{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T19:00:12Z","timestamp":1785870012738,"version":"3.56.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005270","name":"Fujian Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2024N0006"],"award-info":[{"award-number":["2024N0006"]}],"id":[{"id":"10.13039\/501100005270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Sci Food"],"DOI":"10.1038\/s41538-025-00641-2","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T10:55:51Z","timestamp":1765536951000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Volvariella volvacea polysaccharides alleviate acute liver injury by modulating Nrf2\/NF-\u03baB pathway in a dual manner"],"prefix":"10.1038","volume":"9","author":[{"given":"Xiaomin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengpei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linna","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anyan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baisheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"641_CR1","first-page":"47","volume":"32","author":"HP Li","year":"2024","unstructured":"Li, H. P. et al. Resistance identification of 42 Volvariella volvacea strains to Trichoderma viride and Tyrophagus putrescentiae. Edible Med. Mushrooms 32, 47\u201351 (2024).","journal-title":"Edible Med. Mushrooms"},{"key":"641_CR2","unstructured":"Yan, Z. K. Chinese Dietary Therapeutic Materia Medica (China Press of Traditional Chinese Medicine, 2018)."},{"key":"641_CR3","first-page":"323","volume":"31","author":"ES Wu","year":"2023","unstructured":"Wu, E. S., Li, H., Lu, J., Li, Y. J. & Zhao, X. Y. The comparative analysis of nutrient composition of five Volvariella volvacea varieties. Edible Med. Mushrooms 31, 323\u2013326 (2023).","journal-title":"Edible Med. Mushrooms"},{"key":"641_CR4","unstructured":"Yang, J. H. Antioxidation, anti-inflammatory and immunomodulatory activities of polysaccharides from Volvariella volvacea (Jilin Agricultural University, 2017)."},{"key":"641_CR5","doi-asserted-by":"publisher","first-page":"e0179426","DOI":"10.1371\/journal.pone.0179426","volume":"12","author":"E Tasaki","year":"2017","unstructured":"Tasaki, E., Sakurai, H., Nitao, M., Matsuura, K. & Iuchi, Y. Uric acid, an important antioxidant contributing to survival in termites. PLoS ONE 12, e0179426 (2017).","journal-title":"PLoS ONE"},{"key":"641_CR6","first-page":"409","volume":"39","author":"CY Liu","year":"2020","unstructured":"Liu, C. Y. et al. Protective effects of polysaccharides from post-harvest waste substrate of Cordyceps militaris MF27 on oxidative damage to liver cells. Mycosystema 39, 409\u2013420 (2020).","journal-title":"Mycosystema"},{"key":"641_CR7","first-page":"2635","volume":"39","author":"QS Chen","year":"2023","unstructured":"Chen, Q. S. et al. Evodiamine-mediated mitochondrial apoptosis pathway protects L-O2 liver cell injury induced by H2O2. Chin. J. Clin. Pharmacol. 39, 2635\u20132639 (2023).","journal-title":"Chin. J. Clin. Pharmacol."},{"key":"641_CR8","first-page":"703","volume":"59","author":"HF Huang","year":"2024","unstructured":"Huang, H. F. et al. Chaihu Shugan granules improve tetrachloromethane-induced acute liver injury in mice through regulating the Keap1-Nrf2\/HO-1 signal pathway. Chin. Pharm. J. 59, 703\u2013712 (2024).","journal-title":"Chin. Pharm. J."},{"key":"641_CR9","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.jhep.2024.06.016","volume":"81","author":"V Taru","year":"2024","unstructured":"Taru, V., Szabo, G., Mehal, W. & Reiberger, T. Inflammasomes in chronic liver disease: hepatic injury, fibrosis progression and systemic inflammation. J. Hepatol. 81, 895\u2013910 (2024).","journal-title":"J. Hepatol."