{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:49:42Z","timestamp":1792784982716,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":108,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation of China","award":["32330110"],"award-info":[{"award-number":["32330110"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Sci Food"],"DOI":"10.1038\/s41538-026-00958-6","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T02:47:08Z","timestamp":1782182828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synergistic genomic design and thermal processing mitigate anti-nutritional constraints to enhance the nutritional efficacy of diploid potatoes"],"prefix":"10.1038","volume":"10","author":[{"given":"Zhe","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianwen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerou","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna Ottaviani","family":"Aalmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"958_CR1","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1007\/s10620-017-4620-0","volume":"62","author":"L Tasson","year":"2017","unstructured":"Tasson, L., Canova, C., Vettorato, M. G., Savarino, E. & Zanotti, R. Influence of diet on the course of inflammatory bowel disease. Digest. Dis. Sci. 62, 2087\u20132094 (2017).","journal-title":"Digest. Dis. Sci."},{"key":"958_CR2","unstructured":"Food and Agriculture Organization of the United Nations. The State of World Fisheries and Aquaculture 2020: Sustainability in Action (FAO, 2020)."},{"key":"958_CR3","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1016\/j.tjnut.2024.08.017","volume":"154","author":"AM Amr","year":"2024","unstructured":"Amr, A. M., Anderson, G. H., Vien, S. & Fabek, H. Potatoes compared with rice in meals with either animal or plant protein reduce postprandial glycemia and increase satiety in healthy adults: a randomized crossover study. J. Nutr. 154, 2999\u20133011 (2024).","journal-title":"J. Nutr."},{"key":"958_CR4","first-page":"169","volume":"41","author":"SH Jansky","year":"2018","unstructured":"Jansky, S. H. & Spooner, D. M. The evolution of potato breeding. Plant Breed. Rev. 41, 169\u2013214 (2018).","journal-title":"Plant Breed. Rev."},{"key":"958_CR5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.aquaculture.2013.08.027","volume":"416\u2013417","author":"P G\u00f3mez-Requeni","year":"2013","unstructured":"G\u00f3mez-Requeni, P., Mingarro, M., Calduch-Giner, J. A., M\u00e9dale, F. & P\u00e9rez-S\u00e1nchez, J. Effects of increasing the dietary lipid levels on the growth performance, body composition and digestive enzyme activities of the teleost pejerrey (Odontesthes bonariensis). Aquaculture 416\u2013417, 15\u201322 (2013).","journal-title":"Aquaculture"},{"key":"958_CR6","unstructured":"Cal\u0131skan, M. E., Bakhsh, A., & Jabran, K. Potato production worldwide. In Potato Biology and Biotechnology 1\u201325 (Academic Press, 2022)."},{"key":"958_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s12230-010-9174-z","volume":"88","author":"C Li","year":"2011","unstructured":"Li, C., Wang, X., Zhang, Y., Chen, Q. & Liu, J. Cooperation-88: a high yielding, multi-purpose, late blight resistant cultivar growing in Southwest China. Am. J. Potato Res. 88, 190\u2013194 (2011).","journal-title":"Am. J. Potato Res."},{"key":"958_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/s41586-022-04822-x","volume":"606","author":"D Tang","year":"2022","unstructured":"Tang, D. et al. Genome evolution and diversity of wild and cultivated potatoes. Nature 606, 535\u2013541 (2022).","journal-title":"Nature"},{"key":"958_CR9","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1038\/s41588-020-0699-x","volume":"52","author":"Q Zhou","year":"2020","unstructured":"Zhou, Q. et al. Haplotype-resolved genome analyses of a heterozygous diploid potato. Nat. Genet. 52, 1018\u20131023 (2020).","journal-title":"Nat. Genet."},{"key":"958_CR10","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.1016\/j.cell.2022.04.036","volume":"185","author":"X Huang","year":"2022","unstructured":"Huang, X., Huang, S., Han, B. & Li, J. The integrated genomics of crop domestication and breeding. Cell 185, 2828\u20132839 (2022).","journal-title":"Cell"},{"key":"958_CR11","doi-asserted-by":"publisher","first-page":"8655","DOI":"10.1021\/jf061471t","volume":"54","author":"M Friedman","year":"2006","unstructured":"Friedman, M. Potato glycoalkaloids and metabolites: roles in the plant and in the diet. J. Agric Food Chem. 54, 8655\u20138681 (2006).","journal-title":"J. Agric Food Chem."