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Thus, the current study investigates the impact of bacterial biopriming (\n                    <jats:italic>B. pomilus<\/jats:italic>\n                    and\n                    <jats:italic>E. hormaechei)<\/jats:italic>\n                    followed by germination on reshaping the chemical and biological attributes of lentil seeds using UPLC-MS metabolomics and chemometrics approaches. Sixty-nine metabolites spanning amino acids, phenolic acids, flavonoids, proanthocyanidins, gibberellins, and fatty acids were annotated. OPLS\u2013DA analysis exhibited an obvious separation pattern among the samples reflecting their chemical heterogeneity, where the compounds mainly gallocatechin, phloretin, \u03b1-tocotrienol, and eicosapentanoic acid were significantly augmented in sprouted (unprimed) samples, while the sprouted samples bioprimed with\n                    <jats:italic>B. pomilus<\/jats:italic>\n                    witnessed a striking accumulation of carboxyvanillic acid, resveratrol, isorhamnetin, gibberellic acid, and gibberellin A4. Further,\n                    <jats:italic>E. hormaechei<\/jats:italic>\n                    biopriming significantly fortified rosmarinic acid, syringic acid, quercetin, apigenin, and linolenic acid. Functionally, bioprimed sprouts displayed superior\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -amylase and\n                    <jats:italic>\u03b1<\/jats:italic>\n                    -glucosidase inhibition and enhanced glucose uptake relative to raw and unprimed germinated seeds, aligning with higher levels of sinapic acid, apigenin, isorhamnetin, and linolenic acid. These findings position microbe-assisted germination as a sustainable strategy to fortify the functional attributes of lentil seeds for nutraceutical applications.\n                  <\/jats:p>","DOI":"10.1038\/s41538-026-00824-5","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T15:54:55Z","timestamp":1776095695000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbial biopriming and germination cooperatively remodel brown lentil seeds (Lens culinaris L.) metabolome and antidiabetic functionality"],"prefix":"10.1038","volume":"10","author":[{"given":"Dina S.","family":"Ghallab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa A.","family":"Ghareeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab E.","family":"Shawer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal A.","family":"Othman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam M.","family":"Elattar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"824_CR1","doi-asserted-by":"publisher","first-page":"2196","DOI":"10.9734\/jpri\/2021\/v33i60B34864","volume":"33","author":"N Sharma","year":"2021","unstructured":"Sharma, N. & Bora, K. 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