{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:21:33Z","timestamp":1793881293024,"version":"4.7.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":105,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["KGM1312511"],"award-info":[{"award-number":["KGM1312511"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["GTL24022-000"],"award-info":[{"award-number":["GTL24022-000"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["KRISS-GP2025-0007-02"],"award-info":[{"award-number":["KRISS-GP2025-0007-02"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Parkinsons Dis."],"DOI":"10.1038\/s41531-026-01433-5","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T17:46:40Z","timestamp":1781113600000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Spatial multi-omics reveals region-specific molecular signatures in a 6-OHDA model of Parkinson\u2019s disease"],"prefix":"10.1038","volume":"12","author":[{"given":"Sun Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Kyong","family":"Shon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amos Chungwon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Kyoung","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Shim","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga Seul","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghoon","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Hee","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Geol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Gyeong","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"1433_CR1","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","volume":"386","author":"LV Kalia","year":"2015","unstructured":"Kalia, L. V. & Lang, A. E. Parkinson\u2019s disease. Lancet 386, 896\u2013912 (2015).","journal-title":"Lancet"},{"key":"1433_CR2","doi-asserted-by":"publisher","unstructured":"Schapira R. B. and AHV. Parkinson's disease. Eur. J. Neurol. https:\/\/doi.org\/10.1111\/ene.14108 (2019).","DOI":"10.1111\/ene.14108"},{"key":"1433_CR3","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s13024-025-00827-y","volume":"20","author":"JR Mark","year":"2025","unstructured":"Mark, J. R. & Tansey, M. G. Immune cell metabolic dysfunction in Parkinson\u2019s disease. Mol. Neurodegener. 20, 36 (2025).","journal-title":"Mol. Neurodegener."},{"key":"1433_CR4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1750-1326-5-56","volume":"5","author":"P Jiang","year":"2010","unstructured":"Jiang, P. et al. ER stress response plays an important role in aggregation of \u03b1-synuclein. Mol. Neurodegener. 5, 56 (2010).","journal-title":"Mol. Neurodegener."},{"key":"1433_CR5","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.neuron.2021.10.032","volume":"110","author":"I Stojkovska","year":"2022","unstructured":"Stojkovska, I. et al. Rescue of \u03b1-synuclein aggregation in Parkinson\u2019s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking. Neuron 110, 436\u2013451.e11 (2022).","journal-title":"Neuron"},{"key":"1433_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuro.2018.10.005","volume":"70","author":"DF Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves, D. F. et al. 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. NeuroToxicology 70, 1\u201311 (2019).","journal-title":"NeuroToxicology"},{"key":"1433_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nchembio.1750","volume":"11","author":"C Galvagnion","year":"2015","unstructured":"Galvagnion, C. et al. Lipid vesicles trigger \u03b1-synuclein aggregation by stimulating primary nucleation. Nat. Chem. Biol. 11, 229\u2013234 (2015).","journal-title":"Nat. Chem. Biol."},{"key":"1433_CR8","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41593-019-0423-2","volume":"22","author":"SH Shahmoradian","year":"2019","unstructured":"Shahmoradian, S. H. et al. Lewy pathology in Parkinson\u2019s disease consists of crowded organelles and lipid membranes. Nat. Neurosci. 22, 1099\u20131109 (2019).","journal-title":"Nat. Neurosci."},{"key":"1433_CR9","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1002\/mds.25729","volume":"29","author":"SK Abbott","year":"2014","unstructured":"Abbott, S. K. et al. Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson\u2019s disease. Mov. Disord. 29, 518\u2013526 (2014).","journal-title":"Mov. Disord."},{"key":"1433_CR10","doi-asserted-by":"publisher","first-page":"328","DOI":"10.3389\/fnins.2019.00328","volume":"13","author":"I Alecu","year":"2019","unstructured":"Alecu, I. & Bennett, S. A. L. Dysregulated lipid metabolism and its role in \u03b1-synucleinopathy in Parkinson\u2019s disease. Front. Neurosci. 13, 328 (2019).","journal-title":"Front. Neurosci."