{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T14:08:21Z","timestamp":1687356501531},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T00:00:00Z","timestamp":1489622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Prim Care Resp Med"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The parents of a 3-year old boy are anxious about their son who has recurring episodes of wheezing. They are frustrated that no one seems to be able to give them answers to their questions and would like a referral to a specialist. Does their son have asthma and what is the prognosis; how can the recurrent wheezing be managed and can the risk of asthma be reduced; are there lifestyle changes that could improve the environment and avoid triggers? Communication and support from the family practice team were essential. Listening to the parents\u2019 concerns, explaining the diagnostic uncertainty, being realistic about what drug treatments could achieve, and providing practical advice on inhaler use and trigger avoidance reassured the parents that there was a strategy for managing their son\u2019s wheeze. The specialist referral was postponed.<\/jats:p>","DOI":"10.1038\/s41533-017-0020-3","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T16:04:18Z","timestamp":1489507458000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A young child with a history of wheeze"],"prefix":"10.1038","volume":"27","author":[{"given":"James","family":"Paton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Bindels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"McMurray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie","family":"Biggins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Nantanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne Stubbe","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,3,16]]},"reference":[{"key":"20_CR1","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1136\/thx.2007.093187","volume":"63","author":"J Henderson","year":"2008","unstructured":"Henderson, J., Granell, R., Heron, J., Sherriff, A., Simpson, A. & Woodcock, A. et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax \n                           63, 974\u2013980 (2008).","journal-title":"Thorax"},{"key":"20_CR2","unstructured":"Paton, J. British Thoracic Society National Paediatric Asthma Audit Summary Report (November). https:\/\/www.brit-thoracic.org.uk\/document-library\/audit-and-quality-improvement\/audit-reports\/bts-paediatric-asthma-audit-report-2015. Accessed December 2016 (2015)."},{"key":"20_CR3","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1056\/NEJM199501193320301","volume":"332","author":"FD Martinez","year":"1995","unstructured":"Martinez, F. D., Wright, A. L., Taussig, L. M., Holberg, C. J., Halonen, M. & Morgan, W. J., for the Group Health Medical Associates. Asthma and wheezing in the first six years of life. N. Engl. J. Med. \n                           332, 133\u2013138 (1995).","journal-title":"N. Engl. J. Med."},{"key":"20_CR4","doi-asserted-by":"publisher","unstructured":"Granell, R., Henderson, A. J. & Sterne, J. A. Associations of wheezing phenotypes with late asthma outcomes in the Avon longitudinal study of parents and children: a population-based birth cohort. J. Allergy Clin. Immunol. doi:10.1016\/j.jaci.2016.01.046 (2016).","DOI":"10.1016\/j.jaci.2016.01.046"},{"key":"20_CR5","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1183\/13993003.00284-2015","volume":"47","author":"FL Garden","year":"2016","unstructured":"Garden, F. L., Simpson, J. M., Mellis, C. M. & Marks, G. B. Change in the manifestations of asthma and asthma-related traits in childhood: a latent transition analysis. Eur. Respir. J. \n                           47, 499\u2013509 (2016).","journal-title":"Eur. Respir. J."},{"key":"20_CR6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1136\/adc.84.1.31","volume":"84","author":"RS Cane","year":"2001","unstructured":"Cane, R. S. & McKenzie, S. A. Parents\u2019 interpretations of children\u2019s respiratory symptoms on video. Arch. Dis. Child. \n                           84, 31\u201334 (2001).","journal-title":"Arch. Dis. Child."},{"key":"20_CR7","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1136\/adc.2003.038539","volume":"89","author":"L Lowe","year":"2004","unstructured":"Lowe, L., Murray, C. S., Martin, L., Deas, J., Cashin, E. & Poletti, G. et al. Reported versus confirmed wheeze and lung function in early life. Arch. Dis. Child. \n                           89, 540\u2013543 (2004).","journal-title":"Arch. Dis. Child."},{"key":"20_CR8","unstructured":"Global Initiative for Asthma. Global Strategy For Asthma Managment and Prevention. www.ginasthma.org. Accessed July 2016 (2016)."