{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:46:36Z","timestamp":1792125996284,"version":"4.4.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":111,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["399711"],"award-info":[{"award-number":["399711"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Parkinsons Dis."],"DOI":"10.1038\/s41531-026-01440-6","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:46:39Z","timestamp":1782513999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Smartphone-derived digital motor measures to monitor progression in idiopathic REM sleep behavior disorder"],"prefix":"10.1038","volume":"12","author":[{"given":"Sarah","family":"Bouhadoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten I.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lambrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner L.","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Kwasny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lindemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"McKeown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Duquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Jodoin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Soland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dupr\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Anang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrie","family":"Schoffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Grimes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald B.","family":"Postuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"1440_CR1","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41531-025-01004-0","volume":"11","author":"M Palanivel","year":"2025","unstructured":"Palanivel, M. et al. Imaging advances to detect non-motor prodromal markers of Parkinson\u2019s disease and explore therapeutic translation opportunities. npj Parkinsons Dis. 11, 174 (2025).","journal-title":"npj Parkinsons Dis."},{"key":"1440_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1212\/WNL.0000000000200235","volume":"99","author":"RB Postuma","year":"2022","unstructured":"Postuma, R. B. Neuroprotective trials in REM sleep behavior disorder: the way forward becomes clearer. Neurology 99, 19\u201325 (2022).","journal-title":"Neurology"},{"key":"1440_CR3","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/mds.26431","volume":"30","author":"D Berg","year":"2015","unstructured":"Berg, D. et al. MDS research criteria for prodromal Parkinson\u2019s disease. Mov. Disord. 30, 1600\u20131611 (2015).","journal-title":"Mov. Disord."},{"key":"1440_CR4","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov. Disord. 30, 1591\u20131601 (2015).","journal-title":"Mov. Disord."},{"key":"1440_CR5","doi-asserted-by":"publisher","first-page":"3258","DOI":"10.1093\/brain\/awad072","volume":"146","author":"S Joza","year":"2023","unstructured":"Joza, S. et al. Progression of clinical markers in prodromal Parkinson\u2019s disease and dementia with Lewy bodies: a multicentre study. Brain 146, 3258\u20133272 (2023).","journal-title":"Brain"},{"key":"1440_CR6","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.parkreldis.2019.05.013","volume":"64","author":"A Schrag","year":"2019","unstructured":"Schrag, A. et al. Heterogeneity in progression of prodromal features in Parkinson\u2019s disease. Parkinsonism Relat. Disord. 64, 275\u2013279 (2019).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1440_CR7","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/mds.27376","volume":"33","author":"F Lipsmeier","year":"2018","unstructured":"Lipsmeier, F. et al. Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson\u2019s disease clinical trial. Mov. Disord. 33, 1287\u20131297 (2018).","journal-title":"Mov. Disord."},{"key":"1440_CR8","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-021-01101-6","volume":"21","author":"JL Adams","year":"2021","unstructured":"Adams, J. L. et al. Digital technology in movement disorders: updates, applications, and challenges. Curr. Neurol. Neurosci. Rep. 21, 16 (2021).","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"1440_CR9","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1002\/mds.25628","volume":"28","author":"W Maetzler","year":"2013","unstructured":"Maetzler, W. et al. Quantitative wearable sensors for objective assessment of Parkinson\u2019s disease. Mov. Disord. 28, 1628\u20131637 (2013).","journal-title":"Mov. Disord."},{"key":"1440_CR10","doi-asserted-by":"publisher","first-page":"e0154335","DOI":"10.1371\/journal.pone.0154335","volume":"11","author":"VA Block","year":"2016","unstructured":"Block, V. A. et al. Remote physical activity monitoring in neurological disease: a systematic review. PLoS ONE 11, e0154335 (2016).","journal-title":"PLoS ONE"},{"key":"1440_CR11","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12984-016-0136-7","volume":"13","author":"C Godinho","year":"2016","unstructured":"Godinho, C. et al. A systematic review of the characteristics and validity of monitoring technologies to assess Parkinson\u2019s disease. J. Neuroeng. Rehabil. 13, 24 (2016).","journal-title":"J. Neuroeng. Rehabil."