{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:00:31Z","timestamp":1790816431622,"version":"4.1.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":136,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"NIH","award":["R21AG054830"],"award-info":[{"award-number":["R21AG054830"]}]},{"name":"NIH","award":["R01GM047607"],"award-info":[{"award-number":["R01GM047607"]}]},{"name":"NIH","award":["R01AI102893"],"award-info":[{"award-number":["R01AI102893"]}]},{"name":"NIH","award":["R21AG054830"],"award-info":[{"award-number":["R21AG054830"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL178475"],"award-info":[{"award-number":["R01HL178475"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL178475"],"award-info":[{"award-number":["R01HL178475"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"AHA","award":["18TPA34170129"],"award-info":[{"award-number":["18TPA34170129"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Regen Med"],"DOI":"10.1038\/s41536-026-00476-9","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:34:40Z","timestamp":1779118480000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paxillin in mechanosensitive spatial control of lung endothelial cell regeneration"],"prefix":"10.1038","volume":"11","author":[{"given":"Tadanori","family":"Mammoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Kyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikaela","family":"Scheer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tendai","family":"Hunyenyiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaheh","family":"Hashemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher E.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniam","family":"Malarkannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Mammoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"476_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature10144","volume":"473","author":"P Carmeliet","year":"2011","unstructured":"Carmeliet, P. & Jain, R. K. Molecular mechanisms and clinical applications of angiogenesis. Nature 473, 298\u2013307 (2011).","journal-title":"Nature"},{"key":"476_CR2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","volume":"27","author":"AS Chung","year":"2011","unstructured":"Chung, A. S. & Ferrara, N. Developmental and pathological angiogenesis. Annu. Rev. Cell Dev. Biol. 27, 563\u2013584 (2011).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"476_CR3","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3389\/fbioe.2019.00318","volume":"7","author":"A Mammoto","year":"2019","unstructured":"Mammoto, A. & Mammoto, T. Vascular niche in lung alveolar development, homeostasis, and regeneration. Front. Bioeng. Biotechnol. 7, 318 (2019).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"476_CR4","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/nature17040","volume":"529","author":"S Rafii","year":"2016","unstructured":"Rafii, S., Butler, J. M. & Ding, B. S. Angiocrine functions of organ-specific endothelial cells. Nature 529, 316\u2013325 (2016).","journal-title":"Nature"},{"key":"476_CR5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.cell.2011.10.003","volume":"147","author":"BS Ding","year":"2011","unstructured":"Ding, B. S. et al. Endothelial-derived angiocrine signals induce and sustain regenerative lung alveolarization. Cell 147, 539\u2013553 (2011).","journal-title":"Cell"},{"key":"476_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1126\/science.1244880","volume":"343","author":"J Hu","year":"2014","unstructured":"Hu, J. et al. Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science 343, 416\u2013419 (2014).","journal-title":"Science"},{"key":"476_CR7","doi-asserted-by":"publisher","first-page":"L742","DOI":"10.1152\/ajplung.00064.2006","volume":"292","author":"MK Sakurai","year":"2007","unstructured":"Sakurai, M. K. et al. Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy. Am. J. Physiol. Lung Cell Mol. Physiol. 292, L742\u2013L747 (2007).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"476_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s10456-011-9236-y","volume":"15","author":"MA Konerding","year":"2012","unstructured":"Konerding, M. A. et al. Spatial dependence of alveolar angiogenesis in post-pneumonectomy lung growth. Angiogenesis 15, 23\u201332 (2012).","journal-title":"Angiogenesis"},{"key":"476_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1165\/rcmb.2015-0045OC","volume":"54","author":"T Mammoto","year":"2016","unstructured":"Mammoto, T. et al. Platelet-rich plasma extract accelerates lung regeneration through the LRP5-Tie2 pathway. Am. J. Respir. Cell Mol. Biol. 54, 103\u2013113 (2016).