{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:19:02Z","timestamp":1791587942600,"version":"4.3.4"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T00:00:00Z","timestamp":1762214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["30-2022-0250"],"award-info":[{"award-number":["30-2022-0250"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["30-2022-0250"],"award-info":[{"award-number":["30-2022-0250"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["30-2022-0250"],"award-info":[{"award-number":["30-2022-0250"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Parkinsons Dis."],"DOI":"10.1038\/s41531-025-01152-3","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:32:06Z","timestamp":1762273926000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive function correlates with gastric alpha-synuclein seeding activity in early Parkinson\u2019s disease"],"prefix":"10.1038","volume":"11","author":[{"given":"Chaewon","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Pil","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Youn","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bora","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ah","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HoYoung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee Jin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Hwan","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Pyo","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beomseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,4]]},"reference":[{"key":"1152_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov. Disord. 30, 1591\u20131601 (2015).","journal-title":"Mov. Disord."},{"key":"1152_CR2","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/S1474-4422(23)00405-2","volume":"23","author":"T Simuni","year":"2024","unstructured":"Simuni, T. et al. A biological definition of neuronal alpha-synuclein disease: towards an integrated staging system for research. Lancet Neurol. 23, 178\u2013190 (2024).","journal-title":"Lancet Neurol."},{"key":"1152_CR3","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1474-4422(23)00404-0","volume":"23","author":"GU Hoglinger","year":"2024","unstructured":"Hoglinger, G. U. et al. A biological classification of Parkinson\u2019s disease: the SynNeurGe research diagnostic criteria. Lancet Neurol. 23, 191\u2013204 (2024).","journal-title":"Lancet Neurol."},{"key":"1152_CR4","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1002\/mds.27794","volume":"34","author":"K Tsukita","year":"2019","unstructured":"Tsukita, K. et al. Value of in vivo alpha-synuclein deposits in Parkinson\u2019s disease: A systematic review and meta-analysis. Mov. Disord. 34, 1452\u20131463 (2019).","journal-title":"Mov. Disord."},{"key":"1152_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1080\/19336896.2020.1724608","volume":"14","author":"JY Han","year":"2020","unstructured":"Han, J. Y. et al. RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy. Prion 14, 88\u201394 (2020).","journal-title":"Prion"},{"key":"1152_CR6","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01705-x","volume":"29","author":"J Li","year":"2024","unstructured":"Li, J. et al. Detection of skin \u03b1-synuclein using RT-QuIC as a diagnostic biomarker for Parkinson\u2019s disease in the Chinese population. Eur. J. Med. Res. 29, 114 (2024).","journal-title":"Eur. J. Med. Res."},{"key":"1152_CR7","doi-asserted-by":"publisher","unstructured":"Mammana, A. et al. RT-QuIC detection of pathological \u03b1-synuclein in skin punches of patients with Lewy body disease. Mov Disord https:\/\/doi.org\/10.1002\/mds.28651 (2021).","DOI":"10.1002\/mds.28651"},{"key":"1152_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41531-021-00242-2","volume":"7","author":"A Kuzkina","year":"2021","unstructured":"Kuzkina, A. et al. Diagnostic value of skin RT-QuIC in Parkinson\u2019s disease: a two-laboratory study. NPJ Parkinsons Dis. 7, 99 (2021).","journal-title":"NPJ Parkinsons Dis."},{"key":"1152_CR9","doi-asserted-by":"publisher","first-page":"e2513","DOI":"10.1212\/WNL.0000000000011935","volume":"96","author":"V Donadio","year":"2021","unstructured":"Donadio, V. et al. In vivo diagnosis of synucleinopathies: a comparative study of skin biopsy and RT-QuIC. Neurology 96, e2513\u2013e2524 (2021).","journal-title":"Neurology"},{"key":"1152_CR10","first-page":"1","volume":"78","author":"Z Wang","year":"2020","unstructured":"Wang, Z. et al. Skin \u03b1-synuclein aggregation seeding activity as a novel biomarker for Parkinson disease. JAMA Neurol. 78, 1\u201311 (2020).","journal-title":"JAMA Neurol."