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We investigated whether susceptibility to infections and microbiome resilience after antibiotic treatment are associated with key taxa in the early childhood microbiota. Therefore, we performed longitudinal microbiota analysis from stool samples of children within the German LoewenKIDS intensified subcohort. According to the exposure to antibiotic treatment, sample groups were defined as never-treated controls, 45\u2013225 days pre-treatment (pre45-225), 0\u201330 days pre-treatment (pre0-30), 0\u201330 days post-treatment (post0-30), or &gt;90 days post-treatment and age &gt;540 days (post&gt;90). 1176 stool samples of 162 children were included in our analysis, of which 49 children received antibiotics. Using generalized linear mixed models adjusted for age, we show that high abundance of\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    was associated with receiving antibiotic treatment 45-225 days later, while low\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    abundance before treatment was associated with low alpha diversity and increased beta diversity post treatment. Our data suggest a key role of the genus\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    for the susceptibility to infections requiring antibiotic treatment and for microbiome stability and resilience in early childhood.\n                  <\/jats:p>","DOI":"10.1038\/s41522-026-01022-7","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:53:45Z","timestamp":1781132025000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High early-life gut Bacteroides links to microbiome stability, resilience, and risk for childhood infections"],"prefix":"10.1038","volume":"12","author":[{"given":"Matthias","family":"Hauptmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Gottschick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uthayakumar","family":"Muthukumarasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Klee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Strowig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Mikolajczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich Emil","family":"Schaible","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"1022_CR1","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","volume":"17","author":"F B\u00e4ckhed","year":"2015","unstructured":"B\u00e4ckhed, F. et al. 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