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Similarly to PD, short-chain fatty acids-producing genera were decreased in DLB. Additionally,\n                    <jats:italic>Ruminococcus torques<\/jats:italic>\n                    and\n                    <jats:italic>Collinsella<\/jats:italic>\n                    were increased in DLB, which were not changed in PD. Random forest models to differentiate DLB and PD showed that high\n                    <jats:italic>Ruminococcus torques<\/jats:italic>\n                    and high\n                    <jats:italic>Collinsella<\/jats:italic>\n                    , which presumably increase intestinal permeability, as well as low\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , which are also observed in Alzheimer\u2019s disease, were predictive of DLB. As\n                    <jats:italic>Ruminococcus torques<\/jats:italic>\n                    and\n                    <jats:italic>Collinsella<\/jats:italic>\n                    are also major secondary bile acids-producing bacteria, we quantified fecal bile acids and found that the production of ursodeoxycholic acid (UDCA) was high in DLB. Increased UDCA in DLB may mitigate neuroinflammation at the substantia nigra, whereas neuroinflammation may not be critical at the neocortex. Theraeutic intervention to increase\n                    <jats:italic>Bifidobacteirum<\/jats:italic>\n                    and its metabolites may retard the development and progression of DLB.\n                  <\/jats:p>","DOI":"10.1038\/s41531-022-00428-2","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T13:02:38Z","timestamp":1670590958000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Gut microbiota in dementia with Lewy bodies"],"prefix":"10.1038","volume":"8","author":[{"given":"Hiroshi","family":"Nishiwaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ueyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kashihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-7602","authenticated-orcid":false,"given":"Mikako","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonari","family":"Hamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-8343","authenticated-orcid":false,"given":"Tetsuya","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-0981","authenticated-orcid":false,"given":"Yoshio","family":"Tsuboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9453-9311","authenticated-orcid":false,"given":"Masahisa","family":"Katsuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-7837","authenticated-orcid":false,"given":"Masaaki","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1529-2750","authenticated-orcid":false,"given":"Kinji","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"428_CR1","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","volume":"20","author":"H McCann","year":"2014","unstructured":"McCann, H., Stevens, C. 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