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Of 296 patients (189=PD, 107=AP [dementia with Lewy bodies, progressive supranuclear palsy, multiple system atrophy, vascular parkinsonism]), 152 developed delirium (PD\u2009=\u200998, AP\u2009=\u200954). Incidence of first hospital delirium episode per 100 person years was 8.1 (95% confidence interval [CI] 6.6\u20139.9) in PD and 18.5 (95% CI 13.9\u201324.7) in AP. Independent predictors of delirium were atypical parkinsonism (Hazard ratio [HR] vs PD\u2009=\u20092.83 [95% CI 1.60\u20135.03], age in PD but not in AP (HR for 10-year increase 2.29 [95% CI 1.74\u20133.02]), baseline MMSE (HR\u2009=\u20090.94 [95% CI 0.89\u20130.99]), <jats:italic>APOE<\/jats:italic> \u03b54 in PD (HR 2.16 [95% CI 1.15\u20134.08]), and <jats:italic>MAPT<\/jats:italic> H1\/H1 in PD (HR 2.08 [95% CI 1.08\u20134.00]). Hazards of dementia and death after delirium vs before delirium were increased (dementia: HR\u2009=\u20096.93 [95% CI 4.18\u201311.48] in parkinsonism; death: HR\u2009=\u20093.76 [95% CI 2.65\u20135.35] in PD, 1.59 [95% CI 1.04\u20132.42] in AP). Delirium is a common non-motor feature of PD and AP and is associated with increased hazards of dementia and mortality. Whether interventions for early identification and treatment improve outcomes requires investigation.<\/jats:p>","DOI":"10.1038\/s41531-021-00234-2","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T10:18:43Z","timestamp":1633947523000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["First delirium episode in Parkinson\u2019s disease and parkinsonism: incidence, predictors, and outcomes"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3277-8330","authenticated-orcid":false,"given":"Samantha","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8896-1898","authenticated-orcid":false,"given":"Sarah L.","family":"Perrott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"McCleary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isobel","family":"Sleeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-0078","authenticated-orcid":false,"given":"Jodi","family":"Maple-Gr\u00f8dem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl E.","family":"Counsell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-4239","authenticated-orcid":false,"given":"Angus D.","family":"Macleod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"234_CR1","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1136\/emermed-2011-200586","volume":"30","author":"EA Barron","year":"2013","unstructured":"Barron, E. 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