},{"key":"641_CR10","doi-asserted-by":"publisher","first-page":"155100","DOI":"10.1016\/j.phymed.2023.155100","volume":"121","author":"S Datta","year":"2023","unstructured":"Datta, S. et al. Hepatoprotective effects of natural drugs: current trends, scope, relevance and future perspectives. Phytomedicine 121, 155100 (2023).","journal-title":"Phytomedicine"},{"key":"641_CR11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/s41575-023-00759-2","volume":"20","author":"DQ Huang","year":"2023","unstructured":"Huang, D. Q. et al. Global epidemiology of cirrhosis - aetiology, trends and predictions. Nat. Rev. Gastroenterol. Hepatol. 20, 388\u2013398 (2023).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"641_CR12","first-page":"4866","volume":"54","author":"L Tang","year":"2023","unstructured":"Tang, L. et al. Anti-oxidative protection of Panax japonicus polysaccharide on CCl4-induced acute liver injury in rats based on Nrf2-ARE signaling pathway. Chin. Tradit. Herb. Drugs 54, 4866\u20134873 (2023).","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"641_CR13","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1038\/s41419-018-1136-2","volume":"9","author":"CS Dai","year":"2018","unstructured":"Dai, C. S. et al. Chloroquine ameliorates tetrachloromethane-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis. Cell Death Dis. 9, 1164 (2018).","journal-title":"Cell Death Dis."},{"key":"641_CR14","doi-asserted-by":"publisher","first-page":"6858","DOI":"10.1039\/C9FO01808E","volume":"10","author":"GW Shu","year":"2019","unstructured":"Shu, G. W., Qiu, Y. H., Hao, J., Fu, Q. & Deng, X. K. \u03b3-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK\/GSK3\u03b2\/Nrf2 and NF-\u03baB signaling pathways. Food Funct. 10, 6858\u20136872 (2019).","journal-title":"Food Funct."},{"key":"641_CR15","first-page":"1098","volume":"40","author":"L Yang","year":"2016","unstructured":"Yang, L., Deng, J. & Deng, Z. H. Research progress on the relationship between NF-\u03baB and its gene polymorphisms and inflammation and tumors. Guizhou Med. J. 40, 1098\u20131100 (2016).","journal-title":"Guizhou Med. J."},{"key":"641_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1177542","volume":"14","author":"C Zhao","year":"2023","unstructured":"Zhao, C., Xiao, C., Feng, S. & Bai, J. Artemisitene alters LPS-induced oxidative stress, inflammation and ferroptosis in liver through Nrf2\/HO-1 and NF-\u03baB pathway. Front. Pharmacol. 14, 1177542 (2023).","journal-title":"Front. Pharmacol."},{"key":"641_CR17","doi-asserted-by":"publisher","first-page":"4192","DOI":"10.3390\/molecules27134192","volume":"27","author":"P Gong","year":"2022","unstructured":"Gong, P. et al. Structural characteristics, antioxidant and hypoglycemic activities of polysaccharide from Siraitia grosvenorii. Molecules 27, 4192 (2022).","journal-title":"Molecules"},{"key":"641_CR18","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1002\/stem.1764","volume":"32","author":"J Jang","year":"2014","unstructured":"Jang, J., Wang, Y., Kim, H. S., Lalli, M. A. & Kosik, K. S. Nrf2, a regulator of the proteasome, controls self-renewal and pluripotency in human embryonic stem cells. Stem Cells 32, 2616\u20132625 (2014).","journal-title":"Stem Cells"},{"key":"641_CR19","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s13046-021-02062-x","volume":"40","author":"X Xuan","year":"2021","unstructured":"Xuan, X. et al. Phosphorylation of NF-\u03baBp65 drives inflammation-mediated hepatocellular carcinogenesis and is a novel therapeutic target. J. Exp. Clin. Cancer Res. 40, 253 (2021).","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"641_CR20","unstructured":"Yang, Y. Protective Effect of Ganoderma lucidum polysaccharide on acute liver injury and its impact on intestinal microbiota. (Beihua University, 2024)."