{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:03:11Z","timestamp":1793318591878,"version":"4.5.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":81,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R35-DE029083"],"award-info":[{"award-number":["R35-DE029083"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R90-DE031533"],"award-info":[{"award-number":["R90-DE031533"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R35-DE028252"],"award-info":[{"award-number":["R35-DE028252"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R00-DE029228"],"award-info":[{"award-number":["R00-DE029228"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Biofilms Microbiomes"],"DOI":"10.1038\/s41522-026-01006-7","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:14:33Z","timestamp":1778926473000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug repurposing for glucosyltransferase inhibition for targeted oral biofilm disruption"],"prefix":"10.1038","volume":"12","author":[{"given":"Fernanda S.","family":"de Lucena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew G.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Y.","family":"Icimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin L.","family":"Merritt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmem S.","family":"Pfeifer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"1006_CR1","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1177\/0022034517693566","volume":"96","author":"NJ Kassebaum","year":"2017","unstructured":"Kassebaum, N. J. et al. Global, Regional, and National Prevalence, Incidence, and Disability-Adjusted Life Years for Oral Conditions for 195 Countries, 1990-2015: A Systematic Analysis for the Global Burden of Diseases, Injuries, and Risk Factors. J. Dent. Res. 96, 380\u2013387 (2017).","journal-title":"J. Dent. Res"},{"key":"1006_CR2","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S0140-6736(07)60031-2","volume":"369","author":"RH Selwitz","year":"2007","unstructured":"Selwitz, R. H., Ismail, A. I. & Pitts, N. B. Dental caries. Lancet 369, 51\u201359 (2007).","journal-title":"Lancet"},{"key":"1006_CR3","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.drudis.2022.03.006","volume":"27","author":"C Choudhury","year":"2022","unstructured":"Choudhury, C., Arul Murugan, N. & Priyakumar, U. D. Structure-based drug repurposing: Traditional and advanced AI\/ML-aided methods. Drug Discov. Today 27, 1847\u20131861 (2022).","journal-title":"Drug Discov. Today"},{"key":"1006_CR4","doi-asserted-by":"publisher","unstructured":"Balducci, E., Papi, F., Capialbi, D. E. & Del Bino, L. Polysaccharides\u2019 Structures and Functions in Biofilm Architecture of Antimicrobial-Resistant (AMR) Pathogens. Int. J. Mol. Sci. 24, https:\/\/doi.org\/10.3390\/ijms24044030 (2023).","DOI":"10.3390\/ijms24044030"},{"key":"1006_CR5","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1128\/JB.01649-09","volume":"192","author":"H Koo","year":"2010","unstructured":"Koo, H., Xiao, J., Klein, M. I. & Jeon, J. G. Exopolysaccharides produced by Streptococcus mutans glucosyltransferases modulate the establishment of microcolonies within multispecies biofilms. J. Bacteriol. 192, 3024\u20133032 (2010).","journal-title":"J. Bacteriol."},{"key":"1006_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1159\/000324598","volume":"45","author":"WH Bowen","year":"2011","unstructured":"Bowen, W. H. & Koo, H. Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms. Caries Res. 45, 69\u201386 (2011).","journal-title":"Caries Res"},{"key":"1006_CR7","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1128\/iai.61.9.3811-3817.1993","volume":"61","author":"Y Yamashita","year":"1993","unstructured":"Yamashita, Y., Bowen, W. H., Burne, R. A. & Kuramitsu, H. K. Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model. Infect. Immun. 61, 3811\u20133817 (1993).","journal-title":"Infect. Immun."},{"key":"1006_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06168-1","volume":"7","author":"Q Zhang","year":"2017","unstructured":"Zhang, Q. et al. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci. Rep. 7, 5974 (2017).","journal-title":"Sci. Rep."},{"key":"1006_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-021-02707-w","volume":"11","author":"J Khan","year":"2021","unstructured":"Khan, J., Tarar, S. M., Gul, I., Nawaz, U. & Arshad, M. Challenges of antibiotic resistance biofilms and potential combating strategies: a review. 