{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T05:59:28Z","timestamp":1778651968568,"version":"3.51.4"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"the National Science Fund for Distinguished Young Scholars","award":["82025011"],"award-info":[{"award-number":["82025011"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"International Cooperation and Exchange of the National Natural Science Foundation of China","award":["82220108018"],"award-info":[{"award-number":["82220108018"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]},{"name":"the Fundamental Research Funds for the Central Universities","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Biofilms Microbiomes"],"DOI":"10.1038\/s41522-025-00680-3","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T01:24:03Z","timestamp":1742520243000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Elongation factor Tu promotes the onset of periodontitis through mediating bacteria adhesion"],"prefix":"10.1038","volume":"11","author":[{"given":"Leyi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengge","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiange","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanyi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yueqi","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinglun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hebin","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingwen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"680_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1902\/jop.1999.70.1.13","volume":"70","author":"JM Albandar","year":"1999","unstructured":"Albandar, J. M., Brunelle, J. A. & Kingman, A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988\u20131994. J. Periodontol. 70, 13\u201329 (1999).","journal-title":"J. Periodontol."},{"key":"680_CR2","first-page":"248","volume":"11","author":"BA Dye","year":"2007","unstructured":"Dye, B. A. et al. Trends in oral health status: United States, 1988\u20131994 and 1999\u20132004. Natl Cent. Health Stat. 11, 248 (2007).","journal-title":"Natl Cent. Health Stat."},{"key":"680_CR3","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1093\/eurheartj\/ehz646","volume":"40","author":"M Czesnikiewicz-Guzik","year":"2019","unstructured":"Czesnikiewicz-Guzik, M. et al. Causal association between periodontitis and hypertension: evidence from Mendelian randomization and a randomized controlled trial of non-surgical periodontal therapy. Eur. Heart J. 40, 3459\u20133470 (2019).","journal-title":"Eur. Heart J."},{"key":"680_CR4","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/S2213-8587(18)30038-X","volume":"6","author":"F D\u2019Aiuto","year":"2018","unstructured":"D\u2019Aiuto, F. et al. Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial. Lancet Diabetes Endocrinol. 6, 954\u2013965 (2018).","journal-title":"Lancet Diabetes Endocrinol."},{"key":"680_CR5","doi-asserted-by":"publisher","first-page":"2523","DOI":"10.1001\/jama.2013.282431","volume":"310","author":"SP Engebretson","year":"2013","unstructured":"Engebretson, S. P. et al. The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. JAMA 310, 2523\u20132532 (2013).","journal-title":"JAMA"},{"key":"680_CR6","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","volume":"21","author":"G Hajishengallis","year":"2021","unstructured":"Hajishengallis, G. & Chavakis, T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat. Rev. Immunol. 21, 426\u2013440 (2021).","journal-title":"Nat. Rev. Immunol."},{"key":"680_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/prd.12429","volume":"89","author":"G Jungbauer","year":"2022","unstructured":"Jungbauer, G. et al. Periodontal microorganisms and Alzheimer disease\u2014a causative relationship? Periodontology 2000 89, 59\u201382 (2022).","journal-title":"Periodontology 2000"},{"key":"680_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/prd.12329","volume":"83","author":"N Nwizu","year":"2020","unstructured":"Nwizu, N., Wactawski-Wende, J. & Genco, R. J. Periodontal disease and cancer: epidemiologic studies and possible mechanisms. Periodontology 2000 83, 213\u2013233 (2020).","journal-title":"Periodontology 2000"},{"key":"680_CR9","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/prd.12299","volume":"83","author":"M Orlandi","year":"2020","unstructured":"Orlandi, M., Graziani, F. & D\u2019Aiuto, F. Periodontal therapy and cardiovascular risk. Periodontology 2000 83, 107\u2013124 (2020).","journal-title":"Periodontology 2000"},{"key":"680_CR10","doi-asserted-by":"publisher","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","volume":"5","author":"SS Dominy","year":"2019","unstructured":"Dominy, S. S. et al. Porphyromonas gingivalis in Alzheimer\u2019s disease brains: evidence for disease causation and treatment with small-molecule inhibitors. Sci. Adv. 5, eaau3333 (2019).","journal-title":"Sci. Adv."