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This study quantifies the effect of LBNP on intraocular pressure (IOP), mean arterial pressure at eye level (MAP\n                    <jats:sub>eye<\/jats:sub>\n                    ), and ocular perfusion pressure (OPP). Twenty-four subjects (12 male, 12 female) were subjected to graded LBNP in 0\u00b0 supine and 15\u00b0 head-down tilt (HDT) postures from 0\u2009mmHg to \u201350\u2009mmHg in 10\u2009mmHg increments. IOP decreased significantly with LBNP pressure in 0\u00b0 supine (by 0.7\u2009\u00b1\u20090.09\u2009mmHg per 10\u2009mmHg LBNP pressure,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and in 15\u00b0 HDT (by 1.0\u2009\u00b1\u20090.095\u2009mmHg per 10\u2009mmHg of LBNP pressure,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). MAP\n                    <jats:sub>eye<\/jats:sub>\n                    significantly decreased by 0.9\u2009\u00b1\u20090.4\u2009mmHg per 10\u2009mmHg of LBNP pressure in 0\u00b0 supine (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.016) but did not significantly change with LBNP in 15\u00b0 HDT (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.895). OPP did not significantly change with LBNP in 0\u00b0 supine (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.539) but it significantly increased in 15\u00b0 HDT at 1.0\u2009\u00b1\u20090.3\u2009mmHg per 10\u2009mmHg of LBNP pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.010). Sex did not have a significant effect on OPP, MAP\n                    <jats:sub>eye<\/jats:sub>\n                    , or IOP in any condition. In 15\u00b0 HDT, the reduction in IOP during increasing negative pressure, combined with the relatively constant MAP\n                    <jats:sub>eye<\/jats:sub>\n                    , led to the increase in OPP. Furthermore, results suggest that LBNP, while effective in reducing IOP, is not effective in reducing OPP across all postures investigated.\n                  <\/jats:p>","DOI":"10.1038\/s41526-024-00404-5","type":"journal-article","created":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T02:01:52Z","timestamp":1717812112000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ocular perfusion pressure is not reduced in response to lower body negative pressure"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-6964","authenticated-orcid":false,"given":"Eric A.","family":"Hall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7437-5433","authenticated-orcid":false,"given":"Richard S.","family":"Whittle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-9327","authenticated-orcid":false,"given":"Ana","family":"Diaz-Artiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,8]]},"reference":[{"key":"404_CR1","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1038\/eye.1990.107","volume":"4","author":"RM Baer","year":"1990","unstructured":"Baer, R. 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