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The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was previously shown to be protective in non-pregnant mice and rhesus macaques. In this study, we further examined the efficacy of ZPIV against ZIKV infection during pregnancy in immunocompetent C57BL6 mice and common marmoset monkeys (<jats:italic>Callithrix jacchus<\/jats:italic>). We showed that, in C57BL\/6 mice, ZPIV significantly reduced ZIKV-induced fetal malformations. Protection of fetuses was positively correlated with virus-neutralizing antibody levels. In marmosets, the vaccine prevented vertical transmission of ZIKV and elicited neutralizing antibodies that remained above a previously determined threshold of protection for up to 18\u2009months. These proof-of-concept studies demonstrate ZPIV\u2019s protective efficacy is both potent and durable and has the potential to prevent the harmful consequence of ZIKV infection during pregnancy.<\/jats:p>","DOI":"10.1038\/s41541-021-00426-0","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T11:03:15Z","timestamp":1643281395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets"],"prefix":"10.1038","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0408-9589","authenticated-orcid":false,"given":"In-Jeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2958-5973","authenticated-orcid":false,"given":"Paula 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