},{"key":"20_CR9","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1016\/j.jaci.2011.10.024","volume":"128","author":"DJ Jackson","year":"2011","unstructured":"Jackson, D. J., Sykes, A., Mallia, P. & Johnston, S. L. Asthma exacerbations: origin, effect, and prevention. J. Allergy Clin. Immunol. \n                           128, 1165\u20131174 (2011).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20_CR10","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1111\/pai.12318","volume":"25","author":"R Turunen","year":"2014","unstructured":"Turunen, R., Koistinen, A., Vuorinen, T., Arku, B., S\u00f6derlund\u2010Venermo, M. & Ruuskanen, O. et al. The first wheezing episode: respiratory virus etiology, atopic characteristics, and illness severity. Pediatr. Allergy Immunol. \n                           25, 796\u2013803 (2014).","journal-title":"Pediatr. Allergy Immunol."},{"key":"20_CR11","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1164\/rccm.201303-0498OC","volume":"188","author":"DW Cox","year":"2013","unstructured":"Cox, D. W., Bizzintino, J., Ferrari, G., Khoo, S. K., Zhang, G. & Whelan, S. et al. Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions. Am. J. Respir. Crit. Care Med. \n                           188, 1358\u20131364 (2013).","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"20_CR12","doi-asserted-by":"publisher","unstructured":"Rubner, F. J., Jackson, D. J., Evans, M. D., Gangnon, R. E., Tisler, C. J., Pappas, T. E., et al. Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J. Allergy. Clin. Immunol. \n                           139, 501\u2013507. doi:10.1016\/j.jaci.2016.03.049 (2017). Epub 10 May 2016.","DOI":"10.1016\/j.jaci.2016.03.049"},{"key":"20_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1177\/1753465815618113","volume":"10","author":"R Hewitt","year":"2016","unstructured":"Hewitt, R., Farne, H., Ritchie, A., Luke, E., Johnston, S. L. & Mallia, P. The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma. Ther. Adv. Respir. Dis. \n                           10, 158\u2013174 (2016).","journal-title":"Ther. Adv. Respir. Dis."},{"key":"20_CR14","unstructured":"National Collaborating Centre for Women\u2019s and Children\u2019s Health. Bronchiolitis: diagnosis and management of bronchiolitis in children, (London, 2015)."},{"key":"20_CR15","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.jaci.2015.06.034","volume":"136","author":"RJ Geerdink","year":"2015","unstructured":"Geerdink, R. J., Pillay, J., Meyaard, L. & Bont, L. Neutrophils in respiratory syncytial virus infection: a target for asthma prevention. J. Allergy. Clin. Immunol. \n                           136, 838\u2013847 (2015).","journal-title":"J. Allergy. Clin. Immunol."},{"key":"20_CR16","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","volume":"354","author":"RT Stein","year":"1999","unstructured":"Stein, R. T., Sherrill, D., Morgan, W. J., Holberg, C. J., Halonen, M. & Taussig, L. M. et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet \n                           354, 541\u2013545 (1999).","journal-title":"Lancet"},{"key":"20_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12911-015-0224-9","volume":"15","author":"G Luo","year":"2015","unstructured":"Luo, G., Nkoy, F. L., Stone, B. L., Schmick, D. & Johnson, M. D. A systematic review of predicitve models for asthma development in children. BMC. Med. Inform. Decis. Mak. \n                           15, 99 (2015).","journal-title":"BMC. Med. Inform. Decis. Mak."},{"key":"20_CR18","doi-asserted-by":"publisher","first-page":"52","DOI":"10.4104\/pcrj.2014.00003","volume":"23","author":"LB van der Mark","year":"2014","unstructured":"van der Mark, L. B., van Wonderen, K. E., Mohrs, J., van Aalderen, W. M., ter Riet, G. & Bindels, P. J. E. Predicting asthma in preschool children at high risk presenting in primary care: development of a clinical asthma prediction score. Prim. Care Respir. J. \n                           23, 52\u201359 (2014).","journal-title":"Prim. Care Respir. J."},{"key":"20_CR19","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1183\/09031936.00199913","volume":"43","author":"PL Brand","year":"2014","unstructured":"Brand, P. L., Caudri, D., Eber, E., Gaillard, E. A., Garcia-Marcos, L. & Hedlin, G. et al. Classification and pharmacological treatment of preschool wheezing: changes since 2008. Eur. Respir. J. \n                           43, 1172\u20131177 (2014).","journal-title":"Eur. Respir. J."},{"key":"20_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1542\/peds.2015-4496","volume":"137","author":"SV Kaiser","year":"2016","unstructured":"Kaiser, S. V., Huynh, T., Bacharier, L. B. & Rosenthal, J. L. