{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:15:39Z","timestamp":1779257739991,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Parkinsons Dis."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Emerging evidence indicates that movement disorders arise from symptom-specific rather than disease-specific brain network dysfunctions that can be influenced through targeted neuromodulation. Such networks are widely mapped using normative connectome analyses from lesion and stimulation sites. Here, we used [\n                    <jats:sup>18<\/jats:sup>\n                    F]-fluorodeoxyglucose (FDG)-PET in 14 essential tremor patients undergoing thalamic deep brain stimulation (DBS) to identify stimulation-induced and tremor related regional metabolic changes in a within-subject design and combined this with normative connectome results. Stimulation increased metabolism in motor cortical and cerebellar regions - key hubs of the previously proposed tremor treatment network as derived from normative functional connectivity. Importantly, individual alignment with this network predicted clinical tremor improvement (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>2<\/jats:italic>\n                    <\/jats:sup>\n                    \u2009=\u20090.593,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.007). These same regions showed higher metabolism during tremor expression in the untreated condition, suggesting overlap between the circuits involved in symptom generation and therapeutic response. These findings support indirect connectome-based models by linking them to brain glucose metabolism changes and suggest that DBS relieves tremor by modulating the same circuit that underlies symptom expression.\n                  <\/jats:p>","DOI":"10.1038\/s41531-026-01388-7","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:15:16Z","timestamp":1779250516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Converging metabolic and functional networks for tremor expression and deep brain stimulation-mediated control"],"prefix":"10.1038","volume":"12","author":[{"given":"Benedikt","family":"Weigl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Pistorius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joachim","family":"Brumberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicol\u00f3 G.","family":"Pozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muthuraman","family":"Muthuraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis U.","family":"Isaias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Volkmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juho","family":"Joutsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin M.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"1388_CR1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1038\/s41531-024-00774-3","volume":"10","author":"EG Ellis","year":"2024","unstructured":"Ellis, E. G. et al. Multimodal neuroimaging to characterize symptom-specific networks in movement disorders. NPJ Parkinsons Dis. 10, 154 (2024).","journal-title":"NPJ Parkinsons Dis."},{"key":"1388_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-60089-6","volume":"16","author":"LL Goede","year":"2025","unstructured":"Goede, L. L. et al. Convergent mapping of a tremor treatment network. Nat. Commun. 16, 4772 (2025).","journal-title":"Nat. Commun."},{"key":"1388_CR3","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1093\/brain\/awz112","volume":"142","author":"DT Corp","year":"2019","unstructured":"Corp, D. T. et al. Network localization of cervical dystonia based on causal brain lesions. Brain 142, 1660\u20131674 (2019).","journal-title":"Brain"},{"key":"1388_CR4","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1093\/brain\/awy161","volume":"141","author":"J Joutsa","year":"2018","unstructured":"Joutsa, J., Horn, A., Hsu, J. & Fox, M. D. Localizing parkinsonism based on focal brain lesions. Brain 141, 2445\u20132456 (2018).","journal-title":"Brain"},{"key":"1388_CR5","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ana.25285","volume":"84","author":"J Joutsa","year":"2018","unstructured":"Joutsa, J. et al. Identifying therapeutic targets from spontaneous beneficial brain lesions. Ann. Neurol. 84, 153\u2013157 (2018).","journal-title":"Ann. Neurol."},{"key":"1388_CR6","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.biopsych.2019.07.023","volume":"86","author":"JL Padmanabhan","year":"2019","unstructured":"Padmanabhan, J. L. et al. A Human Depression Circuit Derived From Focal Brain Lesions. Biol. Psychiatry 86, 749\u2013758 (2019).","journal-title":"Biol. Psychiatry"},{"key":"1388_CR7","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1093\/brain\/awz236","volume":"142","author":"B Al-Fatly","year":"2019","unstructured":"Al-Fatly, B. et al. 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M.M. was not involved in the journal\u2019s review of, or decisions related to, this manuscript. All further competing interests are unrelated to the submitted work. J.B. has received honoraria from Novartis. J.V. reports honoraria from Boston Scientific, Medtronic, Newronika, UCB, Zambon, and Abbott. J.J. has received consulting fees from Adamant Health, Summaryx, and Teva Finland; lecturer honoraria from Insightec, Novartis, Lundbeck, Addictum, Nordic Infucare; conference travel support from Insightec, AbbVie, Abbott; and owns stock of Neurologic Finland and Suomen Neurolaboratorio and acts as an advisory board member for Teva Finland. M.M.R. has received grant support and honoraria for speaking from Medtronic and Boston Scientific. The other authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"119"}}