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1165\/rcmb.2018-0105OC","volume":"60","author":"T Mammoto","year":"2019","unstructured":"Mammoto, T., Muyleart, M. & Mammoto, A. Endothelial YAP1 in regenerative lung growth through the angiopoietin-Tie2 pathway. Am. J. Respir. Cell Mol. Biol. 60, 117\u2013127 (2019).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR11","doi-asserted-by":"publisher","first-page":"823642","DOI":"10.3389\/fbioe.2022.823642","volume":"10","author":"T Mammoto","year":"2022","unstructured":"Mammoto, T. et al. Hydrostatic Pressure Controls Angiogenesis Through Endothelial YAP1 During Lung Regeneration. Front. Bioeng. Biotechnol. 10, 823642 (2022).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"476_CR12","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7943","volume":"6","author":"HJ Choi","year":"2015","unstructured":"Choi, H. J. et al. Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2. Nat. Commun. 6, 6943 (2015).","journal-title":"Nat. Commun."},{"key":"476_CR13","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.ajpath.2013.06.026","volume":"183","author":"T Mammoto","year":"2013","unstructured":"Mammoto, T. et al. A role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am. J. Pathol. 183, 1293\u20131305 (2013).","journal-title":"Am. J. Pathol."},{"key":"476_CR14","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/nature07765","volume":"457","author":"A Mammoto","year":"2009","unstructured":"Mammoto, A. et al. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 457, 1103\u20131108 (2009).","journal-title":"Nature"},{"key":"476_CR15","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1161\/CIRCRESAHA.116.308870","volume":"119","author":"MM Mahmoud","year":"2016","unstructured":"Mahmoud, M. M. et al. TWIST1 integrates endothelial responses to flow in vascular dysfunction and atherosclerosis. Circ. Res. 119, 450\u2013462 (2016).","journal-title":"Circ. Res."},{"key":"476_CR16","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1161\/CIRCRESAHA.108.192930","volume":"104","author":"CK Thodeti","year":"2009","unstructured":"Thodeti, C. K. et al. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ. Res. 104, 1123\u20131130 (2009).","journal-title":"Circ. Res."},{"key":"476_CR17","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1152\/japplphysiol.00635.2013","volume":"115","author":"N Filipovic","year":"2013","unstructured":"Filipovic, N. et al. Mapping cyclic stretch in the postpneumonectomy murine lung. J. Appl. Physiol. 115, 1370\u20131378 (2013).","journal-title":"J. Appl. Physiol."},{"key":"476_CR18","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1152\/japplphysiol.00503.2009","volume":"107","author":"C Yilmaz","year":"2009","unstructured":"Yilmaz, C. et al. Noninvasive quantification of heterogeneous lung growth following extensive lung resection by high-resolution computed tomography. J. Appl. Physiol. 107, 1569\u20131578 (2009).","journal-title":"J. Appl. Physiol."},{"key":"476_CR19","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1152\/japplphysiol.00527.2011","volume":"111","author":"C Yilmaz","year":"2011","unstructured":"Yilmaz, C. et al. Progressive adaptation in regional parenchyma mechanics following extensive lung resection assessed by functional computed tomography. J. Appl. Physiol. 111, 1150\u20131158 (2011).","journal-title":"J. Appl. Physiol."},{"key":"476_CR20","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1016\/j.celrep.2016.07.020","volume":"16","author":"Z Liu","year":"2016","unstructured":"Liu, Z. et al. MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration. Cell Rep. 16, 1810\u20131819 (2016).","journal-title":"Cell Rep."},{"key":"476_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1152\/japplphysiol.01213.2012","volume":"114","author":"DM Dane","year":"2013","unstructured":"Dane, D. M., Yilmaz, C., Estrera, A. S. & Hsia, C. C. Separating in vivo mechanical stimuli for postpneumonectomy compensation: physiological assessment. J. Appl. Physiol. 