{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:15:30Z","timestamp":1779282930804,"version":"3.51.4"},"reference-count":125,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["400722"],"award-info":[{"award-number":["400722"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["400358"],"award-info":[{"award-number":["400358"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["828442"],"award-info":[{"award-number":["828442"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Regen Med"],"DOI":"10.1038\/s41536-026-00469-8","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:16:38Z","timestamp":1776284198000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Heart ventricle regeneration in the lizard Eublepharis macularius, the leopard gecko"],"prefix":"10.1038","volume":"11","author":[{"given":"Kathy","family":"Jacyniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J. A.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Beaufr\u00e8re","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo N.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew K.","family":"Vickaryous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"469_CR1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cardiores.2005.01.011","volume":"66","author":"G Ertl","year":"2005","unstructured":"Ertl, G. & Frantz, S. Healing after myocardial infarction. Cardiovasc. Res. 66, 22\u201332 (2005).","journal-title":"Cardiovasc. Res."},{"key":"469_CR2","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev.bioeng.7.060804.100453","volume":"7","author":"JW Holmes","year":"2005","unstructured":"Holmes, J. W., Borg, T. K. & Covell, J. W. Structure and mechanics of healing myocardial infarcts. Annu. Rev. Biomed. Eng. 7, 223\u2013253 (2005).","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"469_CR3","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.yjmcc.2009.07.015","volume":"48","author":"M Dobaczewski","year":"2010","unstructured":"Dobaczewski, M., Gonzalez-Quesada, C. & Frangogiannis, N. G. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J. Mol. Cell. Cardiol. 48, 504\u2013511 (2010).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"469_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1161\/01.CIR.9.3.352","volume":"9","author":"WW Smith","year":"1954","unstructured":"Smith, W. W., Wikler, N. S. & Fox, A. C. Hemodynamic studies of patients with myocardial infarction. Circulation 9, 352\u2013362 (1954).","journal-title":"Circulation"},{"key":"469_CR5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0735-1097(84)80203-X","volume":"4","author":"JA Erlebacher","year":"1984","unstructured":"Erlebacher, J. A., Weiss, J. L., Weisfeldt, M. L. & Bulkley, B. H. Early dilation of the infarcted segment in acute transmural myocardial infarction: role of infarct expansion in acute left ventricular enlargement. J. Am. Coll. Cardiol. 4, 201\u2013208 (1984).","journal-title":"J. Am. Coll. Cardiol."},{"key":"469_CR6","first-page":"150","volume":"92","author":"LAM Zornoff","year":"2009","unstructured":"Zornoff, L. A. M., Paiva, S. A. R., Duarte, D. R. & Spadaro, J. Ventricular remodeling after myocardial infarction: concepts and clinical implications. Arq. Bras. Cardiol. 92, 150\u2013164 (2009).","journal-title":"Arq. Bras. Cardiol."},{"key":"469_CR7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1161\/CIRCOUTCOMES.112.965012","volume":"5","author":"AL Miller","year":"2012","unstructured":"Miller, A. L. et al. Left ventricular ejection fraction assessment among patients with acute myocardial infarction and its association with hospital quality of care and evidence-based therapy use. Circ. Cardiovasc. Qual. Outcomes 5, 662\u2013671 (2012).","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"469_CR8","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/j.jacep.2017.12.015","volume":"4","author":"DS Chew","year":"2018","unstructured":"Chew, D. S. et al. Change in left ventricular ejection fraction following first myocardial infarction and outcome. JACC Clin. Electrophysiol. 4, 672\u2013682 (2018).","journal-title":"JACC Clin. Electrophysiol."},{"key":"469_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-213X-11-21","volume":"11","author":"F Chablais","year":"2011","unstructured":"Chablais, F., Veit, J., Rainer, G. & Ja\u017awi\u0144ska, A. The zebrafish heart regenerates after cryoinjury-induced myocardial infarction. BMC Dev. Biol. 11, 21 (2011).","journal-title":"BMC Dev. Biol."},{"key":"469_CR10","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.devcel.2020.02.019","volume":"53","author":"M Cui","year":"2020","unstructured":"Cui, M. et al. Dynamic transcriptional responses to injury of regenerative and non-regenerative cardiomyocytes revealed by single-nucleus RNA sequencing. Dev. Cell 53, 102\u2013116.e8 (2020).","journal-title":"Dev. Cell"},{"key":"469_CR11","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41556-022-00902-2","volume":"24","author":"E Eroglu","year":"2022","unstructured":"Eroglu, E. et al. Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders. Nat. Cell Biol. 24, 645\u2013658 (2022).","journal-title":"Nat. Cell Biol."