},{"key":"1152_CR11","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1002\/mds.28242","volume":"35","author":"S Manne","year":"2020","unstructured":"Manne, S. et al. Blinded RT-QuIC analysis of \u03b1-synuclein biomarker in skin tissue from Parkinson\u2019s disease patients. Mov. Disord. 35, 2230\u20132239 (2020).","journal-title":"Mov. Disord."},{"key":"1152_CR12","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1093\/brain\/awab005","volume":"144","author":"A Stefani","year":"2021","unstructured":"Stefani, A. et al. Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder. Brain 144, 1118\u20131126 (2021).","journal-title":"Brain"},{"key":"1152_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40035-019-0164-x","volume":"8","author":"CMG De Luca","year":"2019","unstructured":"De Luca, C. M. G. et al. Efficient RT-QuIC seeding activity for alpha-synuclein in olfactory mucosa samples of patients with Parkinson\u2019s disease and multiple system atrophy. Transl. Neurodegener. 8, 24 (2019).","journal-title":"Transl. Neurodegener."},{"key":"1152_CR14","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/mds.27907","volume":"35","author":"S Manne","year":"2020","unstructured":"Manne, S. et al. \u03b1-Synuclein real-time quaking-induced conversion in the submandibular glands of Parkinson\u2019s disease patients. Mov. Disord. 35, 268\u2013278 (2020).","journal-title":"Mov. Disord."},{"key":"1152_CR15","doi-asserted-by":"publisher","first-page":"e1011456","DOI":"10.1371\/journal.ppat.1011456","volume":"19","author":"S Vascellari","year":"2023","unstructured":"Vascellari, S. et al. \u03b1-Synuclein seeding activity in duodenum biopsies from Parkinson\u2019s disease patients. PLoS Pathog. 19, e1011456 (2023).","journal-title":"PLoS Pathog."},{"key":"1152_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.parkreldis.2022.08.012","volume":"103","author":"C Shin","year":"2022","unstructured":"Shin, C. et al. In vivo and autopsy validation of alpha-synuclein seeding activity using RT-QuIC assay in the gastrointestinal tract of patients with Parkinson\u2019s disease. Parkinsonism Relat. Disord. 103, 23\u201328 (2022).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1152_CR17","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.nbd.2019.05.002","volume":"129","author":"A Fenyi","year":"2019","unstructured":"Fenyi, A. et al. Detection of alpha-synuclein aggregates in gastrointestinal biopsies by protein misfolding cyclic amplification. Neurobiol. Dis. 129, 38\u201343 (2019).","journal-title":"Neurobiol. Dis."},{"key":"1152_CR18","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/s41582-022-00681-2","volume":"18","author":"AH Tan","year":"2022","unstructured":"Tan, A. H., Lim, S. Y. & Lang, A. E. The microbiome-gut-brain axis in Parkinson disease\u2014from basic research to the clinic. Nat. Rev. Neurol. 18, 476\u2013495 (2022).","journal-title":"Nat. Rev. Neurol."},{"key":"1152_CR19","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1136\/jnnp-2020-324743","volume":"92","author":"C Shin","year":"2021","unstructured":"Shin, C. et al. Gastric synucleinopathy as prodromal pathological biomarker in idiopathic REM sleep behaviour disorder. J. Neurol., Neurosurg., psychiatry 92, 450\u2013451 (2021).","journal-title":"J. Neurol., Neurosurg., psychiatry"},{"key":"1152_CR20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1038\/s41531-024-00766-3","volume":"10","author":"C Shin","year":"2024","unstructured":"Shin, C. et al. Diagnostic accuracy and predictors of alpha-synuclein accumulation in the gastrointestinal tract of Parkinson\u2019s disease. NPJ Parkinsons Dis. 10, 155 (2024).","journal-title":"NPJ Parkinsons Dis."},{"key":"1152_CR21","doi-asserted-by":"publisher","unstructured":"Emmi A. et al. Alpha-synuclein RT-QuIC assay in gastroduodenal and skin biopsies of Parkinson disease patients. Ann. Clin. Transl. Neurol. https:\/\/doi.org\/10.1002\/acn3.52282 (2024).","DOI":"10.1002\/acn3.52282"},{"key":"1152_CR22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/mds.24893","volume":"27","author":"I Litvan","year":"2012","unstructured":"Litvan, I. et al. Diagnostic criteria for mild cognitive impairment in Parkinson\u2019s disease: Movement Disorder Society Task Force guidelines. Mov. Disord. 27, 349\u2013356 (2012).","journal-title":"Mov. Disord."},{"key":"1152_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49402-x","volume":"15","author":"SE Mastenbroek","year":"2024","unstructured":"Mastenbroek, S. E. et al. Disease progression modelling reveals heterogeneity in trajectories of Lewy-type alpha-synuclein pathology. Nat. Commun. 15, 5133 (2024).","journal-title":"Nat. Commun."