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Ageing societies, genetic and environmental factors and access to health care contribute to these increases. Using data of the German National Cohort (NAKO) PD classifications based on self-report, claims data and a brief medication based algorithm to increase validity in the absence of neurologic examinations, were compared and the PD incidence, selected non-motor symptoms, functions and vital status were analysed. The algorithm based PD prevalence among 205.000 participants was 0.13% but it was 2.5-fold higher in claims data. Self-reported PD incidence was 0.13% over a median of 4.8 years follow-up, but cases had a 4-fold higher mortality, worse emotional, motoric and olfactory functions and higher prevalences of diabetes, obesity, depression and anxiety. 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Fox Foundation for Parkinson\u2019s Research and has received research funding from Aligning Science Across Parkinson\u2019s disease (ASAP, CRN). C.T. has received honoraria for consultancy and\/or educational presentations from Abbvie, Bial, Boehringer, Roche, Ono, UCB, Convatec, STADA, Esteve. She has received royalties or licenses from Thieme Publisher, Germany and MAPI and is member of a Data Safety Monitoring Board from UCB and of Guideline Committees of the German Neurological Society, the International Parkinson and Movement Disorder Society, the European Academy of Neurology and the European RLS Study Group. She has received support for attending meetings or travel by the Movement disorder Society, German Parkinson Society, European Academy of Neurology, World Federation of Neurology, M.J. Fox Foundation. MB has received project funding from the German Research Foundation (Deutsche Forschungsgemeinschaft DFG, 413501650) and the Else Kr\u00f6ner-Fresenius-Stiftung (2025_EKEA.03). C.L. was supported by the Heisenberg program of the German Research Foundation (DFG; LI 2654\/4-1). All other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"156"}}