},{"key":"469_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41536-017-0027-y","volume":"2","author":"JW Godwin","year":"2017","unstructured":"Godwin, J. W., Debuque, R., Salimova, E. & Rosenthal, N. A. Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape. Npj Regen. Med. 2, 1\u201311 (2017).","journal-title":"Npj Regen. Med."},{"key":"469_CR13","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1242\/dev.060897","volume":"138","author":"JM Gonz\u00e1lez-Rosa","year":"2011","unstructured":"Gonz\u00e1lez-Rosa, J. M., Mart\u00edn, V., Peralta, M., Torres, M. & Mercader, N. Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish. Development 138, 1663\u20131674 (2011).","journal-title":"Development"},{"key":"469_CR14","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3390\/ijms18071362","volume":"18","author":"SSM Ling","year":"2017","unstructured":"Ling, S. S. M., Chen, Y.-T., Wang, J., Richards, A. M. & Liew, O. W. Ankyrin repeat domain 1 protein: a functionally pleiotropic protein with cardiac biomarker potential. Int. J. Mol. Sci. 18, 1362 (2017).","journal-title":"Int. J. Mol. Sci."},{"key":"469_CR15","doi-asserted-by":"publisher","first-page":"101","DOI":"10.17305\/bjbms.2022.7770","volume":"23","author":"L Liu","year":"2023","unstructured":"Liu, L. et al. Integrated transcriptomic and proteomic analysis reveals potential targets for heart regeneration. Biomol. Biomed. 23, 101\u2013113 (2023).","journal-title":"Biomol. Biomed."},{"key":"469_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13104-021-05574-z","volume":"14","author":"K Pedersen","year":"2021","unstructured":"Pedersen, K., Rasmussen, R. K., Dittrich, A. & Lauridsen, H. Cardiac regeneration in the axolotl is unaffected by alterations in leukocyte numbers induced by lipopolysaccharide and prednisolone. BMC Res. Notes 14, 1\u20136 (2021).","journal-title":"BMC Res. Notes"},{"key":"469_CR17","doi-asserted-by":"crossref","unstructured":"Peng, H. et al. Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction. Npj Regen. Med. 6, 1\u201315 (2021).","DOI":"10.1038\/s41536-021-00186-4"},{"key":"469_CR18","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1126\/science.1077857","volume":"298","author":"KD Poss","year":"2002","unstructured":"Poss, K. D., Wilson, L. G. & Keating, M. T. Heart regeneration in zebrafish. Science 298, 2188\u20132190 (2002).","journal-title":"Science"},{"key":"469_CR19","doi-asserted-by":"publisher","first-page":"e18503","DOI":"10.1371\/journal.pone.0018503","volume":"6","author":"K Schnabel","year":"2011","unstructured":"Schnabel, K., Wu, C.-C., Kurth, T. & Weidinger, G. Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS ONE 6, e18503 (2011).","journal-title":"PLoS ONE"},{"key":"469_CR20","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1016\/j.celrep.2018.10.072","volume":"25","author":"WT Stockdale","year":"2018","unstructured":"Stockdale, W. T. et al. Heart regeneration in the mexican cavefish. Cell Rep. 25, 1997\u20132007.e7 (2018).","journal-title":"Cell Rep."},{"key":"469_CR21","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1161\/CIRCULATIONAHA.118.034886","volume":"138","author":"W Zhu","year":"2018","unstructured":"Zhu, W. et al. Regenerative potential of neonatal porcine hearts. Circulation 138, 2809\u20132816 (2018).","journal-title":"Circulation"},{"key":"469_CR22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1161\/CIRCULATIONAHA.118.033648","volume":"138","author":"NT Lam","year":"2018","unstructured":"Lam, N. T. & Sadek, H. A. Neonatal heart regeneration: comprehensive literature review. Circulation 138, 412\u2013423 (2018).","journal-title":"Circulation"},{"key":"469_CR23","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078\u20131080 (2011).","journal-title":"Science"},{"key":"469_CR24","doi-asserted-by":"crossref","unstructured":"Qi, Y. et al. Intrinsic increased Ace2 expression protects spiny mouse acomys cahirinus against ischemic-induced cardiac dysfunction. FASEB J. 30, 580.4 (2016).","DOI":"10.1096\/fasebj.30.1_supplement.lb561"},{"key":"469_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02891-z","volume":"9","author":"K-I Sereti","year":"2018","unstructured":"Sereti, K.-I. et al. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat. Commun. 9, 754 (2018).","journal-title":"Nat. Commun."},{"key":"469_CR26","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.ijcard.2021.06.015","volume":"338","author":"Y Qi","year":"2021","unstructured":"Qi, Y. et al. Functional heart recovery in an adult mammal, the spiny mouse. Int. J. Cardiol. 338, 196\u2013203 (2021).","journal-title":"Int. J. Cardiol."},{"key":"469_CR27","doi-asserted-by":"crossref","unstructured":"Koopmans, T. et al. Ischemic tolerance and cardiac repair in the spiny mouse (Acomys). Npj Regen. Med. 6, 78 (2021).","DOI":"10.1038\/s41536-021-00188-2"},{"key":"469_CR28","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/eci.12118","volume":"43","author":"P Christia","year":"2013","unstructured":"Christia, P. & Frangogiannis, N. G. Targeting inflammatory pathways in myocardial infarction. Eur. J. Clin. Invest. 43, 986\u2013995 (2013).","journal-title":"Eur. J. Clin. Invest."