{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:13:32Z","timestamp":1784963612503,"version":"3.55.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Parkinsons Dis."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Disrupted sleep has a profound adverse impact on lives of Parkinson\u2019s disease (PD) patients and their caregivers. Sleep disturbances are exceedingly common in PD, with substantial heterogeneity in type, timing, and severity. Among the most common sleep-related symptoms reported by PD patients are insomnia, excessive daytime sleepiness, and sleep fragmentation, characterized by interruptions and decreased continuity of sleep. Alterations in brain wave activity, as measured on the electroencephalogram (EEG), also occur in PD, with changes in the pattern and relative contributions of different frequency bands of the EEG spectrum to overall EEG activity in different vigilance states consistently observed. The mechanisms underlying these PD-associated sleep-wake abnormalities are poorly understood, and they are ineffectively treated by conventional PD therapies. To help fill this gap in knowledge, a new progressive model of PD \u2013 the MCI-Park mouse \u2013 was studied. Near the transition to the parkinsonian state, these mice exhibited significantly altered sleep-wake regulation, including increased wakefulness, decreased non-rapid eye movement (NREM) sleep, increased sleep fragmentation, reduced rapid eye movement (REM) sleep, and altered EEG activity patterns. These sleep-wake abnormalities resemble those identified in PD patients. Thus, this model may help elucidate the circuit mechanisms underlying sleep disruption in PD and identify targets for novel therapeutic approaches.<\/jats:p>","DOI":"10.1038\/s41531-024-00670-w","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T14:02:10Z","timestamp":1710165730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson\u2019s disease"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9541-8458","authenticated-orcid":false,"given":"K. C.","family":"Summa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gonz\u00e1lez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-8347","authenticated-orcid":false,"given":"X.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Vitaterna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6376-5225","authenticated-orcid":false,"given":"D. J.","family":"Surmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. W.","family":"Turek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"670_CR1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe, W. et al. Parkinson disease. Nat. Rev. Dis. Primers 3, 17013 (2017).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"670_CR2","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/s41386-019-0448-y","volume":"45","author":"A Stefani","year":"2020","unstructured":"Stefani, A. & Hogl, B. Sleep in Parkinson\u2019s disease. Neuropsychopharmacology 45, 121\u2013128 (2020).","journal-title":"Neuropsychopharmacology"},{"key":"670_CR3","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.smrv.2016.08.001","volume":"35","author":"LM Chahine","year":"2017","unstructured":"Chahine, L. M., Amara, A. W. & Videnovic, A. A systematic review of the literature on disorders of sleep and wakefulness in Parkinson\u2019s disease from 2005 to 2015. Sleep. Med. Rev. 35, 33\u201350 (2017).","journal-title":"Sleep. Med. Rev."},{"key":"670_CR4","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fnagi.2016.00114","volume":"8","author":"IT French","year":"2016","unstructured":"French, I. T. & Muthusamy, K. A. A Review of Sleep and Its Disorders in Patients with Parkinson\u2019s Disease in Relation to Various Brain Structures. Front. Aging Neurosci. 8, 114 (2016).","journal-title":"Front. Aging Neurosci."},{"key":"670_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s40675-017-0079-y","volume":"3","author":"P Gros","year":"2017","unstructured":"Gros, P. & Videnovic, A. Sleep and Circadian Rhythm Disorders in Parkinson\u2019s Disease. Curr. Sleep Med. Rep. 3, 222\u2013234 (2017).","journal-title":"Curr. Sleep Med. Rep."},{"key":"670_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13024-021-00504-w","volume":"17","author":"J Hunt","year":"2022","unstructured":"Hunt, J. et al. Sleep and circadian rhythms in Parkinson\u2019s disease and preclinical models. Mol. Neurodegener. 17, 2 (2022).","journal-title":"Mol. Neurodegener."