},{"key":"1433_CR11","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.1093\/brain\/awac176","volume":"145","author":"J Galper","year":"2022","unstructured":"Galper, J. et al. Lipid pathway dysfunction is prevalent in patients with Parkinson\u2019s disease. Brain 145, 3472\u20133487 (2022).","journal-title":"Brain"},{"key":"1433_CR12","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.toxlet.2017.11.017","volume":"283","author":"X He","year":"2018","unstructured":"He, X. et al. 6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells. Toxicol. Lett. 283, 58\u201368 (2018).","journal-title":"Toxicol. Lett."},{"key":"1433_CR13","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuint.2010.04.005","volume":"57","author":"B Park","year":"2010","unstructured":"Park, B. et al. Proteomic analysis of expression and protein interactions in a 6-hydroxydopamine-induced rat brain lesion model. Neurochem. Int. 57, 16\u201332 (2010).","journal-title":"Neurochem. Int"},{"key":"1433_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40543-022-00365-y","volume":"14","author":"J-Y Hyon","year":"2023","unstructured":"Hyon, J.-Y., Lee, H. J., Yun, S. H., Han, E. H. & Chung, Y.-H. Comparative proteomics study of mitochondrial electron transport system modulation in SH-SY5Y cells following MPP+ versus 6-OHDA-induced neurodegeneration. J. Anal. Sci. Technol. 14, 1 (2023).","journal-title":"J. Anal. Sci. Technol."},{"key":"1433_CR15","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jmb.2009.05.066","volume":"390","author":"CR Bodner","year":"2009","unstructured":"Bodner, C. R., Dobson, C. M. & Bax, A. Multiple tight phospholipid-binding modes of \u03b1-synuclein revealed by solution NMR spectroscopy. J. Mol. Biol. 390, 775\u2013790 (2009).","journal-title":"J. Mol. Biol."},{"key":"1433_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-018-1543-9","volume":"19","author":"S Kim","year":"2018","unstructured":"Kim, S. et al. PHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing. Genome Biol. 19, 158 (2018).","journal-title":"Genome Biol."},{"key":"1433_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30299-3","volume":"13","author":"AC Lee","year":"2022","unstructured":"Lee, A. C. et al. Spatial epitranscriptomics reveals A-to-I editome specific to cancer stem cell microniches. Nat. Commun. 13, 2540 (2022).","journal-title":"Nat. Commun."},{"key":"1433_CR18","doi-asserted-by":"publisher","first-page":"18126","DOI":"10.1073\/pnas.0801374105","volume":"105","author":"EH Seeley","year":"2008","unstructured":"Seeley, E. H. & Caprioli, R. M. Molecular imaging of proteins in tissues by mass spectrometry. Proc. Natl. Acad. Sci. USA105, 18126\u201318131 (2008).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"1433_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1074\/mcp.M116.065755","volume":"17","author":"V Delcourt","year":"2018","unstructured":"Delcourt, V. et al. Spatially-resolved top-down proteomics bridged to MALDI MS imaging reveals the molecular physiome of brain regions*. Mol. Cell Proteom. 17, 357\u2013372 (2018).","journal-title":"Mol. Cell Proteom."},{"key":"1433_CR20","first-page":"e25653","volume":"6","author":"JK Lukowski","year":"2025","unstructured":"Lukowski, J. K. Advances in spatial multi-omics: a review of multi-modal mass spectrometry imaging and laser capture microdissection-LCMS integration. Proteomics 6, e25653 (2025).","journal-title":"Proteomics"},{"key":"1433_CR21","doi-asserted-by":"publisher","first-page":"e25653","DOI":"10.1371\/journal.pone.0025653","volume":"6","author":"A Ljungdahl","year":"2011","unstructured":"Ljungdahl, A., Hanrieder, J., F\u00e4lth, M., Bergquist, J. & Andersson, M. Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson\u2019s disease. PLoS ONE 6, e25653 (2011).","journal-title":"PLoS ONE"},{"key":"1433_CR22","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41531-022-00299-7","volume":"8","author":"H Hulme","year":"2022","unstructured":"Hulme, H. et al. Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia. npj Park\u2019s. Dis. 8, 41 (2022).","journal-title":"npj Park\u2019s. Dis."},{"key":"1433_CR23","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neuroscience.2011.10.057","volume":"211","author":"J Bov\u00e9","year":"2012","unstructured":"Bov\u00e9, J. & Perier, C. Neurotoxin-based models of Parkinson\u2019s disease. Neuroscience 211, 51\u201376 (2012).","journal-title":"Neuroscience"},{"key":"1433_CR24","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-54066-0","volume":"14","author":"J Cui","year":"2024","unstructured":"Cui, J. et al. Characterization of graded 6-Hydroxydopamine unilateral lesion in medial forebrain bundle of mice. Sci. Rep. 14, 3721 (2024).","journal-title":"Sci. Rep."