{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T18:54:36Z","timestamp":1793904876390,"version":"4.8.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Zhongda Hospital Affiliated to Southeast University, Jiangsu Province High-Level Hospital","award":["2023GSPKY11, GSP-LCYJFH01"],"award-info":[{"award-number":["2023GSPKY11, GSP-LCYJFH01"]}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"crossref","award":["BK20210011, BK20220172"],"award-info":[{"award-number":["BK20210011, BK20220172"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"crossref"}]},{"name":"), National Clinical Key Discipline Construction Funds","award":["czxm-zk-40"],"award-info":[{"award-number":["czxm-zk-40"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82372126, 8207071577, 82301900, 82201853"],"award-info":[{"award-number":["82372126, 8207071577, 82301900, 82201853"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sichuan Science and Technology Program","award":["2025ZNSFSC1671, 2025ZNSFSC1655"],"award-info":[{"award-number":["2025ZNSFSC1671, 2025ZNSFSC1655"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Aging"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Endometriosis (EMs) is characterized by chronic pelvic inflammation, but the etiology of this inflammation remains poorly understood. The senescence-associated secretory phenotype (SASP), whereby senescent cells secrete pro-inflammatory cytokines, is a potential mechanism. This study investigates the pro-inflammatory SASP in EMs and its underlying influences. Through molecular assays and single-cell RNA-seq analysis, we found a subgroup of endometrial stromal cells (ESCs) marked by SASP in both eutopic endometrium and endometriotic lesions of EMs patients. The transcription factor FOSL2 was aberrantly overexpressed in this ESC subgroup; its overexpression induced cellular senescence and the secretion of SASP factors, while FOSL2 knockdown reversed these effects. Conditioned medium from ESCs with high FOSL2 expression promoted M2 macrophage polarization and recruitment. Mechanistically, FOSL2 overexpression in ESCs was regulated by the PGE2\/cAMP\/PKA signaling pathway, and FOSL2 modulated SASP through the activation of NF-\u03baB signaling. In conclusion, the SASP in ESCs, regulated by FOSL2, contributes to chronic pelvic inflammation and immune system disruption in EMs patients. Targeting FOSL2 to reverse the SASP may offer a promising therapeutic strategy for EMs.<\/jats:p>","DOI":"10.1038\/s41514-026-00447-w","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:43:40Z","timestamp":1784868220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["FOSL2-driven SASP in endometrial stroma promotes the inflammation of endometriosis"],"prefix":"10.1038","volume":"12","author":[{"given":"Weiwei","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanbo","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2623-3235","authenticated-orcid":false,"given":"Udo","family":"Jeschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"447_CR1","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1016\/j.molmed.2024.06.008","volume":"30","author":"MJ Griffiths","year":"2024","unstructured":"Griffiths, M. J., Horne, A. W., Gibson, D. A., Roberts, N. & Saunders, P. T. K. Endometriosis: recent advances that could accelerate diagnosis and improve care. Trends Mol. Med. 30, 875\u2013889 (2024).","journal-title":"Trends Mol. Med."},{"key":"447_CR2","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1210\/er.2018-00242","volume":"40","author":"SE Bulun","year":"2019","unstructured":"Bulun, S. E. et al. Endometriosis. Endocr. Rev. 40, 1048\u20131079 (2019).","journal-title":"Endocr. Rev."},{"key":"447_CR3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/S0140-6736(21)00389-5","volume":"397","author":"HS Taylor","year":"2021","unstructured":"Taylor, H. S., Kotlyar, A. M. & Flores, V. A. Endometriosis is a chronic systemic disease: clinical challenges and novel innovations. Lancet 397, 839\u2013852 (2021).","journal-title":"Lancet"},{"key":"447_CR4","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1093\/humrep\/deu172","volume":"29","author":"YJ Kang","year":"2014","unstructured":"Kang, Y. J. et al. An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression. Hum. Reprod. 