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Carriot"},{"name":"Direction G\u00e9n\u00e9rale de l'Armement (DGA) - ANR ASTRID RESSAC"},{"name":"Direction G\u00e9n\u00e9rale de l'Armement (DGA) - ANR ASTRID RESSAC French Ministry of Higher Education, Research and Innovation, the University of Toulon - PhD grant of N. Carriot"},{"name":"Direction G\u00e9n\u00e9rale de l'Armement (DGA) - ANR ASTRID RESSAC French Ministry of Higher Education, Research and Innovation, the University of Toulon - PhD grant of N. Carriot"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Biofilms Microbiomes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Quorum sensing (QS) is a communication system used by bacteria to coordinate a wide panel of biological functions in a cell density-dependent manner. The Gram-negative\n                    <jats:italic>Chromobacterium violaceum<\/jats:italic>\n                    has previously been shown to use an acyl-homoserine lactone (AHL)-based QS to regulate various behaviors, including the production of proteases, hydrogen cyanide, or antimicrobial compounds such as violacein. By using combined metabolomic and proteomic approaches, we demonstrated that QS modulates the production of antimicrobial and toxic compounds in\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    ATCC 12472. We provided the first evidence of anisomycin antibiotic production by this strain as well as evidence of its regulation by QS and identified new AHLs produced by\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    ATCC 12472. Furthermore, we demonstrated that targeting AHLs with lactonase leads to major QS disruption yielding significant molecular and phenotypic changes. These modifications resulted in drastic changes in social interactions between\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    and a Gram-positive bacterium (\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    ), a yeast (\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    ), immune cells (murine macrophages), and an animal model (planarian\n                    <jats:italic>Schmidtea mediterranea<\/jats:italic>\n                    ). These results underscored that AHL-based QS plays a key role in the capacity of\n                    <jats:italic>C. violaceum<\/jats:italic>\n                    to interact with micro- and macroorganisms and that quorum quenching can affect microbial population dynamics beyond AHL-producing bacteria and Gram-negative bacteria.\n                  <\/jats:p>","DOI":"10.1038\/s41522-021-00211-w","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T06:10:11Z","timestamp":1619071811000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Disrupting quorum sensing alters social interactions in Chromobacterium violaceum"],"prefix":"10.1038","volume":"7","author":[{"given":"Sonia","family":"Mion","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Carriot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Plener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Ortalo-Magn\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5229-7745","authenticated-orcid":false,"given":"Eric","family":"Chabri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-6394","authenticated-orcid":false,"given":"G\u00e9rald","family":"Culioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-5554","authenticated-orcid":false,"given":"David","family":"Daud\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"211_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1146\/annurev.micro.55.1.165","volume":"55","author":"MB Miller","year":"2001","unstructured":"Miller, M. 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