},{"key":"1433_CR25","first-page":"247467","volume":"2011","author":"T Farooqui","year":"2011","unstructured":"Farooqui, T. & Farooqui, A. A. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson\u2032s disease. Park. Dis. 2011, 247467 (2011).","journal-title":"Park. Dis."},{"key":"1433_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1186\/s40478-020-01090-6","volume":"8","author":"MF Beal","year":"2020","unstructured":"Beal, M. F. et al. Isotope-reinforced polyunsaturated fatty acids improve Parkinson\u2019s disease-like phenotype in rats overexpressing \u03b1-synuclein. Acta Neuropathol. Commun. 8, 220 (2020).","journal-title":"Acta Neuropathol. Commun."},{"key":"1433_CR27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fncel.2018.00479","volume":"12","author":"M Sancandi","year":"2018","unstructured":"Sancandi, M., Schul, E. V., Economides, G., Constanti, A. & Mercer, A. Structural changes observed in the piriform cortex in a rat model of pre-motor Parkinson\u2019s disease. Front. Cell Neurosci. 12, 479 (2018).","journal-title":"Front. Cell Neurosci."},{"key":"1433_CR28","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41531-025-01109-6","volume":"11","author":"I Kaya","year":"2025","unstructured":"Kaya, I. et al. Brain-region-specific lipid dysregulation in L-DOPA-induced dyskinesia in a primate model of Parkinson\u2019s disease. npj Park\u2019s. Dis. 11, 258 (2025).","journal-title":"npj Park\u2019s. Dis."},{"key":"1433_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainresbull.2017.03.009","volume":"133","author":"A Anandhan","year":"2017","unstructured":"Anandhan, A. et al. Metabolic dysfunction in Parkinson\u2019s disease: bioenergetics, redox homeostasis and central carbon metabolism. Brain Res. Bull. 133, 12\u201330 (2017).","journal-title":"Brain Res. Bull."},{"key":"1433_CR30","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S1474-4422(07)70327-7","volume":"7","author":"AH Schapira","year":"2008","unstructured":"Schapira, A. H. Mitochondria in the aetiology and pathogenesis of Parkinson\u2019s disease. Lancet Neurol. 7, 97\u2013109 (2008).","journal-title":"Lancet Neurol."},{"key":"1433_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.pneurobio.2013.04.004","volume":"106","author":"SR Subramaniam","year":"2013","unstructured":"Subramaniam, S. R. & Chesselet, M.-F. Mitochondrial dysfunction and oxidative stress in Parkinson\u2019s disease. Prog. Neurobiol. 106, 17\u201332 (2013).","journal-title":"Prog. Neurobiol."},{"key":"1433_CR32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bbadis.2009.08.013","volume":"1802","author":"KF Winklhofer","year":"2010","unstructured":"Winklhofer, K. F. & Haass, C. Mitochondrial dysfunction in Parkinson\u2019s disease. Biochim Biophys. Acta 1802, 29\u201344 (2010).","journal-title":"Biochim Biophys. Acta"},{"key":"1433_CR33","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1007\/s12035-019-01733-3","volume":"57","author":"H Xicoy","year":"2020","unstructured":"Xicoy, H., Brouwers, J. F., Kalnytska, O., Wieringa, B. & Martens, G. J. M. Lipid analysis of the 6-hydroxydopamine-treated SH-SY5Y cell model for Parkinson\u2019s disease. Mol. Neurobiol. 57, 848\u2013859 (2020).","journal-title":"Mol. Neurobiol."},{"key":"1433_CR34","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1080\/13813455.2016.1197948","volume":"122","author":"K Kuter","year":"2016","unstructured":"Kuter, K. et al. Native DIGE proteomic analysis of mitochondria from substantia nigra and striatum during neuronal degeneration and its compensation in an animal model of early Parkinson\u2019s disease. Arch. Physiol. Biochem. 122, 238\u2013256 (2016).","journal-title":"Arch. Physiol. Biochem."},{"key":"1433_CR35","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41531-025-00899-z","volume":"11","author":"J Moore","year":"2025","unstructured":"Moore, J. et al. Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson\u2019s disease. npj Park\u2019s. Dis. 11, 46 (2025).","journal-title":"npj Park\u2019s. Dis."},{"key":"1433_CR36","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1111\/j.1742-4658.2010.07896.x","volume":"277","author":"T Alberio","year":"2010","unstructured":"Alberio, T. et al. Proteomic analysis of dopamine and \u03b1-synuclein interplay in a cellular model of Parkinson\u2019s disease pathogenesis. FEBS J. 277, 4909\u20134919 (2010).","journal-title":"FEBS J."},{"key":"1433_CR37","first-page":"699","volume":"5","author":"J Burr\u00e9","year":"2015","unstructured":"Burr\u00e9, J. The synaptic function of \u03b1-synuclein. J. Park\u2019s. Dis. 5, 699\u2013713 (2015).","journal-title":"J. Park\u2019s. Dis."