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However, the evolution of cortical neurophysiological alterations and their relationship to clinical progression remain poorly understood. We conducted a longitudinal resting-state magnetoencephalography (MEG) study in 27 persons with PD and 30 healthy individuals with a mean follow-up time of 4\u2009years. Source-reconstructed MEG data were parcellated into cortical regions, from which power spectra were parameterized to separate oscillatory peaks from the aperiodic component. An increase in the aperiodic exponent in the left postcentral region was associated with progression of rigidity. Peak beta power in parieto-temporo-occipital regions was elevated at baseline, correlating with less severe bradykinesia. This negative relationship weakened over time in patients with progressive symptoms, suggesting an association with compensatory mechanisms. Using partial least squares regression to predict future disease course from baseline neurophysiological features, 19.5% of the variability in motor progression was explained in an independent validation cohort. Our results emphasize the importance of separating aperiodic neural activity from periodic oscillations as a progressive alteration of the aperiodic component represented the most prominent PD-related neurophysiological change. Further, our findings highlight the potential predictive value of resting-state neurophysiology for future disease progression.<\/jats:p>","DOI":"10.1038\/s41531-025-01240-4","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:54:21Z","timestamp":1769064861000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Magnetoencephalography-based prediction of longitudinal symptom progression in Parkinson\u2019s disease"],"prefix":"10.1038","volume":"12","author":[{"given":"Josefine","family":"Waldthaler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igori","family":"Comarovschii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lundqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"1240_CR1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","volume":"12","author":"RL Albin","year":"1989","unstructured":"Albin, R. 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