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics \n                           137, 1\u201315 (2016).","journal-title":"Pediatrics"},{"key":"20_CR21","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1093\/ntr\/ntt033","volume":"15","author":"O Tinuoye","year":"2013","unstructured":"Tinuoye, O., Pell, J. P. & Mackay, D. F. Meta-analysis of the association between secondhand smoke exposure and physician-diagnosed childhood asthma. Nicotine Tob. Res. \n                           15, 1475\u20131483 (2013).","journal-title":"Nicotine Tob. Res."},{"key":"20_CR22","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1056\/NEJMra1413456","volume":"374","author":"HC Meissner","year":"2016","unstructured":"Meissner, H. C. Viral Bronchiolitis in children. N. Engl. J. Med. \n                           374, 62\u201372 (2016).","journal-title":"N. Engl. J. Med."},{"key":"20_CR23","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/S1473-3099(15)00247-9","volume":"15","author":"KL O\u2019Brien","year":"2015","unstructured":"O\u2019Brien, K. L., Chandran, A., Weatherholtz, R., Jafri, H. S., Griffin, M. P. & Bellamy, T. et al. Efficacy of motavizumab for the prevention of respiratory syncytial virus disease in healthy Native American infants: a phase 3 randomised doubleblind placebo-controlled trials. Lancet Infect. Dis. \n                           15, 1398\u20131408 (2015).","journal-title":"Lancet Infect. Dis."},{"key":"20_CR24","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1056\/NEJMoa051378","volume":"354","author":"TW Guilbert","year":"2006","unstructured":"Guilbert, T. W., Morgan, W. J., Zeiger, R. S., Mauger, D. T., Boehmer, S. J. & Szefler, S. J. et al. Long term inhaled corticosteroids in preschool children at high risk for asthma. N. Eng. J. Med. \n                           354, 1985\u20131992 (2006).","journal-title":"N. Eng. J. Med."},{"key":"20_CR25","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1056\/NEJMoa054692","volume":"354","author":"H Bisgaard","year":"2006","unstructured":"Bisgaard, H., Hermansen, M. N., Loland, L., Halkjaer, L. V. & Buchvald, F. Intermittent inhaled corticosteroids in infants with episodic wheezing. N. Eng. J. Med. \n                           354, 1998\u20132005 (2006).","journal-title":"N. Eng. J. Med."},{"key":"20_CR26","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/S0140-6736(06)69285-4","volume":"368","author":"CS Murray","year":"2006","unstructured":"Murray, C. S., Woodcock, A., Langley, S. J., Morris, J. & Custovic, A., for the IFWIN study team. Secondary prevention of asthma by the use of Inhaled Fluticasone propionate in Wheezy INfants (IFWIN): double-blind, randomised, controlled study. Lancet \n                           368, 754\u2013762 (2006).","journal-title":"Lancet"},{"key":"20_CR27","unstructured":"British Thoracic Society\/Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax \n                           69, (Suppl 1), 1\u2013192 (2016), Update 2016 http:\/\/sign.ac.uk\/guidelines\/fulltext\/153\/index.html. Accessed September 2016."},{"key":"20_CR28","doi-asserted-by":"publisher","first-page":"g15","DOI":"10.1136\/bmj.g15","volume":"348","author":"A Bush","year":"2014","unstructured":"Bush, A., Grigg, J. K. & Saglani, S. Managing wheeze in preschool children. BMJ \n                           348, g15 (2014).","journal-title":"BMJ"},{"key":"20_CR29","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1183\/09031936.00002108","volume":"32","author":"PL Brand","year":"2008","unstructured":"Brand, P. L., Baraldi, E., Bisgaard, H., Boner, A. L., Castro-Rodriguez, J. A. & Custovic, A. et al. Definition, assessment and treatment of wheezing disorders in preschool children: an evidence-based approach. Eur. Respir. J. \n                           32, 1096\u20131110 (2008).","journal-title":"Eur. Respir. J."},{"key":"20_CR30","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1056\/NEJMoa0804897","volume":"360","author":"J Panickar","year":"2009","unstructured":"Panickar, J., Lakhanpaul, M., Lambert, P. C., Kenia, P., Stephenson, T. & Smyth, A. et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N. Engl. J. Med. \n                           360, 329\u2013338 (2009).","journal-title":"N. Engl. J. Med."},{"key":"20_CR31","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.jaci.2014.07.001","volume":"135","author":"T Jartti","year":"2015","unstructured":"Jartti, T., Nieminen, R., Vuorinen, T., Lehtinen, P., Vahlberg, T. & Gern, J. et al. Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode. J. Allergy Clin. Immunol. \n                           135, 691\u2013698 (2015).