},{"key":"680_CR11","doi-asserted-by":"publisher","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","volume":"3","author":"DF Kinane","year":"2017","unstructured":"Kinane, D. F., Stathopoulou, P. G. & Papapanou, P. N. Periodontal diseases. Nat. Rev. Dis. Prim. 3, 17038 (2017).","journal-title":"Nat. Rev. Dis. Prim."},{"key":"680_CR12","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/prd.12119","volume":"71","author":"R Krishna","year":"2016","unstructured":"Krishna, R. & De Stefano, J. A. Ultrasonic vs. hand instrumentation in periodontal therapy: clinical outcomes. Periodontology 2000 71, 113\u2013127 (2016).","journal-title":"Periodontology 2000"},{"key":"680_CR13","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/prd.12201","volume":"75","author":"F Graziani","year":"2017","unstructured":"Graziani, F. et al. Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontology 2000 75, 152\u2013188 (2017).","journal-title":"Periodontology 2000"},{"key":"680_CR14","doi-asserted-by":"publisher","first-page":"879423","DOI":"10.3389\/fcimb.2022.879423","volume":"12","author":"R Yang","year":"2022","unstructured":"Yang, R. et al. The regulatory effect of coaggregation between Fusobacterium nucleatum and Streptococcus gordonii on the synergistic virulence to human gingival epithelial cells. Front. Cell. Infect. Microbiol. 12, 879423 (2022).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"680_CR15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1365-2958.2011.07707.x","volume":"81","author":"SE Whitmore","year":"2011","unstructured":"Whitmore, S. E. & Lamont, R. J. The pathogenic persona of community\u2010associated oral Streptococci. Mol. Microbiol. 81, 305\u2013314 (2011).","journal-title":"Mol. Microbiol."},{"key":"680_CR16","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.joen.2008.09.016","volume":"35","author":"Z Metzger","year":"2009","unstructured":"Metzger, Z. et al. Characterization of coaggregation of Fusobacterium nucleatum PK1594 with six Porphyromonas gingivalis strains. J. Endod. 35, 50\u201354 (2009).","journal-title":"J. Endod."},{"key":"680_CR17","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.joen.2008.10.015","volume":"35","author":"Z Metzger","year":"2009","unstructured":"Metzger, Z. et al. Synergistic pathogenicity of Porphyromonas gingivalis and Fusobacterium nucleatum in the mouse subcutaneous chamber model. J. Endod. 35, 86\u201394 (2009).","journal-title":"J. Endod."},{"key":"680_CR18","doi-asserted-by":"crossref","unstructured":"Ali Mohammed, M. M. et al. Characterization of extracellular polymeric matrix, and treatment of Fusobacterium nucleatum and Porphyromonas gingivalis biofilms with DNase I and proteinase K. J. Oral Microbiol. 5, (2013).","DOI":"10.3402\/jom.v5i0.20015"},{"key":"680_CR19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/j.1574-695X.2008.00481.x","volume":"54","author":"A Saito","year":"2008","unstructured":"Saito, A. et al. Fusobacterium nucleatum enhances invasion of human gingival epithelial and aortic endothelial cells by Porphyromonas gingivalis. FEMS Immunol. Med. Microbiol. 54, 349\u2013355 (2008).","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"680_CR20","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/omi.12012","volume":"28","author":"CJ Wright","year":"2012","unstructured":"Wright, C. J. et al. Microbial interactions in building of communities. Mol. Oral Microbiol. 28, 83\u2013101 (2012).","journal-title":"Mol. Oral Microbiol."},{"key":"680_CR21","doi-asserted-by":"publisher","first-page":"377","DOI":"10.21775\/cimb.032.377","volume":"32","author":"Y Chen","year":"2019","unstructured":"Chen, Y., Li, Y. & Zou, J. Intrageneric and intergeneric interactions developed by oral Streptococci: pivotal role in the pathogenesis of oral diseases. Curr. Issues Mol. Biol. 32, 377\u2013434 (2019).","journal-title":"Curr. Issues Mol. Biol."},{"key":"680_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.2041-1014.2011.00634.x","volume":"27","author":"J Merritt","year":"2011","unstructured":"Merritt, J. & Qi, F. The mutacins of Streptococcus mutans: regulation and ecology. Mol. Oral Microbiol. 27, 57\u201369 (2011).","journal-title":"Mol. Oral Microbiol."