3 Biotech 11, 169 (2021).","journal-title":"3 Biotech"},{"key":"1006_CR10","doi-asserted-by":"publisher","first-page":"7645","DOI":"10.1021\/acs.est.2c08244","volume":"57","author":"WA Arnold","year":"2023","unstructured":"Arnold, W. A. et al. Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern. Environ. Sci. Technol. 57, 7645\u20137665 (2023).","journal-title":"Environ. Sci. Technol."},{"key":"1006_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-81-322-1774-9_1","volume":"808","author":"R Bragg","year":"2014","unstructured":"Bragg, R., Jansen, A., Coetzee, M., van der Westhuizen, W. & Boucher, C. Bacterial resistance to Quaternary Ammonium Compounds (QAC) disinfectants. Adv. Exp. Med Biol. 808, 1\u201313 (2014).","journal-title":"Adv. Exp. Med Biol."},{"key":"1006_CR12","doi-asserted-by":"publisher","unstructured":"Rozman, U., Pu\u0161nik, M., Kmetec, S., Duh, D. & \u0160ostar Turk, S. Reduced Susceptibility and Increased Resistance of Bacteria against Disinfectants: A Systematic Review. Microorganisms 9, https:\/\/doi.org\/10.3390\/microorganisms9122550 (2021).","DOI":"10.3390\/microorganisms9122550"},{"key":"1006_CR13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13756-023-01241-z","volume":"12","author":"JM Boyce","year":"2023","unstructured":"Boyce, J. M. Quaternary ammonium disinfectants and antiseptics: tolerance, resistance and potential impact on antibiotic resistance. Antimicrobial Resistance Infect. Control 12, 32 (2023).","journal-title":"Antimicrobial Resistance Infect. Control"},{"key":"1006_CR14","doi-asserted-by":"publisher","unstructured":"Vestby, L. K., Gr\u00f8nseth, T., Simm, R. & Nesse, L. L. Bacterial Biofilm and its Role in the Pathogenesis of Disease. Antibiotics (Basel) 9, https:\/\/doi.org\/10.3390\/antibiotics9020059 (2020).","DOI":"10.3390\/antibiotics9020059"},{"key":"1006_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00359-z","volume":"8","author":"N Rostami","year":"2022","unstructured":"Rostami, N. et al. Interspecies competition in oral biofilms mediated by Streptococcus gordonii extracellular deoxyribonuclease SsnA. npj Biofilms Microbiomes 8, 96 (2022).","journal-title":"npj Biofilms Microbiomes"},{"key":"1006_CR16","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1128\/JB.187.21.7193-7203.2005","volume":"187","author":"J Kreth","year":"2005","unstructured":"Kreth, J., Merritt, J., Shi, W. & Qi, F. Competition and coexistence between Streptococcus mutans and Streptococcus sanguinis in the dental biofilm. J. Bacteriol. 187, 7193\u20137203 (2005).","journal-title":"J. Bacteriol."},{"key":"1006_CR17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.ijantimicag.2015.03.015","volume":"46","author":"Q Zhang","year":"2015","unstructured":"Zhang, Q. et al. New small-molecule inhibitors of dihydrofolate reductase inhibit Streptococcus mutans. Int J. Antimicrob. Agents 46, 174\u2013182 (2015).","journal-title":"Int J. Antimicrob. Agents"},{"key":"1006_CR18","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/90765","volume":"19","author":"S Myers","year":"2001","unstructured":"Myers, S. & Baker, A. Drug discovery-an operating model for a new era. Nat. Biotechnol. 19, 727\u2013730 (2001).","journal-title":"Nat. Biotechnol."},{"key":"1006_CR19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/clpt.2009.295","volume":"87","author":"JA DiMasi","year":"2010","unstructured":"DiMasi, J. A., Feldman, L., Seckler, A. & Wilson, A. Trends in risks associated with new drug development: success rates for investigational drugs. Clin. Pharm. Ther. 87, 272\u2013277 (2010).","journal-title":"Clin. Pharm. Ther."},{"key":"1006_CR20","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/jphp.13273","volume":"72","author":"JP Jourdan","year":"2020","unstructured":"Jourdan, J. P., Bureau, R., Rochais, C. & Dallemagne, P. Drug repositioning: a brief overview. J. Pharm. Pharm. 72, 1145\u20131151 (2020).","journal-title":"J. Pharm. Pharm."},{"key":"1006_CR21","doi-asserted-by":"publisher","first-page":"628144","DOI":"10.3389\/fmolb.2021.628144","volume":"8","author":"BM Sahoo","year":"2021","unstructured":"Sahoo, B. M. et al. Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection. Front Mol. Biosci. 8, 628144 (2021).","journal-title":"Front Mol. Biosci."},{"key":"1006_CR22","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s13195-021-00831-6","volume":"13","author":"A Ancidoni","year":"2021","unstructured":"Ancidoni, A. et al. Anticancer drugs repurposed for Alzheimer\u2019s disease: a systematic review. Alzheimers Res Ther. 13, 96 (2021).","journal-title":"Alzheimers Res Ther."