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(STN-DBS) is an established therapy in advanced Parkinson\u2019s disease (PD). Motor and non-motor outcomes, however, show considerable inter-individual variability. Preoperative morphometry-based metrics have recently received increasing attention to explain treatment effects. As evidence for the prediction of non-motor outcomes is limited, we sought to investigate the association between metrics of voxel-based morphometry and short-term non-motor outcomes following STN-DBS in this prospective open-label study. Forty-nine PD patients underwent structural MRI and a comprehensive clinical assessment at preoperative baseline and 6-month follow-up. Voxel-based morphometry was used to assess associations between cerebral volume and non-motor outcomes corrected for multiple comparisons using a permutation-based approach. We replicated existing results associating volume loss of the superior frontal cortex with subpar motor outcomes. Overall non-motor burden, however, was not significantly associated with morphometric features, limiting its use as a marker to inform patient selection and holistic preoperative counselling.<\/jats:p>","DOI":"10.1038\/s41531-024-00695-1","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T06:02:11Z","timestamp":1714111331000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["No evidence for an association of voxel-based morphometry with short-term non-motor outcomes in deep brain stimulation for Parkinson\u2019s disease"],"prefix":"10.1038","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-2156","authenticated-orcid":false,"given":"Philipp Alexander","family":"Loehrer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wibke","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie T.","family":"Jost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monty","family":"Silverdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0749-3840","authenticated-orcid":false,"given":"Jan Niklas","family":"Petry-Schmelzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Sauerbier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gronostay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5274-7929","authenticated-orcid":false,"given":"Veerle","family":"Visser-Vandewalle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-1856","authenticated-orcid":false,"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-165X","authenticated-orcid":false,"given":"Max","family":"Krause","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rizos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-2807","authenticated-orcid":false,"given":"Angelo","family":"Antonini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyoumars","family":"Ashkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Martinez-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9940-099X","authenticated-orcid":false,"given":"Christian","family":"Gaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2815-0505","authenticated-orcid":false,"given":"K.","family":"Ray Chaudhuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Timmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-9268","authenticated-orcid":false,"given":"Juan Carlos","family":"Baldermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8849-4233","authenticated-orcid":false,"given":"Haidar S.","family":"Dafsari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On behalf of EUROPAR and the International Parkinson and Movement Disorders Society Non-Motor Parkinson\u2019s Disease Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"695_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3233\/JPD-202278","volume":"11","author":"ST Jost","year":"2021","unstructured":"Jost, S. 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WS was supported by the Koeln Fortune Program\/Faculty of Medicine, University of Cologne, and reports no financial relationships with commercial interests. STJ was funded by the Prof. Klaus Thiemann Foundation and the Brandau-Laibach-Foundation, outside of the submitted work. MS has received honoraria from Bial, Britannia, and Medtronic. JNPS is funded by the Cologne Clinician Scientist Program (CCSP)\/Faculty of Medicine\/ University of Cologne; and by the German Research Foundation (DFG, FI 773\/15-464 1). AS reports no financial disclosures. AG reports no financial disclosures. VVV reports compensation for contributions to advisory boards and congresses for Medtronic, Boston Scientific, and Livanova. GRF serves as an editorial board member of Cortex, Neurological Research and Practice, NeuroImage: Clinical, Zeitschrift f\u00fcr Neuropsychologie, DGNeurologie, and Info Neurologie & Psychiatrie; receives royalties from the publication of the books Funktionelle MRT in Psychiatrie und Neurologie, Neurologische Differentialdiagnose, and SOP Neurologie; receives royalties from the publication of the neuropsychological tests KAS and K\u00f6pps; received honoraria for speaking engagements from Deutsche Gesellschaft f\u00fcr Neurologie (DGN) and Forum f\u00fcr medizinische Fortbildung FomF GmbH. JE reports no financial disclosures. MK was funded by the Koeln Fortune program of the Medical Faculty of the University of Cologne and reports no financial relationships with commercial interests. AR received funding from the National Institute for Health and Care Research (NIHR), the Clinical Research Network (CRN) in South London, and grant funding from the International Parkinson and Movement Disorders Society (MDS). AA received compensation for consultancy and speaker-related activities from UCB, Boehringer\u2013Ingelheim, Ever Pharma, General Electric, Britannia, AbbVie, Kyowa Kirin, Zambon, Bial, Theravance Biopharma, Jazz Pharmaceuticals, Roche, and Medscape. He receives research support from Bial, Lundbeck, Roche, Angelini Pharmaceuticals, Horizon 2020 Grant 825785, Horizon 2020 Grant 101016902, Ministry of Education University and Research (MIUR) Grant ARS01_01081, Cariparo Foundation, Movement Disorders Society for NMS Scale validation. He serves as a consultant for Boehringer\u2013Ingelheim for legal cases on pathological gambling. KA has received honoraria for educational meetings, travel, and consultancy from Medtronic, St. Jude Medical and Boston Scientific. PMM received honoraria from the International Parkinson and Movement Disorder Society (IPMDS) for the management of the Clinical Outcome Assessment Program. CG reports no financial disclosures. KRC received grants (IIT) from Britannia Pharmaceuticals, AbbVie, UCB, GKC, EU Horizon 2020, Parkinson\u2019s UK, NIHR, Parkinson\u2019s Foundation, Wellcome Trust, Kirby Laing Foundation, MRC; royalties or licenses from Oxford (book), Cambridge publishers (book), MAPI institute (KPPS, PDSS 2); consulting fees, support for attending meetings or travel, and participated on data safety monitoring board or advisory board for AbbVie, UCB, GKC, Bial, Cynapsus, Lobsor, Stada, Zambon, Profile Pharma, Synovion, Roche, Therevance, Scion, Britannia, Acadia, 4D Pharma, and Medtronic; and served as a committee chair for MDS (unpaid) and EAN (unpaid). LT received payments as a consultant for Medtronic Inc. and Boston Scientific and received honoraria as a speaker on symposia sponsored by Bial, Zambon Pharma, UCB Schwarz Pharma, Desitin Pharma, Medtronic, Boston Scientific, and Abbott. The institution of LT, not LT personally, received funding from the German Research Foundation, the German Ministry of Education and Research, and Deutsche Parkinson Vereinigung. JCB is funded by Else Kroener-Fresenius-Stiftung (2022_EKES.23) and receives funding from the German Research Foundation (Project ID 431549029-C07). HSD was funded by the EU Joint Program \u2013 Neurodegenerative Disease Research (JPND), the Prof. Klaus Thiemann Foundation in the German Society of Neurology, the Felgenhauer Foundation, the Koeln Fortune program of the Medical Faculty of the University of Cologne and has received honoraria by Everpharma, Kyowa Kirin, Bial, Oruen, and Stadapharm.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"91"}}