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Clinical reports suggest that iRBD is more common in individuals with Post-Traumatic Stress Disorder (PTSD) compared to those without PTSD. We conducted polygenic risk score (PRS), genetic correlation, and Mendelian randomization analyses to explore potential genetic and\/or causal associations between PTSD and iRBD. Dopamine transporter imaging binding status was also examined in iRBD patients with (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20096) and without PTSD (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200932). While not supporting a causal relationship, genetic analyses revealed a significant association between PTSD and iRBD, consistent with the exploratory imaging substudy. These findings suggest that individuals genetically at risk for PTSD may also be at higher risk for iRBD. Further investigation of iRBD in individuals with PTSD may help inform potential neurodegenerative risk.\n                  <\/jats:p>","DOI":"10.1038\/s41531-026-01397-6","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:55:49Z","timestamp":1779346549000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder"],"prefix":"10.1038","volume":"12","author":[{"given":"Morvarid","family":"Ghamgosar Shahkhali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H.","family":"Ghamgosar Shahkhali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Asayesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meron","family":"Teferra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Dodet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yo-El","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T. 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(LTI), Idorsia, Prevail Therapeutics, Ono Therapeutics, Denali, Handl Therapeutics, Neuron23, Bial Biotech, Bial, UCB, Capsida, Vanqua Bio, Congruence Therapeutics, Takeda, Jazz Pharmaceuticals, EG427, Guidepoint, Lighthouse and Deerfield. Z.G-O. is affiliated with npj Parkinson\u2019s Disease as Associate Editor. Z.G-O. was not involved in the journal\u2019s review of, or decisions related to, this manuscript. B.M. has received honoraria for consultancy and\/or educational presentations from GE, Bial, Roche, Biogen, AbbVie, Desitin and Amprion, is a member of the executive steering committee of the Parkinson Progression Marker Initiative of the Michael J. Fox Foundation for Parkinson\u2019s Research and has received research funding from Aligning Science Across Parkinson\u2019s disease (ASAP, CRN). A.D. received research grants from Eisai and Takeda, honoraria from serving on the scientific advisory board of Eisai, Takeda, Paladin Labs, as well as honoraria from speaking engagements from AstraZeneca, Eisai, Jazz Pharma and Paladin Labs. None of the financial disclosures is relevant to the submitted work.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"190"}}