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Preclinical animal models with neuropathological and symptomatic significance might contribute to a better understanding of circadian dysfunction. Here, we investigated light-dark phase-dependent modulation of motor and non-motor behavior as well as suprachiasmatic nucleus integrity in\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein-overexpressing rats and wild-type controls. Behavioral testing in 3-month-old animals revealed robust phase-dependent modulation of exploratory activity, locomotion, sucrose preference, and olfaction-guided feeding in wild-type rats, which was absent in their transgenic littermates. Histological analyses demonstrated reduced overall cell density and pronounced\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein accumulation in the suprachiasmatic nucleus of\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein rats, accompanied by altered cellular composition, including altered neuronal, orexinergic, and microglial markers.\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein load was positively correlated with Orexin A\n                    <jats:sup>+<\/jats:sup>\n                    fibers and Iba1\n                    <jats:sup>+<\/jats:sup>\n                    cell counts, suggesting a link between protein aggregation, neuroinflammation, and altered light-dark phase-dependent behavior. These findings indicate that\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -synuclein rats lack phase-dependent behavioral alternations and exhibit suprachiasmatic nucleus pathology already at an early disease stage with very mild motor impairment, providing a translational model to study different aspects of non-motor symptoms in Parkinson\u2019s disease.\n                  <\/jats:p>","DOI":"10.1038\/s41531-026-01436-2","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T04:55:48Z","timestamp":1781844948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Altered light-dark phase-dependent behavioral responses and suprachiasmatic nucleus pathology in an \u03b1-synuclein rat model of Parkinson\u2019s disease"],"prefix":"10.1038","volume":"12","author":[{"given":"Hanna","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Statz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Casadei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Riess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiebke","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mareike","family":"Fauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"1436_CR1","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RBEA Postuma","year":"2015","unstructured":"Postuma, R. 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