29, 2176\u20132189 (2014).","journal-title":"Hum. Reprod."},{"key":"447_CR5","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abq5858","volume":"15","author":"A Nishimoto-Kakiuchi","year":"2023","unstructured":"Nishimoto-Kakiuchi, A. et al. A long-acting anti-IL-8 antibody improves inflammation and fibrosis in endometriosis. Sci. Transl. Med. 15, eabq5858 (2023).","journal-title":"Sci. Transl. Med."},{"key":"447_CR6","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s13287-022-02981-2","volume":"13","author":"J Tan","year":"2022","unstructured":"Tan, J. et al. CCL20\/CCR6 axis mediates macrophages to promote proliferation and migration of ESCs by blocking autophagic flux in endometriosis. Stem Cell Res Ther. 13, 294 (2022).","journal-title":"Stem Cell Res Ther."},{"key":"447_CR7","doi-asserted-by":"crossref","unstructured":"Tai, F.W., Chang, C.Y., Chiang, J.H., Lin, W.C. & Wan, L. Association of pelvic inflammatory disease with risk of endometriosis: a nationwide cohort study involving 141,460 individuals. J. Clin. Med. 7, 379 (2018).","DOI":"10.3390\/jcm7110379"},{"key":"447_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.redox.2016.11.005","volume":"11","author":"A Chandrasekaran","year":"2017","unstructured":"Chandrasekaran, A., Idelchik, M. & Melendez, J. A. Redox control of senescence and age-related disease. Redox Biol. 11, 91\u2013102 (2017).","journal-title":"Redox Biol."},{"key":"447_CR9","doi-asserted-by":"crossref","unstructured":"Wang, B.S., Han, J., Elisseeff, J.H. & Demaria, M. The senescence-associated secretory phenotype and its physiological and pathological implications. Nat. Rev. Mol. Cell Biol. 25, 958\u2013978 (2024).","DOI":"10.1038\/s41580-024-00727-x"},{"key":"447_CR10","doi-asserted-by":"crossref","unstructured":"Zhang, L. et al. Cellular senescence: a key therapeutic target in aging and diseases. J. Clin. Investig. 132, e158450 (2022).","DOI":"10.1172\/JCI158450"},{"key":"447_CR11","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1101\/gad.343129.120","volume":"34","author":"J Birch","year":"2020","unstructured":"Birch, J. & Gil, J. Senescence and the SASP: many therapeutic avenues. Genes Dev. 34, 1565\u20131576 (2020).","journal-title":"Genes Dev."},{"key":"447_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"JP Copp\u00e9","year":"2010","unstructured":"Copp\u00e9, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev. Pathol. 5, 99\u2013118 (2010).","journal-title":"Annu Rev. Pathol."},{"key":"447_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","volume":"8","author":"X Li","year":"2023","unstructured":"Li, X. et al. Inflammation and aging: signaling pathways and intervention therapies. Signal Transduct. Target Ther. 8, 239 (2023).","journal-title":"Signal Transduct. Target Ther."},{"key":"447_CR14","first-page":"249","volume":"5","author":"M Matsui","year":"1990","unstructured":"Matsui, M., Tokuhara, M., Konuma, Y., Nomura, N. & Ishizaki, R. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 5, 249\u2013255 (1990).","journal-title":"Oncogene"},{"key":"447_CR15","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41416-023-02313-y","volume":"129","author":"SJ Zhang","year":"2023","unstructured":"Zhang, S. J. et al. Chromatin accessibility uncovers KRAS-driven FOSL2 promoting pancreatic ductal adenocarcinoma progression through up-regulation of CCL28. Br. J. Cancer 129, 426\u2013443 (2023).","journal-title":"Br. J. Cancer"},{"key":"447_CR16","doi-asserted-by":"crossref","unstructured":"Renoux, F. et al. The AP1 transcription factor Fosl2 promotes systemic autoimmunity and inflammation by repressing treg development. Cell Rep. 31, 107826 (2020).","DOI":"10.1016\/j.celrep.2020.107826"},{"key":"447_CR17","doi-asserted-by":"crossref","unstructured":"Njouendou, A.J. et al. SOX2 dosage sustains tumor-promoting inflammation to drive disease aggressiveness by modulating the FOSL2\/IL6 axis. Mol. Cancer 22, 52 (2023).","DOI":"10.1186\/s12943-023-01734-w"},{"key":"447_CR18","doi-asserted-by":"crossref","unstructured":"Ding, M. et al. Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human liver progenitor-like cell aging by regulating inflammatory factors. BMC Genom. 24, 260 (2023).","DOI":"10.1186\/s12864-023-09349-7"},{"key":"447_CR19","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02500-3","volume":"20","author":"AJ Shih","year":"2022","unstructured":"Shih, A. J. et al. Single-cell analysis of menstrual endometrial tissues defines phenotypes associated with endometriosis. BMC Med. 20, 315 (2022).","journal-title":"BMC Med."},{"key":"447_CR20","first-page":"RA92","volume":"17","author":"HY Liu","year":"2011","unstructured":"Liu, H. Y. & Lang, J. H. Is abnormal eutopic endometrium the cause of endometriosis? The role of eutopic endometrium in pathogenesis of endometriosis. Med. Sci. Monit. 17, RA92\u2013RA99 (2011).","journal-title":"Med. Sci. Monit."},{"key":"447_CR21","doi-asserted-by":"publisher","first-page":"D870","DOI":"10.1093\/nar\/gkac947","volume":"51","author":"C Hu","year":"2023","unstructured":"Hu, C. et al. CellMarker 2.0: an updated database of manually curated cell markers in human\/mouse and web tools based on scRNA-seq data. Nucleic Acids Res. 51, D870\u2013d876 (2023).","journal-title":"Nucleic Acids Res."},{"key":"447_CR22","doi-asserted-by":"publisher","first-page":"D687","DOI":"10.1093\/nar\/gkab1028","volume":"50","author":"M Gillespie","year":"2022","unstructured":"Gillespie, M. et al. The reactome pathway knowledgebase 2022. Nucleic Acids Res. 50, D687\u2013D692 (2022).","journal-title":"Nucleic Acids Res."},{"key":"447_CR23","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3389\/fimmu.2020.00108","volume":"11","author":"JE Miller","year":"2020","unstructured":"Miller, J. E. et al. IL-17A modulates peritoneal macrophage recruitment and M2 polarization in endometriosis. Front. Immunol. 11, 108 (2020).","journal-title":"Front. Immunol."},{"key":"447_CR24","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1080\/09513590.2019.1683821","volume":"36","author":"AS Lagan\u00e0","year":"2020","unstructured":"Lagan\u00e0, A. S. et al. Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease. Gynecol. Endocrinol. 36, 441\u2013444 (2020).","journal-title":"Gynecol. Endocrinol."},{"key":"447_CR25","doi-asserted-by":"publisher","first-page":"11535","DOI":"10.7150\/thno.45261","volume":"10","author":"Y Wang","year":"2020","unstructured":"Wang, Y. et al. FOXO1 promotes tumor progression by increased M2 macrophage infiltration in esophageal squamous cell carcinoma. Theranostics 10, 11535\u201311548 (2020).","journal-title":"Theranostics"},{"key":"447_CR26","doi-asserted-by":"crossref","unstructured":"Shao, Y. et al. CXCL8 induces M2 macrophage polarization and inhibits CD8+T cell infiltration to generate an immunosuppressive microenvironment in colorectal cancer. FASEB J. 37, e23173 (2023).","DOI":"10.1096\/fj.202201982RRR"},{"key":"447_CR27","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/S1043-2760(99)00216-7","volume":"11","author":"SE Bulun","year":"2000","unstructured":"Bulun, S. E., Zeitoun, K. M., Takayama, K., Simpson, E. & Sasano, H. Aromatase as a therapeutic target in endometriosis. Trends Endocrinol. Metab. 11, 22\u201327 (2000).","journal-title":"Trends Endocrinol. Metab."},{"key":"447_CR28","first-page":"600","volume":"82","author":"LS Noble","year":"1997","unstructured":"Noble, L. S. et al. Prostaglandin E(2) stimulates aromatase expression in endometriosis-derived stromal cells. J. Clin. Endocrinol. Metab. 82, 600\u2013606 (1997).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"447_CR29","doi-asserted-by":"publisher","first-page":"42438","DOI":"10.1074\/jbc.M405549200","volume":"279","author":"WZ Chang","year":"2004","unstructured":"Chang, W. Z., Rewari, A., Centrella, M. & McCarthy, T. L. Fos-related antigen 2 controls protein kinase A-induced CCAAT\/enhancer-binding protein \u03b2 expression in osteoblasts. J. Biol. Chem. 279, 42438\u201342444 (2004).","journal-title":"J. Biol. Chem."