},{"key":"1152_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00401-020-02233-8","volume":"141","author":"ZI Tanei","year":"2021","unstructured":"Tanei, Z. I. et al. Lewy pathology of the esophagus correlates with the progression of Lewy body disease: a Japanese cohort study of autopsy cases. Acta Neuropathologica 141, 25\u201337 (2021).","journal-title":"Acta Neuropathologica"},{"key":"1152_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00401-010-0664-3","volume":"119","author":"TG Beach","year":"2010","unstructured":"Beach, T. G. et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathologica 119, 689\u2013702 (2010).","journal-title":"Acta Neuropathologica"},{"key":"1152_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.parkreldis.2017.09.001","volume":"44","author":"C Shin","year":"2017","unstructured":"Shin, C. et al. Fundamental limit of alpha-synuclein pathology in gastrointestinal biopsy as a pathologic biomarker of Parkinson\u2019s disease: Comparison with surgical specimens. Parkinsonism Relat. Disord. 44, 73\u201378 (2017).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1152_CR27","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3233\/JPD-171088","volume":"7","author":"CH Gibbons","year":"2017","unstructured":"Gibbons, C. H., Wang, N. & Freeman, R. Cutaneous Alpha-synuclein from paraffin embedded autopsy specimens in Parkinson\u2019s disease. J. Parkinson\u2019s Dis. 7, 503\u2013509 (2017).","journal-title":"J. Parkinson\u2019s Dis."},{"key":"1152_CR28","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.parkreldis.2022.10.007","volume":"104","author":"D Yoo","year":"2022","unstructured":"Yoo, D. et al. Diagnostic value of \u03b1-synuclein seeding amplification assays in \u03b1-synucleinopathies: a systematic review and meta-analysis. Parkinsonism Relat. Disord. 104, 99\u2013109 (2022).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1152_CR29","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s40478-024-01873-1","volume":"12","author":"Z Wang","year":"2024","unstructured":"Wang, Z. et al. A minimally invasive biomarker for sensitive and accurate diagnosis of Parkinson\u2019s disease. Acta Neuropathol. Commun. 12, 167 (2024).","journal-title":"Acta Neuropathol. Commun."},{"key":"1152_CR30","doi-asserted-by":"publisher","unstructured":"Schaeffer, E. et al. Association of misfolded \u03b1-synuclein derived from neuronal exosomes in blood with Parkinson\u2019s disease diagnosis and duration. J. Parkinsons Dis. https:\/\/doi.org\/10.3233\/jpd-230390 (2024).","DOI":"10.3233\/jpd-230390"},{"key":"1152_CR31","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1038\/s41591-023-02358-9","volume":"29","author":"A Okuzumi","year":"2023","unstructured":"Okuzumi, A. et al. Propagative \u03b1-synuclein seeds as serum biomarkers for synucleinopathies. Nat. Med. 29, 1448\u20131455 (2023).","journal-title":"Nat. Med."},{"key":"1152_CR32","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1515\/cclm-2023-1472","volume":"62","author":"A Mammana","year":"2024","unstructured":"Mammana, A. et al. Improving protocols for \u03b1-synuclein seed amplification assays: analysis of preanalytical and analytical variables and identification of candidate parameters for seed quantification. Clin. Chem. Lab Med. 62, 2001\u20132010 (2024).","journal-title":"Clin. Chem. Lab Med."},{"key":"1152_CR33","doi-asserted-by":"publisher","unstructured":"Mastrangelo, A. et al. Alpha-synuclein seed amplification assay longitudinal outcomes in Lewy body disease spectrum. Brain https:\/\/doi.org\/10.1093\/brain\/awae405 (2024).","DOI":"10.1093\/brain\/awae405"},{"key":"1152_CR34","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s40478-023-01653-3","volume":"11","author":"S Br\u00e4uer","year":"2023","unstructured":"Br\u00e4uer, S. et al. Kinetic parameters of alpha-synuclein seed amplification assay correlate with cognitive impairment in patients with Lewy body disorders. Acta Neuropathol. Commun. 11, 162 (2023).","journal-title":"Acta Neuropathol. Commun."},{"key":"1152_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.106101","volume":"122","author":"J Horsager","year":"2024","unstructured":"Horsager, J. & Borghammer, P. Brain-first vs. body-first Parkinson\u2019s disease: an update on recent evidence. Parkinsonism Relat. Disord. 122, 106101 (2024).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1152_CR36","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz, C. G. et al. Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov. Disord. 23, 2129\u20132170 (2008).","journal-title":"Mov. Disord."