J. et al. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562, 578\u2013582 (2018).","journal-title":"Nature"},{"key":"187_CR79","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1111\/jnc.14860","volume":"151","author":"DM Angelova","year":"2019","unstructured":"Angelova, D. M. & Brown, D. R. Microglia and the aging brain: are senescent microglia the key to neurodegeneration? J. Neurochem. 151, 676\u2013688 (2019).","journal-title":"J. Neurochem."},{"key":"187_CR80","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40035-024-00402-3","volume":"13","author":"C Rim","year":"2024","unstructured":"Rim, C., You, M.-J., Nahm, M. & Kwon, M.-S. Emerging role of senescent microglia in brain aging-related neurodegenerative diseases. Transl. Neurodegener. 13, 10 (2024).","journal-title":"Transl. Neurodegener."},{"key":"187_CR81","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/s42003-023-05027-2","volume":"6","author":"T Matsudaira","year":"2023","unstructured":"Matsudaira, T. et al. Cellular senescence in white matter microglia is induced during ageing in mice and exacerbates the neuroinflammatory phenotype. Commun. Biol. 6, 665 (2023).","journal-title":"Commun. Biol."},{"key":"187_CR82","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1089\/rej.2006.9096","volume":"10","author":"BE Flanary","year":"2007","unstructured":"Flanary, B. E., Sammons, N. W., Nguyen, C., Walker, D. & Streit, W. J. Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation Res. 10, 61\u201374 (2007).","journal-title":"Rejuvenation Res."},{"key":"187_CR83","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/j.1474-9726.2010.00660.x","volume":"10","author":"MR Damani","year":"2011","unstructured":"Damani, M. R. et al. Age-related alterations in the dynamic behavior of microglia. Aging Cell 10, 263\u2013276 (2011).","journal-title":"Aging Cell"},{"key":"187_CR84","doi-asserted-by":"publisher","first-page":"1322451","DOI":"10.3389\/fncel.2023.1322451","volume":"17","author":"S Lei","year":"2023","unstructured":"Lei, S., Hu, M. & Wei, Z. Single-cell sequencing reveals an important role of SPP1 and microglial activation in age-related macular degeneration. Front. Cell. Neurosci. 17, 1322451 (2023).","journal-title":"Front. Cell. Neurosci."},{"key":"187_CR85","doi-asserted-by":"crossref","unstructured":"Bloomfield, C. L. et al. Retinal microglia express more MHC class I and promote greater T-cell-driven inflammation than brain microglia. Front. Immunol. 15, 1399989 (2024).","DOI":"10.3389\/fimmu.2024.1399989"},{"key":"187_CR86","doi-asserted-by":"crossref","unstructured":"Wolf, J. et al. In-depth molecular profiling specifies human retinal microglia identity. Front. Immunol. 13, 863158 (2022).","DOI":"10.3389\/fimmu.2022.863158"},{"key":"187_CR87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95344-5","volume":"11","author":"C Torres-Querol","year":"2021","unstructured":"Torres-Querol, C. et al. Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype. Sci. Rep. 11, 15752 (2021).","journal-title":"Sci. Rep."},{"key":"187_CR88","doi-asserted-by":"publisher","first-page":"112129","DOI":"10.1016\/j.celrep.2023.112129","volume":"42","author":"S Matsuda","year":"2023","unstructured":"Matsuda, S. et al. TGF-\u03b2 in the microenvironment induces a physiologically occurring immune-suppressive senescent state. Cell Rep. 42, 112129 (2023).","journal-title":"Cell Rep."},{"key":"187_CR89","doi-asserted-by":"publisher","first-page":"C324","DOI":"10.1152\/ajpcell.00553.2022","volume":"325","author":"CM Dungan","year":"2023","unstructured":"Dungan, C. M., Wells, J. M. & Murach, K. A. The life and times of cellular senescence in skeletal muscle: friend or foe for homeostasis and adaptation? Am. J. Physiol. Cell Physiol. 325, C324\u2013C331 (2023).","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"187_CR90","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.semcancer.2021.01.004","volume":"87","author":"H Gal","year":"2022","unstructured":"Gal, H., Majewska, J. & Krizhanovsky, V. The intricate nature of senescence in development and cell plasticity. Semin. Cancer Biol. 87, 214\u2013219 (2022).","journal-title":"Semin. Cancer Biol."},{"key":"187_CR91","doi-asserted-by":"publisher","first-page":"1344116","DOI":"10.3389\/fphys.2024.1344116","volume":"15","author":"A Kita","year":"2024","unstructured":"Kita, A., Yamamoto, S., Saito, Y. & Chikenji, T. S. Cellular senescence and wound healing in aged and diabetic skin. Front. Physiol. 15, 1344116 (2024).","journal-title":"Front. Physiol."