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We propose here an in vivo validated numerical framework to simulate the acute ocular-cerebrovascular response to 6\u00b0 HDT, to explore the etiology and pathophysiology of SANS. The model links cerebral and ocular posture-induced hemodynamics, simulating the response of the main cerebrovascular mechanisms, as well as the relationship between intracranial and intraocular pressure to HDT. Our results from short-term (10\u2009min) 6\u00b0 HDT show increased hemodynamic pulsatility in the proximal-to-distal\/capillary-venous cerebral direction, a marked decrease (-43%) in ocular translaminar pressure, and an increase (+31%) in ocular perfusion pressure, suggesting a plausible explanation of the underlying mechanisms at the onset of ocular globe deformation and edema formation over longer time scales.<\/jats:p>","DOI":"10.1038\/s41526-024-00366-8","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T08:02:40Z","timestamp":1709020960000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-7245","authenticated-orcid":false,"given":"Matteo","family":"Fois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-9327","authenticated-orcid":false,"given":"Ana","family":"Diaz-Artiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syeda Yasmin","family":"Zaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Ridolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-6491","authenticated-orcid":false,"given":"Stefania","family":"Scarsoglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"366_CR1","unstructured":"Gunga, H.-C. in Human physiology in extreme environments, chap. 7, 2nd edn. 273\u2013311 (Academic Press, 2020)."},{"key":"366_CR2","doi-asserted-by":"crossref","unstructured":"Young, L. 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