},{"key":"1006_CR23","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3934\/microbiol.2022019","volume":"8","author":"R Mirghani","year":"2022","unstructured":"Mirghani, R. et al. Biofilms: Formation, drug resistance and alternatives to conventional approaches. AIMS Microbiol 8, 239\u2013277 (2022).","journal-title":"AIMS Microbiol"},{"key":"1006_CR24","doi-asserted-by":"publisher","unstructured":"Sharma, S. et al. Microbial Biofilm: A Review on Formation, Infection, Antibiotic Resistance, Control Measures, and Innovative Treatment. Microorganisms 11, https:\/\/doi.org\/10.3390\/microorganisms11061614 (2023).","DOI":"10.3390\/microorganisms11061614"},{"key":"1006_CR25","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1555497","volume":"16","author":"M Xu","year":"2025","unstructured":"Xu, M. et al. Glucosyltransferase activity-based screening identifies tannic acid as an inhibitor of Streptococcus mutans biofilm. Front Microbiol 16, 1555497 (2025).","journal-title":"Front Microbiol"},{"key":"1006_CR26","doi-asserted-by":"publisher","first-page":"106942","DOI":"10.1016\/j.mimet.2024.106942","volume":"221","author":"AJ Kendall","year":"2024","unstructured":"Kendall, A. J., Scaffa, P. M. C., Logan, M. G. & Pfeifer, C. S. Revisiting gas-chromatography\/mass-spectrometry molar response factors for quantitative analysis (FID or TIC) of glycosidic linkages in polysaccharides produced by oral bacterial biofilms. J. Microbiol. Methods 221, 106942 (2024).","journal-title":"J. Microbiol. Methods"},{"key":"1006_CR27","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1021\/acsmedchemlett.0c00373","volume":"12","author":"B Nijampatnam","year":"2021","unstructured":"Nijampatnam, B. et al. Discovery of Potent Inhibitors of Streptococcus mutans Biofilm with Antivirulence Activity. ACS Med Chem. Lett. 12, 48\u201355 (2021).","journal-title":"ACS Med Chem. Lett."},{"key":"1006_CR28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jmb.2011.02.028","volume":"408","author":"K Ito","year":"2011","unstructured":"Ito, K. et al. Crystal Structure of Glucansucrase from the Dental Caries Pathogen Streptococcus mutans. J. Mol. Biol. 408, 177\u2013186 (2011).","journal-title":"J. Mol. Biol."},{"key":"1006_CR29","doi-asserted-by":"publisher","first-page":"7909","DOI":"10.1021\/acs.jmedchem.3c00272","volume":"66","author":"P Ahirwar","year":"2023","unstructured":"Ahirwar, P. et al. Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of Streptococcus mutans. J. Med. Chem. 66, 7909\u20137925 (2023).","journal-title":"J. Med. Chem."},{"key":"1006_CR30","doi-asserted-by":"publisher","first-page":"W448","DOI":"10.1093\/nar\/gkv306","volume":"43","author":"CM Labb\u00e9","year":"2015","unstructured":"Labb\u00e9, C. M. et al. MTiOpenScreen: a web server for structure-based virtual screening. Nucleic Acids Res. 43, W448\u2013W454 (2015).","journal-title":"Nucleic Acids Res."},{"key":"1006_CR31","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrd.2018.168","volume":"18","author":"S Pushpakom","year":"2019","unstructured":"Pushpakom, S. et al. Drug repurposing: progress, challenges and recommendations. Nat. Rev. Drug Discov. 18, 41\u201358 (2019).","journal-title":"Nat. Rev. Drug Discov."},{"key":"1006_CR32","doi-asserted-by":"publisher","unstructured":"Tanoli, Z. et al. Computational drug repurposing: approaches, evaluation of in silico resources and case studies. Nat. Rev. Drug Dis. https:\/\/doi.org\/10.1038\/s41573-025-01164-x (2025).","DOI":"10.1038\/s41573-025-01164-x"},{"key":"1006_CR33","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.drudis.2021.09.007","volume":"27","author":"K Crampon","year":"2022","unstructured":"Crampon, K., Giorkallos, A., Deldossi, M., Baud, S. & Steffenel, L. A. Machine-learning methods for ligand\u2013protein molecular docking. Drug Discov. Today 27, 151\u2013164 (2022).","journal-title":"Drug Discov. Today"},{"key":"1006_CR34","doi-asserted-by":"publisher","first-page":"e0265958","DOI":"10.1371\/journal.pone.0265958","volume":"17","author":"S-K Heo","year":"2022","unstructured":"Heo, S.-K. et al. Radotinib inhibits multiple myeloma cell proliferation via suppression of STAT3 signaling. Plos one 17, e0265958 (2022).","journal-title":"Plos one"},{"key":"1006_CR35","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1002\/cam4.1436","volume":"7","author":"H Noh","year":"2018","unstructured":"Noh, H. et al. Determination of a radotinib dosage regimen based on dose-response relationships for the treatment of newly diagnosed patients with chronic myeloid leukemia. Cancer Med. 7, 1766\u20131773 (2018).","journal-title":"Cancer Med."