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We analysed data from the Parkinson\u2019s Incidence Cohorts Collaboration, composed of incident community-based cohorts of PD patients assessed longitudinally over 8 years. Constipation was assessed with the MDS-UPDRS constipation item or a comparable categorical scale. Primary PD outcomes of interest were dementia, postural instability and death. PD patients were stratified according to constipation severity at diagnosis: none (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009313, 67.3%), minor (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200997, 20.9%) and major (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200955, 11.8%). Clinical progression to all three outcomes was more rapid in those with more severe constipation at baseline (Kaplan\u2013Meier survival analysis). Cox regression analysis, adjusting for relevant confounders, confirmed a significant relationship between constipation severity and progression to dementia, but not postural instability or death. Early constipation may predict an accelerated progression of neurodegenerative pathology.\n                  <\/jats:p>","DOI":"10.1038\/s41531-021-00191-w","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T06:03:33Z","timestamp":1622009013000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Early constipation predicts faster dementia onset in Parkinson\u2019s disease"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1490-5703","authenticated-orcid":false,"given":"M.","family":"Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-4239","authenticated-orcid":false,"given":"A. 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