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Gerald Xuan Zhong Ng reports no conflict of interest. Ishita Goel reports no conflict of interest. Shao Wei Lam reports no conflict of interest. Jun Tian Wu reports no conflict of interest. Chun Fan Lee reports no conflict of interest. Marcus Eng Hock Ong reports no conflict of interest. David Bruce Matchar reports no conflict of interest. Ngiap Chuan Tan reports no conflict of interest. Chian Min Loo reports no conflict of interest. Mariko Siyue Koh reports grant support from Astra-Zeneca, and honoraria for lectures and advisory board meetings paid to her hospital (Singapore General Hospital) from GlaxoSmithKline, Astra-Zeneca, Novartis, Sanofi, Boehringer Ingelheim and Roche outside the submitted work.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethics board approval was obtained as part of the SDG-CARE collaboration, prior to developing the SCDM (SingHealth Centralized Institutional Review Board Ref No. 2017\/2950). 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