},{"key":"469_CR29","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1093\/eurheartj\/ehv195","volume":"36","author":"N Ruparelia","year":"2015","unstructured":"Ruparelia, N. et al. Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans. Eur. Heart J. 36, 1923\u20131934 (2015).","journal-title":"Eur. Heart J."},{"key":"469_CR30","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","volume":"11","author":"NG Frangogiannis","year":"2014","unstructured":"Frangogiannis, N. G. The inflammatory response in myocardial injury, repair, and remodelling. Nat. Rev. Cardiol. 11, 255\u2013265 (2014).","journal-title":"Nat. Rev. Cardiol."},{"key":"469_CR31","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/j.bbamcr.2012.08.023","volume":"1833","author":"W Chen","year":"2013","unstructured":"Chen, W. & Frangogiannis, N. G. Fibroblasts in post-infarction inflammation and cardiac repair. Biochim. Biophys. Acta 1833, 945\u2013953 (2013).","journal-title":"Biochim. Biophys. Acta"},{"key":"469_CR32","first-page":"1113","volume":"466","author":"Y Ma","year":"2014","unstructured":"Ma, Y. et al. Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling. Pfl\u00fcg. Arch. Eur. J. Physiol. 466, 1113\u20131127 (2014).","journal-title":"Pfl\u00fcg. Arch. Eur. J. Physiol."},{"key":"469_CR33","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling, C. et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464, 606\u2013609 (2010).","journal-title":"Nature"},{"key":"469_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo, S. E. et al. Mammalian heart renewal by preexisting cardiomyocytes. Nature 493, 433\u2013436 (2013).","journal-title":"Nature"},{"key":"469_CR35","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.ydbio.2014.12.002","volume":"399","author":"P Sallin","year":"2015","unstructured":"Sallin, P., de Preux Charles, A.-S., Duruz, V., Pfefferli, C. & Ja\u017awi\u0144ska, A. A dual epimorphic and compensatory mode of heart regeneration in zebrafish. Dev. Biol. 399, 27\u201340 (2015).","journal-title":"Dev. Biol."},{"key":"469_CR36","doi-asserted-by":"publisher","first-page":"e115604","DOI":"10.1371\/journal.pone.0115604","volume":"9","author":"JM Gonz\u00e1lez-Rosa","year":"2014","unstructured":"Gonz\u00e1lez-Rosa, J. M. et al. Use of echocardiography reveals reestablishment of ventricular pumping efficiency and partial ventricular wall motion recovery upon ventricular cryoinjury in the Zebrafish. PLoS ONE 9, e115604 (2014).","journal-title":"PLoS ONE"},{"key":"469_CR37","first-page":"63","volume":"10","author":"LW Wang","year":"2017","unstructured":"Wang, L. W. et al. Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models. Dis. Model. Mech. 10, 63\u201376 (2017).","journal-title":"Dis. Model. Mech."},{"key":"469_CR38","doi-asserted-by":"publisher","first-page":"e0122665","DOI":"10.1371\/journal.pone.0122665","volume":"10","author":"SJ Hein","year":"2015","unstructured":"Hein, S. J. et al. Advanced echocardiography in adult zebrafish reveals delayed recovery of heart function after myocardial cryoinjury. PloS ONE 10, e0122665 (2015).","journal-title":"PloS ONE"},{"key":"469_CR39","doi-asserted-by":"publisher","first-page":"2858","DOI":"10.1242\/jeb.126862","volume":"220","author":"K Jacyniak","year":"2017","unstructured":"Jacyniak, K., McDonald, R. P. & Vickaryous, M. K. Tail regeneration and other phenomena of wound healing and tissue restoration in lizards. J. Exp. Biol. 220, 2858\u20132869 (2017).","journal-title":"J. Exp. Biol."},{"key":"469_CR40","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1002\/ar.22490","volume":"295","author":"SL Delorme","year":"2012","unstructured":"Delorme, S. L., Lungu, I. M. & Vickaryous, M. K. Scar-free wound healing and regeneration following tail loss in the leopard gecko, Eublepharis macularius. Anat. Rec. 295, 1575\u20131595 (2012).","journal-title":"Anat. Rec."},{"key":"469_CR41","doi-asserted-by":"crossref","unstructured":"McLean, K. E. & Vickaryous, M. K. A novel amniote model of epimorphic regeneration: the leopard gecko, Eublepharis macularius. BMC Dev. Biol. 11, 50 (2011).","DOI":"10.1186\/1471-213X-11-50"},{"key":"469_CR42","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2230.1978.tb01518.x","volume":"3","author":"IW Whimster","year":"1978","unstructured":"Whimster, I. W. Nerve supply as a stimulator of the growth of tissues including skin. II. Animal evidence. Clin. Exp. Dermatol. 3, 389\u2013410 (1978).","journal-title":"Clin. Exp. Dermatol."},{"key":"469_CR43","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1096\/fj.15-272468","volume":"30","author":"D Szarek","year":"2016","unstructured":"Szarek, D. et al. Lizard tail spinal cord: a new experimental model of spinal cord injury without limb paralysis. FASEB J. 30, 1391\u20131403 (2016).","journal-title":"FASEB J."},{"key":"469_CR44","doi-asserted-by":"crossref","unstructured":"Gilbert, E.A.B. & Vickaryous, M. K. Neural stem\/progenitor cells are activated during tail regeneration in the leopard gecko (Eublepharis macularius). J. Comp. Neurol. 526, 285\u2013309 (2018).","DOI":"10.1002\/cne.24335"},{"key":"469_CR45","doi-asserted-by":"crossref","unstructured":"Beazley, L. D., Sheard, P. W., Tennant, M., Starac, D. & Dunlop, S. A. Optic nerve regenerates but does not restore topographic projections in the lizard Ctenophorus ornatus. J. Comp. Neurol. 