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This paper focused on an in-depth review compiling the most recent information on health benefits of insect bioactive metabolites as well as their purification and identification, in addition to consumer attitudes towards edible insects. It was found that, insect bioactive metabolites, including marcocarpal, grandinol, trolline, pancratistatin, narciclasin, ungeremin, cantharidin, cordycepin, roseoflavin, lecithin, reblastatin, chitin, chitosan and desmosterol deemed to have biological activities, such as tumor suppression, anticancer, antihypertensive, anti-inflammatory, antioxidant, immunomodulator, neuroprotective, glycemic and lipid regulation, blood pressure reduction, regulation of intestinal bacterial flora and cardiovascular protection among others. Furthermore, proper sample preparation and extraction is the first step in the purification of bioactive metabolites from edible insects. After concentration, bioactive metabolites are purified using chromatographic and separation techniques including High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Thin-Layer Chromatography (TLC), Size-Exclusion Chromatography (SEC). Finally, their nutritional potential, health benefits, environmentally friendly, great taste, traditions, taboo, safety concerns, unpleasant past experiences, allergies, and unnaturalness are among the main factors influencing attitudes towards insect consumption.<\/jats:p>","DOI":"10.1038\/s41538-025-00549-x","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T12:43:38Z","timestamp":1758890618000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Potential health benefits of insect bioactive metabolites and consumer attitudes towards edible insects"],"prefix":"10.1038","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-4040","authenticated-orcid":false,"given":"Jackson","family":"Ishara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2254-9584","authenticated-orcid":false,"given":"Idaresit","family":"Ekaette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-7166","authenticated-orcid":false,"given":"Rehema","family":"Matendo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9172-7595","authenticated-orcid":false,"given":"Grant","family":"Vandenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-4041","authenticated-orcid":false,"given":"Saliou","family":"Niassy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1146-8808","authenticated-orcid":false,"given":"Karume","family":"Katcho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-5599","authenticated-orcid":false,"given":"John","family":"Kinyuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"549_CR1","first-page":"125","volume":"11","author":"UN Desa","year":"2019","unstructured":"Desa, U. 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