},{"key":"1152_CR37","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1002\/mds.20213","volume":"19","author":"CG Goetz","year":"2004","unstructured":"Goetz, C. G. et al. Movement Disorder Society Task Force report on the Hoehn and Yahr staging scale: status and recommendations. Mov. Disord. 19, 1020\u20131028 (2004).","journal-title":"Mov. Disord."},{"key":"1152_CR38","volume":"8","author":"C Adams","year":"2023","unstructured":"Adams, C. et al. Updated Parkinson\u2019s disease motor subtypes classification and correlation to cerebrospinal homovanillic acid and 5-hydroxyindoleacetic acid levels. Clin. Park Relat. Disord. 8, 100187 (2023).","journal-title":"Clin. Park Relat. Disord."},{"key":"1152_CR39","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1002\/mds.29410","volume":"38","author":"ST Jost","year":"2023","unstructured":"Jost, S. T. et al. Levodopa dose equivalency in Parkinson\u2019s disease: updated systematic review and proposals. Mov. Disord. 38, 1236\u20131252 (2023).","journal-title":"Mov. Disord."},{"key":"1152_CR40","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine, Z. S. et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J. Am. Geriatr. Soc. 53, 695\u2013699 (2005).","journal-title":"J. Am. Geriatr. Soc."},{"key":"1152_CR41","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","volume":"55","author":"B Dubois","year":"2000","unstructured":"Dubois, B. et al. The FAB: a Frontal Assessment Battery at bedside. Neurology 55, 1621\u20131626 (2000).","journal-title":"Neurology"},{"key":"1152_CR42","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1002\/mds.21596","volume":"22","author":"KR Chaudhuri","year":"2007","unstructured":"Chaudhuri, K. R. et al. The metric properties of a novel non-motor symptoms scale for Parkinson\u2019s disease: results from an international pilot study. Mov. Disord. 22, 1901\u20131911 (2007).","journal-title":"Mov. Disord."},{"key":"1152_CR43","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1136\/jnnp.2004.057984","volume":"76","author":"FS Ertan","year":"2005","unstructured":"Ertan, F. S. et al. Reliability and validity of the Geriatric Depression Scale in depression in Parkinson\u2019s disease. J. Neurol. Neurosurg. Psychiatry 76, 1445\u20131447 (2005).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"1152_CR44","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.sleep.2011.01.015","volume":"12","author":"T Nomura","year":"2011","unstructured":"Nomura, T. et al. Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson\u2019s disease patients. Sleep. Med. 12, 711\u2013713 (2011).","journal-title":"Sleep. Med."},{"key":"1152_CR45","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40478-018-0508-2","volume":"6","author":"BR Groveman","year":"2018","unstructured":"Groveman, B. R. et al. Rapid and ultra-sensitive quantitation of disease-associated \u03b1-synuclein seeds in brain and cerebrospinal fluid by \u03b1Syn RT-QuIC. Acta Neuropathol. Commun. 6, 7 (2018).","journal-title":"Acta Neuropathol. Commun."},{"key":"1152_CR46","doi-asserted-by":"publisher","unstructured":"Han, J. Y., Shin, C. & Choi, Y. P. Preclinical Detection of Alpha-Synuclein Seeding Activity in the Colon of a Transgenic Mouse Model of Synucleinopathy by RT-QuIC. Viruses 13 https:\/\/doi.org\/10.3390\/v13050759 (2021).","DOI":"10.3390\/v13050759"},{"key":"1152_CR47","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s00401-023-02663-0","volume":"147","author":"GM Bentivenga","year":"2024","unstructured":"Bentivenga, G. M. et al. Performance of a seed amplification assay for misfolded alpha-synuclein in cerebrospinal fluid and brain tissue in relation to Lewy body disease stage and pathology burden. Acta Neuropathol. 147, 18 (2024).","journal-title":"Acta Neuropathol."},{"key":"1152_CR48","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s40478-021-01175-w","volume":"9","author":"C Bargar","year":"2021","unstructured":"Bargar, C. et al. Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson\u2019s disease and dementia with Lewy bodies. Acta Neuropathol. Commun. 9, 62 (2021).","journal-title":"Acta Neuropathol. Commun."}],"container-title":["npj Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41531-025-01152-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-025-01152-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-025-01152-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:07:52Z","timestamp":1762319272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41531-025-01152-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1152"],"URL":"https:\/\/doi.org\/10.1038\/s41531-025-01152-3","relation":{},"ISSN":["2373-8057"],"issn-type":[{"value":"2373-8057","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"311"}}