},{"key":"187_CR92","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-47317-1","volume":"15","author":"Y Fan","year":"2024","unstructured":"Fan, Y. et al. Senescent-like macrophages mediate angiogenesis for endplate sclerosis via IL-10 secretion in male mice. Nat. Commun. 15, 2939 (2024).","journal-title":"Nat. Commun."},{"key":"187_CR93","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8847","volume":"6","author":"R Nakamura","year":"2015","unstructured":"Nakamura, R. et al. IL10-driven STAT3 signalling in senescent macrophages promotes pathological eye angiogenesis. Nat. Commun. 6, 7847 (2015).","journal-title":"Nat. Commun."},{"key":"187_CR94","doi-asserted-by":"publisher","first-page":"109445","DOI":"10.1016\/j.cellsig.2019.109445","volume":"66","author":"YH Huang","year":"2020","unstructured":"Huang, Y. H. et al. Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis. Cell. Signal. 66, 109445 (2020).","journal-title":"Cell. Signal."},{"key":"187_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104717","volume":"94","author":"R Wan","year":"2023","unstructured":"Wan, R. et al. Cellular senescence in asthma: from pathogenesis to therapeutic challenges. eBioMedicine 94, 104717 (2023).","journal-title":"eBioMedicine"},{"key":"187_CR96","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. Mech. Dis. 5, 99\u2013118 (2010).","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"187_CR97","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1002\/art.42052","volume":"74","author":"SN Min","year":"2022","unstructured":"Min, S. N. et al. Contribution of interleukin-4\u2013induced epithelial cell senescence to glandular fibrosis in IgG4-related sialadenitis. Arthritis Rheumatol. 74, 1070\u20131082 (2022).","journal-title":"Arthritis Rheumatol."},{"key":"187_CR98","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s43587-021-00072-0","volume":"1","author":"CN Byrns","year":"2021","unstructured":"Byrns, C. N., Saikumar, J. & Bonini, N. M. Glial AP1 is activated with aging and accelerated by traumatic brain injury. Nat. Aging 1, 585\u2013597 (2021).","journal-title":"Nat. Aging"},{"key":"187_CR99","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/cdd.2013.86","volume":"20","author":"OV Leontieva","year":"2013","unstructured":"Leontieva, O. V., Demidenko, Z. N. & Blagosklonny, M. V. MEK drives cyclin D1 hyperelevation during geroconversion. Cell Death Differ. 20, 1241\u20131249 (2013).","journal-title":"Cell Death Differ."},{"key":"187_CR100","doi-asserted-by":"publisher","first-page":"4642","DOI":"10.4161\/cc.22937","volume":"11","author":"OV Leontieva","year":"2012","unstructured":"Leontieva, O. V., Lenzo, F., Demidenko, Z. N. & Blagosklonny, M. V. Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells. Cell Cycle 11, 4642\u20134649 (2012).","journal-title":"Cell Cycle"},{"key":"187_CR101","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.cellsig.2010.09.001","volume":"23","author":"S Bustany","year":"2011","unstructured":"Bustany, S., Tchakarska, G. & Sola, B. Cyclin D1 regulates p27Kip1 stability in B cells. Cell. Signal. 23, 171\u2013179 (2011).","journal-title":"Cell. Signal."},{"key":"187_CR102","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13792","volume":"22","author":"EO Karakaslar","year":"2023","unstructured":"Karakaslar, E. O. et al. Transcriptional activation of Jun and Fos members of the AP-1 complex is a conserved signature of immune aging that contributes to inflammaging. Aging Cell 22, e13792 (2023).","journal-title":"Aging Cell"},{"key":"187_CR103","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587.e29 (2021).","journal-title":"Cell"},{"key":"187_CR104","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1016\/j.celrep.2019.10.084","volume":"29","author":"D Pauly","year":"2019","unstructured":"Pauly, D. et al. Cell-type-specific complement expression in the healthy and diseased retina. Cell Rep. 29, 2835\u20132848.e4 (2019).","journal-title":"Cell Rep."},{"key":"187_CR105","first-page":"705","volume":"26","author":"BR Fadl","year":"2020","unstructured":"Fadl, B. R. et al. An optimized protocol for retina single-cell RNA sequencing. Mol. Vis. 26, 705\u2013717 (2020).","journal-title":"Mol. Vis."