377, 105\u2013120 (1997).","DOI":"10.1002\/(SICI)1096-9861(19970106)377:1<105::AID-CNE10>3.0.CO;2-P"},{"key":"469_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/reg2.9","volume":"1","author":"P Wu","year":"2014","unstructured":"Wu, P., Alibardi, L. & Chuong, C.-M. Regeneration of reptilian scales after wounding: neogenesis, regional difference, and molecular modules. Regeneration 1, 15\u201326 (2014).","journal-title":"Regeneration"},{"key":"469_CR47","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/joa.12784","volume":"232","author":"N Subramaniam","year":"2018","unstructured":"Subramaniam, N., Petrik, J. J. & Vickaryous, M. K. VEGF, FGF-2 and TGF\u03b2 expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles. J. Anat. 232, 768\u2013782 (2018).","journal-title":"J. Anat."},{"key":"469_CR48","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/joa.12368","volume":"227","author":"HM Peacock","year":"2015","unstructured":"Peacock, H. M., Gilbert, E. A. B. & Vickaryous, M. K. Scar-free cutaneous wound healing in the leopard gecko, Eublepharis macularius. J. Anat. 227, 596\u2013610 (2015).","journal-title":"J. Anat."},{"key":"469_CR49","doi-asserted-by":"publisher","first-page":"576816","DOI":"10.3389\/fphys.2021.576816","volume":"12","author":"KS Brink","year":"2021","unstructured":"Brink, K. S. et al. Tooth removal in the Leopard Gecko and the de novo formation of replacement teeth. Front. Physiol. 12, 576816 (2021).","journal-title":"Front. Physiol."},{"key":"469_CR50","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1159\/000057570","volume":"58","author":"E Font","year":"2002","unstructured":"Font, E., Desfilis, E., P\u00e9rez-Ca\u00f1ellas, M. M. & Garc\u00eda-Verdugo, J. M. Neurogenesis and neuronal regeneration in the adult reptilian brain. Brain. Behav. Evol. 58, 276\u2013295 (2002).","journal-title":"Brain. Behav. Evol."},{"key":"469_CR51","doi-asserted-by":"crossref","unstructured":"Austin, L. E., Graham, C. & Vickaryous, M. K. Spontaneous neuronal regeneration in the forebrain of the leopard gecko (Eublepharis macularius) following neurochemical lesioning. Dev. Dyn. 252, 186\u2013207 (2023).","DOI":"10.1002\/dvdy.525"},{"key":"469_CR52","first-page":"56","volume":"55","author":"VI Sulima","year":"1968","unstructured":"Sulima, V. I. On regeneration of myocardium in various injuries to the cardiac wall of reptiles. Arkh. Anat. Gistol. Embriol. 55, 56\u201363 (1968).","journal-title":"Arkh. Anat. Gistol. Embriol."},{"key":"469_CR53","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/BF00306596","volume":"139","author":"PP Rumyantsev","year":"1973","unstructured":"Rumyantsev, P. P. Post-injury DNA synthesis, mitosis and ultrastructural reorganization of adult frog cardiac myocytes. An electron microscopic-autoradiographic study. Z. Zellforsch. Mikrosk. Anat. 139, 431\u2013450 (1973).","journal-title":"Z. Zellforsch. Mikrosk. Anat."},{"key":"469_CR54","unstructured":"Rumyantsev, P. P. Growth and Hyperplasia of Cardiac Muscle Cells. (Taylor & Francis, 1991)."},{"key":"469_CR55","doi-asserted-by":"crossref","unstructured":"Agarwal, I. et al. The evolutionary history of an accidental model organism, the leopard gecko Eublepharis macularius (Squamata: Eublepharidae). Mol. Phylogenet. Evol. 168, 107414 (2022).","DOI":"10.1016\/j.ympev.2022.107414"},{"key":"469_CR56","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/978-1-4939-9009-2_13","volume":"1920","author":"MK Vickaryous","year":"2019","unstructured":"Vickaryous, M. K. & Gilbert, E. A. B. Reptile embryology and regeneration. Methods Mol. Biol. 1920, 219\u2013246 (2019).","journal-title":"Methods Mol. Biol."},{"key":"469_CR57","doi-asserted-by":"crossref","unstructured":"Tousignant, A. & Crews, D. Incubation temperature and gonadal sex affect growth and physiology in the leopard gecko (Eublepharis macularius), a lizard with temperature-dependent sex determination. J. Morphol. 224, 159\u2013170 (1995).","DOI":"10.1002\/jmor.1052240205"},{"key":"469_CR58","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S1055-937X(99)80047-4","volume":"8","author":"SJ Divers","year":"1999","unstructured":"Divers, S. J. Lizard endoscopic techniques with particular reference to the green iguana (Iguana iguana). Semin. Avian Exot. Pet. Med. 8, 122\u2013129 (1999).","journal-title":"Semin. Avian Exot. Pet. Med."},{"key":"469_CR59","doi-asserted-by":"crossref","unstructured":"Jacyniak, K. & Vickaryous, M. K. Constitutive cardiomyocyte proliferation in the leopard gecko (Eublepharis macularius). J. Morphol. 279, 1355\u20131367 (2018).","DOI":"10.1002\/jmor.20850"},{"key":"469_CR60","doi-asserted-by":"publisher","unstructured":"Jacyniak, K., Barrera Jaimes, K., Doan, M. H., Chartrand, J. M. & Vickaryous, M. K. Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius). Dev. Dyn. dvdy.70015 https:\/\/doi.org\/10.1002\/dvdy.70015 (2025).","DOI":"10.1002\/dvdy.70015"},{"key":"469_CR61","doi-asserted-by":"publisher","unstructured":"Chablais, F. & Ja\u017awi\u0144ska, A. Induction of myocardial infarction in adult zebrafish using cryoinjury. J. Vis. Exp. 18, 3666 https:\/\/doi.org\/10.3791\/3666 (2012).","DOI":"10.3791\/3666"},{"key":"469_CR62","doi-asserted-by":"publisher","unstructured":"Dittrich, A. & Lauridsen, H. Cryo-injury induced heart regeneration in the Axolotl and echocardiography and unbiased quantitative histology to evaluate regenerative progression. J. Vis. Exp. 172, e61966 https:\/\/doi.org\/10.3791\/61966 (2021).","DOI":"10.3791\/61966"},{"key":"469_CR63","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/nprot.2012.025","volume":"7","author":"JM Gonz\u00e1lez-Rosa","year":"2012","unstructured":"Gonz\u00e1lez-Rosa, J. M. & Mercader, N. Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish. Nat. Protoc. 7, 782\u2013788 (2012).","journal-title":"Nat. Protoc."},{"key":"469_CR64","doi-asserted-by":"publisher","first-page":"H1291","DOI":"10.1152\/ajpheart.00111.2005","volume":"289","author":"EJ van den Bos","year":"2005","unstructured":"van den Bos, E. J., Mees, B. M. E., de Waard, M. C., de Crom, R. & Duncker, D. J. A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation. Am. J. Physiol. Heart Circ. Physiol. 289, H1291\u2013H1300 (2005).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"469_CR65","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.mri.2010.02.001","volume":"28","author":"Y Yang","year":"2010","unstructured":"Yang, Y. et al. Characterization of cryoinjury-induced infarction with manganese-and gadolinium-enhanced MRI and optical spectroscopy in pig hearts. Magn. Reson. Imaging 28, 753\u2013766 (2010).","journal-title":"Magn. Reson. Imaging"},{"key":"469_CR66","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jvc.2015.10.011","volume":"18","author":"S Silverman","year":"2016","unstructured":"Silverman, S., Sanchez-Migallon Guzman, D., Stern, J., Gustavsen, K. A. & Griffiths, L. G. Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps). J. Vet. Cardiol. 18, 168\u2013178 (2016).","journal-title":"J. Vet. Cardiol."},{"key":"469_CR67","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.yjmcc.2019.09.008","volume":"136","author":"N Fillmore","year":"2019","unstructured":"Fillmore, N. et al. A knock-in mutation at cysteine 144 of TRIM72 is cardioprotective and reduces myocardial TRIM72 release. J. Mol. Cell. Cardiol. 136, 95\u2013101 (2019).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"469_CR68","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1161\/CIRCRESAHA.122.321123","volume":"132","author":"RD Hume","year":"2023","unstructured":"Hume, R. D. et al. Tropoelastin improves post-infarct cardiac function. Circ. Res. 132, 72\u201386 (2023).","journal-title":"Circ. Res."},{"key":"469_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37198-1","volume":"14","author":"Y Ma","year":"2023","unstructured":"Ma, Y., Ding, L., Li, Z. & Zhou, C. Structural basis for TRIM72 oligomerization during membrane damage repair. Nat. Commun. 14, 1555 (2023).","journal-title":"Nat. Commun."},{"key":"469_CR70","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/dvdy.556","volume":"253","author":"K Shin","year":"2024","unstructured":"Shin, K., Begeman, I. J., Cao, J. & Kang, J. leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts. Dev. Dyn. 253, 91\u2013106 (2024).","journal-title":"Dev. Dyn."},{"key":"469_CR71","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1161\/CIRCRESAHA.118.313285","volume":"124","author":"A Petz","year":"2019","unstructured":"Petz, A. et al. Cardiac hyaluronan synthesis is critically involved in the cardiac macrophage response and promotes healing after ischemia reperfusion injury. Circ. Res. 124, 1433\u20131447 (2019).","journal-title":"Circ. Res."},{"key":"469_CR72","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.yjmcc.2025.10.014","volume":"210","author":"D Wong","year":"2026","unstructured":"Wong, D. et al. Slit2-robo signaling regulates angiogenesis and repair following myocardial infarction. J. Mol. Cell. Cardiol. 210, 28\u201342 (2026).","journal-title":"J. Mol. Cell. Cardiol."},{"key":"469_CR73","doi-asserted-by":"publisher","first-page":"15546","DOI":"10.1073\/pnas.0607382103","volume":"103","author":"FB Engel","year":"2006","unstructured":"Engel, F. B., Hsieh, P. C. H., Lee, R. T. & Keating, M. T. FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl. Acad. Sci. 103, 15546\u201315551 (2006).","journal-title":"Proc. Natl. Acad. Sci."},{"key":"469_CR74","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.stem.2022.03.009","volume":"29","author":"J Du","year":"2022","unstructured":"Du, J. et al. A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration. Cell Stem Cell 29, 545\u2013558.e13 (2022).","journal-title":"Cell Stem Cell"},{"key":"469_CR75","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201949752","volume":"21","author":"R Fukuda","year":"2020","unstructured":"Fukuda, R. et al. Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish. EMBO Rep. 21, e49752 (2020).","journal-title":"EMBO Rep."},{"key":"469_CR76","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50163","volume":"8","author":"H Honkoop","year":"2019","unstructured":"Honkoop, H. et al. Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLife 8, e50163 (2019).","journal-title":"eLife"},{"key":"469_CR77","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1007\/s00018-021-03831-9","volume":"78","author":"PD Nguyen","year":"2021","unstructured":"Nguyen, P. D., de Bakker, D. E. M. & Bakkers, J. Cardiac regenerative capacity: an evolutionary afterthought? Cell. Mol. Life Sci. 78, 5107\u20135122 (2021).","journal-title":"Cell. Mol. Life Sci."},{"key":"469_CR78","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.ydbio.2013.08.002","volume":"382","author":"SE Mercer","year":"2013","unstructured":"Mercer, S. E., Odelberg, S. J. & Simon, H.-G. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev. Biol. 382, 457\u2013469 (2013).","journal-title":"Dev. Biol."},{"key":"469_CR79","doi-asserted-by":"publisher","DOI":"10.1242\/dev.191320","volume":"148","author":"CJ Derrick","year":"2021","unstructured":"Derrick, C. J. & No\u00ebl, E. S. The ECM as a driver of heart development and repair. Development 148, dev191320 (2021).","journal-title":"Development"},{"key":"469_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-32272-6","volume":"13","author":"MA Botos","year":"2023","unstructured":"Botos, M. A., Arora, P., Chouvardas, P. & Mercader, N. Transcriptomic data meta-analysis reveals common and injury model specific gene expression changes in the regenerating zebrafish heart. Sci. Rep. 13, 5418 (2023).","journal-title":"Sci. Rep."},{"key":"469_CR81","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1371\/journal.pbio.0040260","volume":"4","author":"C-L Lien","year":"2006","unstructured":"Lien, C.-L., Schebesta, M., Makino, S., Weber, G. J. & Keating, M. T. Gene expression analysis of zebrafish heart regeneration. PLOS Biol. 4, e260 (2006).","journal-title":"PLOS Biol."},{"key":"469_CR82","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.1073\/pnas.1716713115","volume":"115","author":"H S\u00e1nchez-Iranzo","year":"2018","unstructured":"S\u00e1nchez-Iranzo, H. et al. Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart. Proc. Natl. Acad. Sci. USA 115, 4188\u20134193 (2018).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"469_CR83","doi-asserted-by":"publisher","first-page":"621644","DOI":"10.3389\/fcell.2020.621644","volume":"8","author":"AC Silva","year":"2021","unstructured":"Silva, A. C., Pereira, C., Fonseca, A. C. R. G., Pinto-do-\u00d3, P. & Nascimento, D. S. Bearing my heart: the role of extracellular matrix on cardiac development, homeostasis, and injury response. Front. Cell Dev. Biol. 8, 621644 (2021).","journal-title":"Front. Cell Dev. Biol."},{"key":"469_CR84","first-page":"29","volume":"6","author":"L Hortells","year":"2019","unstructured":"Hortells, L., Johansen, A. K. Z. & Yutzey, K. E. Cardiac fibroblasts and the extracellular matrix in regenerative and nonregenerative hearts. J. Cardiovasc. Dev. Dis. 6, 29 (2019).","journal-title":"J. Cardiovasc. Dev. Dis."},{"key":"469_CR85","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1074\/mcp.RA118.001193","volume":"18","author":"A Garcia-Puig","year":"2019","unstructured":"Garcia-Puig, A. et al. Proteomics analysis of extracellular matrix remodeling during zebrafish heart regeneration. Mol. Cell. Proteom. 18, 1745\u20131755 (2019).","journal-title":"Mol. Cell. Proteom."},{"key":"469_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09234-6","volume":"10","author":"Y Zhou","year":"2019","unstructured":"Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10, 1523 (2019).","journal-title":"Nat. Commun."},{"key":"469_CR87","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1093\/molbev\/msx116","volume":"34","author":"S Kumar","year":"2017","unstructured":"Kumar, S., Stecher, G., Suleski, M. & Hedges, S. B. TimeTree: a resource for timelines, timetrees, and divergence times. Mol. Biol. Evol. 34, 1812\u20131819 (2017).","journal-title":"Mol. Biol. Evol."},{"key":"469_CR88","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-27880-6","volume":"8","author":"RP McDonald","year":"2018","unstructured":"McDonald, R. P. & Vickaryous, M. K. Evidence for neurogenesis in the medial cortex of the leopard gecko, Eublepharis macularius. Sci. Rep. 8, 9648 (2018).","journal-title":"Sci. Rep."},{"key":"469_CR89","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.cell.2015.10.035","volume":"163","author":"K Alkass","year":"2015","unstructured":"Alkass, K. et al. No evidence for cardiomyocyte number expansion in preadolescent mice. Cell 163, 1026\u20131036 (2015).","journal-title":"Cell"},{"key":"469_CR90","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98\u2013102 (2009).","journal-title":"Science"},{"key":"469_CR91","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1016\/j.cell.2015.05.026","volume":"161","author":"O Bergmann","year":"2015","unstructured":"Bergmann, O. et al. Dynamics of cell generation and turnover in the human heart. Cell 161, 1566\u20131575 (2015).","journal-title":"Cell"},{"key":"469_CR92","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cell.2006.08.052","volume":"127","author":"A Lepilina","year":"2006","unstructured":"Lepilina, A. et al. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127, 607\u2013619 (2006).","journal-title":"Cell"},{"key":"469_CR93","doi-asserted-by":"crossref","unstructured":"Bertelsen, M. Squamates (Snakes and Lizards). in Zoo Animal and Wildlife Immobilization and Anesthesia (eds West, G., Heard, D. & Caulkett, N.) 351\u2013363 (John Wiley & Sons, Inc., 2014).","DOI":"10.1002\/9781118792919.ch21"},{"key":"469_CR94","doi-asserted-by":"crossref","unstructured":"Williams, C. J. A. & Bertelsen, M. F. Anesthesia and analgesia in amphibians. in Anesthesia and Analgesia in Laboratory Animals (eds Fish, R. E., Danneman, P. J., Brown, M. & Karas, A.) 629\u2013646 (Elsevier, 2023).","DOI":"10.1016\/B978-0-12-822215-7.00006-8"},{"key":"469_CR95","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1161\/CIRCULATIONAHA.118.033648","volume":"138","author":"NT Lam","year":"2018","unstructured":"Lam, N. T. & Sadek, H. A. Neonatal heart regeneration. Circulation 138, 412\u2013423 (2018).","journal-title":"Circulation"},{"key":"469_CR96","first-page":"1477","volume":"243","author":"J Itou","year":"2014","unstructured":"Itou, J. et al. Regenerative responses after mild heart injuries for cardiomyocyte proliferation in zebrafish. Dev. Dyn. Publ. Am. Assoc. Anat. 243, 1477\u20131486 (2014).","journal-title":"Dev. Dyn. Publ. Am. Assoc. Anat."},{"key":"469_CR97","doi-asserted-by":"crossref","unstructured":"Liao, S. et al. Heart regeneration in adult Xenopus tropicalis after apical resection. Cell Biosci. 7, 1\u201316 (2017).","DOI":"10.1186\/s13578-017-0199-6"},{"key":"469_CR98","first-page":"4133","volume":"139","author":"J Itou","year":"2012","unstructured":"Itou, J. et al. Migration of cardiomyocytes is essential for heart regeneration in zebrafish. Dev. Camb. Engl. 139, 4133\u20134142 (2012).","journal-title":"Dev. Camb. Engl."},{"key":"469_CR99","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1038\/nature08804","volume":"464","author":"K Kikuchi","year":"2010","unstructured":"Kikuchi, K. et al. Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes. Nature 464, 601\u2013605 (2010).","journal-title":"Nature"},{"key":"469_CR100","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nprot.2016.031","volume":"11","author":"BD Polizzotti","year":"2016","unstructured":"Polizzotti, B. D., Ganapathy, B., Haubner, B., Penninger, J. & K\u00fchn, B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat. Protoc. 11, 542\u2013552 (2016).","journal-title":"Nat. Protoc."},{"key":"469_CR101","doi-asserted-by":"crossref","unstructured":"Gustavsen, K. A., Saunders, A. B., Young, B. D., Winter, R. L. & Hoppes, S. M. Echocardiographic and radiographic findings in a cohort of healthy adult green iguanas (Iguana iguana). J. Vet. Cardiol. 16, 185\u2013196 (2014).","DOI":"10.1016\/j.jvc.2014.05.002"},{"key":"469_CR102","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1002\/vms3.426","volume":"7","author":"M Bagardi","year":"2021","unstructured":"Bagardi, M. et al. Two-dimensional and doppler echocardiographic evaluation in twenty-one healthy python regius. Vet. Med. Sci. 7, 1006\u20131014 (2021).","journal-title":"Vet. Med. Sci."},{"key":"469_CR103","doi-asserted-by":"publisher","unstructured":"Dittrich, A., Thygesen, M. M. & Lauridsen, H. 2D and 3D echocardiography in the axolotl (Ambystoma mexicanum). J. Vis. Exp. https:\/\/doi.org\/10.3791\/57089 (2018).","DOI":"10.3791\/57089"},{"key":"469_CR104","unstructured":"Ashley, E. A. & Niebauer, J. Understanding the echocardiogram. In Cardiology Explained (Remedica, 2004)."},{"key":"469_CR105","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25653-w","volume":"12","author":"M Cui","year":"2021","unstructured":"Cui, M. et al. Nrf1 promotes heart regeneration and repair by regulating proteostasis and redox balance. Nat. Commun. 12, 5270 (2021).","journal-title":"Nat. Commun."},{"key":"469_CR106","doi-asserted-by":"publisher","first-page":"265","DOI":"10.15252\/emmm.201606602","volume":"9","author":"M Malek Mohammadi","year":"2017","unstructured":"Malek Mohammadi, M. et al. The transcription factor GATA 4 promotes myocardial regeneration in neonatal mice. EMBO Mol. Med. 9, 265\u2013279 (2017).","journal-title":"EMBO Mol. Med."},{"key":"469_CR107","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02650-6","volume":"9","author":"H S\u00e1nchez-Iranzo","year":"2018","unstructured":"S\u00e1nchez-Iranzo, H. et al. Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nat. Commun. 9, 428 (2018).","journal-title":"Nat. Commun."},{"key":"469_CR108","doi-asserted-by":"publisher","first-page":"3112","DOI":"10.1242\/dev.106336","volume":"141","author":"YL Schindler","year":"2014","unstructured":"Schindler, Y. L. et al. Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. Development 141, 3112\u20133122 (2014).","journal-title":"Development"},{"key":"469_CR109","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nature11139","volume":"485","author":"K Song","year":"2012","unstructured":"Song, K. et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485, 599\u2013604 (2012).","journal-title":"Nature"},{"key":"469_CR110","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1161\/CIRCULATIONAHA.123.067504","volume":"151","author":"Y Yamada","year":"2025","unstructured":"Yamada, Y. et al. Cardiac Reprogramming and Gata4 overexpression reduce fibrosis and improve diastolic dysfunction in heart failure with preserved ejection fraction. Circulation 151, 379\u2013395 (2025).","journal-title":"Circulation"},{"key":"469_CR111","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42945-w","volume":"9","author":"Z Zhang","year":"2019","unstructured":"Zhang, Z., Zhang, A. D., Kim, L. J. & Nam, Y.