114, 99\u2013106 (2013).","journal-title":"J. Appl. Physiol."},{"key":"476_CR22","doi-asserted-by":"publisher","first-page":"L1279","DOI":"10.1152\/ajplung.2001.281.5.L1279","volume":"281","author":"CC Hsia","year":"2001","unstructured":"Hsia, C. C., Wu, E. Y., Wagner, E. & Weibel, E. R. Preventing mediastinal shift after pneumonectomy impairs regenerative alveolar tissue growth. Am. J. Physiol. Lung Cell Mol. Physiol. 281, L1279\u2013L1287 (2001).","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"476_CR23","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1152\/japplphysiol.00297.2016","volume":"121","author":"DM Dane","year":"2016","unstructured":"Dane, D. M. et al. Perfusion-related stimuli for compensatory lung growth following pneumonectomy. J. Appl Physiol. 121, 312\u2013323 (2016).","journal-title":"J. Appl Physiol."},{"key":"476_CR24","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1038\/ncomms2774","volume":"4","author":"A Mammoto","year":"2013","unstructured":"Mammoto, A. et al. Control of lung vascular permeability and endotoxin-induced pulmonary edema by changes in extracellular matrix mechanics. Nat. Commun. 4, 1759 (2013).","journal-title":"Nat. Commun."},{"key":"476_CR25","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1165\/rcmb.2013-0147OC","volume":"49","author":"T Mammoto","year":"2013","unstructured":"Mammoto, T., Jiang, E., Jiang, A. & Mammoto, A. ECM structure and tissue stiffness control postnatal lung development through the LRP5-Tie2 signaling system. Am. J. Respir. Cell Mol. Biol. 49, 1009\u20131018 (2013).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.eml.2018.02.003","volume":"21","author":"A Malandrino","year":"2018","unstructured":"Malandrino, A., Mak, M., Kamm, R. D. & Moeendarbary, E. Complex mechanics of the heterogeneous extracellular matrix in cancer. Extrem. Mech. Lett. 21, 25\u201334 (2018).","journal-title":"Extrem. Mech. Lett."},{"key":"476_CR27","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.devcel.2011.07.006","volume":"21","author":"T Mammoto","year":"2011","unstructured":"Mammoto, T. et al. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev. Cell 21, 758\u2013769 (2011).","journal-title":"Dev. Cell"},{"key":"476_CR28","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1002\/dvdy.24264","volume":"244","author":"T Mammoto","year":"2015","unstructured":"Mammoto, T. et al. Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Dev. Dyn. 244, 713\u2013723 (2015).","journal-title":"Dev. Dyn."},{"key":"476_CR29","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1242\/jcs.195362","volume":"130","author":"B Stutchbury","year":"2017","unstructured":"Stutchbury, B., Atherton, P., Tsang, R., Wang, D. Y. & Ballestrem, C. Distinct focal adhesion protein modules control different aspects of mechanotransduction. J. Cell Sci. 130, 1612\u20131624 (2017).","journal-title":"J. Cell Sci."},{"key":"476_CR30","doi-asserted-by":"publisher","first-page":"e28303","DOI":"10.1371\/journal.pone.0028303","volume":"6","author":"JE Sero","year":"2011","unstructured":"Sero, J. E. et al. Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS ONE 6, e28303 (2011).","journal-title":"PLoS ONE"},{"key":"476_CR31","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.cell.2012.11.034","volume":"151","author":"SV Plotnikov","year":"2012","unstructured":"Plotnikov, S. V., Pasapera, A. M., Sabass, B. & Waterman, C. M. Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell 151, 1513\u20131527 (2012).","journal-title":"Cell"},{"key":"476_CR32","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1152\/physrev.00002.2004","volume":"84","author":"MC Brown","year":"2004","unstructured":"Brown, M. C. & Turner, C. E. Paxillin: adapting to change. Physiol. Rev. 84, 1315\u20131339 (2004).","journal-title":"Physiol. Rev."},{"key":"476_CR33","first-page":"4002","volume":"144","author":"M Rashid","year":"2017","unstructured":"Rashid, M., Belmont, J., Carpenter, D., Turner, C. E. & Olson, E. C. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development 144, 4002\u20134014 (2017).","journal-title":"Development"},{"key":"476_CR34","doi-asserted-by":"publisher","first-page":"502","DOI":"10.4161\/cam.21672","volume":"6","author":"JE Sero","year":"2012","unstructured":"Sero, J. E., German, A. E., Mammoto, A. & Ingber, D. E. Paxillin controls directional cell motility in response to physical cues. Cell Adh. Migr. 6, 502\u2013508 (2012).","journal-title":"Cell Adh. Migr."