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20_CR32","doi-asserted-by":"publisher","unstructured":"Brodlie, M., Gupta, A., Rodriguez-Martinez, C. E., Castro-Rodriguez, J. A., Ducharme, F. M. & McKean M. C. Leukotriene receptor antagonists as maintenance and intermittent therapy for episodic viral wheeze in children. Cochrane Database Syst. Rev. \n                           19(10). Art. No.: CD008202. doi:10.1002\/14651858.CD008202.pub2 (2015).","DOI":"10.1002\/14651858.CD008202.pub2"},{"key":"20_CR33","doi-asserted-by":"publisher","unstructured":"Chauhan, B. F., Chartrand, C., Ni Chroinin, M., Milan, S. J. & Ducharme, F. M. Addition of long-acting beta2-agonists to inhaled corticosteroids for chronic asthma in children. Cochrane Database Syst. Rev. Issue 11. Art. No.: CD007949. doi:10.1002\/14651858.CD007949.pub2 (2015).","DOI":"10.1002\/14651858.CD007949.pub2"},{"key":"20_CR34","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jaci.2012.05.007","volume":"130","author":"OE Savenije","year":"2012","unstructured":"Savenije, O. E., Kerkhof, M., Koppelman, G. H. & Postma, D. S. Predicting who will have asthma at school age among preschool children. J. Allergy Clin. Immunol. \n                           130, 325\u2013331 (2012).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20_CR35","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jaci.2013.06.002","volume":"133","author":"AM Pescatore","year":"2014","unstructured":"Pescatore, A. M., Dogaru, C. M., Duembgen, L., Silverman, M., Gaillard, E. A. & Spycher, B. D. et al. A simple asthma prediction tool for preschool children with wheeze or cough. J. Allergy Clin. Immunol. \n                           133, 111\u2013118 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jaci.2011.11.021","volume":"129","author":"RJ Laumbach","year":"2012","unstructured":"Laumbach, R. J. & Kipen, H. M. Respiratory health effects of air pollution: update on biomass smoke and traffic pollution. J. Allergy Clin. Immunol. \n                           129, 3\u201311 (2012).","journal-title":"J. Allergy Clin. Immunol."},{"key":"20_CR37","doi-asserted-by":"publisher","first-page":"e003827","DOI":"10.1136\/bmjopen-2013-003827","volume":"4","author":"S Dick","year":"2014","unstructured":"Dick, S., Doust, E., Cowie, H., Ayres, J. G. & Turner, S. Associations between environmental exposures and asthma control and exacerbations in young children: a systematic review. BMJ Open. \n                           4, e003827 (2014).","journal-title":"BMJ Open."},{"key":"20_CR38","doi-asserted-by":"publisher","first-page":"e1439","DOI":"10.1542\/peds.2015-3110","volume":"136","author":"HJ Farber","year":"2015","unstructured":"Farber, H. J., Groner, J., Walley, S. & Nelson, K. Protecting children from tobacco, nicotine, and tobacco smoke. Pediatrics \n                           136, e1439\u2013e1467 (2015).","journal-title":"Pediatrics"},{"key":"20_CR39","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1056\/NEJM199306103282303","volume":"328","author":"BA Chilmonczyk","year":"1993","unstructured":"Chilmonczyk, B. A., Salmun, L. M., Megathlin, K. N., Neveux, L. M., Palomaki, G. E. & Knight, G. J. et al. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N. Engl. J. Med. \n                           328, 1665\u20131669 (1993).","journal-title":"N. Engl. J. Med."},{"key":"20_CR40","unstructured":"Moore, F. Literature review: second-hand smoke prevention, (NHS Health Scotland, 2009)"},{"key":"20_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1136\/tc.2003.003889","volume":"13","author":"GE Matt","year":"2004","unstructured":"Matt, G. E., Quintana, P. J., Hovell, M. F., Bernert, J. T., Song, S. & Novianti, N. et al. Households contaminated by environmental tobacco smoke: sources of infant exposures. Tob. Control \n                           13, 29\u201337 (2004).","journal-title":"Tob. Control"},{"key":"20_CR42","first-page":"103","volume":"32","author":"W Kanchongkittiphon","year":"2014","unstructured":"Kanchongkittiphon, W., Gaffin, J. M. & Phipatanakul, W. The indoor environment and inner-city childhood asthma. Asian Pac. J. Allergy Immunol. \n                           32, 103\u2013110 (2014).","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"20_CR43","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1289\/ehp.123-A6","volume":"123","author":"W Kanchongkittiphon","year":"2015","unstructured":"Kanchongkittiphon, W., Mendell, M. J., Gaffin, J. M., Wang, G. & Phipatanakul, W. Indoor environmental exposures and exacerbation of asthma: an update to the 2000 review by the institute of medicine. Environ. Health Perspect. \n                           123, 6\u201320 (2015).","journal-title":"Environ. Health Perspect."