},{"key":"958_CR12","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/j.1365-2109.2009.02426.x","volume":"41","author":"\u00c5 Krogdahl","year":"2010","unstructured":"Krogdahl, \u00c5, Penn, M., Thorsen, J., Refstie, S. & Bakke, A. M. Important antinutrients in plant feedstuffs for aquaculture: an update on recent findings regarding responses in salmonids. Aquac. Res. 41, 333\u2013344 (2010).","journal-title":"Aquac. Res."},{"key":"958_CR13","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","volume":"168","author":"RA Saxton","year":"2017","unstructured":"Saxton, R. A. & Sabatini, D. M. mTOR signaling in growth, metabolism, and disease. Cell 168, 960\u2013976 (2017).","journal-title":"Cell"},{"key":"958_CR14","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/nrg2091","volume":"8","author":"GJ Lieschke","year":"2007","unstructured":"Lieschke, G. J. & Currie, P. D. Animal models of human disease: zebrafish swim into view. Nat. Rev. Genet 8, 353\u2013367 (2007).","journal-title":"Nat. Rev. Genet"},{"key":"958_CR15","first-page":"313","volume":"53","author":"X Ma","year":"2013","unstructured":"Ma, X. Systems pharmacology: bridging systems biology and pharmacokinetics\/pharmacodynamics (PK\/PD) for personalized medicine. Annu Rev. Pharm. Toxicol. 53, 313\u2013339 (2013).","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"958_CR16","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0140-6736(18)31788-4","volume":"393","author":"W Willett","year":"2019","unstructured":"Willett, W. et al. Food in the anthropocene: the EAT\u2013Lancet Commission on healthy diets from sustainable food systems. Lancet 393, 447\u2013492 (2019).","journal-title":"Lancet"},{"key":"958_CR17","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","volume":"15","author":"A Tripathi","year":"2018","unstructured":"Tripathi, A. et al. The gut\u2013liver axis and the intersection with the microbiome. Nat. Rev. Gastroenterol. Hepatol. 15, 397\u2013411 (2018).","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"958_CR18","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","volume":"454","author":"R Medzhitov","year":"2008","unstructured":"Medzhitov, R. Origin and physiological roles of inflammation. Nature 454, 428\u2013435 (2008).","journal-title":"Nature"},{"key":"958_CR19","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1038\/nri3901","volume":"15","author":"T Weichhart","year":"2015","unstructured":"Weichhart, T., Hengstschl\u00e4ger, M. & Linke, M. Regulation of innate immune cell function by mTOR. Nat. Rev. Immunol. 15, 589\u2013602 (2015).","journal-title":"Nat. Rev. Immunol."},{"key":"958_CR20","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/nature12820","volume":"505","author":"LA David","year":"2014","unstructured":"David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559\u2013563 (2014).","journal-title":"Nature"},{"key":"958_CR21","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1038\/ismej.2011.38","volume":"5","author":"G Roeselers","year":"2011","unstructured":"Roeselers, G. et al. Evidence for a core gut microbiota in the zebrafish. ISME J. 5, 1595\u20131608 (2011).","journal-title":"ISME J."},{"key":"958_CR22","doi-asserted-by":"publisher","first-page":"4596","DOI":"10.1073\/pnas.0400706101","volume":"101","author":"JF Rawls","year":"2004","unstructured":"Rawls, J. F., Samuel, B. S. & Gordon, J. I. Gnotobiotic zebrafish reveal evolutionarily conserved responses to the gut microbiota. Proc. Natl. Acad. Sci. USA. 101, 4596\u20134601 (2004).","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"958_CR23","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.cell.2017.01.022","volume":"168","author":"N Geva-Zatorsky","year":"2017","unstructured":"Geva-Zatorsky, N. et al. Mining the human gut microbiota for immunomodulatory organisms. Cell 168, 414\u2013427.e11 (2017).","journal-title":"Cell"},{"key":"958_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.cell.2012.10.052","volume":"152","author":"CF Maurice","year":"2013","unstructured":"Maurice, C. F., Haiser, H. J. & Turnbaugh, P. J. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152, 39\u201350 (2013).","journal-title":"Cell"},{"key":"958_CR25","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0144-8617(00)00260-5","volume":"45","author":"RJ Hoover","year":"2001","unstructured":"Hoover, R. J. Modification of starch structure and properties through irradiation: effects on crystallinity and pasting properties. Carbohydr. Polym. 45, 329\u2013336 (2001).","journal-title":"Carbohydr. Polym."},{"key":"958_CR26","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3945\/an.113.004325","volume":"4","author":"DF Birt","year":"2013","unstructured":"Birt, D. F. et al. Resistant starch: promise for improving human health. Adv. Nutr. 4, 587\u2013601 (2013).","journal-title":"Adv. Nutr."