},{"key":"641_CR21","unstructured":"Fan, G. L. Preparation of Cordyceps militaris polysaccharide effervescent tablets and its protective effect on CCl\u2084-induced acute liver injury in mice. (Xihua University, 2020)."},{"key":"641_CR22","first-page":"4396","volume":"22","author":"WN Ma","year":"2016","unstructured":"Ma, W. N. & Meng, Y. J. Action mechanism and clinical application progress of lentinan. Med. Recapitul. 22, 4396\u20134399 (2016).","journal-title":"Med. Recapitul."},{"key":"641_CR23","unstructured":"Zhang, X. X. Polygonatum sibiricum polysaccharide alleviates CCl\u2084-induced acute liver injury in rats via the PI3K\/AKT\/mTOR pathway. (Anhui Agricultural University, 2023)."},{"key":"641_CR24","first-page":"7714","volume":"55","author":"SY Yang","year":"2024","unstructured":"Yang, S. Y. et al. Prophylactic effect and mechanism of protocatechuic aldehyde on cyclophosphamide-induced acute liver injury. Chin. Tradit. Herb. Drugs 55, 7714\u20137723 (2024).","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"641_CR25","doi-asserted-by":"publisher","first-page":"164808","DOI":"10.1016\/j.scitotenv.2023.164808","volume":"892","author":"Y Tang","year":"2023","unstructured":"Tang, Y. et al. Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine. Sci. Total Environ. 892, 164808 (2023).","journal-title":"Sci. Total Environ."},{"key":"641_CR26","first-page":"421","volume":"39","author":"CY Liu","year":"2020","unstructured":"Liu, C. Y. et al. A comparative study of intracellular and extracellular polysaccharides in mycelia of Cordyceps cicadae against oxidative damage of hepatocytes. Mycosystema 39, 421\u2013433 (2020).","journal-title":"Mycosystema"},{"key":"641_CR27","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s10719-021-10013-z","volume":"38","author":"QY Li","year":"2021","unstructured":"Li, Q. Y. et al. Effect of steaming process on the structural characteristics and antioxidant activities of polysaccharides from Polygonatum sibiricum rhizomes. Glycoconj. J. 38, 561\u2013572 (2021).","journal-title":"Glycoconj. J."},{"key":"641_CR28","first-page":"124","volume":"45","author":"XY Zhou","year":"2024","unstructured":"Zhou, X. Y. et al. Research progress on the effect of molecular weight on the biological activity of polysaccharides. J. Henan Univ. Technol. (Nat. Sci. Ed.) 45, 124\u2013132 (2024).","journal-title":"J. Henan Univ. Technol. (Nat. Sci. Ed.)"},{"key":"641_CR29","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","volume":"53","author":"Q Ma","year":"2013","unstructured":"Ma, Q. Role of Nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 53, 401\u2013426 (2013).","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"641_CR30","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3390\/antiox9100980","volume":"9","author":"M Galicia-Moreno","year":"2020","unstructured":"Galicia-Moreno, M. et al. Roles of Nrf2 in liver diseases: molecular, pharmacological, and epigenetic aspects. Antioxidants 9, 980 (2020).","journal-title":"Antioxidants"},{"key":"641_CR31","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/med.21257","volume":"32","author":"S Magesh","year":"2012","unstructured":"Magesh, S., Chen, Y. & Hu, L. Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents. Med. Res. Rev. 32, 687\u2013726 (2012).","journal-title":"Med. Res. Rev."},{"key":"641_CR32","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1007\/s00011-019-01241-z","volume":"68","author":"SM Abd El-Twab","year":"2019","unstructured":"Abd El-Twab, S. M. et al. Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-\u03baB\/NLRP3 inflammasome activation and up-regulating Nrf2\/ARE\/HO-1 signaling. Inflamm. Res. 68, 511\u2013523 (2019).","journal-title":"Inflamm. Res."