},{"key":"1440_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41746-023-00767-1","volume":"6","author":"L Masanneck","year":"2023","unstructured":"Masanneck, L. et al. Evidence from ClinicalTrials.gov on the growth of digital health technologies in neurology trials. npj Digit Med. 6, 23 (2023).","journal-title":"npj Digit Med."},{"key":"1440_CR13","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.parkreldis.2006.04.004","volume":"12","author":"SL Chien","year":"2006","unstructured":"Chien, S. L. et al. The efficacy of quantitative gait analysis by the GAITRite system in evaluation of Parkinsonian bradykinesia. Parkinsonism Relat. Disord. 12, 438\u2013442 (2006).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1440_CR14","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1515\/bmt-2012-4426","volume":"57","author":"RM Adame","year":"2012","unstructured":"Adame, R. M. et al. TUG test instrumentation for Parkinson\u2019s disease patients using inertial sensors and dynamic time warping. Biomed. Tech. 57, 1071\u20131074 (2012).","journal-title":"Biomed. Tech."},{"key":"1440_CR15","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.parkreldis.2014.02.022","volume":"20","author":"DA Heldman","year":"2014","unstructured":"Heldman, D. A. et al. Clinician versus machine: reliability and responsiveness of motor endpoints in Parkinson\u2019s disease. Parkinsonism Relat. Disord. 20, 590\u2013595 (2014).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1440_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-15874-4","volume":"12","author":"F Lipsmeier","year":"2022","unstructured":"Lipsmeier, F. et al. Reliability and validity of the Roche PD Mobile Application for remote monitoring of early Parkinson\u2019s disease. Sci. Rep. 12, 12081 (2022).","journal-title":"Sci. Rep."},{"key":"1440_CR17","doi-asserted-by":"publisher","first-page":"107257","DOI":"10.1016\/j.parkreldis.2024.107257","volume":"132","author":"T Nikolcheva","year":"2025","unstructured":"Nikolcheva, T. et al. A phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous prasinezumab in early-stage Parkinson\u2019s disease (PADOVA): rationale, design, and baseline data. Parkinsonism Relat. Disord. 132, 107257 (2025).","journal-title":"Parkinsonism Relat. Disord."},{"key":"1440_CR18","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214108","volume":"105","author":"A Delva","year":"2025","unstructured":"Delva, A. et al. Evolution of motor and nonmotor characteristics in an idiopathic\/isolated REM sleep behavior disorder cohort. Neurology 105, e214108 (2025).","journal-title":"Neurology"},{"key":"1440_CR19","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1093\/brain\/awz111","volume":"142","author":"SM Fereshtehnejad","year":"2019","unstructured":"Fereshtehnejad, S. M. et al. Evolution of prodromal Parkinson\u2019s disease and dementia with Lewy bodies: a prospective study. Brain 142, 2051\u20132067 (2019).","journal-title":"Brain"},{"key":"1440_CR20","doi-asserted-by":"publisher","first-page":"1914","DOI":"10.1002\/mds.27869","volume":"34","author":"F Alotaibi","year":"2019","unstructured":"Alotaibi, F. et al. Prodromal marker progression in idiopathic rapid eye movement sleep behavior disorder: sample size for clinical trials. Mov. Disord. 34, 1914\u20131919 (2019).","journal-title":"Mov. Disord."},{"key":"1440_CR21","doi-asserted-by":"publisher","first-page":"e93","DOI":"10.2196\/jmir.2645","volume":"15","author":"NG Choi","year":"2013","unstructured":"Choi, N. G. & Dinitto, D. M. The digital divide among low-income homebound older adults: internet use patterns, eHealth literacy, and attitudes toward computer\/internet use. J. Med. Internet Res. 15, e93 (2013).","journal-title":"J. Med. Internet Res."},{"key":"1440_CR22","doi-asserted-by":"publisher","first-page":"884208","DOI":"10.3389\/fdgth.2022.884208","volume":"4","author":"EW Paolillo","year":"2022","unstructured":"Paolillo, E. W. et al. Wearable use in an observational study among older adults: adherence, feasibility, and effects of clinicodemographic factors. Front. Digit Health 4, 884208 (2022).","journal-title":"Front. Digit Health"},{"key":"1440_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/s41746-025-01572-8","volume":"8","author":"KI Taylor","year":"2025","unstructured":"Taylor, K. I. et al. Exploratory digital outcome measures of motor sign progression in Parkinson\u2019s disease patients treated with prasinezumab. npj Digit Med. 8, 365 (2025).","journal-title":"npj Digit Med."}],"container-title":["npj Parkinson's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01440-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01440-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01440-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T04:10:57Z","timestamp":1792123857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41531-026-01440-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,27]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1440"],"URL":"https:\/\/doi.org\/10.1038\/s41531-026-01440-6","relation":{},"ISSN":["2373-8057"],"issn-type":[{"value":"2373-8057","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,27]]},"assertion":[{"value":"28 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was funded by an unrestricted grant from Roche to R.P. K.I.T., S.L., W.L.P., D.K. and M.L are employees of F. Hoffmann-La Roche Ltd. The other authors do not have a competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"252"}}