{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:34:28Z","timestamp":1792510468255,"version":"4.5.0"},"reference-count":0,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Japanese Agency for Medical Research and Development","award":["JP23ym0126124"],"award-info":[{"award-number":["JP23ym0126124"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Regen Med"],"DOI":"10.1038\/s41536-026-00491-w","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:06:34Z","timestamp":1783667194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tie2-enriched nucleus pulposus cell transplantation enables severity-independent disc repair in a canine model with induced and controlled disc degeneration severity"],"prefix":"10.1038","author":[{"given":"Jordy","family":"Schol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Warita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takano","family":"Susumu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Kawachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Tamagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Ogasawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,10]]},"container-title":["npj Regenerative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00491-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:06:34Z","timestamp":1783667194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41536-026-00491-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,10]]},"references-count":0,"alternative-id":["491"],"URL":"https:\/\/doi.org\/10.1038\/s41536-026-00491-w","relation":{},"ISSN":["2057-3995"],"issn-type":[{"value":"2057-3995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,10]]},"assertion":[{"value":"17 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Takayuki Warita and Asami Kawachi are paid employees of TUNZ Pharma Inc. Takafumi Konishi serves as Chief Executive Officer of Nippon Zoki Pharmaceutical Co., Ltd., a corporate sponsor of this study. Daisuke Sakai has received consulting fees from TUNZ Pharma Inc. Daisuke Sakai and Erika Matsushita are inventors on multiple patents and patent applications assigned to Tokai University and\/or Nippon Zoki Pharmaceutical Co., Ltd. relating to nucleus pulposus cell evaluation, intervertebral disc regeneration, and the culture of Tie2-positive stem\/progenitor cell-containing populations. Relevant granted patents include JP5863639B2, JP6712740B1, JP6779492B2, JP6905234B2, JP7421182B2, JP7554436B2, and JP7626993B2, as well as earlier foundational patents (e.g., JP4036881B2, expired). A related patent application is pending (JP2025036316A). Additionally, Jordy Schol and Daisuke Sakai are co-inventors on patent assigned to Tokai University and\/or Kyoto University relating to the generation of nucleus pulposus and progenitor cells via transcription factor-based approaches (JP7298858B2 and JP7388755B2). The study design, data collection, data analysis, interpretation of results, and manuscript preparation were conducted independently of the funding sources. The other authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}