},{"key":"1433_CR38","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fneur.2018.00295","volume":"9","author":"V Ghiglieri","year":"2018","unstructured":"Ghiglieri, V., Calabrese, V. & Calabresi, P. Alpha-synuclein: from early synaptic dysfunction to neurodegeneration. Front. Neurol. 9, 295 (2018).","journal-title":"Front. Neurol."},{"key":"1433_CR39","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1477-5956-12-20","volume":"12","author":"HR Fuller","year":"2014","unstructured":"Fuller, H. R., Hurtado, M. L., Wishart, T. M. & Gates, M. A. The rat striatum responds to nigro-striatal degeneration via the increased expression of proteins associated with growth and regeneration of neuronal circuitry. Proteome Sci. 12, 20 (2014).","journal-title":"Proteome Sci."},{"key":"1433_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.621121","volume":"15","author":"H Dakik","year":"2021","unstructured":"Dakik, H. et al. Analysis of the neuroproteome associated with cell therapy after intranigral grafting in a mouse model of Parkinson disease. Front. Neurosci. 15, 621121 (2021).","journal-title":"Front. Neurosci."},{"key":"1433_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-323-85555-6.00002-3","volume":"193","author":"E Simons","year":"2023","unstructured":"Simons, E. & Fleming, S. M. Chapter 1 Role of rodent models in advancing precision medicine for Parkinson\u2019s disease. Handb. Clin. Neurol. 193, 3\u201316 (2023).","journal-title":"Handb. Clin. Neurol."},{"key":"1433_CR42","doi-asserted-by":"publisher","first-page":"16245","DOI":"10.3390\/ijms242216245","volume":"24","author":"D Troshev","year":"2023","unstructured":"Troshev, D. et al. Compensatory processes in striatal neurons expressing the tyrosine hydroxylase gene in transgenic mice in a model of Parkinson\u2019s disease. Int. J. Mol. Sci. 24, 16245 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"1433_CR43","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1016\/j.neuron.2019.03.004","volume":"101","author":"MM McGregor","year":"2019","unstructured":"McGregor, M. M. & Nelson, A. B. Circuit mechanisms of Parkinson\u2019s disease. Neuron 101, 1042\u20131056 (2019).","journal-title":"Neuron"},{"key":"1433_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36538-2","volume":"9","author":"W Zhang","year":"2019","unstructured":"Zhang, W. et al. Partial depletion of dopaminergic neurons in the substantia nigra impairs olfaction and alters neural activity in the olfactory bulb. Sci. Rep. 9, 254 (2019).","journal-title":"Sci. Rep."},{"key":"1433_CR45","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak, H. et al. Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol. Aging 24, 197\u2013211 (2003).","journal-title":"Neurobiol. Aging"},{"key":"1433_CR46","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.nbd.2016.02.013","volume":"89","author":"H-Y Park","year":"2016","unstructured":"Park, H.-Y. et al. Gadd45\u03b2 ameliorates L-DOPA-induced dyskinesia in a Parkinson\u2019s disease mouse model. Neurobiol. Dis. 89, 169\u2013179 (2016).","journal-title":"Neurobiol. Dis."},{"key":"1433_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108173","volume":"175","author":"Y-K Ryu","year":"2020","unstructured":"Ryu, Y.-K. et al. Metformin regulates astrocyte reactivity in Parkinson\u2019s disease and normal aging. Neuropharmacology 175, 108173 (2020).","journal-title":"Neuropharmacology"},{"key":"1433_CR48","doi-asserted-by":"publisher","first-page":"13643","DOI":"10.3390\/ijms222413643","volume":"22","author":"RK Saini","year":"2021","unstructured":"Saini, R. K., Prasad, P., Shang, X. & Keum, Y.-S. Advances in lipid extraction methods\u2014a review. Int. J. Mol. Sci. 22, 13643 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"1433_CR49","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nmeth.3393","volume":"12","author":"H Tsugawa","year":"2015","unstructured":"Tsugawa, H. et al. MS-DIAL: data-independent MS\/MS deconvolution for comprehensive metabolome analysis. Nat. Methods 12, 523\u2013526 (2015).","journal-title":"Nat. Methods"}],"container-title":["npj Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01433-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01433-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01433-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:56:10Z","timestamp":1790117770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01433-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1433"],"URL":"https:\/\/doi.org\/10.1038\/s41531-026-01433-5","relation":{},"ISSN":["2373-8057"],"issn-type":[{"value":"2373-8057","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,10]]},"assertion":[{"value":"15 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"230"}}