},{"key":"670_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2023.101759","volume":"68","author":"G Maggi","year":"2023","unstructured":"Maggi, G., Vitale, C., Cerciello, F. & Santangelo, G. Sleep and wakefulness disturbances in Parkinson\u2019s disease: A meta-analysis on prevalence and clinical aspects of REM sleep behavior disorder, excessive daytime sleepiness and insomnia. Sleep. Med. Rev. 68, 101759 (2023).","journal-title":"Sleep. Med. Rev."},{"key":"670_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12673","volume":"27","author":"S Mantovani","year":"2018","unstructured":"Mantovani, S., Smith, S. S., Gordon, R. & O\u2019Sullivan, J. D. An overview of sleep and circadian dysfunction in Parkinson\u2019s disease. J. Sleep. Res. 27, e12673 (2018).","journal-title":"J. Sleep. Res."},{"key":"670_CR9","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jsmc.2017.09.006","volume":"13","author":"RK Malhotra","year":"2018","unstructured":"Malhotra, R. K. Neurodegenerative Disorders and Sleep. Sleep. Med. Clin. 13, 63\u201370 (2018).","journal-title":"Sleep. Med. Clin."},{"key":"670_CR10","first-page":"384","volume":"28","author":"A Morita","year":"2011","unstructured":"Morita, A., Kamei, S. & Mizutani, T. Relationship between slowing of the EEG and cognitive impairment in Parkinson disease. J. Clin. Neurophysiol. 28, 384\u2013387 (2011).","journal-title":"J. Clin. Neurophysiol."},{"key":"670_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0013-4694(91)90134-P","volume":"79","author":"R Soikkeli","year":"1991","unstructured":"Soikkeli, R., Partanen, J., Soininen, H., Paakkonen, A. & Riekkinen, P. Sr. Slowing of EEG in Parkinson\u2019s disease. Electroencephalogr. Clin. Neurophysiol. 79, 159\u2013165 (1991).","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"670_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jns.2010.03.008","volume":"293","author":"J Dushanova","year":"2010","unstructured":"Dushanova, J., Philipova, D. & Nikolova, G. Beta and gamma frequency-range abnormalities in parkinsonian patients under cognitive sensorimotor task. J. Neurol. Sci. 293, 51\u201358 (2010).","journal-title":"J. Neurol. Sci."},{"key":"670_CR13","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1007\/s12264-022-00881-2","volume":"38","author":"X Liu","year":"2022","unstructured":"Liu, X. et al. Altered Motor Performance, Sleep EEG, and Parkinson\u2019s Disease Pathology Induced by Chronic Sleep Deprivation in Lrrk2(G2019S) Mice. Neurosci. Bull. 38, 1170\u20131182 (2022).","journal-title":"Neurosci. Bull."},{"key":"670_CR14","doi-asserted-by":"publisher","first-page":"531","DOI":"10.3233\/JPD-140374","volume":"4","author":"KA McDowell","year":"2014","unstructured":"McDowell, K. A., Shin, D., Roos, K. P. & Chesselet, M. F. Sleep dysfunction and EEG alterations in mice overexpressing alpha-synuclein. J. Parkinsons. Dis. 4, 531\u2013539 (2014).","journal-title":"J. Parkinsons. Dis."},{"key":"670_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203170","volume":"10","author":"K Fifel","year":"2023","unstructured":"Fifel, K., Yanagisawa, M. & Deboer, T. Mechanisms of Sleep\/Wake Regulation under Hypodopaminergic State: Insights from MitoPark Mouse Model of Parkinson\u2019s Disease. Adv. Sci. 10, e2203170 (2023).","journal-title":"Adv. Sci."},{"key":"670_CR16","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.clinph.2021.01.001","volume":"132","author":"A Jaramillo-Jimenez","year":"2021","unstructured":"Jaramillo-Jimenez, A. et al. Resting-state EEG alpha\/theta ratio related to neuropsychological test performance in Parkinson\u2019s Disease. Clin. Neurophysiol. 132, 756\u2013764 (2021).","journal-title":"Clin. Neurophysiol."},{"key":"670_CR17","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/S0165-0173(98)00056-3","volume":"29","author":"W Klimesch","year":"1999","unstructured":"Klimesch, W. EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis. Brain Res. Brain Res. Rev. 29, 169\u2013195 (1999).","journal-title":"Brain Res. Brain Res. Rev."},{"key":"670_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac096","volume":"4","author":"Z Ye","year":"2022","unstructured":"Ye, Z., Heldmann, M., Herrmann, L., Bruggemann, N. & Munte, T. F. Altered alpha and theta oscillations correlate with sequential working memory in Parkinson\u2019s disease. Brain. Commun. 4, fcac096 (2022).","journal-title":"Brain. Commun."},{"key":"670_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101922","volume":"23","author":"M Zhu","year":"2019","unstructured":"Zhu, M. et al. Altered EEG alpha and theta oscillations characterize apathy in Parkinson\u2019s disease during incentivized movement. Neuroimage Clin. 23, 101922 (2019).","journal-title":"Neuroimage Clin."