},{"key":"447_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02359-4","volume":"20","author":"J Vallv\u00e9-Juanico","year":"2022","unstructured":"Vallv\u00e9-Juanico, J. et al. Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood. BMC Med. 20, 158 (2022).","journal-title":"BMC Med."},{"key":"447_CR31","doi-asserted-by":"publisher","first-page":"547","DOI":"10.2353\/ajpath.2009.081011","volume":"175","author":"M Bacci","year":"2009","unstructured":"Bacci, M. et al. Macrophages are alternatively activated in patients with endometriosis and required for growth and vascularization of lesions in a mouse model of disease. Am. J. Pathol. 175, 547\u2013556 (2009).","journal-title":"Am. J. Pathol."},{"key":"447_CR32","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.rbmo.2018.05.017","volume":"37","author":"J Duan","year":"2018","unstructured":"Duan, J., Liu, X., Wang, H. & Guo, S. W. The M2a macrophage subset may be critically involved in the fibrogenesis of endometriosis in mice. Reprod. Biomed. Online 37, 254\u2013268 (2018).","journal-title":"Reprod. Biomed. Online"},{"key":"447_CR33","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-024-01265-z","volume":"22","author":"J Delenko","year":"2024","unstructured":"Delenko, J. et al. Quercetin enhances decidualization through AKT-ERK-p53 signaling and supports a role for senescence in endometriosis. Reprod. Biol. Endocrinol. 22, 100 (2024).","journal-title":"Reprod. Biol. Endocrinol."},{"key":"447_CR34","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s13046-019-1198-8","volume":"38","author":"M Mazzoni","year":"2019","unstructured":"Mazzoni, M. et al. Senescent thyrocytes and thyroid tumor cells induce M2-like macrophage polarization of human monocytes via a PGE2-dependent mechanism. J. Exp. Clin. Cancer Res. 38, 208 (2019).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"447_CR35","doi-asserted-by":"crossref","unstructured":"Liu, H. et al. Blocking iASPP\/Nrf2\/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization. Cell Death Dis. 13, 166 (2022).","DOI":"10.1038\/s41419-022-04611-4"},{"key":"447_CR36","doi-asserted-by":"crossref","unstructured":"Wu, M.W., Han, J.S., Wu, H. & Liu, Z.W. Proteasome-dependent senescent tumor cells mediate immunosuppression through CCL20 secretion and M2 polarization in pancreatic ductal adenocarcinoma. Front. Immunol. 14, 1216376 (2023).","DOI":"10.3389\/fimmu.2023.1216376"},{"key":"447_CR37","doi-asserted-by":"crossref","unstructured":"Sen, B. et al. Secretome of senescent hepatoma cells modulate immune cell fate by macrophage polarization and neutrophil extracellular traps formation. Med. Oncol. 39, 134 (2022).","DOI":"10.1007\/s12032-022-01732-w"},{"key":"447_CR38","doi-asserted-by":"crossref","unstructured":"Song, P. et al. Cellular senescence primes liver fibrosis regression through Notch-EZH2. Medcomm 4, e346 (2023).","DOI":"10.1002\/mco2.346"},{"key":"447_CR39","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1016\/j.cmet.2023.10.014","volume":"35","author":"HG Lee","year":"2023","unstructured":"Lee, H. G. et al. Stress-induced (3 cell early senescence confers protection against type 1 diabetes. Cell Metab. 35, 2200 (2023).","journal-title":"Cell Metab."},{"key":"447_CR40","doi-asserted-by":"publisher","first-page":"5847","DOI":"10.1007\/s00018-021-03883-x","volume":"78","author":"Y Liu","year":"2021","unstructured":"Liu, Y. et al. AP-1 activity is a major barrier of human somatic cell reprogramming. Cell Mol. Life Sci. 78, 5847\u20135863 (2021).","journal-title":"Cell Mol. Life Sci."},{"key":"447_CR41","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/s41556-021-00742-6","volume":"23","author":"J Choi","year":"2021","unstructured":"Choi, J. et al. Release of Notch activity coordinated by IL-1\u03b2 signalling confers differentiation plasticity of airway progenitors via Fosl2 during alveolar regeneration. Nat. Cell Biol. 23, 953 (2021).","journal-title":"Nat. Cell Biol."