-J. Ensuring expression of four core cardiogenic transcription factors enhances cardiac reprogramming. Sci. Rep. 9, 6362 (2019).","journal-title":"Sci. Rep."},{"key":"469_CR112","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.stem.2013.11.007","volume":"14","author":"T Sandoval-Guzm\u00e1n","year":"2014","unstructured":"Sandoval-Guzm\u00e1n, T. et al. Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species. Cell Stem Cell 14, 174\u2013187 (2014).","journal-title":"Cell Stem Cell"},{"key":"469_CR113","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/cvr\/cvaa320","volume":"117","author":"JR Sayers","year":"2021","unstructured":"Sayers, J. R. & Riley, P. R. Heart regeneration: beyond new muscle and vessels. Cardiovasc. Res. 117, 727\u2013742 (2021).","journal-title":"Cardiovasc. Res."},{"key":"469_CR114","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68200-1","volume":"10","author":"T Bise","year":"2020","unstructured":"Bise, T., Sallin, P., Pfefferli, C. & Ja\u017awi\u0144ska, A. Multiple cryoinjuries modulate the efficiency of zebrafish heart regeneration. Sci. Rep. 10, 11551 (2020).","journal-title":"Sci. Rep."},{"key":"469_CR115","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pbio.1000412","volume":"8","author":"C Kilkenny","year":"2010","unstructured":"Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol. 8, e1000412 (2010).","journal-title":"PLoS Biol."},{"key":"469_CR116","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96050-y","volume":"11","author":"LM Ogilvie","year":"2021","unstructured":"Ogilvie, L. M. et al. A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence. Sci. Rep. 11, 17223 (2021).","journal-title":"Sci. Rep."},{"key":"469_CR117","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1016\/j.cmet.2022.04.011","volume":"34","author":"JY Lu","year":"2022","unstructured":"Lu, J. Y. et al. Comparative transcriptomics reveals circadian and pluripotency networks as two pillars of longevity regulation. Cell Metab. 34, 836\u2013856.e5 (2022).","journal-title":"Cell Metab."},{"key":"469_CR118","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","volume":"37","author":"D Kim","year":"2019","unstructured":"Kim, D., Paggi, J. M., Park, C., Bennett, C. & Salzberg, S. L. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotechnol. 37, 907\u2013915 (2019).","journal-title":"Nat. Biotechnol."},{"key":"469_CR119","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1910-1","volume":"20","author":"S Kovaka","year":"2019","unstructured":"Kovaka, S. et al. Transcriptome assembly from long-read RNA-seq alignments with StringTie2. Genome Biol. 20, 278 (2019).","journal-title":"Genome Biol."},{"key":"469_CR120","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.1093\/bioinformatics\/bts565","volume":"28","author":"L Fu","year":"2012","unstructured":"Fu, L., Niu, B., Zhu, Z., Wu, S. & Li, W. CD-HIT: accelerated for clustering the next-generation sequencing data. Bioinformatics 28, 3150\u20133152 (2012).","journal-title":"Bioinformatics"},{"key":"469_CR121","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-421","volume":"10","author":"C Camacho","year":"2009","unstructured":"Camacho, C. et al. BLAST+: architecture and applications. BMC Bioinformatics 10, 421 (2009).","journal-title":"BMC Bioinformatics"},{"key":"469_CR122","doi-asserted-by":"publisher","first-page":"D766","DOI":"10.1093\/nar\/gky955","volume":"47","author":"A Frankish","year":"2019","unstructured":"Frankish, A. et al. GENCODE reference annotation for the human and mouse genomes. Nucleic Acids Res. 47, D766\u2013D773 (2019).","journal-title":"Nucleic Acids Res."},{"key":"469_CR123","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).","journal-title":"Genome Biol."},{"key":"469_CR124","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010).","journal-title":"Bioinformatics"},{"key":"469_CR125","unstructured":"Oliveros, J. C. Venny. An interactive tool for comparing lists with Venn\u2019s diagrams. Available at: https:\/\/www.editage.com\/insights\/if-a-journals-name-and-if-change-does-this-affect-its-published-papers (2015)."}],"container-title":["npj Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00469-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00469-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00469-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:03:12Z","timestamp":1779282192000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00469-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":125,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["469"],"URL":"https:\/\/doi.org\/10.1038\/s41536-026-00469-8","relation":{},"ISSN":["2057-3995"],"issn-type":[{"value":"2057-3995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]},"assertion":[{"value":"8 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22"}}