},{"key":"670_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","volume":"4","author":"Y Dauvilliers","year":"2018","unstructured":"Dauvilliers, Y. et al. REM sleep behaviour disorder. Nat. Rev. Dis. Primers 4, 19 (2018).","journal-title":"Nat. Rev. Dis. Primers"},{"key":"670_CR21","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/nrneurol.2017.157","volume":"14","author":"B Hogl","year":"2018","unstructured":"Hogl, B., Stefani, A. & Videnovic, A. Idiopathic REM sleep behaviour disorder and neurodegeneration - an update. Nat. Rev. Neurol. 14, 40\u201355 (2018).","journal-title":"Nat. Rev. Neurol."},{"key":"670_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105599","volume":"163","author":"N Van Den Berge","year":"2022","unstructured":"Van Den Berge, N. & Ulusoy, A. Animal models of brain-first and body-first Parkinson\u2019s disease. Neurobiol. Dis. 163, 105599 (2022).","journal-title":"Neurobiol. Dis."},{"key":"670_CR23","volume":"2011","author":"TN Taylor","year":"2011","unstructured":"Taylor, T. N., Caudle, W. M. & Miller, G. W. VMAT2-Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson\u2019s Disease. Parkinsons Dis. 2011, 124165 (2011).","journal-title":"Parkinsons Dis."},{"key":"670_CR24","doi-asserted-by":"publisher","first-page":"3374","DOI":"10.1093\/brain\/awaa283","volume":"143","author":"Y Shen","year":"2020","unstructured":"Shen, Y. et al. Propagated alpha-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice. Brain 143, 3374\u20133392 (2020).","journal-title":"Brain"},{"key":"670_CR25","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1093\/brain\/awz380","volume":"143","author":"T Taguchi","year":"2020","unstructured":"Taguchi, T. et al. alpha-Synuclein BAC transgenic mice exhibit RBD-like behaviour and hyposmia: a prodromal Parkinson\u2019s disease model. Brain 143, 249\u2013265 (2020).","journal-title":"Brain"},{"key":"670_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3233\/JPD-120130","volume":"3","author":"SM Rothman","year":"2013","unstructured":"Rothman, S. M. et al. Neuronal expression of familial Parkinson\u2019s disease A53T alpha-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice. J. Parkinsons Dis. 3, 215\u2013229 (2013).","journal-title":"J. Parkinsons Dis."},{"key":"670_CR27","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.expneurol.2011.08.003","volume":"232","author":"T Kudo","year":"2011","unstructured":"Kudo, T., Loh, D. H., Truong, D., Wu, Y. & Colwell, C. S. Circadian dysfunction in a mouse model of Parkinson\u2019s disease. Exp. Neurol. 232, 66\u201375 (2011).","journal-title":"Exp. Neurol."},{"key":"670_CR28","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abe7099","volume":"13","author":"MM Morawska","year":"2021","unstructured":"Morawska, M. M. et al. Slow-wave sleep affects synucleinopathy and regulates proteostatic processes in mouse models of Parkinson\u2019s disease. Sci. Transl Med. 13, eabe7099 (2021).","journal-title":"Sci. Transl Med."},{"key":"670_CR29","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","volume":"599","author":"P Gonzalez-Rodriguez","year":"2021","unstructured":"Gonzalez-Rodriguez, P. et al. Disruption of mitochondrial complex I induces progressive parkinsonism. Nature 599, 650\u2013656 (2021).","journal-title":"Nature"},{"key":"670_CR30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.jneumeth.2016.02.016","volume":"264","author":"V Gao","year":"2016","unstructured":"Gao, V., Turek, F. & Vitaterna, M. Multiple classifier systems for automatic sleep scoring in mice. J. Neurosci. Methods 264, 33\u201339 (2016).","journal-title":"J. Neurosci. Methods"},{"key":"670_CR31","doi-asserted-by":"publisher","first-page":"e5161","DOI":"10.1371\/journal.pone.0005161","volume":"4","author":"CJ Winrow","year":"2009","unstructured":"Winrow, C. J. et al. Uncovering the genetic landscape for multiple sleep-wake traits. PLoS One 4, e5161 (2009).","journal-title":"PLoS One"},{"key":"670_CR32","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1007\/s00415-020-09757-9","volume":"268","author":"Y Guo","year":"2021","unstructured":"Guo, Y. et al. Predictors of cognitive impairment in Parkinson\u2019s disease: a systematic review and meta-analysis of prospective cohort studies. J. Neurol. 268, 2713\u20132722 (2021).","journal-title":"J. Neurol."},{"key":"670_CR33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-22381-z","volume":"12","author":"A Davin","year":"2022","unstructured":"Davin, A. et al. Early onset of sleep\/wake disturbances in a progressive macaque model of Parkinson\u2019s disease. Sci. Rep. 12, 17499 (2022).","journal-title":"Sci. Rep."