{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:44:44Z","timestamp":1761767084962,"version":"3.37.3"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T00:00:00Z","timestamp":1656460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["npj Vaccines"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Since January 2018, mandatory vaccination against meningococci serogroup C has been implemented in France for children &lt;2 years with a recommended catch-up vaccination until the age of 24 years. We aimed to analyse the impact of mandatory vaccination on populations not targeted by it (2\u201324 years old). We used the database of the national reference centre for meningococci to collect the number of invasive meningococcal disease (IMD) cases before (2016\u20132017) and after (2018\u20132019) the mandatory vaccination. The cultured isolates were sequenced and submitted for genomic comparison. The total number of cases was 1706, including 376 cases of IMD serogroup C. Mandatory vaccination correlated with a significant decrease among the &lt;2 years old and a decreasing trend among the 2\u201314 years old group but not among 15\u201325 years of age. This observation may be explained by the vaccine coverage that is still low among adolescents and young adults. Moreover, the genomic analysis revealed the co-circulation of two major genotypes belonging to the clonal complex ST-11 whose distribution differed across the age groups in accord with cyclic variations of genotypes. It is important to increase specific knowledge on meningococcal epidemiology and vaccination to involve them in establishing the vaccination strategy.<\/jats:p>","DOI":"10.1038\/s41541-022-00488-8","type":"journal-article","created":{"date-parts":[[2022,6,29]],"date-time":"2022-06-29T12:03:11Z","timestamp":1656504191000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impact of mandatory vaccination against serogroup C meningococci in targeted and non-targeted populations in France"],"prefix":"10.1038","volume":"7","author":[{"given":"Samy","family":"Taha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhamed-Kheir","family":"Taha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2887-1732","authenticated-orcid":false,"given":"Ala-Eddine","family":"Deghmane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,29]]},"reference":[{"key":"488_CR1","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1099\/jmm.0.45529-0","volume":"53","author":"SP Yazdankhah","year":"2004","unstructured":"Yazdankhah, S. P. & Caugant, D. A. Neisseria meningitidis: an overview of the carriage state. J. Med Microbiol. 53, 821\u2013832 (2004).","journal-title":"J. Med Microbiol."},{"key":"488_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1080\/14760584.2019.1557520","volume":"18","author":"R Acevedo","year":"2019","unstructured":"Acevedo, R. et al. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations. Expert Rev. Vaccines 18, 15\u201330 (2019).","journal-title":"Expert Rev. Vaccines"},{"key":"488_CR3","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","volume":"95","author":"MC Maiden","year":"1998","unstructured":"Maiden, M. C. et al. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc. Natl Acad. Sci. 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Meningococcal vaccines: WHO position paper, November 2011. Wkly Epidemiol. Rec. 86, 521\u2013539 (2011).","journal-title":"Wkly Epidemiol. Rec."},{"key":"488_CR7","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s40121-021-00468-w","volume":"10","author":"C Weil-Olivier","year":"2021","unstructured":"Weil-Olivier, C. et al. Healthcare resource consumption and cost of invasive meningococcal disease in france: a study of the national health insurance database. Infect. Dis. Ther. 10, 1607\u20131623 (2021).","journal-title":"Infect. Dis. Ther."},{"key":"488_CR8","doi-asserted-by":"publisher","unstructured":"Parikh, S. R. et al. Meningococcal B vaccine failure with a penicillin-resistant strain in a young adult on long-term eculizumab. 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M.T.K. and A.E.D. reported a patent 630133 issued. S.T. has no conflict to declare.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The study was conducted in accordance with the Helsinki Declaration of 1964, and its later amendments, as well as with relevant international and French regulatory requirements. Patient data in the database is anonymized using irreversible double encryption. Data and isolates collection was conducted as part of the mission of the NRCMHi in the national surveillance approved by the Ministry of Health. The procedure for collecting samples and information was submitted and approved by the CNIL N\u00b01475242\/2011 (<i>Commission Nationale de l\u2019Informatique et des Libert\u00e9s<\/i>).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}],"article-number":"73"}}