},{"key":"447_CR42","doi-asserted-by":"publisher","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","volume":"49","author":"D Szklarczyk","year":"2021","unstructured":"Szklarczyk, D. et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets. Nucleic Acids Res. 49, D605\u2013D612 (2021).","journal-title":"Nucleic Acids Res."},{"key":"447_CR43","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1128\/JVI.79.1.95-105.2005","volume":"79","author":"X Wang","year":"2005","unstructured":"Wang, X. & Sonenshein, G. E. Induction of the RelB NF-kappaB subunit by the cytomegalovirus IE1 protein is mediated via Jun kinase and c-Jun\/Fra-2 AP-1 complexes. J. Virol. 79, 95\u2013105 (2005).","journal-title":"J. Virol."},{"key":"447_CR44","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/ncb1559","volume":"9","author":"X Wang","year":"2007","unstructured":"Wang, X. et al. Oestrogen signalling inhibits invasive phenotype by repressing RelB and its target BCL2. Nat. Cell Biol. 9, 470\u2013478 (2007).","journal-title":"Nat. Cell Biol."},{"key":"447_CR45","doi-asserted-by":"publisher","DOI":"10.1038\/srep16811","volume":"5","author":"S Gupta","year":"2015","unstructured":"Gupta, S. et al. Selective participation of c-Jun with Fra-2\/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Sci. Rep. 5, 16811 (2015).","journal-title":"Sci. Rep."},{"key":"447_CR46","doi-asserted-by":"crossref","unstructured":"Luo, Y.B. et al. Fra-2 expression in osteoblasts regulates systemic inflammation and lung injury through osteopontin. Mol. Cell. Biol. 38, e00022-18 (2018).","DOI":"10.1128\/MCB.00022-18"},{"key":"447_CR47","first-page":"570","volume":"27","author":"D Adiguzel","year":"2021","unstructured":"Adiguzel, D. & Celik-Ozenci, C. FoxOI is a cell-specific core transcription factor for endometrial remodeling and homeostasis during menstrual cycle and early pregnancy. Hum. Reprod. Update 27, 570\u2013583 (2021).","journal-title":"Hum. Reprod. Update"},{"key":"447_CR48","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.bbalip.2013.04.005","volume":"1831","author":"S Martien","year":"2013","unstructured":"Martien, S. et al. Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts. Biochim. Biophys. Acta-Mol. Cell Biol. Lipids 1831, 1217\u20131227 (2013).","journal-title":"Biochim. Biophys. Acta-Mol. Cell Biol. Lipids"},{"key":"447_CR49","doi-asserted-by":"crossref","unstructured":"Goncalves, S. et al. COX2 regulates senescence secretome composition and senescence surveillance through PGE2. Cell Rep. 34, 108860 (2021).","DOI":"10.1016\/j.celrep.2021.108860"},{"key":"447_CR50","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.fertnstert.2014.04.001","volume":"102","author":"CW Tan","year":"2014","unstructured":"Tan, C. W. et al. CD26\/DPPIV down-regulation in endometrial stromal cell migration in endometriosis. Fertil. Steril. 102, 167\u2013177.e169 (2014).","journal-title":"Fertil. Steril."},{"key":"447_CR51","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/s41556-020-0511-2","volume":"22","author":"F Li","year":"2020","unstructured":"Li, F. et al. FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome. Nat. Cell Biol. 22, 728\u2013739 (2020).","journal-title":"Nat. Cell Biol."}],"container-title":["npj Aging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41514-026-00447-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41514-026-00447-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41514-026-00447-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:07:51Z","timestamp":1784869671000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41514-026-00447-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,24]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["447"],"URL":"https:\/\/doi.org\/10.1038\/s41514-026-00447-w","relation":{},"ISSN":["2731-6068"],"issn-type":[{"value":"2731-6068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,24]]},"assertion":[{"value":"15 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"101"}}