},{"key":"187_CR106","doi-asserted-by":"crossref","unstructured":"Zappia, L. & Oshlack, A. Clustering trees: a visualization for evaluating clusterings at multiple resolutions. Gigascience 7, giy083 (2018).","DOI":"10.1093\/gigascience\/giy083"},{"key":"187_CR107","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1016\/j.cell.2019.01.004","volume":"176","author":"YR Peng","year":"2019","unstructured":"Peng, Y. R. et al. Molecular classification and comparative taxonomics of foveal and peripheral cells in primate retina. Cell 176, 1222\u20131237.e22 (2019).","journal-title":"Cell"},{"key":"187_CR108","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s42003-020-01625-6","volume":"4","author":"N Borcherding","year":"2021","unstructured":"Borcherding, N. et al. Mapping the immune environment in clear cell renal carcinoma by single-cell genomics. Commun. Biol. 4, 122 (2021).","journal-title":"Commun. Biol."},{"key":"187_CR109","doi-asserted-by":"publisher","first-page":"D1083","DOI":"10.1093\/nar\/gkx1042","volume":"46","author":"R Tacutu","year":"2018","unstructured":"Tacutu, R. et al. Human ageing genomic resources: new and updated databases. Nucleic Acids Res. 46, D1083\u2013D1090 (2018).","journal-title":"Nucleic Acids Res."},{"key":"187_CR110","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"187_CR111","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A. et al. Molecular signatures database (MSigDB) 3.0. Bioinformatics 27, 1739\u20131740 (2011).","journal-title":"Bioinformatics"},{"key":"187_CR112","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v032.i06","volume":"32","author":"T Benaglia","year":"2009","unstructured":"Benaglia, T., Chauveau, D., Hunter, D. R. & Young, D. S. Mixtools: an R package for analyzing finite mixture models. J. Stat. Softw. 32, 1\u201329 (2009).","journal-title":"J. Stat. Softw."},{"key":"187_CR113","first-page":"100141","volume":"2","author":"T Wu","year":"2021","unstructured":"Wu, T. et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation 2, 100141 (2021).","journal-title":"Innovation"},{"key":"187_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21246-9","volume":"12","author":"S Jin","year":"2021","unstructured":"Jin, S. et al. Inference and analysis of cell-cell communication using CellChat. Nat. Commun. 12, 1088 (2021).","journal-title":"Nat. Commun."},{"key":"187_CR115","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","volume":"30","author":"A Kr\u00e4mer","year":"2014","unstructured":"Kr\u00e4mer, A., Green, J., Pollard, J. Jr & Tugendreich, S. Causal analysis approaches in ingenuity pathway analysis. Bioinformatics 30, 523\u2013530 (2014).","journal-title":"Bioinformatics"},{"key":"187_CR116","doi-asserted-by":"crossref","unstructured":"Yu, C. et al. Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2. J. Exp. Med. 221, e20231011 (2024).","DOI":"10.1084\/jem.20231011"},{"key":"187_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.109916","volume":"27","author":"J Li","year":"2024","unstructured":"Li, J. et al. Comprehensive single-cell atlas of the mouse retina. iScience 27, 109916 (2024).","journal-title":"iScience"},{"key":"187_CR118","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/s41586-020-2496-1","volume":"583","author":"N Almanzar","year":"2020","unstructured":"Almanzar, N. et al. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse. Nature 583, 590\u2013595 (2020).","journal-title":"Nature"},{"key":"187_CR119","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1038\/s43587-023-00479-x","volume":"3","author":"X Li","year":"2023","unstructured":"Li, X. et al. Transcriptional and epigenetic decoding of the microglial aging process. Nat. Aging 3, 1288\u20131311 (2023).","journal-title":"Nat. Aging"}],"container-title":["npj Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41514-024-00187-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41514-024-00187-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41514-024-00187-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T22:12:43Z","timestamp":1733004763000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41514-024-00187-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,30]]},"references-count":119,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["187"],"URL":"https:\/\/doi.org\/10.1038\/s41514-024-00187-9","relation":{},"ISSN":["2731-6068"],"issn-type":[{"value":"2731-6068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,30]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All breeding and experimental procedures were undertaken in accordance with the Association for Research for Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Research and were approved by the SingHealth Institutional Animal Care and Use Committee (2019\/SHS\/1534).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}],"article-number":"60"}}