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This study evaluated the feasibility of performing restorative dentistry procedures in a microgravity environment. A parabolic flight campaign aboard the Airbus A310 was conducted through the ESA Academy Experiments programme. The campaign included 90 parabolas over 3 days, each providing ~22\u2009s of microgravity. Two senior dentistry students performed 72 caries preparations and 36 composite restorations on artificial teeth in three environments: ground, microgravity, and steady flight. Accuracy was evaluated using computer-aided 2D image analysis for preparation errors and 3D scanning for restoration errors. Statistical analysis using two-way ANOVA revealed no significant impact of environmental conditions on preparation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.623) or restoration (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.139) accuracy, although operator differences were observed. These findings indicate that microgravity does not significantly impair the accuracy of restorative dentistry procedures, highlighting the potential to expand dental treatment in space.\n                  <\/jats:p>","DOI":"10.1038\/s41526-025-00552-2","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T03:35:31Z","timestamp":1765596931000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effect of microgravity on the feasibility and accuracy of dental procedures"],"prefix":"10.1038","volume":"12","author":[{"given":"Tine","family":"\u0160efic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hana","family":"Prtenjak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Oman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Fidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,13]]},"reference":[{"key":"552_CR1","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1177\/00220345740530053201","volume":"53","author":"LR Brown","year":"1974","unstructured":"Brown, L. 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