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This article provides a strategic perspective on how shifting investments, policy, and R&amp;D to orbital biomanufacturing could revolutionize defense, commercial, and civil sectors by enhancing supply chain resiliency, operational flexibility, ethical debris management, and commercial viability in Earth orbit.<\/jats:p>","DOI":"10.1038\/s41526-026-00571-7","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T14:35:49Z","timestamp":1772202949000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Orbital biomanufacturing: the key to space resiliency, operational persistence, and ethical sustainability"],"prefix":"10.1038","volume":"12","author":[{"given":"Andrew KD","family":"Younger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"571_CR1","doi-asserted-by":"publisher","first-page":"20140715","DOI":"10.1098\/rsif.2014.0715","volume":"12","author":"A Menezes","year":"2015","unstructured":"Menezes, A. et al. 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