},{"key":"680_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1111\/omi.12106","volume":"30","author":"CR Back","year":"2015","unstructured":"Back, C. R. et al. Streptococcus gordoniiDL1 adhesin SspB V\u2010region mediates coaggregation via receptor polysaccharide of Actinomyces oris T14V. Mol. Oral Microbiol. 30, 411\u2013424 (2015).","journal-title":"Mol. Oral Microbiol."},{"key":"680_CR24","first-page":"1222","volume":"26","author":"BA Bensing","year":"2016","unstructured":"Bensing, B. A. et al. Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology 26, 1222\u20131234 (2016).","journal-title":"Glycobiology"},{"key":"680_CR25","doi-asserted-by":"crossref","unstructured":"Abranches, J. et al. Biology of oral Streptococci. Microbiol. Spectr. 6, 5 (2018).","DOI":"10.1128\/microbiolspec.GPP3-0042-2018"},{"key":"680_CR26","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/omi.12132","volume":"31","author":"WH Bowen","year":"2015","unstructured":"Bowen, W. H. Dental caries\u2014not just holes in teeth! A perspective. Mol. Oral Microbiol. 31, 228\u2013233 (2015).","journal-title":"Mol. Oral Microbiol."},{"key":"680_CR27","doi-asserted-by":"publisher","first-page":"130017","DOI":"10.1098\/rsob.130017","volume":"3","author":"MW Robinson","year":"2013","unstructured":"Robinson, M. W. et al. MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae. Open Biol. 3, 130017 (2013).","journal-title":"Open Biol."},{"key":"680_CR28","doi-asserted-by":"publisher","first-page":"e0126600","DOI":"10.1371\/journal.pone.0126600","volume":"10","author":"MF Balish","year":"2015","unstructured":"Balish, M. F. et al. Subunits of the pyruvate dehydrogenase cluster of Mycoplasma pneumoniae are surface-displayed proteins that bind and activate human plasminogen. PLoS ONE 10, e0126600 (2015).","journal-title":"PLoS ONE"},{"key":"680_CR29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.vetmic.2006.11.018","volume":"121","author":"PM Pinto","year":"2007","unstructured":"Pinto, P. M. et al. Proteomic survey of the pathogenic Mycoplasma hyopneumoniae strain 7448 and identification of novel post-translationally modified and antigenic proteins. Vet. Microbiol. 121, 83\u201393 (2007).","journal-title":"Vet. Microbiol."},{"key":"680_CR30","doi-asserted-by":"publisher","first-page":"e110011","DOI":"10.1371\/journal.pone.0110011","volume":"9","author":"H Ariga","year":"2014","unstructured":"Ariga, H. et al. Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumoniae bacteremia. PLoS ONE 9, e110011 (2014).","journal-title":"PLoS ONE"},{"key":"680_CR31","doi-asserted-by":"publisher","first-page":"10893","DOI":"10.1007\/s13277-016-4933-1","volume":"37","author":"R Mirzaei","year":"2016","unstructured":"Mirzaei, R. et al. Identification of proteins derived from Listeria monocytogenes inducing human dendritic cell maturation. Tumor Biol. 37, 10893\u201310907 (2016).","journal-title":"Tumor Biol."},{"key":"680_CR32","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1111\/j.1365-2958.2010.07132.x","volume":"76","author":"KN Cowles","year":"2010","unstructured":"Cowles, K. N. & Gitai, Z. Surface association and the MreB cytoskeleton regulate pilus production, localization and function in Pseudomonas aeruginosa. Mol. Microbiol. 76, 1411\u20131426 (2010).","journal-title":"Mol. Microbiol."},{"key":"680_CR33","doi-asserted-by":"publisher","first-page":"e1000669","DOI":"10.1371\/journal.ppat.1000669","volume":"5","author":"RR Isberg","year":"2009","unstructured":"Isberg, R. R. et al. A novel system of cytoskeletal elements in the human pathogen Helicobacter pylori. PLoS Pathog. 5, e1000669 (2009).","journal-title":"PLoS Pathog."},{"key":"680_CR34","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nrmicro2381","volume":"8","author":"PE Kolenbrander","year":"2010","unstructured":"Kolenbrander, P. E. et al. Oral multispecies biofilm development and the key role of cell\u2013cell distance. Nat. Rev. Microbiol. 8, 471\u2013480 (2010).","journal-title":"Nat. Rev. Microbiol."},{"key":"680_CR35","doi-asserted-by":"publisher","first-page":"129130","DOI":"10.1016\/j.foodchem.2021.129130","volume":"349","author":"F Yan","year":"2021","unstructured":"Yan, F. et al. Isolation, purification, gene cloning and expression of antifungal protein from Bacillus amyloliquefaciens MG-3. Food Chem. 349, 129130 (2021).","journal-title":"Food Chem."},{"key":"680_CR36","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.ijbiomac.2019.03.108","volume":"131","author":"GS de Amo","year":"2019","unstructured":"de Amo, G. S. et al. Heterologous expression, purification and biochemical characterization of a new xylanase from Myceliophthora heterothallica F.2.1.4. Int. J. Biol. Macromol. 