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To advance mechanistic understanding and support therapeutic discovery, we developed a comprehensive Molecular Interaction Map (MIM). Differential expression analyses were conducted on peripheral blood samples from SjD patients and healthy controls across three datasets (GSE51092, UKPSSR, PRECISESADS), identifying 1,625 differentially expressed genes (DEGs), of which 25 were shared across all datasets. Nine common DEGs were linked to interferon signalling, reinforcing its pivotal role in SjD pathogenesis. Pathway enrichment analysis revealed 137 pathways, 43 of which were integrated into the MIM alongside literature-derived knowledge. The resulting SjD Map, freely available at\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/sjdmap.elixir-luxembourg.org\/\" ext-link-type=\"uri\">https:\/\/sjdmap.elixir-luxembourg.org\/<\/jats:ext-link>\n                    , encompasses 829 molecular entities connected by 598 interactions by transcriptomic data and by curated evidence. This first comprehensive SjD Map provides an integrative framework for visualising pathways, overlaying omics data, and exploring therapeutic opportunities.\n                  <\/jats:p>","DOI":"10.1038\/s41540-026-00670-x","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T10:14:31Z","timestamp":1774692871000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The SjD Map: an interactive pathway tour into Sj\u00f6gren\u2019s disease signalling mechanisms"],"prefix":"10.1038","volume":"12","author":[{"given":"Sacha","family":"E Silva-Saffar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Mariette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques-Eric","family":"Gottenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bombardieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divi","family":"Cornec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta E.","family":"Alarcon-Riquelme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the PRECISEADS consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Fai","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetane","family":"Nocturne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Niarakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,28]]},"reference":[{"key":"670_CR1","doi-asserted-by":"publisher","first-page":"e002955","DOI":"10.1136\/rmdopen-2022-002955","volume":"9","author":"M Beydon","year":"2023","unstructured":"Beydon, M. et al. 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Behring, and AstraZeneca; M.E.A.-R. : None; M.R.B.: None; S.N.: None; W.-F.N. received royalties from Oxford University Press for a book on Sjogren\u2019s syndrome he has edited, provided consultations for Asahi Kasei Pharma, Amgen, Argenx, B.M.S, E.Q.T., IQVIA, Johnsons & Johnsons Innovations, Novartis, Quotients, Resolves Therapeutics, Sanofi & Veloxis; G.N. received honoraria from Biogen, Pfizer, AbbVie, Novartis, Lilly, and Amgen; A.N.: has received funding from Sanofi R&D and consulting fees from L\u2019Or\u00e9al R&I.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"78"}}