},{"key":"958_CR27","doi-asserted-by":"publisher","first-page":"S315","DOI":"10.1017\/S0007114512002371","volume":"108","author":"GS Gilani","year":"2012","unstructured":"Gilani, G. S., Xiao, C. W. & Cockell, K. A. Impact of antinutritional factors in food proteins on the digestibility of protein and the bioavailability of amino acids and on protein quality. Br. J. Nutr. 108, S315\u2013S332 (2012).","journal-title":"Br. J. Nutr."},{"key":"958_CR28","doi-asserted-by":"crossref","first-page":"6857","DOI":"10.1021\/jf200439q","volume":"59","author":"JA Milner","year":"2011","unstructured":"Milner, J. A., Davis, C. D. & Ross, S. A. Nutrigenomics and personalized diets: from single nucleotide polymorphisms to metabolomics. J. Agric Food Chem. 59, 6857\u20136864 (2011).","journal-title":"J. Agric Food Chem."},{"key":"958_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116925","volume":"279","author":"P-P Jia","year":"2021","unstructured":"Jia, P.-P. et al. Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: a special reference to zebrafish. Environ. Pollut. 279, 116925 (2021).","journal-title":"Environ. Pollut."},{"key":"958_CR30","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.cell.2012.03.017","volume":"149","author":"M Laplante","year":"2012","unstructured":"Laplante, M. & Sabatini, D. M. mTOR signaling in growth control and disease. Cell 149, 274\u2013293 (2012).","journal-title":"Cell"},{"key":"958_CR31","volume":"568","author":"Y Wang","year":"2023","unstructured":"Wang, Y. et al. Enzymatically treated Artemisia annua L. improved growth performance, intestinal antioxidant capacity and apical junctional complex in adult grass carp (Ctenopharyngodon idella). Aquaculture 568, 739402 (2023).","journal-title":"Aquaculture"},{"key":"958_CR32","first-page":"325","volume":"16","author":"MAB Siddik","year":"2024","unstructured":"Siddik, M. A. B., Fotedar, R., Howieson, J., Foysal, M. J. & Chaklader, M. R. Transformation of fish waste protein to Hermetia illucens protein improves the efficacy of poultry by-products in the culture of juvenile barramundi, Lates calcarifer. Rev. Aquac. 16, 325\u2013342 (2024).","journal-title":"Rev. Aquac."},{"key":"958_CR33","doi-asserted-by":"publisher","first-page":"3071","DOI":"10.1016\/j.cell.2025.06.034","volume":"188","author":"Z Zhang","year":"2025","unstructured":"Zhang, Z. et al. Ancient hybridization underlies tuberization and radiation of the potato lineage. Cell 188, 3071\u20133085 (2025).","journal-title":"Cell"},{"key":"958_CR34","first-page":"428","volume":"631","author":"L Cheng","year":"2025","unstructured":"Cheng, L. et al. Leveraging a phased pangenome for haplotype design of hybrid potato. Nature 631, 428\u2013435 (2025).","journal-title":"Nature"},{"key":"958_CR35","first-page":"859","volume":"14","author":"I Guerreiro","year":"2022","unstructured":"Guerreiro, I., Pous\u00e3o-Ferreira, P. & Oliva-Teles, A. Microalgae as a sustainable source of nutrients and bioactive compounds for aquaculture feeds: a review. Rev. Aquac. 14, 859\u2013883 (2022).","journal-title":"Rev. Aquac."},{"key":"958_CR36","first-page":"375","volume":"198","author":"DS Francis","year":"2001","unstructured":"Francis, D. S., Higgs, D. A., Markert, J. R. & Dosanjh, B. S. Effects of dietary vitamin C and E on growth, survival, immune response and disease resistance of juvenile coho salmon (Oncorhynchus kisutch) fed oxidized oil. Aquaculture 198, 375\u2013391 (2001).","journal-title":"Aquaculture"},{"key":"958_CR37","first-page":"153","volume":"18","author":"J Parada","year":"2007","unstructured":"Parada, J. & Aguilera, J. M. Food microstructure affects the bioavailability of several nutrients. Trends Food Sci. Technol. 18, 153\u2013160 (2007).","journal-title":"Trends Food Sci. Technol."},{"key":"958_CR38","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3390\/antiox8030068","volume":"8","author":"J-P Jacquot","year":"2019","unstructured":"Jacquot, J.-P. & Zaffagnini, M. Thioredoxin and glutaredoxin systems. Antioxidants 8, 68 (2019).","journal-title":"Antioxidants"},{"key":"958_CR39","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrg2291","volume":"9","author":"MP Mattson","year":"2008","unstructured":"Mattson, M. P. Hormesis and disease resistance: activation of cellular stress response pathways. Nat. Rev. Neurosci. 9, 192\u2013203 (2008).","journal-title":"Nat. Rev. Neurosci."},{"key":"958_CR40","first-page":"1","volume":"44","author":"H Sies","year":"2017","unstructured":"Sies, H., Jones, D. P., Menger, M., Klotz, L. O. & Brigelius-Floh\u00e9, R. Redox biology: from redox regulation to clinical application. J. Nutrition. Biochem. 