131, 798\u2013805 (2019).","journal-title":"Int. J. Biol. Macromol."},{"key":"680_CR37","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1177\/154405910608500407","volume":"85","author":"ACR Tanner","year":"2006","unstructured":"Tanner, A. C. R. et al. Subgingival and tongue microbiota during early periodontitis. J. Dent. Res. 85, 318\u2013323 (2006).","journal-title":"J. Dent. Res."},{"key":"680_CR38","doi-asserted-by":"publisher","first-page":"2126272","DOI":"10.1080\/19490976.2022.2126272","volume":"14","author":"J Lu","year":"2022","unstructured":"Lu, J. et al. Periodontitis-related salivary microbiota aggravates Alzheimer\u2019s disease via gut\u2013brain axis crosstalk. Gut Microbes 14, 2126272 (2022).","journal-title":"Gut Microbes"},{"key":"680_CR39","doi-asserted-by":"crossref","unstructured":"Enersen, M., Nakano, K. & Amano, A. Porphyromonas gingivalis fimbriae. J. Oral Microbiol. 5, (2013).","DOI":"10.3402\/jom.v5i0.20265"},{"key":"680_CR40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1002\/mbo3.177","volume":"3","author":"CJ Wright","year":"2014","unstructured":"Wright, C. J. et al. Characterization of a bacterial tyrosine kinase in Porphyromonas gingivalis involved in polymicrobial synergy. MicrobiologyOpen 3, 383\u2013394 (2014).","journal-title":"MicrobiologyOpen"},{"key":"680_CR41","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01323-x","volume":"10","author":"V Morillo-Lopez","year":"2022","unstructured":"Morillo-Lopez, V. et al. Corncob structures in dental plaque reveal microhabitat taxon specificity. Microbiome 10, 145 (2022).","journal-title":"Microbiome"},{"key":"680_CR42","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.micpath.2017.11.001","volume":"113","author":"P Gholizadeh","year":"2017","unstructured":"Gholizadeh, P. et al. Oral pathogenesis of Aggregatibacter actinomycetemcomitans. Microb. Pathog. 113, 303\u2013311 (2017).","journal-title":"Microb. Pathog."},{"key":"680_CR43","doi-asserted-by":"publisher","first-page":"7819","DOI":"10.1073\/pnas.1400586111","volume":"111","author":"A Stacy","year":"2014","unstructured":"Stacy, A. et al. Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection. Proc. Natl Acad. Sci. USA 111, 7819\u20137824 (2014).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"680_CR44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nrmicro.2015.8","volume":"14","author":"A Stacy","year":"2015","unstructured":"Stacy, A. et al. The biogeography of polymicrobial infection. Nat. Rev. Microbiol. 14, 93\u2013105 (2015).","journal-title":"Nat. Rev. Microbiol."},{"key":"680_CR45","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.femsle.2005.06.052","volume":"249","author":"M Balbo","year":"2005","unstructured":"Balbo, M. et al. Infection of human B lymphoma cells by Mycoplasma fermentans induces interaction of its elongation factor with the intracytoplasmic domain of Epstein-Barr virus receptor (gp140, EBV\/C3dR, CR2, CD21). FEMS Microbiol. Lett. 249, 359\u2013366 (2005).","journal-title":"FEMS Microbiol. Lett."},{"key":"680_CR46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1002\/jcp.20061","volume":"201","author":"TM O\u2019Connor","year":"2004","unstructured":"O\u2019Connor, T. M. et al. The role of substance P in inflammatory disease. J. Cell. Physiol. 201, 167\u2013180 (2004).","journal-title":"J. Cell. Physiol."},{"key":"680_CR47","doi-asserted-by":"publisher","first-page":"e78773","DOI":"10.1371\/journal.pone.0078773","volume":"8","author":"R Amendola","year":"2013","unstructured":"Amendola, R. et al. Effects of a skin neuropeptide (substance P) on cutaneous microflora. PLoS ONE 8, e78773 (2013).","journal-title":"PLoS ONE"},{"key":"680_CR48","first-page":"506","volume":"7","author":"A N\u2019Diaye","year":"2016","unstructured":"N\u2019Diaye, A. et al. Effect of substance P in Staphylococcus aureus and Staphylococcus epidermidis virulence: implication for skin homeostasis. Front. Microbiol. 7, 506 (2016).","journal-title":"Front. Microbiol."},{"key":"680_CR49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10644-z","volume":"7","author":"M Widjaja","year":"2017","unstructured":"Widjaja, M. et al. Elongation factor Tu is a multifunctional and processed moonlighting protein. Sci. Rep. 7, 11227 (2017).","journal-title":"Sci. Rep."},{"key":"680_CR50","doi-asserted-by":"publisher","first-page":"S74","DOI":"10.1016\/j.identj.2023.08.010","volume":"73","author":"Z Brookes","year":"2023","unstructured":"Brookes, Z. et al. Mouthwash effects on the oral microbiome: are they good, bad, or balanced? Int. Dent. J. 73, S74\u2013S81 (2023).","journal-title":"Int. Dent. J."