},{"key":"641_CR33","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.yexcr.2017.10.020","volume":"361","author":"Y Yang","year":"2017","unstructured":"Yang, Y. et al. Hemoglobin pretreatment endows rat cortical astrocytes resistance to hemin-induced toxicity via Nrf2\/HO-1 pathway. Exp. Cell Res. 361, 217\u2013224 (2017).","journal-title":"Exp. Cell Res."},{"key":"641_CR34","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/cld.562","volume":"8","author":"G Kasarala","year":"2016","unstructured":"Kasarala, G. & Tillmann, H. L. Standard liver tests. Clin. Liver Dis. 8, 13\u201318 (2016).","journal-title":"Clin. Liver Dis."},{"key":"641_CR35","unstructured":"Huang, X. Extract of Averrhoa carambola L. (Oxalidaceae) roots ameliorates CCl\u2084-induced acute liver injury in mice and hepatic fibrosis in rats. (Guangxi Medical University, 2019)."},{"key":"641_CR36","first-page":"333","volume":"25","author":"HY Li","year":"2024","unstructured":"Li, H. Y., Zeng, P. Y. & Han, J. N. Protective effect of Coreopsis tinctoria extract on acute liver injury of mice induced by carbon tetrachloride. J. Beihua Univ. (Nat. Sci.) 25, 333\u2013338 (2024).","journal-title":"J. Beihua Univ. (Nat. Sci.)"},{"key":"641_CR37","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1631\/jzus.B2200612","volume":"24","author":"X Zhang","year":"2023","unstructured":"Zhang, X. et al. Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2\/HO-1 pathway and inhibiting inflammation by regulating the AKT, p38 MAPK\/NF-\u03baB pathways. J. Zhejiang Univ. Sci. B 24, 617\u2013631 (2023).","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"641_CR38","doi-asserted-by":"publisher","first-page":"13565","DOI":"10.1074\/jbc.M708916200","volume":"283","author":"N Hanawa","year":"2008","unstructured":"Hanawa, N. et al. Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J. Biol. Chem. 283, 13565\u201313577 (2008).","journal-title":"J. Biol. Chem."},{"key":"641_CR39","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3390\/nu12061742","volume":"12","author":"CY Huang","year":"2020","unstructured":"Huang, C. Y., Deng, J. S., Huang, W. C., Jiang, W. P. & Huang, G. J. Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the TLR4\/PI3K\/Akt\/mTOR and Keap1\/Nrf2\/HO-1 pathways, and suppressing oxidative stress-mediated ER stress-induced apoptosis and autophagy. Nutrients 12, 1742 (2020).","journal-title":"Nutrients"},{"key":"641_CR40","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1186\/s12906-023-04081-x","volume":"23","author":"X Mi","year":"2023","unstructured":"Mi, X. et al. Cardioprotective effects of Schisantherin A against isoproterenol-induced acute myocardial infarction through amelioration of oxidative stress and inflammation via modulation of PI3K-AKT\/Nrf2\/ARE and TLR4\/MAPK\/NF-\u03baB pathways in rats. BMC Complement. Med. Ther. 23, 277 (2023).","journal-title":"BMC Complement. Med. Ther."},{"key":"641_CR41","doi-asserted-by":"publisher","first-page":"4581","DOI":"10.1021\/acs.jafc.8b00493","volume":"66","author":"QB Han","year":"2018","unstructured":"Han, Q. B. Critical problems stalling progress in natural bioactive polysaccharide research and development. J. Agric. Food Chem. 66, 4581\u20134583 (2018).","journal-title":"J. Agric. Food Chem."},{"key":"641_CR42","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1016\/j.intimp.2004.05.013","volume":"4","author":"PJ Rice","year":"2004","unstructured":"Rice, P. J. et al. Pharmacokinetics of fungal (1-3)-\u03b2-D-glucans following intravenous administration in rats. Int. Immunopharmacol. 4, 1209\u20131215 (2004).","journal-title":"Int. Immunopharmacol."},{"key":"641_CR43","first-page":"230","volume":"26","author":"X Xu","year":"2021","unstructured":"Xu, X. et al. Research progress on pharmacokinetics of polysaccharides. Chin. J. Clin. Pharmacol. Ther. 26, 230\u2013235 (2021).","journal-title":"Chin. J. Clin. Pharmacol. Ther."