},{"key":"20_CR44","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/cea.12107","volume":"43","author":"G Weinmayr","year":"2013","unstructured":"Weinmayr, G., Gehring, U., Genuneit, J., B\u00fcchele, G., Kleiner, A. & Siebers, R. et al. Dampness and moulds in relation to respiratory and allergic symptoms in children: results from Phase Two of the International Study of Asthma and Allergies in Childhood (ISAAC Phase Two). Clin. Exp. Allergy \n                           43, 762\u2013774 (2013).","journal-title":"Clin. Exp. Allergy"},{"key":"20_CR45","doi-asserted-by":"publisher","first-page":"727","DOI":"10.3109\/02770903.2014.1001904","volume":"52","author":"D Vicendese","year":"2015","unstructured":"Vicendese, D., Dharmage, S. C., Tang, M. L., Olenko, A., Allen, K. J. & Abramson, M. J. et al. Bedroom air quality and vacuuming frequency are associated with repeat child asthma hospital admissions. J. Asthma \n                           52, 727\u2013731 (2015).","journal-title":"J. Asthma"},{"key":"20_CR46","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1001\/archpedi.157.6.540","volume":"157","author":"K Yeatts","year":"2003","unstructured":"Yeatts, K., Shy, C., Sotir, M., Music, S. & Herget, C. Health consequences for children with undiagnosed asthma-like symptoms. Arch. Pediatr. Adolesc. Med. \n                           157, 540\u2013544 (2003).","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"20_CR47","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1002\/ppul.20486","volume":"41","author":"R Oostenbrink","year":"2006","unstructured":"Oostenbrink, R., Jansingh-Piepers, E. M., Raat, H., Nuijsink, M., Landgraf, J. M. & Essink-Bot, M. L. et al. Health-related quality of life of pre-school children with wheezing illness. Pediatr. Pulmonol. \n                           41, 993\u20131000 (2006).","journal-title":"Pediatr. Pulmonol."},{"key":"20_CR48","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1378\/chest.07-2369","volume":"133","author":"HJ Farber","year":"2008","unstructured":"Farber, H. J., Knowles, S. B., Brown, N. L., Caine, L., Luna, V. & Qian, Y. et al. Secondhand tobacco smoke in children with asthma: sources of and parental perceptions about exposure in children and parental readiness to change. Chest \n                           133, 1367\u20131374 (2008).","journal-title":"Chest"},{"key":"20_CR49","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1097\/01.FCH.0000290545.56199.c9","volume":"30","author":"MC Kegler","year":"2007","unstructured":"Kegler, M. C., Escoffery, C., Groff, A., Butler, S. & Foreman, A. A qualitative study of how families decide to adopt household smoking restrictions. Fam. Community Health \n                           30, 328\u2013341 (2007).","journal-title":"Fam. Community Health"},{"key":"20_CR50","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1186\/s12889-015-2024-7","volume":"15","author":"E Thomas","year":"2015","unstructured":"Thomas, E., Wickramasinghe, K., Mendis, S., Roberts, N. & Foster, C. Improved stove interventions to reduce household air pollution in low and middle income countries: a descriptive systematic review. BMC Public Health \n                           15, 650 (2015).","journal-title":"BMC Public Health"},{"key":"20_CR51","doi-asserted-by":"publisher","first-page":"10310","DOI":"10.3390\/ijerph111010310","volume":"11","author":"EL Rhodes","year":"2014","unstructured":"Rhodes, E. L., Dreibelbis, R., Klasen, E., Naithani, N., Baliddawa, J. & Menya, D. et al. Behavioral attitudes and preferences in cooking practices with traditional open-fire stoves in Peru, Nepal, and Kenya: implications for improved cookstove interventions. Int. J. Environ. Res. Public Health \n                           11, 10310\u201310326 (2014).","journal-title":"Int. J. Environ. Res. Public Health"}],"container-title":["npj Primary Care Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41533-017-0020-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41533-017-0020-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41533-017-0020-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T01:49:06Z","timestamp":1671760146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41533-017-0020-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,16]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12]]}},"alternative-id":["20"],"URL":"https:\/\/doi.org\/10.1038\/s41533-017-0020-3","relation":{},"ISSN":["2055-1010"],"issn-type":[{"value":"2055-1010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,16]]},"assertion":[{"value":"17 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2017","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2017","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2017","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}