},{"key":"680_CR51","first-page":"311","volume":"3","author":"W Tang","year":"2006","unstructured":"Tang, W. et al. Expression, purification and identification of recombinant mouse interleukin 21 protein in E. coli. Cell. Mol. Immunol. 3, 311\u2013315 (2006).","journal-title":"Cell. Mol. Immunol."},{"key":"680_CR52","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1038\/s41564-022-01134-8","volume":"7","author":"MV Berlanga-Clavero","year":"2022","unstructured":"Berlanga-Clavero, M. V. et al. Bacillus subtilis biofilm matrix components target seed oil bodies to promote growth and anti-fungal resistance in melon. Nat. Microbiol. 7, 1001\u20131015 (2022).","journal-title":"Nat. Microbiol."},{"key":"680_CR53","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1093\/bioinformatics\/btx754","volume":"34","author":"LJ McIver","year":"2018","unstructured":"McIver, L. J. et al. bioBakery: a meta\u2019omic analysis environment. Bioinformatics 34, 1235\u20131237 (2018).","journal-title":"Bioinformatics"},{"key":"680_CR54","doi-asserted-by":"crossref","unstructured":"Beghini, F., et al. Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3. Elife 10, (2021).","DOI":"10.7554\/eLife.65088"},{"key":"680_CR55","unstructured":"Hadley, W. ggplot2 Elegant Graphics for Data Analysis (ed. Parmigiani, R.G.K.H.G.) (Springer, 2016)."},{"key":"680_CR56","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1179\/000870403235002042","volume":"40","author":"M Harrower","year":"2003","unstructured":"Harrower, M. & Brewer, C. A. ColorBrewer.org: an online tool for selecting colour schemes for maps. Cartogr. J. 40, 27\u201337 (2003).","journal-title":"Cartogr. J."},{"key":"680_CR57","doi-asserted-by":"publisher","unstructured":"Ahlmann-Eltze, C. & Patil, I. ggsignif: R Package for Displaying Significance Brackets for \u2018ggplot2\u2019. Preprint at: https:\/\/doi.org\/10.31234\/osf.io\/7awm6 (2021).","DOI":"10.31234\/osf.io\/7awm6"},{"key":"680_CR58","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"680_CR59","unstructured":"Oksanen, J. et al. Community Ecology Package. Preprint at: https:\/\/github.com\/vegandevs\/vegan (2022)."},{"key":"680_CR60","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41564-023-01329-7","volume":"8","author":"Y Sun","year":"2023","unstructured":"Sun, Y., Hurlimann, S. & Garner, E. Growth rate is modulated by monitoring cell wall precursors in Bacillus subtilis. Nat. Microbiol. 8, 469\u2013480 (2023).","journal-title":"Nat. Microbiol."},{"key":"680_CR61","doi-asserted-by":"publisher","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","volume":"45","author":"M Kanehisa","year":"2017","unstructured":"Kanehisa, M. et al. KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45, D353\u2013D361 (2017).","journal-title":"Nucleic Acids Res."},{"key":"680_CR62","doi-asserted-by":"publisher","first-page":"W317","DOI":"10.1093\/nar\/gkab447","volume":"49","author":"D Bu","year":"2021","unstructured":"Bu, D. et al. KOBAS-i: intelligent prioritization and exploratory visualization of biological functions for gene enrichment analysis. Nucleic Acids Res. 49, W317\u2013W325 (2021).","journal-title":"Nucleic Acids Res."},{"key":"680_CR63","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504 (2003).","journal-title":"Genome Res."},{"key":"680_CR64","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.actbio.2024.11.026","volume":"191","author":"J Zhou","year":"2025","unstructured":"Zhou, J. et al. Deoxygenated hydroxyapatite inhibits macrophage inflammation through fibronectin restricted adsorption. Acta Biomater. 191, 177\u2013188 (2025).","journal-title":"Acta Biomater."}],"container-title":["npj Biofilms and Microbiomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41522-025-00680-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41522-025-00680-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41522-025-00680-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T01:41:33Z","timestamp":1742607693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41522-025-00680-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,21]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["680"],"URL":"https:\/\/doi.org\/10.1038\/s41522-025-00680-3","relation":{},"ISSN":["2055-5008"],"issn-type":[{"value":"2055-5008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,21]]},"assertion":[{"value":"28 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"47"}}