},{"key":"1006_CR36","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1128\/IAI.00087-14","volume":"82","author":"ML Falsetta","year":"2014","unstructured":"Falsetta, M. L. et al. Symbiotic Relationship between Streptococcus mutans and Candida albicans Synergizes Virulence of Plaque Biofilms In Vivo. Infect. Immun. 82, 1968\u20131981 (2014).","journal-title":"Infect. Immun."},{"key":"1006_CR37","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/omi.12231","volume":"33","author":"S Redanz","year":"2018","unstructured":"Redanz, S. et al. Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome. Mol. Oral. Microbiol 33, 337\u2013352 (2018).","journal-title":"Mol. Oral. Microbiol"},{"key":"1006_CR38","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/1462-2920.12953","volume":"18","author":"J Merritt","year":"2016","unstructured":"Merritt, J., Senpuku, H. & Kreth, J. Let there be bioluminescence: development of a biophotonic imaging platform for in situ analyses of oral biofilms in animal models. Environ. Microbiol 18, 174\u2013190 (2016).","journal-title":"Environ. Microbiol"},{"key":"1006_CR39","doi-asserted-by":"publisher","unstructured":"O\u2019Toole, G. A. Microtiter dish biofilm formation assay. J. Vis. Exp. https:\/\/doi.org\/10.3791\/2437 (2011).","DOI":"10.3791\/2437"},{"key":"1006_CR40","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1006\/cbir.2000.0648","volume":"25","author":"KJ Bundy","year":"2001","unstructured":"Bundy, K. J., Harris, L. G., Rahn, B. A. & Richards, R. G. MEASUREMENT OF FIBROBLAST AND BACTERIAL DETACHMENT FROM BIOMATERIALS USING JET IMPINGEMENT. Cell Biol. Int. 25, 289\u2013307 (2001).","journal-title":"Cell Biol. Int."},{"key":"1006_CR41","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1017\/S1479050504001516","volume":"1","author":"J Kreth","year":"2004","unstructured":"Kreth, J. et al. Quantitative analyses of Streptococcus mutans biofilms with quartz crystal microbalance, microjet impingement and confocal microscopy. Biofilms 1, 277\u2013284 (2004).","journal-title":"Biofilms"},{"key":"1006_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01502-6","volume":"21","author":"RV Sionov","year":"2021","unstructured":"Sionov, R. V. et al. Tooth mousse containing casein phosphopeptide-amorphous calcium phosphate prevents biofilm formation of Streptococcus mutans. BMC Oral. Health 21, 136 (2021).","journal-title":"BMC Oral. Health"},{"key":"1006_CR43","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1159\/000154783","volume":"42","author":"CP Aires","year":"2008","unstructured":"Aires, C. P. et al. Effect of Starch and Sucrose on Dental Biofilm Formation and on Root Dentine Demineralization. Caries Res. 42, 380\u2013386 (2008).","journal-title":"Caries Res."},{"key":"1006_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-39125-2","volume":"13","author":"PMC Scaffa","year":"2023","unstructured":"Scaffa, P. M. C. et al. The potential use of glycosyl-transferase inhibitors for targeted reduction of S. mutans biofilms in dental materials. Sci. Rep. 13, 11889 (2023).","journal-title":"Sci. Rep."},{"key":"1006_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2024.106942","volume":"221","author":"AJ Kendall","year":"2024","unstructured":"Kendall, A. J., Scaffa, P. M. C., Logan, M. G. & Pfeifer, C. S. Revisiting gas-chromatography\/mass-spectrometry molar response factors for quantitative analysis (FID or TIC) of glycosidic linkages in polysaccharides produced by oral bacterial biofilms. J. Microbiol Methods 221, 106942 (2024).","journal-title":"J. Microbiol Methods"},{"key":"1006_CR46","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/s41564-020-00817-4","volume":"6","author":"R Hartmann","year":"2021","unstructured":"Hartmann, R. et al. Quantitative image analysis of microbial communities with BiofilmQ. Nat. Microbiol. 6, 151\u2013156 (2021).","journal-title":"Nat. Microbiol."}],"container-title":["npj Biofilms and Microbiomes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41522-026-01006-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41522-026-01006-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41522-026-01006-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:45:08Z","timestamp":1785883508000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41522-026-01006-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1006"],"URL":"https:\/\/doi.org\/10.1038\/s41522-026-01006-7","relation":{},"ISSN":["2055-5008"],"issn-type":[{"value":"2055-5008","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"13 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"146"}}