},{"key":"476_CR35","doi-asserted-by":"publisher","first-page":"E231","DOI":"10.1038\/35046659","volume":"2","author":"CE Turner","year":"2000","unstructured":"Turner, C. E. Paxillin and focal adhesion signalling. Nat. Cell Biol. 2, E231\u2013E236 (2000).","journal-title":"Nat. Cell Biol."},{"key":"476_CR36","doi-asserted-by":"crossref","unstructured":"Xu, W., Gulvady, A. C., Goreczny, G. J., Olson, E. C. & Turner, C. E. Paxillin-dependent regulation of apical-basal polarity in mammary gland morphogenesis. Development 146, dev174367 (2019).","DOI":"10.1242\/dev.174367"},{"key":"476_CR37","doi-asserted-by":"publisher","first-page":"28787","DOI":"10.1074\/jbc.M110.134064","volume":"285","author":"A Sen","year":"2010","unstructured":"Sen, A. et al. Paxillin regulates androgen- and epidermal growth factor-induced MAPK signaling and cell proliferation in prostate cancer cells. J. Biol. Chem. 285, 28787\u201328795 (2010).","journal-title":"J. Biol. Chem."},{"key":"476_CR38","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1177\/1947601912458582","volume":"3","author":"NO Deakin","year":"2012","unstructured":"Deakin, N. O., Pignatelli, J. & Turner, C. E. Diverse roles for the paxillin family of proteins in cancer. Genes Cancer 3, 362\u2013370 (2012).","journal-title":"Genes Cancer"},{"key":"476_CR39","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1242\/jcs.132316","volume":"127","author":"AE German","year":"2014","unstructured":"German, A. E., Mammoto, T., Jiang, E., Ingber, D. E. & Mammoto, A. Paxillin controls endothelial cell migration and tumor angiogenesis by altering Neuropilin2 expression. J. Cell Sci. 127, 1672\u20131683 (2014).","journal-title":"J. Cell Sci."},{"key":"476_CR40","doi-asserted-by":"crossref","unstructured":"Scheer, M., Kyi, P., Mammoto, T. & Mammoto, A. Alveolar epithelial paxillin in postnatal lung alveolar development. Biol Open 14, bio061939 (2025).","DOI":"10.1242\/bio.061939"},{"key":"476_CR41","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1165\/rcmb.2014-0076OC","volume":"52","author":"T Mammoto","year":"2015","unstructured":"Mammoto, T., Jiang, A., Jiang, E. & Mammoto, A. Platelet-rich-plasma extract prevents pulmonary edema through angiopoietin-Tie2 Signaling. Am. J. Respir. Cell Mol. Biol. 52, 56\u201364 (2015).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR42","doi-asserted-by":"publisher","first-page":"e40484","DOI":"10.1371\/journal.pone.0040484","volume":"7","author":"V Deleuze","year":"2012","unstructured":"Deleuze, V. et al. Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1, and LMO2 in endothelial cells. PLoS ONE 7, e40484 (2012).","journal-title":"PLoS ONE"},{"key":"476_CR43","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nature09002","volume":"465","author":"Y Wang","year":"2010","unstructured":"Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465, 483\u2013486 (2010).","journal-title":"Nature"},{"key":"476_CR44","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1165\/rcmb.2008-0099OC","volume":"40","author":"AA Birukova","year":"2009","unstructured":"Birukova, A. A., Cokic, I., Moldobaeva, N. & Birukov, K. G. Paxillin is involved in the differential regulation of endothelial barrier by HGF and VEGF. Am. J. Respir. Cell Mol. Biol. 40, 99\u2013107 (2009).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR45","doi-asserted-by":"crossref","unstructured":"Hunyenyiwa, T. K. et al. Inhibition of angiogenesis and regenerative lung growth in Lepob\/ob mice through adiponectin-VEGF\/VEGFR2 signaling. Front. Cardiovasc. Med. 11, 1491971 (2024).","DOI":"10.3389\/fcvm.2024.1491971"},{"key":"476_CR46","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1038\/s41586-020-2822-7","volume":"586","author":"A Gillich","year":"2020","unstructured":"Gillich, A. et al. Capillary cell-type specialization in the alveolus. Nature 586, 785\u2013789 (2020).","journal-title":"Nature"},{"key":"476_CR47","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1161\/CIRCULATIONAHA.120.052318","volume":"144","author":"JC Schupp","year":"2021","unstructured":"Schupp, J. C. et al. Integrated single-cell atlas of endothelial cells of the human lung. Circulation 144, 286\u2013302 (2021).","journal-title":"Circulation"},{"key":"476_CR48","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.devcel.2020.01.009","volume":"52","author":"L