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However, the mechanisms of LPCs regeneration are unclear. Here, we utilised rat liver stem-like epithelial cells (WB-F344) in a wound-healing assay. The scratched near-confluent monolayer (70% area removed) underwent G1-arrest, transient bi-nucleation at 10\u201312\u2009h post-injury, the epithelial-mesenchymal transition, and motion of cell fraction into the wounded areas. The transient displacement of the nuclear NANOG with upregulated p16\n                    <jats:sup>Ink4a<\/jats:sup>\n                    , loss of epithelial albumin and CK7 markers, along with transient YAP1\/Hippo and TWIST 1 activation, was seen near the wound edge. At 24\u2009h, G1-arrest was overcome, followed by a proliferation boost. At 40\u201348\u2009h, proliferation was accomplished by reconstitution of epithelial tissue, NANOG was restored in the cell nucleus, and p16\n                    <jats:sup>Ink4a<\/jats:sup>\n                    left it. Thus, wound healing was performed by concerted, molecular and cellular, bistable circuits.\n                  <\/jats:p>","DOI":"10.1038\/s41540-026-00724-0","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T06:26:58Z","timestamp":1777098418000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liver progenitor cells perform wound healing in a scratch assay by concerted bistable circuits"],"prefix":"10.1038","volume":"12","author":[{"given":"Marija","family":"Lazovska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Salmina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dace","family":"Pjanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Zayakin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan I.","family":"Gerashchenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jekaterina","family":"Erenpreisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"724_CR1","first-page":"186","volume":"12","author":"G Higgins","year":"1931","unstructured":"Higgins, G. & Anderson, G. \u201cExperimental pathology of the liver restoration of the liver of the white rat following partial surgical removal\u201d. 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