{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:23:16Z","timestamp":1789233796391,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Traditional Chinese Medicine and Ethnic Medicine of Guizhou Province","award":["[QZYY-2025-185]"],"award-info":[{"award-number":["[QZYY-2025-185]"]}]},{"name":"Traditional Chinese Medicine and Ethnic Medicine of Guizhou Province","award":["[QZYY-2025-185]"],"award-info":[{"award-number":["[QZYY-2025-185]"]}]},{"name":"Traditional Chinese Medicine and Ethnic Medicine of Guizhou Province","award":["[QZYY-2025-185]"],"award-info":[{"award-number":["[QZYY-2025-185]"]}]},{"name":"Traditional Chinese Medicine and Ethnic Medicine of Guizhou Province","award":["[QZYY-2025-185]"],"award-info":[{"award-number":["[QZYY-2025-185]"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Sci Food"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Mulberroside A, naturally existent from the mulberry plant, is known for its diverse biological activities. Our research indicates that mulberroside A may possess significant anti-aging effects. We assessed its anti-aging properties using naturally aging animal models and by inducing senescence in human-derived endothelial cells and mouse-derived endothelial cells through treatment with angiotensin II. We found that mulberroside A promotes the proliferation of HMEC-1 and bEnd.3 endothelial cells, while significantly reducing the levels of senescence biomarkers p16, p21, and Rb in both these endothelial cell types and in the hippocampus, kidney, spleen and liver of naturally aging animals. Additionally, mulberroside A was found to mitigate telomerase depletion in the blood of naturally aging animals, enhance the body\u2019s resistance ability to oxidative stress, and inhibit the overexpression of inflammatory factors in vivo.<\/jats:p>","DOI":"10.1038\/s41538-025-00559-9","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:08:16Z","timestamp":1759234096000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In vitro and in vivo investigation of the capacity of mulberroside A to inhibit senescence"],"prefix":"10.1038","volume":"9","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"559_CR1","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1042\/CS20230140","volume":"137","author":"N Rex","year":"2023","unstructured":"Rex, N., Melk, A. & Schmitt, R. Cellular senescence and kidney aging. Clin. Sci. 137, 1805\u20131821 (2023).","journal-title":"Clin. Sci."},{"key":"559_CR2","doi-asserted-by":"publisher","first-page":"15468","DOI":"10.3390\/ijms242015468","volume":"24","author":"D Holmannova","year":"2023","unstructured":"Holmannova, D. et al. Nongenomic hallmarks of aging-the review. Int. J. Mol. Sci. 24, 15468 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"559_CR3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43491-w","volume":"14","author":"YH Kim","year":"2023","unstructured":"Kim, Y. H. et al. Mid-old cells are a potential target for anti-aging interventions in the elderly. Nat. Commun. 14, 7619 (2023).","journal-title":"Nat. Commun."},{"key":"559_CR4","doi-asserted-by":"publisher","first-page":"101275","DOI":"10.1016\/j.smim.2019.04.003","volume":"40","author":"LGPL Prata","year":"2018","unstructured":"Prata, L. G. P. L., Ovsyannikova, I. G., Tchkonia, T. & Kirkland, J. L. 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