},{"key":"670_CR34","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1111\/j.1460-9568.2004.03694.x","volume":"20","author":"C Monaca","year":"2004","unstructured":"Monaca, C. et al. Vigilance states in a parkinsonian model, the MPTP mouse. Eur. J. Neurosci. 20, 2474\u20132478 (2004).","journal-title":"Eur. J. Neurosci."},{"key":"670_CR35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nrn.2016.178","volume":"18","author":"DJ Surmeier","year":"2017","unstructured":"Surmeier, D. J., Obeso, J. A. & Halliday, G. M. Selective neuronal vulnerability in Parkinson disease. Nat. Rev. Neurosci. 18, 101\u2013113 (2017).","journal-title":"Nat. Rev. Neurosci."},{"key":"670_CR36","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/mds.27383","volume":"33","author":"JH Kordower","year":"2018","unstructured":"Kordower, J. H. & Burke, R. E. Disease Modification for Parkinson\u2019s Disease: Axonal Regeneration and Trophic Factors. Mov. Disord. 33, 678\u2013683 (2018).","journal-title":"Mov. Disord."},{"key":"670_CR37","doi-asserted-by":"publisher","unstructured":"Lai, Y. Y., Kodama, T., Hsieh, K. C., Nguyen, D. & Siegel, J. M. Substantia nigra pars reticulata-mediated sleep and motor activity regulation. Sleep 44 https:\/\/doi.org\/10.1093\/sleep\/zsaa151 (2021).","DOI":"10.1093\/sleep\/zsaa151"},{"key":"670_CR38","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1126\/science.aaz0956","volume":"367","author":"D Liu","year":"2020","unstructured":"Liu, D. et al. A common hub for sleep and motor control in the substantia nigra. Science 367, 440\u2013445 (2020).","journal-title":"Science"},{"key":"670_CR39","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1002\/mds.23884","volume":"26","author":"K Seppi","year":"2011","unstructured":"Seppi, K. et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the non-motor symptoms of Parkinson\u2019s disease. Mov. Disord. 26,S42\u2013S80 (2011).","journal-title":"Mov. Disord."},{"key":"670_CR40","doi-asserted-by":"publisher","first-page":"603","DOI":"10.3233\/JPD-191627","volume":"9","author":"NI Bohnen","year":"2019","unstructured":"Bohnen, N. I. & Hu, M. T. M. Sleep Disturbance as Potential Risk and Progression Factor for Parkinson\u2019s Disease. J. Parkinsons Dis. 9, 603\u2013614 (2019).","journal-title":"J. Parkinsons Dis."},{"key":"670_CR41","doi-asserted-by":"publisher","first-page":"e0229001","DOI":"10.1371\/journal.pone.0229001","volume":"15","author":"SJ Bowers","year":"2020","unstructured":"Bowers, S. J. et al. Repeated sleep disruption in mice leads to persistent shifts in the fecal microbiome and metabolome. PLoS One 15, e0229001 (2020).","journal-title":"PLoS One"},{"key":"670_CR42","doi-asserted-by":"publisher","first-page":"e0224642","DOI":"10.1371\/journal.pone.0224642","volume":"14","author":"Z Barger","year":"2019","unstructured":"Barger, Z., Frye, C. G., Liu, D., Dan, Y. & Bouchard, K. E. Robust, automated sleep scoring by a compact neural network with distributional shift correction. PLoS One 14, e0224642 (2019).","journal-title":"PLoS One"},{"key":"670_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v099.i15","volume":"99","author":"J Frossard","year":"2021","unstructured":"Frossard, J. & Renaud, O. Permutation Tests for Regression, ANOVA, and Comparison of Signals: The permuco Package. J. Stat. Softw. 99, 1\u201332 (2021).","journal-title":"J. Stat. Softw."},{"key":"670_CR44","unstructured":"Fox, J., Wesiberg, S. An R. Companion to Applied Regression, 3rd edn, (Sage, 2019)."}],"updated-by":[{"DOI":"10.1038\/s41531-024-00746-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000}}],"container-title":["npj Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41531-024-00670-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-024-00670-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-024-00670-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T03:05:09Z","timestamp":1721099109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41531-024-00670-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["670"],"URL":"https:\/\/doi.org\/10.1038\/s41531-024-00670-w","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.11.09.566376","asserted-by":"object"}]},"ISSN":["2373-8057"],"issn-type":[{"value":"2373-8057","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"7 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41531-024-00746-7","URL":"https:\/\/doi.org\/10.1038\/s41531-024-00746-7","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}