44, 1\u201310 (2017).","journal-title":"J. Nutrition. Biochem."},{"key":"958_CR41","first-page":"893","volume":"64","author":"DF Holihan","year":"1991","unstructured":"Holihan, D. F. Protein synthesis in fish: maximal rates of protein synthesis and their relationship to maintenance metabolism. Physiol. Zool. 64, 893\u2013906 (1991).","journal-title":"Physiol. Zool."},{"key":"958_CR42","first-page":"211","volume":"155","author":"LEC Concei\u00e7\u00e3o","year":"1997","unstructured":"Concei\u00e7\u00e3o, L. E. C. et al. Amino acid metabolism and protein turnover in larval turbot (Scophthalmus maximus) fed natural zooplankton or Artemia. Aquaculture 155, 211\u2013219 (1997).","journal-title":"Aquaculture"},{"key":"958_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2024.114226","volume":"183","author":"F Ge","year":"2024","unstructured":"Ge, F. et al. Exploring the relationship between starch structure and physicochemical properties: the impact of extrusion on highland barley flour. Food Res. Int. 183, 114226 (2024).","journal-title":"Food Res. Int."},{"key":"958_CR44","doi-asserted-by":"crossref","unstructured":"Mario Hirth, Rebecca Prei\u00df, Esther Mayer-Miebach & Heike P. Schuchmann Influence of HTST extrusion cooking process parameters on the stability of anthocyanins, procyanidins and hydroxycinnamic acids as the main bioactive chokeberry polyphenols. LWT Food Sci. Technol. 62, 511\u2013516 (2015).","DOI":"10.1016\/j.lwt.2014.08.032"},{"key":"958_CR45","doi-asserted-by":"crossref","unstructured":"Marla Silvia Diamante, Cristine Vanz Borges, Igor Otavio Minatel, Angelo Pedro Jacomino, Leticia Silva Pereira Bas\u00edlio, Gean Charles Monteiro & Giuseppina Pace Pereira Lima Domestic cooking practices influence the carotenoid and tocopherol content in colored cauliflower. Food Chem. 340, 127901 (2021).","DOI":"10.1016\/j.foodchem.2020.127901"},{"key":"958_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2023.108681","volume":"135","author":"Z Yu","year":"2023","unstructured":"Yu, Z. et al. The positive effects of postbiotic (SWF concentration\u00ae) supplemented diet on skin mucus, liver, gut health, the structure and function of gut microbiota of common carp (Cyprinus carpio) fed with high-fat diet. Fish. Shellfish Immunol. 135, 108681 (2023).","journal-title":"Fish. Shellfish Immunol."},{"key":"958_CR47","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.foodchem.2011.10.015","volume":"133","author":"A Tajner-Czopek","year":"2012","unstructured":"Tajner-Czopek, A., Rytel, E., Kita, A., P\u0119ksa, A. & Hamouz, K. The influence of thermal process of coloured potatoes on the content of glycoalkaloids in the potato products. Food Chem. 133, 983\u2013988 (2012).","journal-title":"Food Chem."},{"key":"958_CR48","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1006\/jfca.1999.0823","volume":"12","author":"MC M\u00e1rquez","year":"1999","unstructured":"M\u00e1rquez, M. C. & Alonso, R. Inactivation of trypsin inhibitor in chickpea. J. Food Comp. Anal. 12, 211\u2013217 (1999).","journal-title":"J. Food Comp. Anal."},{"key":"958_CR49","doi-asserted-by":"crossref","unstructured":"Yu, Z., Zhang, Z., Teame, T., Leluo Guan, Ruiguo Wang, Ronghua Zhu & Zhigang Zhou Yeast cell wall extract as a strategy to mitigate the effects of aflatoxin B1 and deoxynivalenol on liver and intestinal health, and gut microbiota of largemouth bass (Micropterus salmoides). Aquaculture 597, 741917(2025).","DOI":"10.1016\/j.aquaculture.2024.741917"},{"key":"958_CR50","doi-asserted-by":"publisher","first-page":"570344","DOI":"10.3389\/fnut.2020.570344","volume":"7","author":"T Teame","year":"2020","unstructured":"Teame, T. et al. Paraprobiotics and postbiotics of probiotic lactobacilli, their positive effects on the host and action mechanisms: a review. Front Nutr. 7, 570344 (2020).","journal-title":"Front Nutr."}],"container-title":["npj Science of Food"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41538-026-00958-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41538-026-00958-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41538-026-00958-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:56:39Z","timestamp":1791500199000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41538-026-00958-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["958"],"URL":"https:\/\/doi.org\/10.1038\/s41538-026-00958-6","relation":{},"ISSN":["2396-8370"],"issn-type":[{"value":"2396-8370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"10 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Ethics"}}],"article-number":"311"}}