},{"key":"641_CR44","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ijbiomac.2010.02.006","volume":"46","author":"W Liu","year":"2010","unstructured":"Liu, W., Wang, H., Pang, X., Yao, W. & Gao, X. Characterization and antioxidant activity of two low-molecular-weight polysaccharides purified from the fruiting bodies of Ganoderma lucidum. Int. J. Biol. Macromol. 46, 451\u2013457 (2010).","journal-title":"Int. J. Biol. Macromol."},{"key":"641_CR45","doi-asserted-by":"publisher","unstructured":"Irvine, G. B. Determination of molecular size by size-exclusion chromatography (gel filtration). Curr. Protoc. Cell Biol. Chapter 5, Unit 5.5 https:\/\/doi.org\/10.1002\/0471143030.cb0505s06 (2001).","DOI":"10.1002\/0471143030.cb0505s06"},{"key":"641_CR46","first-page":"188","volume":"44","author":"Y Liu","year":"2023","unstructured":"Liu, Y. et al. Extraction process optimization and antioxidant activity evaluation of crude polysaccharides from Lonicera japonica. Food Ind. Sci. Technol. 44, 188\u2013196 (2023).","journal-title":"Food Ind. Sci. Technol."},{"key":"641_CR47","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1016\/j.ijbiomac.2019.11.183","volume":"156","author":"Z Chen","year":"2020","unstructured":"Chen, Z. et al. Characterization of physicochemical and biological properties of Schizophyllum commune polysaccharide extracted with different methods. Int. J. Biol. Macromol. 156, 1425\u20131434 (2020).","journal-title":"Int. J. Biol. Macromol."},{"key":"641_CR48","first-page":"915","volume":"35","author":"RJ Du","year":"2023","unstructured":"Du, R. J., Shi, Z. H., Zhan, Z. L., Hu, J. J. & Zheng, G. H. Optimization of the extraction process of total phenolic acid from Trollii Flos by response surface methodology and study on its whitening activity. Nat. Prod. Res. Dev. 35, 915\u2013924 (2023).","journal-title":"Nat. Prod. Res. Dev."},{"key":"641_CR49","first-page":"92","volume":"37","author":"FP Zhang","year":"2021","unstructured":"Zhang, F. P. et al. Study on antioxidant and liver protection of polysaccharide from Lyophyllum decastes. Biotechnol. Bull. 37, 92\u2013100 (2021).","journal-title":"Biotechnol. Bull."},{"key":"641_CR50","first-page":"25","volume":"53","author":"J Wang","year":"2025","unstructured":"Wang, J. et al. Protective effects of extract of Atractylodes japonica Koidz. ex Kitam on carbon tetrachloride-induced acute liver injury in mice. Acta Chin. Med. Pharmacol. 53, 25\u201329 (2025).","journal-title":"Acta Chin. Med. Pharmacol."},{"key":"641_CR51","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-1136-2","volume":"9","author":"C Dai","year":"2018","unstructured":"Dai, C. et al. Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis. Cell Death Dis. 9, 1164 (2018).","journal-title":"Cell Death Dis."},{"key":"641_CR52","first-page":"1592","volume":"44","author":"W Tan","year":"2024","unstructured":"Tan, W. et al. Effects of astragaloside \u2163 on oxidative damage of vascular endothelial cells by regulating Nrf2\/HO-1 signaling pathway. J. Hunan Univ. Chin. Med. 44, 1592\u20131600 (2024).","journal-title":"J. Hunan Univ. Chin. Med."}],"container-title":["npj Science of Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41538-025-00641-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41538-025-00641-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41538-025-00641-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:09:29Z","timestamp":1772446169000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41538-025-00641-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,12]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["641"],"URL":"https:\/\/doi.org\/10.1038\/s41538-025-00641-2","relation":{},"ISSN":["2396-8370"],"issn-type":[{"value":"2396-8370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,12]]},"assertion":[{"value":"23 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"278"}}