Vila Ellis","year":"2020","unstructured":"Vila Ellis, L. et al. Epithelial vegfa specifies a distinct endothelial population in the mouse lung. Dev. Cell 52, 617\u2013630.e616 (2020).","journal-title":"Dev. Cell"},{"key":"476_CR49","doi-asserted-by":"crossref","unstructured":"Niethamer, T. K. et al. Defining the role of pulmonary endothelial cell heterogeneity in the response to acute lung injury. eLife 9, e53072 (2020).","DOI":"10.7554\/eLife.53072"},{"key":"476_CR50","doi-asserted-by":"publisher","first-page":"3042","DOI":"10.1016\/j.devcel.2021.10.020","volume":"56","author":"JM Gomez-Salinero","year":"2021","unstructured":"Gomez-Salinero, J. M., Itkin, T. & Rafii, S. Developmental angiocrine diversification of endothelial cells for organotypic regeneration. Dev. Cell 56, 3042\u20133051 (2021).","journal-title":"Dev. Cell"},{"key":"476_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-38177-2","volume":"14","author":"F Bian","year":"2023","unstructured":"Bian, F. et al. Lung endothelial cells regulate pulmonary fibrosis through FOXF1\/R-Ras signaling. Nat. Commun. 14, 2560 (2023).","journal-title":"Nat. Commun."},{"key":"476_CR52","doi-asserted-by":"publisher","first-page":"1172114","DOI":"10.3389\/fcell.2023.1172114","volume":"11","author":"D Bishop","year":"2023","unstructured":"Bishop, D., Schwarz, Q. & Wiszniak, S. Endothelial-derived angiocrine factors as instructors of embryonic development. Front. Cell Dev. Biol. 11, 1172114 (2023).","journal-title":"Front. Cell Dev. Biol."},{"key":"476_CR53","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1038\/s41556-020-0542-8","volume":"22","author":"Y Kobayashi","year":"2020","unstructured":"Kobayashi, Y. et al. Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nat. Cell Biol. 22, 934\u2013946 (2020).","journal-title":"Nat. Cell Biol."},{"key":"476_CR54","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1080\/19336918.2016.1215785","volume":"10","author":"D Ito","year":"2016","unstructured":"Ito, D. & Kumanogoh, A. The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems. Cell Adh. Migr. 10, 692\u2013699 (2016).","journal-title":"Cell Adh. Migr."},{"key":"476_CR55","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1158\/1078-0432.CCR-09-1810","volume":"15","author":"P Gaur","year":"2009","unstructured":"Gaur, P. et al. Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin. Cancer Res. 15, 6763\u20136770 (2009).","journal-title":"Clin. Cancer Res."},{"key":"476_CR56","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28693-y","volume":"13","author":"M Garcia-Garcia","year":"2022","unstructured":"Garcia-Garcia, M. et al. Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP. Nat. Commun. 13, 1174 (2022).","journal-title":"Nat. Commun."},{"key":"476_CR57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/annurev-cellbio-101512-122340","volume":"29","author":"T Mammoto","year":"2013","unstructured":"Mammoto, T., Mammoto, A. & Ingber, D. E. Mechanobiology and developmental control. Annu. Rev. Cell Dev. Biol. 29, 27\u201361 (2013).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"476_CR58","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1006\/excr.1999.4540","volume":"250","author":"M Ruhl","year":"1999","unstructured":"Ruhl, M. et al. Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase Erk2 in fibroblasts. Exp. Cell Res. 250, 548\u2013557 (1999).","journal-title":"Exp. Cell Res."},{"key":"476_CR59","doi-asserted-by":"publisher","first-page":"109382","DOI":"10.1016\/j.cellsig.2019.109382","volume":"63","author":"A Husari","year":"2019","unstructured":"Husari, A. et al. On the relationship of YAP and FAK in hMSCs and osteosarcoma cells: discrimination of FAK modulation by nuclear YAP depletion or YAP silencing. Cell Signal. 63, 109382 (2019).","journal-title":"Cell Signal."},{"key":"476_CR60","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.stem.2017.03.023","volume":"21","author":"JK Hu","year":"2017","unstructured":"Hu, J. K. et al. An FAK-YAP-mTOR signaling axis regulates stem cell-based tissue renewal in mice. Cell Stem Cell 21, 91\u2013106.e106 (2017).","journal-title":"Cell Stem Cell"},{"key":"476_CR61","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/s41556-021-00702-0","volume":"23","author":"S Wang","year":"2021","unstructured":"Wang, S. et al. CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP\/TAZ signalling. Nat. Cell Biol. 23, 758\u2013770 (2021).","journal-title":"Nat. Cell Biol."