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In cases of East Asian (EAS) ancestry, p.A419V was significantly associated with increased risk of PD (OR\u2009=\u20092.9; 95% CI: 1.66\u20135.10;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002), and was not in linkage disequilibrium with other\n                    <jats:italic>LRRK2<\/jats:italic>\n                    coding variants. The variant was significantly associated with a lower age at PD onset in the study cohort, while a meta-analysis of the EAS cases indicated a similar, albeit non-significant trend. LRRK2 protein modelling prediction indicated that binding sites for RAB8A, RAB29 and RAB32 were in close proximity to the p.A419V variant within the ARM domain. 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