},{"key":"476_CR62","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.kint.2022.10.007","volume":"103","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. Kidney tubular transcription co-activator, Yes-associated protein 1 (YAP), controls the expression of collecting duct aquaporins and water homeostasis. Kidney Int. 103, 501\u2013513 (2023).","journal-title":"Kidney Int."},{"key":"476_CR63","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07660-6","volume":"9","author":"SC Liu","year":"2018","unstructured":"Liu, S. C. et al. Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK\/PXN signaling. Nat. Commun. 9, 5105 (2018).","journal-title":"Nat. Commun."},{"key":"476_CR64","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/ncb1607","volume":"9","author":"H Iioka","year":"2007","unstructured":"Iioka, H., Iemura, S., Natsume, T. & Kinoshita, N. Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility. Nat. Cell Biol. 9, 813\u2013821 (2007).","journal-title":"Nat. Cell Biol."},{"key":"476_CR65","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1091\/mbc.e09-01-0046","volume":"20","author":"M Mori","year":"2009","unstructured":"Mori, M. et al. Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. Mol. Biol. Cell 20, 3115\u20133124 (2009).","journal-title":"Mol. Biol. Cell"},{"key":"476_CR66","doi-asserted-by":"crossref","unstructured":"Hendee, K. et al. Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration. Aging 13, 7781-7799 (2021).","DOI":"10.18632\/aging.202875"},{"key":"476_CR67","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1160\/th13-12-1031","volume":"112","author":"C Veith","year":"2014","unstructured":"Veith, C. et al. Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1alpha depletion or imatinib treatment. Thromb. Haemost. 112, 1288\u20131303 (2014).","journal-title":"Thromb. Haemost."},{"key":"476_CR68","doi-asserted-by":"crossref","unstructured":"Kyi, P. et al. Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression. Front. Med. 20, 908639 (2022).","DOI":"10.3389\/fmed.2022.908639"},{"key":"476_CR69","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1161\/CIRCRESAHA.120.317025","volume":"127","author":"JT Brash","year":"2020","unstructured":"Brash, J. T. et al. Tamoxifen-activated CreERT impairs retinal angiogenesis independently of gene deletion. Circ. Res. 127, 849\u2013850 (2020).","journal-title":"Circ. Res."},{"key":"476_CR70","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3109\/01902149009087879","volume":"16","author":"TB Zeltner","year":"1990","unstructured":"Zeltner, T. B., Bertacchini, M., Messerli, A. & Burri, P. H. Morphometric estimation of regional differences in the rat lung. Exp. Lung Res. 16, 145\u2013158 (1990).","journal-title":"Exp. Lung Res."},{"key":"476_CR71","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1136\/thx.5.3.207","volume":"5","author":"P Marchand","year":"1950","unstructured":"Marchand, P., Gilroy, J. C. & Wilson, V. H. An anatomical study of the bronchial vascular system and its variations in disease. Thorax 5, 207\u2013221 (1950).","journal-title":"Thorax"},{"key":"476_CR72","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.biocel.2003.11.002","volume":"36","author":"SE Herrick","year":"2004","unstructured":"Herrick, S. E. & Mutsaers, S. E. Mesothelial progenitor cells and their potential in tissue engineering. Int. J. Biochem. Cell Biol. 36, 621\u2013642 (2004).","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"476_CR73","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1146\/annurev-pathol-012513-104644","volume":"10","author":"JA Whitsett","year":"2015","unstructured":"Whitsett, J. A., Wert, S. E. & Weaver, T. E. Diseases of pulmonary surfactant homeostasis. Annu. Rev. Pathol. 10, 371\u2013393 (2015).","journal-title":"Annu. Rev. Pathol."},{"key":"476_CR74","first-page":"463","volume":"2","author":"L Plantier","year":"2007","unstructured":"Plantier, L., Boczkowski, J. & Crestani, B. Defect of alveolar regeneration in pulmonary emphysema: role of lung fibroblasts. Int. J. Chron. Obstruct Pulmon Dis. 2, 463\u2013469 (2007).","journal-title":"Int. J. Chron. Obstruct Pulmon Dis."},{"key":"476_CR75","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1513\/pats.200605-127SF","volume":"3","author":"D Massaro","year":"2006","unstructured":"Massaro, D. & Massaro, G. D. Toward therapeutic pulmonary alveolar regeneration in humans. Proc. Am. Thorac. Soc. 3, 709\u2013712 (2006).","journal-title":"Proc. Am. Thorac. Soc."},{"key":"476_CR76","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21865-2","volume":"12","author":"M Hurskainen","year":"2021","unstructured":"Hurskainen, M. et al. Single cell transcriptomic analysis of murine lung development on hyperoxia-induced damage. Nat. Commun. 12, 1565 (2021).","journal-title":"Nat. Commun."},{"key":"476_CR77","doi-asserted-by":"crossref","unstructured":"Zhang, L. et al. Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations. JCI Insight 7, e158079 (2022).","DOI":"10.1172\/jci.insight.158079"},{"key":"476_CR78","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1165\/rcmb.2016-0323OC","volume":"58","author":"T Mammoto","year":"2018","unstructured":"Mammoto, T., Muyleart, M., Konduri, G. G. & Mammoto, A. Twist1 in hypoxia-induced pulmonary hypertension through TGF\u03b2-Smad signaling. Am. J. Respir. Cell Mol. Biol. 58, 194\u2013207 (2018).","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"476_CR79","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1101\/gad.1602907","volume":"21","author":"B Zhao","year":"2007","unstructured":"Zhao, B. et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21, 2747\u20132761 (2007).","journal-title":"Genes Dev."},{"key":"476_CR80","doi-asserted-by":"publisher","first-page":"100241","DOI":"10.1016\/j.xpro.2020.100241","volume":"2","author":"Q Chen","year":"2021","unstructured":"Chen, Q. & Liu, Y. Isolation and culture of mouse alveolar type II cells to study type II to type I cell differentiation. STAR Protoc. 2, 100241 (2021).","journal-title":"STAR Protoc."},{"key":"476_CR81","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","volume":"184","author":"Y Hao","year":"2021","unstructured":"Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573\u20133587.e3529 (2021).","journal-title":"Cell"},{"key":"476_CR82","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","volume":"172","author":"X Han","year":"2018","unstructured":"Han, X. et al. Mapping the mouse cell atlas microwell Seq. Cell 172, 1091\u20131107.e1017 (2018).","journal-title":"Cell"},{"key":"476_CR83","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-015-0844-5","volume":"16","author":"G Finak","year":"2015","unstructured":"Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 278 (2015).","journal-title":"Genome Biol."},{"key":"476_CR84","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/s41586-019-0969-x","volume":"566","author":"J Cao","year":"2019","unstructured":"Cao, J. et al. The single-cell transcriptional landscape of mammalian organogenesis. Nature 566, 496\u2013502 (2019).","journal-title":"Nature"},{"key":"476_CR85","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","volume":"560","author":"G La Manno","year":"2018","unstructured":"La Manno, G. et al. RNA velocity of single cells. Nature 560, 494\u2013498 (2018).","journal-title":"Nature"},{"key":"476_CR86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28857-1","volume":"8","author":"SD Sackett","year":"2018","unstructured":"Sackett, S. D. et al. Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas. Sci. Rep. 8, 10452 (2018).","journal-title":"Sci. Rep."},{"key":"476_CR87","doi-asserted-by":"crossref","unstructured":"Mammoto, T. & Mammoto, A. Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis. J. Vis. Exp. 21, 52012 (2014).","DOI":"10.3791\/52012-v"}],"container-title":["npj Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00476-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00476-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00476-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:02:58Z","timestamp":1790812978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00476-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":87,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["476"],"URL":"https:\/\/doi.org\/10.1038\/s41536-026-00476-9","relation":{},"ISSN":["2057-3995"],"issn-type":[{"value":"2057-3995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"assertion":[{"value":"24 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"39"}}